• Vaccine Name: T. parva Subunit p67 Protein Vaccine
• Target Pathogen: Theileria parva
• Target Disease: East Coast Fever
• Vaccine Ontology ID: VO_0011494
• Type: Subunit vaccine
• Status: Research
• p67 gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001267
• Immunization Route: Subcutaneous Injection

Cattle Response

• Vaccination Protocol: The immunization regimen consisted of five inoculations in 2-ml vol containing 1 mg of recombinant p67 emulsified in 3% saponin (Merck) and administered subcutaneously at monthly intervals (Musoke et al., 1992).
• Challenge Protocol: Immunized groups were challenged 10 days after the final inoculation along with four nonimmunized control animals. In both experiments, the nonimmunized controls served to test the infectivity of the sporozoite stabilate (Musoke et al., 1992).
• Efficacy: Immunization with p67 induced protection in 70% of the immunized cattle (Musoke et al., 1992).