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Vaccine Detail

ALVAC-RV
Vaccine Information
  • Vaccine Name: ALVAC-RV
  • Target Pathogen: Rabies virus
  • Target Disease: Rabies
  • Vaccine Ontology ID: VO_0004728
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Vector: ALVAC vaccine vector
  • Preparation: A non-adjuvanted feline rabies vaccine developed using the canarypoxvirus vector (Jas et al., 2012).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Cat Response

  • Vaccination Protocol: Seronegative cats were vaccinated at 12 weeks of age and received a booster vaccination one year later (Jas et al., 2012).
  • Vaccine Immune Response Type: VO_0000287
  • Challenge Protocol: The cats were challenged by inoculation of 1 mL of rabies virus in the neck muscles (0.5 mL on the left and right side of the spine). The inoculum was a homogenate of salivary glands of foxes and each cat received 107.7 mouse Lethal Dose 50, the equivalent of 106.8 CCID50.
  • Efficacy: This vaccination regimen induced a strong and sustained antibody response, and all vaccinated animals were protected against virulent rabies challenge carried out 3 years after vaccination (Jas et al., 2012).
References
Jas et al., 2012: Jas D, Coupier C, Toulemonde CE, Guigal PM, Poulet H. Three-year duration of immunity in cats vaccinated with a canarypox-vectored recombinant rabies virus vaccine. Vaccine. 2012; 30(49); 6991-6996. [PubMed: 23059358].