• Vaccine Name: VC-TetC/Tcf
• Target Pathogen: Bordetella pertussis
• Target Disease: Whooping Cough
• Product Name: VC expressing B. pertussis TetC/Tcf
• Vaccine Ontology ID: VO_0004781
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• TcfA gene engineering:
  • Type: Recombinant protein preparation
  • Description: An attenuated strain of Vibrio cholerae was used as a carrier for the expression of heterologous antigens such as fragment C from tetanus toxin (TetC) and tracheal colonization factor from Bordetella pertussis (Tcf) (Chen et al., 1998).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001044
  • Description: (Chen et al., 1998)
• Preparation: An attenuated strain of Vibrio cholerae was used as a carrier for the expression of heterologous antigens such as fragment C from tetanus toxin (TetC) and tracheal colonization factor from Bordetella pertussis (Tcf) (Chen et al., 1998).
• Immunization Route: intranasal immunization

Mouse Response

• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: Mice were challenged with wild-type B. pertussis (Chen et al., 1998).
• Efficacy: Mice vaccinated with IEM101 expressing Tcf experienced significant reduction in bacterial colonization of their tracheas (Chen et al., 1998).