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Vaccine Comparison

Aro-deleted S. Typhi
Vaccine Information
  • Type: Live, attenuated vaccine
  • Antigen: The antigen used was aro-deleted S. Typhi, a strain designated as CVD 908 (Tacket and Levine, 2007).
  • AroD gene engineering:
    • Type: Recombinant protein preparation
    • Description: Inactivation of AroD results in attenuation, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain "CVD 908" (Tacket and Levine, 2007).
    • Detailed Gene Information: Click Here.
  • AroC gene engineering:
    • Type: Recombinant protein preparation
    • Description: Inactivation of AroC results in attenuation, and the deletions of both AroC and AroD provide a high level of safety against restoration of pathogenicity by recombination. An aroC/aroD-deleted derivative of S. Typhi strain Ty2 (the parent strain of Ty21a) is designated the strain "CVD 908" (Tacket and Levine, 2007).
    • Detailed Gene Information: Click Here.
  • Preparation: CVD 908 was created by deleting both aroC and aroD, preventing restoration of pathogenicity by recombination (Tacket and Levine, 2007).
  • Virulence: After a single dose of the vaccine (5 × 10^4 or 5 × 10^5 cfu), vaccine bacteremia was not detected in serial blood cultures. Half of the subjects tested with this dose developed serum IgG anti–lipopolysaccharide antibodies and IgA anti-LPS antibody-secreting cells (Tacket and Levine, 2007).
  • Description: The aromatic metabolites, such as aroC and aroD, force Salmonella to be nutritionally dependent on p-aminobenzoic acid and 2,3-dihydroxy, both of which are not available in mammilian tissues, preventing proliferation in the host cells (Tacket and Levine, 2007).
References
Tacket and Levine, 2007: Tacket CO, Levine MM. CVD 908, CVD 908-htrA, and CVD 909 live oral typhoid vaccines: a logical progression. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007; 45 Suppl 1; S20-23. [PubMed: 17582563].
CVD 908-htrA
Vaccine Information
  • Vaccine Ontology ID: VO_0002865
  • Type: Live, attenuated vaccine
  • Antigen: The antigen was htrA-deleted S.Typhi (Tacket and Levine, 2007).
  • AroC gene engineering:
    • Type: Recombinant protein preparation
    • Description: HtrA was deleted in Salmonella organisms, which created a mutant that was less virulent and more susceptible to oxidative killing. HtrA encodes a heat-shock protein in Salmonella (Tacket and Levine, 2007).

    • Detailed Gene Information: Click Here.
  • Preparation: Formation of CVD 908-htrA was conducted from original CVC 908, and the vaccine created consisted of live lyophilized organisms in single-dose glass vials to be resuspended in buffer solution (Tacket and Levine, 2007).
  • Virulence: CVD 908-htrA retained the immunogenicity of the parent CVD 908, but no vaccine bacteremias were detected among people who received a single dose of 5 × 10^7, 5 × 10^8, or 5 × 10^9 cfu, despite surveillance for bacteremias after vaccination. The immune responses measured by seroconversion rates with IgG anti-LPS after vaccination with CVD 908 and CVD 908-htrA were very similar. Most volunteers developed ASC responses, regardless of the vaccine strain received. Some lymphoproliferative responses to flagella and particulate antigen after CVD 908-htrA vaccination were also observed (Tacket and Levine, 2007).
References
Tacket and Levine, 2007: Tacket CO, Levine MM. CVD 908, CVD 908-htrA, and CVD 909 live oral typhoid vaccines: a logical progression. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2007; 45 Suppl 1; S20-23. [PubMed: 17582563].
Salmonella enterica fliC/guaB mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse, chicken
  • fliC gene engineering:
    • Type: Gene mutation
    • Description: This fliC/guaB mutant is from Salmonella enterica (Adriaensen et al., 2007).
    • Detailed Gene Information: Click Here.
