|
|
Vaccine Detail
|
NY-ESO-1/MART-1 Peptide-pulsed Dendritic Cell Vaccine |
| Vaccine Information |
- Vaccine Name: NY-ESO-1/MART-1 Peptide-pulsed Dendritic Cell Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007095
- Type: Recombinant vector vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- Antigen: NY-ESO-1, MLANA
- CTAG1B
gene engineering:
- Type: Recombinant protein preparation
- Description: (Lopes et al., 2006)
- Detailed Gene Information: Click Here.
- MLANA
gene engineering:
- Type: Recombinant protein preparation
- Description: (Lopes et al., 2006)
- Detailed Gene Information: Click Here.
- Preparation: The vaccine is a direct injection of a lentiviral vector encoding the melanoma antigen NY-ESO-1 (Lopes et al., 2006).
- Description: This is for Melanoma Cancer (NCT00798629). A cell-based cancer vaccine composed of dendritic cells (DC) pulsed with peptides derived from the tumor-associated antigens human cancer/testis antigen NY-ESO-1 and melanoma antigen recognized by T-cells (MART-1/Melan-A), with potential immunostimulatory and antineoplastic activities. Upon administration, the NY-ESO-1/MART-1-peptide pulsed DC vaccine may stimulate the immune system to mount an anti-tumor cytotoxic T-lymphocyte (CTL) response against NY-ESO-1/MART-1-expressing tumor cells, which may result in tumor cell lysis. NY-ESO-1 is expressed both in normal testes and on the surfaces of various tumor cells. MART-1 is expressed by melanoma cells (Lopes et al., 2006; NCIT_C120129).
|
| Host Response |
|
|
| References |
Lopes et al., 2006: Lopes L, Fletcher K, Ikeda Y, Collins M. Lentiviral vector expression of tumour antigens in dendritic cells as an immunotherapeutic strategy. Cancer immunology, immunotherapy : CII. 2006; 55(8); 1011-1016. [PubMed: 16311731].
NCIT_C120129: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C120129]
NCT00798629: [https://clinicaltrials.gov/ct2/show/NCT00798629?term=gp100+Adenovirus+Vaccine&rank=1]
|
|
