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Vaccine Detail

Ad5.MERS-S1 vaccine
Vaccine Information
  • Vaccine Name: Ad5.MERS-S1 vaccine
  • Target Pathogen: MERS-CoV
  • Target Disease: Middle East Respiratory Syndrome (MERS)
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Mouse
  • Antigen: S1 subunit of S from MERS-CoV (Kim et al., 2014).
  • Immunization Route: Intramuscular injection (i.m.)
  • Description: Recombinant adenoviral vector encoding the the S1 extracellular domain of S protein (Ad5.MERS-S1). (Kim et al., 2014)
Host Response

Mouse Response

  • Host Strain: BALB/C
  • Vaccination Protocol: inoculated intramuscularly with 1e11 viral particles of Vaccine 5720 and boosted intranasally 3 weeks after with 1e11 viral particles of Vaccine 5720 (Kim et al., 2014)
  • Immune Response: increased titers of neutralizing antibodies (Kim et al., 2014)
References
Kim et al., 2014: Kim E, Okada K, Kenniston T, Raj VS, AlHajri MM, Farag EA, AlHajri F, Osterhaus AD, Haagmans BL, Gambotto A. Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice. Vaccine. 2014; 32(45); 5975-5982. [PubMed: 25192975].