  • guaB from S. enteritidis str. P125109 gene engineering:
    • Type: Gene mutation
    • Description: This fliC/guaB mutant is from Salmonella enterica (Adriaensen et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
References
Adriaensen et al., 2007: Adriaensen C, De Greve H, Tian JQ, De Craeye S, Gubbels E, Eeckhaut V, Van Immerseel F, Ducatelle R, Kumar M, Hernalsteens JP. A live Salmonella enterica serovar Enteritidis vaccine allows serological differentiation between vaccinated and infected animals. Infection and immunity. 2007; 75(5); 2461-2468. [PubMed: 17261603].
Salmonella Enteritidis guaBA/clpP mutant vaccine
Vaccine Information
  • Product Name: CVD 1941
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • clpP gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Enteritidis (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • guaA gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Enteritidis (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • guaB from S. enteritidis str. P125109 gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Enteritidis (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Tennant et al., 2011: Tennant SM, Wang JY, Galen JE, Simon R, Pasetti MF, Gat O, Levine MM. Engineering and pre-clinical evaluation of attenuated non-typhoidal Salmonella strains serving as live oral vaccines and as reagent strains. Infection and immunity. 2011; ; . [PubMed: 21807911].
Salmonella Gallinarum cbiA/cobS mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • cbiA gene engineering:
    • Type: Gene mutation
    • Description: This cbiA/cobS mutant is from Salmonella Gallinarum (Penha et al., 2010).
    • Detailed Gene Information: Click Here.
  • cobS gene engineering:
    • Type: Gene mutation
    • Description: This cbiA/cobS mutant is from Salmonella Gallinarum (Penha et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
References
Penha et al., 2010: Penha Filho RA, de Paiva JB, da Silva MD, de Almeida AM, Berchieri A Jr. Control of Salmonella Enteritidis and Salmonella Gallinarum in birds by using live vaccine candidate containing attenuated Salmonella Gallinarum mutant strain. Vaccine. 2010; 28(16); 2853-2859. [PubMed: 20153354].
Salmonella Gallinarum cpxR/Ion mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • cpxR gene engineering:
    • Type: Gene mutation
    • Description: This cpxR/Ion mutant is from Salmonella Gallinarum (Matsuda et al., 2010).
    • Detailed Gene Information: Click Here.
  • lon gene engineering:
    • Type: Gene mutation
    • Description: This cpxR/Ion mutant is from Salmonella Gallinarum (Matsuda et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
References
Matsuda et al., 2010: Matsuda K, Chaudhari AA, Kim SW, Lee KM, Lee JH. Physiology, pathogenicity and immunogenicity of lon and/or cpxR deleted mutants of Salmonella Gallinarum as vaccine candidates for fowl typhoid. Veterinary research. 2010; 41(5); 59. [PubMed: 20487719].
Salmonella Gallinarum crp mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002879
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • crp gene engineering:
    • Type: Gene mutation
    • Description: This crp mutant is from Salmonella Gallinarum (Rosu et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
References
Rosu et al., 2007: Rosu V, Chadfield MS, Santona A, Christensen JP, Thomsen LE, Rubino S, Olsen JE. Effects of crp deletion in Salmonella enterica serotype Gallinarum. Acta veterinaria Scandinavica. 2007; 49; 14. [PubMed: 17488512].
Salmonella Gallinarum nuoG mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002901
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • nuoG gene engineering:
    • Type: Gene mutation
    • Description: This nuoG mutant is from Salmonella Gallinarum (Zhang-Barber et al., 1998).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
References
Zhang-Barber et al., 1998: Zhang-Barber L, Turner AK, Dougan G, Barrow PA. Protection of chickens against experimental fowl typhoid using a nuoG mutant of Salmonella serotype Gallinarum. Vaccine. 1998; 16(9-10); 899-903. [PubMed: 9682335].
Salmonella Gallinarum relA/spoT mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • relA gene engineering:
    • Type: Gene mutation
    • Description: This relA/spoT mutant is from Salmonella Gallinarum (Park et al., 2010).
