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Vaccine Detail

VSVΔG-MERS vaccine
Vaccine Information
  • Vaccine Name: VSVΔG-MERS vaccine
  • Target Pathogen: MERS-CoV
  • Target Disease: Middle East Respiratory Syndrome (MERS)
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: None
  • Host Species as Laboratory Animal Model: mouse
  • Antigen: S from MERS-CoV (Liu et al., 2018)
  • Immunization Route: Intramuscular injection (i.m.)
  • Description: Chimeric virus based on the vesicular stomatitis virus (VSV) in which the G gene was replaced by MERS-CoV S gene (VSVΔG-MERS) (Liu et al., 2018)
Host Response

Macaque Response

  • Vaccination Protocol: intramuscularly immunized with 2e7 FFU VSVΔG-MERS (preparation described below) in 2 ml medium via hind limb muscle injection or intranasally immunized with 2e7 FFU VSVΔG-MERS as via nostril instillation under anesthesia (Liu et al., 2018)
  • Immune Response: recombinant virus induced high level of S protein specific IgG in both groups (Liu et al., 2018)
References
Liu et al., 2018: Liu R, Wang J, Shao Y, Wang X, Zhang H, Shuai L, Ge J, Wen Z, Bu Z. A recombinant VSV-vectored MERS-CoV vaccine induces neutralizing antibody and T cell responses in rhesus monkeys after single dose immunization. Antiviral research. 2018; 150; 30-38. [PubMed: 29246504].