VIOLIN: Vaccine Investigation and Online Information Network

Vaccine Detail

LNP-nCoVsaRNA

Vaccine Information

Vaccine Name: LNP-nCoVsaRNA
Target Pathogen: SARS-CoV-2
Target Disease: COVID-19
Product Name: COVAC1
Manufacturer: Imperial College London
Vaccine Ontology ID: VO_0005143
Type: RNA Vaccine
Status: Clinical trial
Host Species for Licensed Use: Human
Antigen: spike (S) protein (McKay et al., 2020)
Immunization Route: Intramuscular injection (i.m.)
Description: A SARS-CoV-2 vaccine made of self-coding RNA encoding SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle (McKay et al., 2020).

Host Response

References

McKay et al., 2020: McKay PF, Hu K, Blakney AK, Samnuan K, Brown JC, Penn R, Zhou J, Bouton CR, Rogers P, Polra K, Lin PJC, Barbosa C, Tam YK, Barclay WS, Shattock RJ. Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice. Nature communications. 2020; 11(1); 3523. [PubMed: 32647131].