|
|
Vaccine Detail
|
MVA-MERS-S vaccine |
| Vaccine Information |
- Vaccine Name: MVA-MERS-S vaccine
- Target Pathogen: MERS-CoV
- Target Disease: Middle East Respiratory Syndrome (MERS)
- Type: Recombinant vector vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: camel, mouse
- Antigen: S protein (Song et al., 2013)
- Immunization Route: Intramuscular injection (i.m.)
- Description: recombinant modified vaccinia virus Ankara (rMVA) vaccine vector carrying full MERS-CoV spike glycoprotein(Koch et al., 2020)
|
| Host Response |
|
Human Response
- Vaccination Protocol: 1e7 plaque-forming unit or 1e8 PFU MVA-MERS-S intramuscularly injected at 0 and 28 days (Koch et al., 2020)
- Immune Response: Following booster immunization, nine (75%) of 12 participants in the low-dose group and 11 (100%) participants in the high-dose group showed seroconversion using a MERS-CoV S1 ELISA at any timepoint during the study which correlated with MERS-CoV-specific neutralising antibodies (Spearman's correlation r=0·86 [95% CI 0·6960-0·9427], p=0·0001). MERS-CoV spike-specific T-cell responses were detected in ten (83%) of 12 immunised participants in the low-dose group and ten (91%) of 11 immunized participants in the high-dose group. (Koch et al., 2020)
- Side Effects: Participants had no severe or serious adverse events. 67 vaccine-related adverse events were reported in ten (71%) of 14 participants in the low-dose group, and 111 were reported in ten (83%) of 12 participants in the high-dose group. Pain (seven at 1e7 vaccinationgroup vs ten 1e8 PFU vaccination group), swelling (two vs eight), induration (one vs nine), fatigue or maliase (ten vs seven) were most common events (Koch et al., 2020)
- Description: Phase 1 trial results of MVA-MERS-S showed a benign safety profile
|
| References |
Koch et al., 2020: Koch T, Dahlke C, Fathi A, Kupke A, Krähling V, Okba NMA, Halwe S, Rohde C, Eickmann M, Volz A, Hesterkamp T, Jambrecina A, Borregaard S, Ly ML, Zinser ME, Bartels E, Poetsch JSH, Neumann R, Fux R, Schmiedel S, Lohse AW, Haagmans BL, Sutter G, Becker S, Addo MM. Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial. The Lancet. Infectious diseases. 2020; ; . [PubMed: 32325037].
Song et al., 2013: Song F, Fux R, Provacia LB, Volz A, Eickmann M, Becker S, Osterhaus AD, Haagmans BL, Sutter G. Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies. Journal of virology. 2013; 87(21); 11950-11954. [PubMed: 23986586].
|
|
