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Vaccine Detail

S. pneumoniae detoxified PlyD1 Protein Vaccine
Vaccine Information
  • Vaccine Name: S. pneumoniae detoxified PlyD1 Protein Vaccine
  • Target Pathogen: Streptococcus pneumoniae
  • Target Disease: Pneumonia
  • Type: Recombinant vector vaccine
  • Status: Licensed
  • Host Species for Licensed Use: Baboon
  • PlyD1 gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Preparation: Recombinant PLY was produced from Escherichia coli containing the entire gene sequence of wild-type pneumolysin from strain R36A; the protein was column purified. PlyD1, a highly detoxified PLY variant, was generated by site-directed mutagenesis and differs from the wild-type form by three amino acid substitutions of T65C, G293C, and C428A. Recombinant PlyD1 protein was expressed in E. coli as soluble protein and column purified.(Salha et al., 2012)
  • Immunization Route: Intramuscular injection (i.m.)
Host Response
References
Salha et al., 2012: Salha D, Szeto J, Myers L, Claus C, Sheung A, Tang M, Ljutic B, Hanwell D, Ogilvie K, Ming M, Messham B, van den Dobbelsteen G, Hopfer R, Ochs MM, Gallichan S. Neutralizing antibodies elicited by a novel detoxified pneumolysin derivative, PlyD1, provide protection against both pneumococcal infection and lung injury. Infection and immunity. 2012; 80(6); 2212-2220. [PubMed: 22473606].