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Baculovirus vaccine vector |
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Vaxvec ID |
19 |
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Vaccine Vector Name |
Baculovirus vaccine vector |
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Vector VO ID |
VO_0001084
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Advantage |
These vectors possess a great capacity for cloning and low cytotoxicity. These vectors allow for biosafety and are easy to manipulate and produce. They allow for efficient gene delivery and can express foreign protein in mammalian cells, given that the gene in question is regulated on the level of transcription of mammalian cell-active promoter (Lu et al., 2012). |
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Safety |
Baculovirus does not replicate inside the transduced cells and does not integrate its DNA into host chromosomes when this is not specifically selected for. Baculovirus affects insects in nature and can transduce a variety of animal cells. However, remians non-pathogenic in the case of humans (Lu et al., 2012). |
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Description |
Baculovirus is known for being able to transfer genes in vivo. This includes the liver, spleen, testes, heart and skeletal muscle of mice, retinal vasculature and brain of rats, and carotid artery and intervertebral discs of rabbit. The latter indicates its potential for broad tissue tropism (Madhan et al., 2010). Success with baculovirus has been reported in vitro as well as in vivo. The cloning capacity of baculovirus is as large as 38 kb, which provides for the ability to deliver many genes and regulatory elements (Lu et al., 2012). |
| Related Vaccine(s) |
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| References |
Lu et al., 2012: Lu HY, Chen YH, Liu HJ. Baculovirus as a vaccine vector. Bioengineered. 2012; 3(5); 271-274. [PubMed: 22705893].
Madhan et al., 2010: Madhan S, Prabakaran M, Kwang J. Baculovirus as vaccine vectors. Current gene therapy. 2010; 10(3); 201-213. [PubMed: 20394572].
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