• Vaccine Name: rVCG- MOMP/HSV-2-gD
• Target Pathogen: Chlamydia trachomatis
• Target Disease: Chlamydia
• Vaccine Ontology ID: VO_0004722
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• Vector:
  • Vector name:
  • VO vector ID: VO_0001044
• Preparation: A bivalent combination vaccine formulation comprising rVCG expressing chlamydial MOMP and HSV-2 glycoprotein D (Macmillan et al., 2007).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: Mice were immunized with the combination vaccine that elicited secretory IgA and IgG2a antibodies to both chlamydial and HSV-2 antigens in serum and vaginal secretions (Macmillan et al., 2007).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: Immunized mice then experienced a genital challenge with high doses of live Chlamydia and HSV-2 (Macmillan et al., 2007).
• Efficacy: Mice immunized with the combination vaccine were prophylactically protected (Macmillan et al., 2007).