    • Detailed Gene Information: Click Here.
  • spoT gene engineering:
    • Type: Gene mutation
    • Description: This relA/spoT mutant is from Salmonella Gallinarum (Park et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
References
Park et al., 2010: Park SI, Jeong JH, Choy HE, Rhee JH, Na HS, Lee TH, Her M, Cho KO, Hong Y. Immune response induced by ppGpp-defective Salmonella enterica serovar Gallinarum in chickens. Journal of microbiology (Seoul, Korea). 2010; 48(5); 674-681. [PubMed: 21046347].
Salmonella typhi aroA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002863
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • aroA gene engineering:
    • Type: Gene mutation
    • Description: This aroA was mutated from Salmonella typhi strain Ty2 (Dougan et al., 1987).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Dougan et al., 1987: Dougan G, Maskell D, Pickard D, Hormaeche C. Isolation of stable aroA mutants of Salmonella typhi Ty2: properties and preliminary characterisation in mice. Molecular & general genetics : MGG. 1987; 207(2-3); 402-405. [PubMed: 3039297].
Salmonella Typhi galE mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002883
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • galE gene engineering:
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Germanier and Füer, 1975: Germanier R, Füer E. Isolation and characterization of Gal E mutant Ty 21a of Salmonella typhi: a candidate strain for a live, oral typhoid vaccine. The Journal of infectious diseases. 1975; 131(5); 553-558. [PubMed: 1092768].
Salmonella Typhi phoP mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002903
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • PhoP gene engineering:
    • Type: Gene mutation
    • Description: This phoP mutant is from Salmonella Typhi (Lee et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Lee et al., 2007: Lee HY, Cho SA, Lee IS, Park JH, Seok SH, Baek MW, Kim DJ, Lee SH, Hur SJ, Ban SJ, Lee YK, Han YK, Cho YK, Park JH. Evaluation of phoP and rpoS mutants of Salmonella enterica serovar Typhi as attenuated typhoid vaccine candidates: virulence and protective immune responses in intranasally immunized mice. FEMS immunology and medical microbiology. 2007; 51(2); 310-318. [PubMed: 17725620].
Salmonella Typhimurium asd mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002867
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • asd gene engineering:
    • Type: Gene mutation
    • Description: This asd mutant is from Salmonella Typhimurium (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Piao et al., 2010: Piao HH, Tam VT, Na HS, Kim HJ, Ryu PY, Kim SY, Rhee JH, Choy HE, Kim SW, Hong Y. Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice. Journal of microbiology (Seoul, Korea). 2010; 48(4); 486-495. [PubMed: 20799091].
Salmonella Typhimurium asd/rfc mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • asd gene engineering:
    • Type: Gene mutation
    • Description: This asd/rfc mutant is from Salmonella Typhimurium (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
  • rfc gene engineering:
    • Type: Gene mutation
    • Description: This asd/rfc mutant is from Salmonella Typhimurium (Piao et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Piao et al., 2010: Piao HH, Tam VT, Na HS, Kim HJ, Ryu PY, Kim SY, Rhee JH, Choy HE, Kim SW, Hong Y. Immunological responses induced by asd and wzy/asd mutant strains of Salmonella enterica serovar Typhimurium in BALB/c mice. Journal of microbiology (Seoul, Korea). 2010; 48(4); 486-495. [PubMed: 20799091].
Salmonella Typhimurium atpA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002869
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • atpA gene engineering:
    • Type: Gene mutation
    • Description: This atpA mutant is from Salmonella Typhimurium (Chaudhuri et al., 2009).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
References
Chaudhuri et al., 2009: Chaudhuri RR, Peters SE, Pleasance SJ, Northen H, Willers C, Paterson GK, Cone DB, Allen AG, Owen PJ, Shalom G, Stekel DJ, Charles IG, Maskell DJ. Comprehensive identification of Salmonella enterica serovar typhimurium genes required for infection of BALB/c mice. PLoS pathogens. 2009; 5(7); e1000529. [PubMed: 19649318].
