• Vaccine Name: Marburg Virus Nucleoprotein Vaccine
• Target Pathogen: Marburg Virus
• Target Disease: Hemorrhagic fever
• Vaccine Ontology ID: VO_0011394
• Type: Recombinant vector vaccine
• Status: Research
• NP from Lake Victoria marburgvirus gene engineering:
  • Type: Recombinant vector construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Subcutaneous injection

Macaque Response

• Host Strain: Macaca fascicularis
• Vaccination Protocol: Twelve cynomolgus macaques (Macaca fascicularis), 11 females and 1 male, ranging from 2.8 to 4.5 kg, were inoculated subcutaneously with 10^7 FFU of VRP in a total volume of 0.5 ml at one site. Monkeys were anesthetized with ketamine, bled, and inoculated (as described for the first vaccine dose) 28 days after the primary injection, and again 28 days after the second (Hevey et al., 1998).
• Challenge Protocol: Animals were challenged 14 days after 3rd vaccine dose with 10^3.9 PFU MBGV
  subcutaneously (Hevey et al., 1998).
• Efficacy: MBGV NP afforded incomplete (partial) protection, sufficient to prevent death but not disease in two of three macaques (Hevey et al., 1998).