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Vaccine Detail
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Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine |
| Vaccine Information |
- Vaccine Name: Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007102
- Type: Subunit vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- Antigen: gp100
- gp100 (PMEL)
gene engineering:
- Type: Recombinant protein preparation
- Description: recombinant protein preparation (Wang et al., 2003)
- Detailed Gene Information: Click Here.
- Preparation: BacPAK baculovirous expression system is used to express hsp100, meanwhile Escherichia coli JM109 (DE3) cells is used to express gp100 (Wang et al., 2003).
- Description: This is for Melanoma Cancer (NCT01744171). A recombinant chaperone-peptide complex-based vaccine composed of a complex between heat shock protein hsp110 and the human melanoma-associated antigen gp100, with potential antineoplastic activity. Upon vaccination, recombinant hsp110-gp100 chaperone complex activates the immune system to exert a cytotoxic T cell immune response and antigen-specific interferon-gamma production against gp100-overexpressing cancer cells. Gp100, is overexpressed in a variety of cancer cell types. Hsp110, binds to and chaperones full-length proteins during heat shock; as an immunoadjuvant it is able to enhance an immune response against antigen(s) and stimulate T-lymphocyte activation (Wang et al., 2003; NCIT_C103830).
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| Host Response |
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| References |
NCIT_C103830: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C103830]
NCT01744171: [https://clinicaltrials.gov/ct2/show/NCT01744171]
Wang et al., 2003: Wang T, Fan L, Watanabe Y, McNeill PD, Moulton GG, Bangur C, Fanger GR, Okada M, Inoue Y, Persing DH, Reed SG. L523S, an RNA-binding protein as a potential therapeutic target for lung cancer. British journal of cancer. 2003; 88(6); 887-894. [PubMed: 12644826].
Wang et al., 2003: Wang XY, Chen X, Manjili MH, Repasky E, Henderson R, Subjeck JR. Targeted immunotherapy using reconstituted chaperone complexes of heat shock protein 110 and melanoma-associated antigen gp100. Cancer research. 2003; 63(10); 2553-2560. [PubMed: 12750279].
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