Salmonella Typhimurium clpP mutant vaccine
Vaccine Information
  • Product Name: CS2007
  • Vaccine Ontology ID: VO_0002872
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • clpP from S. typhimurium str. LT2 gene engineering:
    • Type: Gene mutation
    • Description: This clpP mutant is from Salmonella Typhimurium (Matsui et al., 2003).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Matsui et al., 2003: Matsui H, Suzuki M, Isshiki Y, Kodama C, Eguchi M, Kikuchi Y, Motokawa K, Takaya A, Tomoyasu T, Yamamoto T. Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar typhimurium. Infection and immunity. 2003; 71(1); 30-39. [PubMed: 12496146].
Salmonella Typhimurium cya/crp mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • crp from S. Typhimurium gene engineering:
    • Type: Gene mutation
    • Description: This crp mutant is from S. Typhimurium (Curtiss and Kelly, 1987).
    • Detailed Gene Information: Click Here.
  • cya gene engineering:
    • Type: Gene mutation
    • Description: This cya mutant is from S. Typhimurium (Curtiss and Kelly, 1987).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Peroral Inoculation
References
Curtiss and Kelly, 1987: Curtiss R 3rd, Kelly SM. Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic. Infection and immunity. 1987; 55(12); 3035-3043. [PubMed: 3316029].
Salmonella Typhimurium guaBA/clpP mutant vaccine
Vaccine Information
  • Product Name: CVD 1921
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • clpP from S. typhimurium str. LT2 gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Typhimurium (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • guaA from S. typhimurium str. LT2 gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Typhimurium (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • guaB gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP mutant is from Salmonella Typhimurium (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Tennant et al., 2011: Tennant SM, Wang JY, Galen JE, Simon R, Pasetti MF, Gat O, Levine MM. Engineering and pre-clinical evaluation of attenuated non-typhoidal Salmonella strains serving as live oral vaccines and as reagent strains. Infection and immunity. 2011; ; . [PubMed: 21807911].
Salmonella Typhimurium guaBA/clpP/fliD mutant vaccine
Vaccine Information
  • Product Name: CVD 1923
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • clpP from S. typhimurium str. LT2 gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP/fliD mutant is from Salmonella Typhimurium (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • fliD gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP/fliD mutant is from Salmonella Typhimurium (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • guaA from S. typhimurium str. LT2 gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP/fliD mutant is from Salmonella Typhimurium (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • guaB gene engineering:
    • Type: Gene mutation
    • Description: This guaBA/clpP/fliD mutant is from Salmonella Typhimurium (Tennant et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Tennant et al., 2011: Tennant SM, Wang JY, Galen JE, Simon R, Pasetti MF, Gat O, Levine MM. Engineering and pre-clinical evaluation of attenuated non-typhoidal Salmonella strains serving as live oral vaccines and as reagent strains. Infection and immunity. 2011; ; . [PubMed: 21807911].
Salmonella Typhimurium gyrA/cpxA/rpoB mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pigs
  • cpxA gene engineering:
    • Type: Gene mutation
    • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
    • Detailed Gene Information: Click Here.
  • gyrA gene engineering:
    • Type: Gene mutation
    • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
    • Detailed Gene Information: Click Here.
  • rpoB gene engineering:
    • Type: Gene mutation
    • Description: This gyrA/cpxA/rpoB mutant is from Salmonella Typhimurium (Roesler et al., 2004).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Roesler et al., 2004: Roesler U, Marg H, Schröder I, Mauer S, Arnold T, Lehmann J, Truyen U, Hensel A. Oral vaccination of pigs with an invasive gyrA-cpxA-rpoB Salmonella Typhimurium mutant. Vaccine. 2004; 23(5); 595-603. [PubMed: 15542179].
