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Vaccine Detail

MERS-CoV S vaccine adjuvanted with CpG and Alum
Vaccine Information
  • Vaccine Name: MERS-CoV S vaccine adjuvanted with CpG and Alum
  • Target Pathogen: MERS-CoV
  • Target Disease: Middle East Respiratory Syndrome (MERS)
  • Type: Subunit vaccine
  • Status: Research
  • Host Species for Licensed Use: None
  • Host Species as Laboratory Animal Model: mouse
  • S from MERS-CoV gene engineering:
    • Type: Recombinant protein preparation
    • Description: The S spike protein was conjugated with CpG or Alum as a subunit MERS vaccine (Deng et al., 2018).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
  • Description: The spike protein of middle east respiratory syndrome coronavirus adjuvanted with CpG and Alum provided protection against infection of MERS-CoV (Deng et al., 2018).
Host Response

Mouse Response

  • Host Strain: Balb/c
  • Host gender: Female (Deng et al., 2018)
  • Vaccination Protocol: Mice were given intramuscular immunizations at 4-week intervals of S protein + adjuvant at a dosage of 1 μg of S protein. (Deng et al., 2018)
  • Immune Response: Induced S-specific neutralizing antibodies after 2 weeks, though titres were lower than in vaccine 5721. S-specific IgG tires were 105 at 6 weeks (after second dose), similar to titres of vaccine 5721. S-specific IgG titres did not increase after the third dosage. The IgG2a/IgG1 and IgG2b/IgG1 ratios were ~1. (Deng et al., 2018)
References
Deng et al., 2018: Deng Y, Lan J, Bao L, Huang B, Ye F, Chen Y, Yao Y, Wang W, Qin C, Tan W. Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus. Emerging microbes & infections. 2018; 7(1); 60. [PubMed: 29618723].