• Vaccine Name: T. cruzi vaccine using Sendai virus vector expressing amastigote surface protein-2
• Target Pathogen: Trypanosoma cruzi
• Target Disease: Chagas disease
• Vaccine Ontology ID: VO_0001394
• Type: Recombinant vector vaccine
• Status: Research
• Host Species as Laboratory Animal Model: mouse
• Antigen: Parasite antigen amastigote surface protein-2 (ASP2) (Duan et al., 2009).
• amastigote surface protein-2 gene engineering:
  • Type: Recombinant vector construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Intranasally

Mouse Response

• Host Strain: C57BL/6
• Vaccination Protocol: B6 mice were administrated intranasally with 5 × 10^6 CIU SeV-GFP or SeV-ASP2 (Duan et al., 2009).
• Challenge Protocol: For challenge infections, mice were inoculated with 1000 blood-derived trypomastigotes at the base of the tail 2 weeks after immunization (Duan et al., 2009).
• Efficacy: C57BL/6 mice immunized intranasally with rSeV/dF expressing ASP2 showed significantly suppressed parasitemia and could be protected from lethal T. cruzi challenge (Duan et al., 2009).