Salmonella Typhimurium hfq mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002892
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • hfq gene engineering:
    • Type: Gene mutation
    • Description: This hfq mutant is from Salmonella Typhimurium (Allam et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Allam et al., 2011: Allam US, Krishna MG, Lahiri A, Joy O, Chakravortty D. Salmonella enterica Serovar Typhimurium Lacking hfq Gene Confers Protective Immunity against Murine Typhoid. PloS one. 2011; 6(2); e16667. [PubMed: 21347426].
Salmonella Typhimurium htrA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002893
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • htrA gene engineering:
    • Type: Gene mutation
    • Description: This htrA mutant is from Salmonella Typhimurium (Chatfield et al., 1992).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
References
Chatfield et al., 1992: Chatfield SN, Strahan K, Pickard D, Charles IG, Hormaeche CE, Dougan G. Evaluation of Salmonella typhimurium strains harbouring defined mutations in htrA and aroA in the murine salmonellosis model. Microbial pathogenesis. 1992; 12(2); 145-151. [PubMed: 1584006].
Salmonella Typhimurium IppA/IppB/msbB
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • lppA gene engineering:
    • Type: Gene mutation
    • Description: This IppA/IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • lppB gene engineering:
    • Type: Gene mutation
    • Description: This IppA/IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • msbB gene engineering:
    • Type: Gene mutation
    • Description: This IppA/IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Liu et al., 2008: Liu T, König R, Sha J, Agar SL, Tseng CT, Klimpel GR, Chopra AK. Immunological responses against Salmonella enterica serovar Typhimurium Braun lipoprotein and lipid A mutant strains in Swiss-Webster mice: potential use as live-attenuated vaccines. Microbial pathogenesis. 2008; 44(3); 224-237. [PubMed: 17997275].
Salmonella Typhimurium IppB/msbB mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • lppB gene engineering:
    • Type: Gene mutation
    • Description: This IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • msbB gene engineering:
    • Type: Gene mutation
    • Description: This IppB/msbB mutant is from Salmonella Typhimurium (Liu et al., 2008).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Liu et al., 2008: Liu T, König R, Sha J, Agar SL, Tseng CT, Klimpel GR, Chopra AK. Immunological responses against Salmonella enterica serovar Typhimurium Braun lipoprotein and lipid A mutant strains in Swiss-Webster mice: potential use as live-attenuated vaccines. Microbial pathogenesis. 2008; 44(3); 224-237. [PubMed: 17997275].
Salmonella Typhimurium ompD/nmpC mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002900
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • NmpC gene engineering:
    • Type: Gene mutation
    • Description: This ompD/nmpC mutant is from Salmonella Typhimurium (Selke et al., 2007).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Selke et al., 2007: Selke M, Meens J, Springer S, Frank R, Gerlach GF. Immunization of pigs to prevent disease in humans: construction and protective efficacy of a Salmonella enterica serovar Typhimurium live negative-marker vaccine. Infection and immunity. 2007; 75(5); 2476-2483. [PubMed: 17296750].
Salmonella Typhimurium ompR mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002902
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • ompR gene engineering:
    • Type: Gene mutation
    • Description: This ompR mutant is from Salmonella Typhimurium (Dorman et al., 1989).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
References
Dorman et al., 1989: Dorman CJ, Chatfield S, Higgins CF, Hayward C, Dougan G. Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo. Infection and immunity. 1989; 57(7); 2136-2140. [PubMed: 2543631].
Salmonella Typhimurium poxA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002904
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • poxA gene engineering:
    • Type: Gene mutation
    • Description: This poxA mutant is from Salmonella Typhimurium (Kaniga et al., 1998).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Kaniga et al., 1998: Kaniga K, Compton MS, Curtiss R 3rd, Sundaram P. Molecular and functional characterization of Salmonella enterica serovar typhimurium poxA gene: effect on attenuation of virulence and protection. Infection and immunity. 1998; 66(12); 5599-5606. [PubMed: 9826331].
