• Vaccine Name: Ac-CMV-S1 (infectious bronchitis virus)
• Target Pathogen: Infectious Bronchitis Virus (IBV)
• Target Disease: Infectious Bronchitis
• Vaccine Ontology ID: VO_0004753
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• S1 gene engineering:
  • Type: Recombinant vector construction
  • Description: The BacMam virus Ac-CMV-S1, which expressed the S1 glycoprotein of IBV-M41 (Zhang et al., 2014).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001084
• Preparation: BV-Dual-S1 expresses the S1 glycoprotein of IBV-M41 on the baculovirus envelope, and is capable of expressing it in mammalian cells (Zhang et al., 2014).
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: The chickens were immunized with BV-Dual-S1 or an inactivated vaccine (Zhang et al., 2014).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The immunized chickens were challenged with a virulent IBV-M41 (Zhang et al., 2014).
• Efficacy: A significant difference was not observed for protection rates between chickens immunized with BV-Dual-S1 (83%) or inactivated vaccine (89%) following challenge with virulent IBV-M41. Our findings show that the protective efficacy of BV-Dual-S1 could be significantly enhanced by baculovirus display technology (Zhang et al., 2014).