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Vaccine Detail

Inactivated whole MERS-CoV (IV) vaccine with CpG and Alum
Vaccine Information
  • Vaccine Name: Inactivated whole MERS-CoV (IV) vaccine with CpG and Alum
  • Target Pathogen: MERS-CoV
  • Target Disease: Middle East Respiratory Syndrome (MERS)
  • Type: Inactivated or "killed" vaccine
  • Status: Research
  • Host Species for Licensed Use: None
  • Host Species as Laboratory Animal Model: mouse
  • Antigen: whole virus (Deng et al., 2018)
  • Immunization Route: Intramuscular injection (i.m.)
  • Description: inactivated whole MERS-CoV (IV) with a combined adjuvant (alum+CpG) as a vaccine formulation caused protection (Deng et al., 2018).
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: intramuscularly injected with 1 μg IV protein adjuvant with 100 μL of alum and 10 μg of CpG at weeks 0, 4, and 8 (Deng et al., 2018)
  • Immune Response: anti-S protein IgG response and neutralizing activity  (Deng et al., 2018)
  • Challenge Protocol: 9 days of the last immunization, the remaining mice were lightly anesthetized with isoflurane and transduced intranasally with 2.5e8 plaque-forming units (pfu) of Ad5-hDPP443. After 5 days, transduced mice were infected intranasally with MERS-CoV (1e5 pfu) in 50 μL of DMEM (Deng et al., 2018)
  • Efficacy: protected (Deng et al., 2018)
References
Deng et al., 2018: Deng Y, Lan J, Bao L, Huang B, Ye F, Chen Y, Yao Y, Wang W, Qin C, Tan W. Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus. Emerging microbes & infections. 2018; 7(1); 60. [PubMed: 29618723].