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Vaccine Detail

S. equi Subunit CNE Protein Vaccine
Vaccine Information
  • Vaccine Name: S. equi Subunit CNE Protein Vaccine
  • Target Pathogen: Streptococcus equi
  • Target Disease: Strangles (also equine distemper)
  • Vaccine Ontology ID: VO_0011546
  • Type: Subunit vaccine
  • Status: Research
  • collagen binding, ancillary pilus subunit Cne gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: Matrix-S
  • Immunization Route: Intranasally
Host Response

Mouse Response

  • Host Strain: NMRI mice
  • Vaccination Protocol: Fifteen to twenty microgram of each antigen and 10 μg of the adjuvant in a total volume of 12–16 μl were given to the mice by placing the antigens onto the nares and allowing the mice to inhale. This was done at three occasions at 1-week intervals. In each experiment, control animals were given only adjuvant at the same concentration omitting the antigen (Flock et al., 2006).
  • Challenge Protocol: A dose containing 106 CFU in a 10-μl volume was used for infection of mice (Flock et al., 2006).
  • Efficacy: Mice immunized with recombinant CNE lost less weight and had less nasal colonization than the unvaccinated controls (Flock et al., 2006).
References
Flock et al., 2006: Flock M, Karlström A, LannergÄrd J, Guss B, Flock JI. Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse. Vaccine. 2006; 24(19); 4144-4151. [PubMed: 16580099].