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Vaccine Detail

S. pneumoniae PspA Protein Vaccine
Vaccine Information
  • Vaccine Name: S. pneumoniae PspA Protein Vaccine
  • Target Pathogen: Streptococcus pneumoniae
  • Target Disease: Pneumonia
  • Vaccine Ontology ID: VO_0004007
  • Type: Subunit vaccine
  • Status: Research
  • PspA gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: aluminum vaccine adjuvant
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Mouse Response

  • Host Strain: BALB/c and CD1
  • Vaccination Protocol: The mice received three doses of 10 μg of each antigen alone (or in combination) in 100 μg of alum adjuvant via Intraperitoneal injection (i.p.) at 14-day intervals or a placebo (Ogunniyi et al., 2007).
  • Challenge Protocol: Mice were challenged i.p. 2 weeks after the third immunization with either the highly virulent capsular type 2 strain D39 or a serotype 6A (WCH16) strain (Ogunniyi et al., 2007).
  • Efficacy: PspA elicited protection by using moderate challenge doses of S. pneumoniae (Ogunniyi et al., 2007).
References
Ogunniyi et al., 2007: Ogunniyi AD, Grabowicz M, Briles DE, Cook J, Paton JC. Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infection and immunity. 2007; 75(1); 350-357. [PubMed: 17088353].