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Vaccine Detail
mixture of Salmonella strains delivering ApxIA, ApxIIA, ApxIIIA and OmpA of A. pleuropneumoniae |
Vaccine Information |
- Vaccine Name: mixture of Salmonella strains delivering ApxIA, ApxIIA, ApxIIIA and OmpA of A. pleuropneumoniae
- Target Pathogen: Actinobacillus pleuropneumoniae
- Target Disease: porcine pleuropneumonia
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Host Species as Laboratory Animal Model: Mice
- apxIA
gene engineering:
- Type: Recombinant vector construction
- Description: An attenuated Salmonella Typhimurium was used to express ApxIA (Hur et al., 2016).
- Detailed Gene Information: Click Here.
- ompA
gene engineering:
- Type: Recombinant vector construction
- Description: An attenuated Salmonella Typhimurium was used to express OmpA (Hur et al., 2016).
- Detailed Gene Information: Click Here.
- apxIIA
gene engineering:
- Type: Recombinant vector construction
- Description: An attenuated Salmonella Typhimurium was used to express ApxIIA (Hur et al., 2016).
- Detailed Gene Information: Click Here.
- apxIIIA
gene engineering:
- Type: Recombinant vector construction
- Description: An attenuated Salmonella Typhimurium was used to express ApxIIIA (Hur et al., 2016).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
- Description: (Hur et al., 2016)
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Host Response |
Mouse Response
- Immune Response: The splenic lymphocyte proliferation and the levels of IL-4, IL-6 and IL-12 of the inoculated mice were significantly increased, and the T- and B-cell populations were also elevated. Collectively, the candidate may efficiently induce the Th1- and Th2-type immune responses.(Hur et al., 2016)
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References |
Hur et al., 2016: Hur J, Eo SK, Park SY, Choi Y, Lee JH. Immunological study of an attenuated Salmonella Typhimurium expressing ApxIA, ApxIIA, ApxIIIA and OmpA of Actinobacillus pleuropneumoniae in a mouse model. The Journal of veterinary medical science. 2016; 77(12); 1693-1696. [PubMed: 26227587].
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