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Edwardsiella tarda EIB202 vaccine vector |
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Vaxvec ID |
25 |
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Vaccine Vector Name |
Edwardsiella tarda EIB202 vaccine vector |
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Alternative Names |
E. tarda EIB202 |
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Vector VO ID |
VO_0001032
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Advantage |
Because E. tarda is commonnly a fish pathogen, it is useful as a vector for other pathogens in fish. It has been shown to elicit strong immune responses and in one study of E. tarda EIB202 expression of A. hydrophila LSA34 (another fish pathogen) over 60% of fish challenged with A. hydrophila survived (Mu et al., 2011). |
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Disadvantage |
Because the bacteria are live yet attenuated, they have the potential to be released into the environment upon vaccination. Therefore, the attenuation procedures must be carefully monitored to avoid environmental hazards (Yan et al., 2013). |
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Host |
48 |
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Description |
Edwardsiella tarda is a common invasive pathogen of fish, causing enteric septicemia (Yan et al., 2013). Its attenuated forms are effective recombinant vaccine vectors in such hosts as zebrafish (Mu et al., 2011). |
| Related Vaccine(s) |
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| References |
Mu et al., 2011: Mu W, Guan L, Yan Y, Liu Q, Zhang Y. A novel in vivo inducible expression system in Edwardsiella tarda for potential application in bacterial polyvalence vaccine. Fish & shellfish immunology. 2011; 31(6); 1097-1105. [PubMed: 21964456].
Yan et al., 2013: Yan Y, Mu W, Zhang L, Guan L, Liu Q, Zhang Y. Asd-based balanced-lethal system in attenuated Edwardsiella tarda to express a heterologous antigen for a multivalent bacterial vaccine. Fish & shellfish immunology. 2013; 34(5); 1188-1194. [PubMed: 23454428].
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