• Vaccine Name: ALVAC-NiV-G
• Target Pathogen: Nipah virus
• Target Disease: Nipah virus disease
• Vaccine Ontology ID: VO_0004733
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• F fusion protein gene engineering:
  • Type: Recombinant vector construction
  • Description: Canarypox virus-based vaccine vectors carrying the gene for NiV glycoprotein (ALVAC-G) or the fusion protein (ALVAC-F) (Weingartl et al., 2006).
  • Detailed Gene Information: Click Here.
• G glycoprotein gene engineering:
  • Type: Recombinant protein preparation
  • Description: Canarypox virus-based vaccine vectors carrying the gene for NiV glycoprotein (ALVAC-G) or the fusion protein (ALVAC-F) (Weingartl et al., 2006).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001128
• Preparation: Canarypox virus-based vaccine vectors carrying the gene for NiV glycoprotein (ALVAC-G) (Weingartl et al., 2006).
• Immunization Route: Intramuscular injection (i.m.)

Pig Response

• Vaccination Protocol: Four pigs per group were intramuscularly challenged, with either with 10^8 PFU each or in combination of (ALVAC-NiV-G and ALVAC-NiV-F) (Weingartl et al., 2006).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The pigs were challenged with 2.5 x 10^5 PFU of NiV two weeks later (Weingartl et al., 2006).
• Efficacy: The combined ALVAC-F/G vaccine induced the highest levels of neutralization antibodies (2,560); despite the low neutralizing antibody levels in the F vaccinees (160), all vaccinated animals appeared to be protected against challenge (Weingartl et al., 2006).