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Vaccine Detail

Pseudorabies recombinant vector vaccine encoding gp50 and gII protein
Vaccine Information
  • Vaccine Name: Pseudorabies recombinant vector vaccine encoding gp50 and gII protein
  • Target Pathogen: Pseudorabies virus
  • Target Disease: Aujeszky's disease
  • Vaccine Ontology ID: VO_0004156
  • Type: Recombinant vector vaccine
  • Status: Licensed
  • gp50 gene engineering:
    • Type: Recombinant vector construction
    • Description:
    • Detailed Gene Information: Click Here.
  • GII gene engineering:
    • Type: Recombinant vector construction
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Pig Response

  • Vaccination Protocol: 4-6 wk old male pigs from a PRV negative herd were vaccinated intramuscularly with two injections in the thigh of 107 CCID50 of NYVAC/gp50gpII 4 weeks apart. The control group was not vaccinated (Brockmeier and Mengeling, 1996).
  • Challenge Protocol: Challenge consisted of administering 108 PFU of Indiana-Funkhauser strain of PRV oranasally, 4 weeks after the 2nd immunization (Brockmeier and Mengeling, 1996).
  • Efficacy: Vaccinated pigs were protected from PRV challenge (Brockmeier and Mengeling, 1996).
References
Brockmeier and Mengeling, 1996: Brockmeier SL, Mengeling WL. Comparison of the protective response induced by NYVAC vaccinia recombinants expressing either gp50 or gII and gp50 of pseudorabies virus. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 1996; 60(4); 315-317. [PubMed: 8904669].