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Vaccine Comparison
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rMA15-ΔE vaccine |
SARS-CoV E gene mutant vaccine |
| Vaccine Information |
Vaccine Information |
- Type: Live, attenuated vaccine
- Status: Research
- Host Species for Licensed Use: None
- Host Species as Laboratory Animal Model: mouse
- Antigen: virulent mouse-adapted SARS-CoV with E-deletion (rMA15-ΔE) (Fett et al., 2013)
- envelope protein (E) gene of SARS-CoV
gene engineering:
- Type: Gene mutation
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
- Description: recombinant MA15 virulent mouse-adapted SARS-CoV (MA15) background of E-deleted vaccine candidate (rMA15-ΔE) (Fett et al., 2013)
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- Vaccine Ontology ID: VO_0002993
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Hamster
- envelope protein (E) gene of SARS-CoV
gene engineering:
- Type: Gene mutation
- Description: This E gene is from SARS coronavirus (Lamirande et al., 2008).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| References |
References |
Fett et al., 2013: Fett C, DeDiego ML, Regla-Nava JA, Enjuanes L, Perlman S. Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein. Journal of virology. 2013; 87(12); 6551-6559. [PubMed: 23576515].
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Lamirande et al., 2008: Lamirande EW, DeDiego ML, Roberts A, Jackson JP, Alvarez E, Sheahan T, Shieh WJ, Zaki SR, Baric R, Enjuanes L, Subbarao K. A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters. Journal of virology. 2008; 82(15); 7721-7724. [PubMed: 18463152].
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