VO Banner
Search: for Help
Vaxvec Home
News and Updates
Vaxvec Vectors
Vaxvec Vaccines
Vaxvec Antigens
VaxvecAg BLAST
Selected Vectors
B. abortus RB51 vector
RSV vaccine vector
SL3261 vaccine vector
VSV vaccine vector
Data Submission
Data Exchange
Data Download
Contact Us

Brucella abortus RB51 vaccine vector

Vaxvec ID 13
Vaccine Vector Name Brucella abortus RB51 vaccine vector
Vector VO ID VO_0000020
Function RB51 is able to stimulate strong cell-mediated immunity (He et al., 2001).
Advantage RB51 is able to induce strong CD4+ and CD8+ T-cell mediated immune responses (He et al., 2001).
Disadvantage Other so many DNA plasmids are able to survive inside the RB51 bacteria. Also, known DNA plasmids able to survive and replicate inside RB51 tend not to have high copy number.
Preparation RB51 was derived by repeated passage of virulent B. abortus strain 2308 on Trypticase soy supplemented with 1.5% agar and varying concentrations rifampin or penicillin (Schurig et al., 1991).
Storage Usually at 2-8 degree.
Host 12
Safety While RB51 is licensed for cattle use, it cannot be used for human due to its capability of potentially causing human infection. So the safety concern is a main disadvantage for its use. However, since it is a licensed cattle vaccine, it is very suitable to express protective antigens in other pathogens as a bacterial vaccine vector. Such a vaccine would protect the cattle against brucellosis and the other pathogen infection.
Stability The stability of RB51 as a vaccine vector is high.
Description RB51 is a live attenuated cattle brucellosis vaccine strain that has been licensed for cattle use in the USA and many other countries. This B. abortus strain has been experimentally verified to be a bacterial vaccine vector (Vemulapalli et al., 2007).
Related Vaccine(s)
He et al., 2001: He Y, Vemulapalli R, Zeytun A, Schurig GG. Induction of specific cytotoxic lymphocytes in mice vaccinated with Brucella abortus RB51. Infection and immunity. 2001; 69(9); 5502-5508. [PubMed: 11500423].
Schurig et al., 1991: Schurig GG, Roop RM 2nd, Bagchi T, Boyle S, Buhrman D, Sriranganathan N. Biological properties of RB51; a stable rough strain of Brucella abortus. Veterinary microbiology. 1991; 28(2); 171-188. [PubMed: 1908158].
Vemulapalli et al., 2007: Vemulapalli R, Sanakkayala N, Gulani J, Schurig GG, Boyle SM, Lindsay DS, Sriranganathan N. Reduced cerebral infection of Neospora caninum in BALB/c mice vaccinated with recombinant Brucella abortus RB51 strains expressing N. caninum SRS2 and GRA7 proteins. Veterinary parasitology. 2007; 148(3-4); 219-230. [PubMed: 17651896].