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Vaccine Detail
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Recombinant Vaccinia-gp100:209-217 Vaccine |
| Vaccine Information |
- Vaccine Name: Recombinant Vaccinia-gp100:209-217 Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007103
- Type: Recombinant vector vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: Human
- Antigen: gp100
- gp100 (PMEL)
gene engineering:
- Type: Recombinant protein preparation
- Description: (Zajac et al., 2003)
- Detailed Gene Information: Click Here.
- Preparation: The vaccine is made from the expression of endoplasmic reticulum-targeted HLA-A0201-restricted Melan-A/MART-1(27-35), gp100(280-288), and tyrosinase(1-9) epitopes, together with CD80 and CD86 costimulatory proteins through inactivated nonreplicating recombinant vaccinia virus (Zajac et al., 2003; Oertli et al., 2002).
- Description: This is for Melanoma Cancer (NCT00116597). A recombinant vaccinia virus encoding a modified peptide of the gp100 melanoma-melanocyte antigen with potential use in cancer immunotherapy. gp100 human antigen is a wild type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. gp100p209 is a fragment epitope of gp100 in which the threonine in position 2 is replaced with methionine; this modification may stimulate tumor infiltrating lymphocytes (TIL) more efficiently (NCI04) (Nagorsen et al., 2004; NCIT_C29566).
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| Host Response |
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| References |
Nagorsen et al., 2004: Nagorsen D, Servis C, Lévy N, Provenzano M, Dudley ME, Marincola FM, Lévy F. Proteasomal cleavage does not determine immunogenicity of gp100-derived peptides gp100 209-217 and gp100 209-217T210M. Cancer immunology, immunotherapy : CII. 2004; 53(9); 817-824. [PubMed: 15133631].
NCIT_C29566: [https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C29566]
NCT00116597: [https://clinicaltrials.gov/show/NCT00116597/]
Oertli et al., 2002: Oertli D, Marti WR, Zajac P, Noppen C, Kocher T, Padovan E, Adamina M, Schumacher R, Harder F, Heberer M, Spagnoli GC. Rapid induction of specific cytotoxic T lymphocytes against melanoma-associated antigens by a recombinant vaccinia virus vector expressing multiple immunodominant epitopes and costimulatory molecules in vivo. Human gene therapy. 2002; 13(4); 569-575. [PubMed: 11874634].
Zajac et al., 2003: Zajac P, Oertli D, Marti W, Adamina M, Bolli M, Guller U, Noppen C, Padovan E, Schultz-Thater E, Heberer M, Spagnoli G. Phase I/II clinical trial of a nonreplicative vaccinia virus expressing multiple HLA-A0201-restricted tumor-associated epitopes and costimulatory molecules in metastatic melanoma patients. Human gene therapy. 2003; 14(16); 1497-1510. [PubMed: 14577912].
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