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Vaccine Detail
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Allogeneic Tumor Cell Vaccine |
| Vaccine Information |
- Vaccine Name: Allogeneic Tumor Cell Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007233
- Type: Other
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- Preparation: (Flores et al., 2007; Kelsen et al., 2007; Manegold and Thatcher, 2007)
- Description: A vaccine composed of tumor cells isolated from the tumor of one patient, killed and processed, and administered to another patient to stimulate cytotoxic immune responses to a similar tumor cell type. The cells found in this type of whole-cell vaccine express many cell-surface tumor-associated antigens. This vaccine is frequently administered with an adjuvant immunostimulant. (NCIT_C1983).
This vaccine has been used in multiple cancer types including pancreatic, multiple myeloma, breast cancer. https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/allogeneic-tumor-cell-vaccine
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| Host Response |
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| References |
Flores et al., 2007: Flores RM, Zakowski M, Venkatraman E, Krug L, Rosenzweig K, Dycoco J, Lee C, Yeoh C, Bains M, Rusch V. Prognostic factors in the treatment of malignant pleural mesothelioma at a large tertiary referral center. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2007; 2(10); 957-965. [PubMed: 17909360].
Kelsen et al., 2007: Kelsen DP, Winter KA, Gunderson LL, Mortimer J, Estes NC, Haller DG, Ajani JA, Kocha W, Minsky BD, Roth JA, Willett CG. Long-term results of RTOG trial 8911 (USA Intergroup 113): a random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for esophageal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007; 25(24); 3719-3725. [PubMed: 17704421].
Manegold and Thatcher, 2007: Manegold C, Thatcher N. Survival improvement in thoracic cancer: progress from the last decade and beyond. Lung cancer (Amsterdam, Netherlands). 2007; 57 Suppl 2; S3-5. [PubMed: 17686443].
NCIT_C1983: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1983]
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