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Salmonella enterica SL3261 vaccine vector |
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Vaxvec ID |
17 |
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Vaccine Vector Name |
Salmonella enterica SL3261 vaccine vector |
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Alternative Names |
Salmonella enterica serovar Typhimurium SL3261 |
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Vector VO ID |
VO_0001031
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Advantage |
S. enterica can effectively colonize antigen-presenting cells, like dendritic cells and macrophages (Hernández-Luna et al., 2013). Live, attenuated S. enterica strains are particularly useful because they elicit mucosal immunity, which can be used to control pathogenic outbreaks such as Trichinella spiralis infection in the intestines (Pompa-Mera et al., 2011). |
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Description |
The S. enterica strain SL3261 can be engineered to display the Ag30 antigen derived from the 43 kDa glycoprotein of T. spiralis muscle larvae, and protective immune responses were shown (Pompa-Mera et al., 2011). |
| Related Vaccine(s) |
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| References |
Breau et al., 2012: Breau C, Cameron DW, Desjardins M, Lee BC. Oral immunization using HgbA in a recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261 in the temperature-dependent rabbit model. Journal of immunological methods. 2012; 375(1-2); 232-242. [PubMed: 22100216].
Gómez-Duarte et al., 1998: Gómez-Duarte OG, Lucas B, Yan ZX, Panthel K, Haas R, Meyer TF. Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B. Vaccine. 1998; 16(5); 460-471. [PubMed: 9491500].
Hernández-Luna et al., 2013: Hernández-Luna MA, Luria-Pérez R, Huerta-Yépez S. [Therapeutic intervention alternatives in cancer, using attenuated live bacterial vectors: Salmonella enterica as a carrier of heterologous molecules]. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. 2013; 65(1); 65-73. [PubMed: 23745445].
Pogonka et al., 2003: Pogonka T, Klotz C, Kovács F, Lucius R. A single dose of recombinant Salmonella typhimurium induces specific humoral immune responses against heterologous Eimeria tenella antigens in chicken. International journal for parasitology. 2003; 33(1); 81-88. [PubMed: 12547349].
Pompa-Mera et al., 2011: Pompa-Mera EN, Yépez-Mulia L, Ocaña-Mondragón A, GarcÃa-Zepeda EA, Ortega-Pierres G, González-Bonilla CR. Trichinella spiralis: intranasal immunization with attenuated Salmonella enterica carrying a gp43 antigen-derived 30mer epitope elicits protection in BALB/c mice. Experimental parasitology. 2011; 129(4); 393-401. [PubMed: 21907709].
Qi et al., 2006: Qi H, Li YH, Zheng SB. [Oral gene therapy via live attenuated Salmonella leads to tumor regression and survival prolongation in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2006; 26(12); 1738-1741. [PubMed: 17259109].
Schroeder et al., 2011: Schroeder J, Brown N, Kaye P, Aebischer T. Single dose novel Salmonella vaccine enhances resistance against visceralizing L. major and L. donovani infection in susceptible BALB/c mice. PLoS neglected tropical diseases. 2011; 5(12); e1406. [PubMed: 22216363].
Tite et al., 1990: Tite JP, Gao XM, Hughes-Jenkins CM, Lipscombe M, O'Callaghan D, Dougan G, Liew FY. Anti-viral immunity induced by recombinant nucleoprotein of influenza A virus. III. Delivery of recombinant nucleoprotein to the immune system using attenuated Salmonella typhimurium as a live carrier. Immunology. 1990; 70(4); 540-546. [PubMed: 2168340].
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