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Vaccine Detail

Newcastle Disease Virus HN Glycoprotein Subunit Vaccine
Vaccine Information
  • Vaccine Name: Newcastle Disease Virus HN Glycoprotein Subunit Vaccine
  • Target Pathogen: Newcastle disease virus
  • Target Disease: Newcastle disease
  • Vaccine Ontology ID: VO_0011552
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: Hemagglutinin-neuraminidase (HN) glycoprotein (Lee et al., 2008).
  • HN hemagglutinin-neuraminidase gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant: Montanide incomplete Seppic adjuvant
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Vaccination Protocol: For vaccination, chickens were inoculated intramuscularly with the Seppic-adjuvanted antigen (Lee et al., 2008).
  • Challenge Protocol: Each group of vaccinated and unvaccinated chickens was challenged with the vvNDV Kr-005/00 strain through an intraocular inoculation with an 105.5 EID50 per bird. vvNDV Kr-005/00 was the representative strain of genotype VII, which is the dominant epizootic genotype in Korea. The chickens were kept under observation for 14 days after infection (Lee et al., 2008).
  • Efficacy: A single dose of rNDHN(V) had a protective effect against mortality (p <0.01) in chickens (Lee et al., 2008).
References
Lee et al., 2008: Lee YJ, Sung HW, Choi JG, Lee EK, Yoon H, Kim JH, Song CS. Protection of chickens from Newcastle disease with a recombinant baculovirus subunit vaccine expressing the fusion and hemagglutininneuraminidase proteins. Journal of veterinary science. 2008; 9(3); 301-308. [PubMed: 18716451].