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Retroviral vaccine vector |
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Vaxvec ID |
23 |
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Vaccine Vector Name |
Retroviral vaccine vector |
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Alternative Names |
Retrovirus vaccine vector |
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Vector VO ID |
VO_0001102
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Function |
Retroviral vectors are prime gene carriers to genetically alter cells being targeted. Their administration has been to result in stable, longstanding expression of transgenes (Liechtenstein et al., 2013). |
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Safety |
Retroviral vectors allow for stable integration of a cDNA copy of their RNA genome into the host cell chromosomes. This is accomplished through the mechanisms of reverse transcription and integration (Liechtenstein et al., 2013). |
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Description |
Retroviral vectors encompass a large class of virus-based gene vector. This class of vectors, developed from the retroviridae family, is subdivided into simple and complex retroviruses (Liechtenstein et al., 2013). These viruses are positive-sense single-stranded (ss) RNA diploid viruses which posses a somewhat spherical shape (Liechtenstein et al., 2013). Retrovirus genomes posses similar configuration. Read from the 5′ to the 3′ end, genomes of retroviruses encompass the genes gag, pol, and env. An important event in a retrovirus' replication cycle occurs when the pol gene is expressed. The pol gene is responsible for encoding reverse transcriptase (RT), integrase, and RNase H (Nikolic et al., 2012). |
| Related Vaccine(s) |
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| References |
Hunt et al., 1988: Hunt LA, Brown DW, Robinson HL, Naeve CW, Webster RG. Retrovirus-expressed hemagglutinin protects against lethal influenza virus infections. Journal of virology. 1988; 62(8); 3014-3019. [PubMed: 2839718].
Liechtenstein et al., 2013: Liechtenstein T, Perez-Janices N, Escors D. Lentiviral vectors for cancer immunotherapy and clinical applications. Cancers. 2013; 5(3); 815-837. [PubMed: 24078865].
Nikolic et al., 2012: Nikolic EI, King LM, Vidakovic M, Irigoyen N, Brierley I. Modulation of ribosomal frameshifting frequency and its effect on the replication of Rous sarcoma virus. Journal of virology. 2012; 86(21); 11581-11594. [PubMed: 22896611].
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