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Vaccine Detail

URLC10 Peptide Vaccine
Vaccine Information
  • Vaccine Name: URLC10 Peptide Vaccine
  • Target Pathogen: Cancer
  • Target Disease: Cancer
  • Vaccine Ontology ID: VO_0007051
  • Type: Peptide vaccine
  • Status: Clinical trial
  • Host Species for Licensed Use: Human
  • Host Species as Laboratory Animal Model: Human
  • LY6K gene engineering:
    • Type: Recombinant protein preparation
    • Description: (Rini et al., 2016)
    • Detailed Gene Information: Click Here.
  • Preparation: The peptides were synthesized using a solid phase automatic peptide synthesizer utilizing Fmoc chemistry (Correale et al., 2005; Date et al., 1996; Dauer et al., 2005).
  • Description: This is for Bile Duct Cancer (NCT00624182). A cancer vaccine containing URLC10 (up-regulated lung cancer 10) epitopes with potential immunostimulatory and antineoplastic activities. Upon administration, URL peptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against URLC10-expressing tumor cells. Up-regulated in lung and esophageal cancers, the function of URLC10 is unknown (Rini et al., 2016; NCIT_C74087).
Host Response
References
Correale et al., 2005: Correale P, Cusi MG, Del Vecchio MT, Aquino A, Prete SP, Tsang KY, Micheli L, Nencini C, La Placa M, Montagnani F, Terrosi C, Caraglia M, Formica V, Giorgi G, Bonmassar E, Francini G. Dendritic cell-mediated cross-presentation of antigens derived from colon carcinoma cells exposed to a highly cytotoxic multidrug regimen with gemcitabine, oxaliplatin, 5-fluorouracil, and leucovorin, elicits a powerful human antigen-specific CTL response with antitumor activity in vitro. Journal of immunology (Baltimore, Md. : 1950). 2005; 175(2); 820-828. [PubMed: 16002679].
Date et al., 1996: Date Y, Kimura A, Kato H, Sasazuki T. DNA typing of the HLA-A gene: population study and identification of four new alleles in Japanese. Tissue antigens. 1996; 47(2); 93-101. [PubMed: 8851721].
Dauer et al., 2005: Dauer M, Herten J, Bauer C, Renner F, Schad K, Schnurr M, Endres S, Eigler A. Chemosensitization of pancreatic carcinoma cells to enhance T cell-mediated cytotoxicity induced by tumor lysate-pulsed dendritic cells. Journal of immunotherapy (Hagerstown, Md. : 1997). 2005; 28(4); 332-342. [PubMed: 16000951].
NCIT_C74087: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74087]
NCT00624182: [https://clinicaltrials.gov/show/NCT00624182/]
Rini et al., 2016: Rini BI, Stenzl A, Zdrojowy R, Kogan M, Shkolnik M, Oudard S, Weikert S, Bracarda S, Crabb SJ, Bedke J, Ludwig J, Maurer D, Mendrzyk R, Wagner C, Mahr A, Fritsche J, Weinschenk T, Walter S, Kirner A, Singh-Jasuja H, Reinhardt C, Eisen T. IMA901, a multipeptide cancer vaccine, plus sunitinib versus sunitinib alone, as first-line therapy for advanced or metastatic renal cell carcinoma (IMPRINT): a multicentre, open-label, randomised, controlled, phase 3 trial. The Lancet. Oncology. 2016; 17(11); 1599-1611. [PubMed: 27720136].