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Vaccine Detail

Y. enterocolititica Subunit V Antigen Protein Vaccine
Vaccine Information
  • Vaccine Name: Y. enterocolititica Subunit V Antigen Protein Vaccine
  • Target Pathogen: Yersinia enterocolitica
  • Target Disease: Yersiniosis
  • Vaccine Ontology ID: VO_0011503
  • Type: Subunit vaccine
  • Status: Research
  • LcrV gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: complete Freunds adjuvant
  • Immunization Route: Subcutaneous injection
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: Mice were injected subcutaneously (s.c.) with 30 lg rVagHis in CFA and boostered with 30 lg rVagHis in ICFA four weeks later. Control mice were treated similarily with CFA or ICFA, but lacking rVagHis (Schmidt et al., 1999).
  • Challenge Protocol: Mice were challenged intraperitoneally (i.p.) with 0.5 ml bacterial suspension containing either 3x103 cells of Y. enterocolitica 0:8 strain NCTC10938 or 4x104 cells of Y. pseudotuberculosis strain YPlll/pIB102. Survival of mice was monitored over 2 months (Schmidt et al., 1999).
  • Efficacy: Mice actively immunized using a recombinant V antigen (rVagHis, encoded by lcrV gene) of Y. enterocolitica were completely protected against challenge with both, Y. enterocolitica 0:8 and Y. pseudotuberculosis serotype III (Schmidt et al., 1999).
References
Schmidt et al., 1999: Schmidt A, Schaffelhofer S, Müller K, Röllinghoff M, Beuscher HU. Analysis of the Yersinia enterocolitica 0:8 V antigen for cross protectivity. Microbial pathogenesis. 1999; 26(4); 221-233. [PubMed: 10089162].