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Vaccine Detail

NIpah Virus G and F Proteins Subunit Vaccine
Vaccine Information
  • Vaccine Name: NIpah Virus G and F Proteins Subunit Vaccine
  • Target Pathogen: Nipah virus
  • Target Disease: Nipah virus disease
  • Vaccine Ontology ID: VO_0011407
  • Type: Subunit vaccine
  • Status: Research
  • F fusion protein gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • G glycoprotein gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: Subcutaneous injection
Host Response

Hamster Response

  • Vaccination Protocol: For protection studies, inbred golden hamsters (Janvier, Le Fenest St. Isles, France) were vaccinated twice (1 month apart) with 107 PFU of vaccinia virus recombinants expressing either the G or F Nipah virus glycoprotein or with 5 × 106 of each of the recombinants when they were used for coimmunization (Guillaume et al., 2004).
  • Challenge Protocol: The animals were challenged 3 months after the last immunization with Nipah virus administered interperitoneally (Guillaume et al., 2004).
  • Efficacy: Hamsters immunized with F and G proteins were completely protected from lethal Nipah virus challenge (Guillaume et al., 2004).
References
Guillaume et al., 2004: Guillaume V, Contamin H, Loth P, Georges-Courbot MC, Lefeuvre A, Marianneau P, Chua KB, Lam SK, Buckland R, Deubel V, Wild TF. Nipah virus: vaccination and passive protection studies in a hamster model. Journal of virology. 2004; 78(2); 834-840. [PubMed: 14694115].