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Vaccine Detail

Pseudorabies Subunit gI Protein Vaccine
Vaccine Information
  • Vaccine Name: Pseudorabies Subunit gI Protein Vaccine
  • Target Pathogen: Pseudorabies virus
  • Target Disease: Aujeszky's disease
  • Vaccine Ontology ID: VO_0004040
  • Type: Subunit vaccine
  • Status: Research
  • GI gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Mouse Response

  • Host Strain: C57BL/10
  • Vaccination Protocol: For active immunization mice were injected i.m. (hind leg) with different concentrations of emulsified purified (by electroelution) fusion protein (Fuchs et al., 1990).
  • Challenge Protocol: Twenty-four h later the animals were infected intramuscularly (i.m.) into a hind leg using 0-1 ml of a lethal dose ( > 100 LD50) of strain Phylaxia, and the mice were observed for at least 10 days (Fuchs et al., 1990).
  • Efficacy: Vaccination of mice with fusion proteins containing the N terminus of gI from Suid herpesvirus 1 are able to confer protection to mice against a lethal challenge of PRV (Fuchs et al., 1990).
References
Fuchs et al., 1990: Fuchs W, Rziha HJ, Lukàcs N, Braunschweiger I, Visser N, Lütticken D, Schreurs CS, Thiel HJ, Mettenleiter TC. Pseudorabies virus glycoprotein gI: in vitro and in vivo analysis of immunorelevant epitopes. The Journal of general virology. 1990; 71 ( Pt 5); 1141-1151. [PubMed: 1693164].