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Vaccine Detail
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Ad5.MERS-S1 vaccine |
| Vaccine Information |
- Vaccine Name: Ad5.MERS-S1 vaccine
- Target Pathogen: MERS-CoV
- Target Disease: Middle East Respiratory Syndrome (MERS)
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Antigen: S1 subunit of S from MERS-CoV (Kim et al., 2014).
- Immunization Route: Intramuscular injection (i.m.)
- Description: Recombinant adenoviral vector encoding the the S1 extracellular domain of S protein (Ad5.MERS-S1). (Kim et al., 2014)
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| Host Response |
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Mouse Response
- Host Strain: BALB/C
- Vaccination Protocol: inoculated intramuscularly with 1e11 viral particles of Vaccine 5720 and boosted intranasally 3 weeks after with 1e11 viral particles of Vaccine 5720 (Kim et al., 2014)
- Immune Response: increased titers of neutralizing antibodies (Kim et al., 2014)
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| References |
Kim et al., 2014: Kim E, Okada K, Kenniston T, Raj VS, AlHajri MM, Farag EA, AlHajri F, Osterhaus AD, Haagmans BL, Gambotto A. Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice. Vaccine. 2014; 32(45); 5975-5982. [PubMed: 25192975].
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