• Vaccine Name: rFPV-IBDV-VP 2.4.3
• Target Pathogen: Infectious Bursal Disease Virus (IBDV)
• Target Disease: Infectious Bursal Disease
• Vaccine Ontology ID: VO_0004750
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• VP2-VP4-VP3 gene engineering:
  • Type: Recombinant vector construction
  • Description: Recombinant FPV-VP 2.4.3 contained the gene for the VP 2-VP4-VP3 polyprotein under the control of the vaccinia virus late promoter P.L 11 inserted within the thymidine kinase (TK) gene of FPV (Heine and Boyle, 1993).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001040
• Preparation: Recombinant FPV-VP 2.4.3 contained the gene for the VP 2-VP4-VP3 polyprotein under the control of the vaccinia virus late promoter P.L 11 inserted within the thymidine kinase (TK) gene of FPV (Heine and Boyle, 1993).
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: Vaccination with FPV-VP2 (Heine and Boyle, 1993).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The birds were challenged with IBDV (strain 002-73) (Heine and Boyle, 1993).
• Efficacy: A significant level of protection was provided by FPV-VP2 vaccination, although the level was lower than the protection provided by an oil adjuvanted inactivated whole IBDV vaccine. Birds vaccinated with FPV-VP2.4.3 were not protected from infection as assessed by ELISA for the presence of IBD virus in bursae (Heine and Boyle, 1993).