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Vaccine Comparison
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VEE virus DNA vaccine VEEV IA/B parent encoding structural genes |
VEE Virus PE2/E1 mutant vaccine |
| Vaccine Information |
Vaccine Information |
- Vaccine Ontology ID: VO_0004421
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: VEEV subtype IA/B capsid protein (C) and envelope glycoproteins (E1 and E2) (Dupuy et al., 2009)
- E1 glycoprotein
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- E2 envelope protein
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- Vector: pES (Dupuy et al., 2009)
- Immunization Route: Intradermal injection (i.d.)
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- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- E1 glycoprotein
gene engineering:
- Type: Gene mutation
- Description: This PE2/E1 mutant is from Venezuelan equine encephalitis virus (Davis et al., 1995).
- Detailed Gene Information: Click Here.
- PE2
gene engineering:
- Type: Gene mutation
- Description: This PE2/E1 mutant is from Venezuelan equine encephalitis virus (Davis et al., 1995).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| References |
References |
Dupuy et al., 2009: Dupuy LC, Locher CP, Paidhungat M, Richards MJ, Lind CM, Bakken R, Parker MD, Whalen RG, Schmaljohn CS. Directed molecular evolution improves the immunogenicity and protective efficacy of a Venezuelan equine encephalitis virus DNA vaccine. Vaccine. 2009; 27(31); 4152-4160. [PubMed: 19406186].
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Davis et al., 1995: Davis NL, Brown KW, Greenwald GF, Zajac AJ, Zacny VL, Smith JF, Johnston RE. Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1. Virology. 1995; 212(1); 102-110. [PubMed: 7676619].
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