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Vaccine Detail

N. caninum NcDG1 protein vaccine
Vaccine Information
  • Vaccine Name: N. caninum NcDG1 protein vaccine
  • Target Pathogen: Neospora caninum
  • Target Disease: Neosporosis
  • Vaccine Ontology ID: VO_0004010
  • Type: Subunit vaccine
  • Status: Research
  • NcDG1 gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
Host Response

Gerbil Response

  • Vaccination Protocol: Gerbils (5-6 weeks of age) were used for the challenge experiments. Uninfected control group animals were injected intraperitoneally with only PBS. The other experimental groups were injected intraperitoneally with NcWL or recombinant proteins. Animals in the first experimental group were injected with NcDG1 at 100 µg/gerbil intraperitoneally, whereas animals in the second group were injected intraperitoneally the recombinant proteins in combinations. Gerbils were boosted with the same inoculums 2 weeks after the first injection (Cho et al., 2005).
  • Challenge Protocol: For parasite challenge, gerbils were inoculated intraperitoneally with live N. caninum tachyzoites (105) suspended in PBS, 1 week after boosting (3 weeks after the first injection). The protective efficacies of the vaccinations against infection were determined by comparing survival rates after challenge infection of the control group and each of the experimental groups (Cho et al., 2005).
  • Efficacy: Vaccination with NcDG1 alone elicited 62.5% survival in the challenge model compared to a 17.4% survival rate of the control group after challenge (Cho et al., 2005).
References
Cho et al., 2005: Cho JH, Chung WS, Song KJ, Na BK, Kang SW, Song CY, Kim TS. Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against experimental Neospora caninum infection. The Korean journal of parasitology. 2005; 43(1); 19-25. [PubMed: 15793355].