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Vaccine Detail

rCPV-BTV-Cpox
Vaccine Information
  • Vaccine Name: rCPV-BTV-Cpox
  • Target Pathogen: Bluetongue virus
  • Target Disease: Bluetongue disesase
  • Vaccine Ontology ID: VO_0004788
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Vector: capripoxvirus vaccine vector
  • Preparation: BTV recombinant capripoxviruses (BTV-Cpox) individually expressing four different genes encoding two capsid proteins (VP2 and VP7) and two non-structural proteins (NS1, NS3) of BTV serotype 2 (BTV-2) (Perrin et al., 2007).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Sheep Response

  • Vaccination Protocol: Sheep were immunized with BTV recombinant capripoxviruses (BTV-Cpox) (Perrin et al., 2007).
  • Vaccine Immune Response Type: VO_0000287
  • Challenge Protocol: The sheep were challenged with a virulent strain of BTV-2 (Perrin et al., 2007).
  • Efficacy: Sheep challenged 3 weeks after BTV-Cpox vaccination exhibited partial protection (Perrin et al., 2007).
References
Perrin et al., 2007: Perrin A, Albina E, Bréard E, Sailleau C, Promé S, Grillet C, Kwiatek O, Russo P, Thiéry R, Zientara S, Cêtre-Sossah C. Recombinant capripoxviruses expressing proteins of bluetongue virus: evaluation of immune responses and protection in small ruminants. Vaccine. 2007; 25(37-38); 6774-6783. [PubMed: 17669563].