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Vaccine Detail

S. pneumoniae PiaA Protein Vaccine
Vaccine Information
  • Vaccine Name: S. pneumoniae PiaA Protein Vaccine
  • Target Pathogen: Streptococcus pneumoniae
  • Target Disease: Pneumonia
  • Vaccine Ontology ID: VO_0004070
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: Recombinant PiaA protein (Brown et al., 2001).
  • PiaA gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: aluminum vaccine adjuvant
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: For the active protection experiments, each mouse was immunized by intraperitoneal (i.p.) injection of 100 μl of each protein preparation in alum adjuvant on days 0, 10, and 20 (Brown et al., 2001).
  • Challenge Protocol: On day 34 mice were challenged i.p. with ca. 106 CFU of S. pneumoniae strain D39 organisms (Brown et al., 2001).
  • Efficacy: After 14 days the mortality of the group of mice immunized PiuA was 52%, showing that immunization with these proteins protects against systemic infection with S. pneumoniae (Brown et al., 2001).
References
Brown et al., 2001: Brown JS, Ogunniyi AD, Woodrow MC, Holden DW, Paton JC. Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infection and immunity. 2001; 69(11); 6702-6706. [PubMed: 11598041].