Salmonella Typhimurium rpoS mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002908
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • rpoS gene engineering:
    • Type: Gene mutation
    • Description: This rpoS mutant is from Salmonella Typhimurium (Coynault et al., 1996).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Coynault et al., 1996: Coynault C, Robbe-Saule V, Norel F. Virulence and vaccine potential of Salmonella typhimurium mutants deficient in the expression of the RpoS (sigma S) regulon. Molecular microbiology. 1996; 22(1); 149-160. [PubMed: 8899717].
Salmonella Typhimurium ruvB mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002909
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • ruvB gene engineering:
    • Type: Gene mutation
    • Description: This ruvB mutant is from Salmonella Typhimurium (Choi et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Choi et al., 2010: Choi J, Shin D, Ryu S. Salmonella enterica serovar Typhimurium ruvB mutant can confer protection against salmonellosis in mice. Vaccine. 2010; 28(39); 6436-6444. [PubMed: 20670908].
Salmonella Typhimurium surA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002911
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • surA gene engineering:
    • Type: Gene mutation
    • Description: This surA mutant is from Salmonella Typhimurium (Sydenham et al., 2000).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
References
Sydenham et al., 2000: Sydenham M, Douce G, Bowe F, Ahmed S, Chatfield S, Dougan G. Salmonella enterica serovar typhimurium surA mutants are attenuated and effective live oral vaccines. Infection and immunity. 2000; 68(3); 1109-1115. [PubMed: 10678914].
Salmonella Typhimurium tolA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002912
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • tolA gene engineering:
    • Type: Gene mutation
    • Description: This tolA mutant is from Salmonella Typhimurium (Paterson et al., 2009).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
References
Paterson et al., 2009: Paterson GK, Northen H, Cone DB, Willers C, Peters SE, Maskell DJ. Deletion of tolA in Salmonella Typhimurium generates an attenuated strain with vaccine potential. Microbiology (Reading, England). 2009; 155(Pt 1); 220-228. [PubMed: 19118362].
Salmonella Typhimurium trxA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002913
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • trxA gene engineering:
    • Type: Gene mutation
    • Description: A trxA mutant is attenuated in mice and induced significant protection from challenge with wild type S. Typhimurium (Peters et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intravenous injection (i.v.)
References
Peters et al., 2010: Peters SE, Paterson GK, Bandularatne ES, Northen HC, Pleasance S, Willers C, Wang J, Foote AK, Constantino-Casas F, Scase TJ, Blacklaws BA, Bryant CE, Mastroeni P, Charles IG, Maskell DJ. Salmonella enterica serovar typhimurium trxA mutants are protective against virulent challenge and induce less inflammation than the live-attenuated vaccine strain SL3261. Infection and immunity. 2010; 78(1); 326-336. [PubMed: 19884329].
Salmonella Typhimurium wecA mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002914
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • wecA gene engineering:
    • Type: Gene mutation
    • Description: This wecA mutant is from Salmonella Typhimurium (Gilbreath et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intraperitoneal injection (i.p.)
References
Gilbreath et al., 2011: Gilbreath JJ, Colvocoresses Dodds J, Rick PD, Soloski MJ, Merrell DS, Metcalf ES. Enterobacterial Common Antigen Mutants of Salmonella enterica serovar Typhimurium Establish a Persistent Infection and Provide Protection Against Subsequent Lethal Challenge. Infection and immunity. 2011; ; . [PubMed: 22025511].
Salmonella Typhimurium znuABC mutant vaccine
Vaccine Information
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Mouse
  • znuA gene engineering:
    • Type: Gene mutation
    • Description: This znuABC mutant is from Salmonella Typhimurium (Pesciaroli et al., 2011).
    • Detailed Gene Information: Click Here.
  • znuB gene engineering:
    • Type: Gene mutation
    • Description: This znuABC mutant is from Salmonella Typhimurium (Pesciaroli et al., 2011).
    • Detailed Gene Information: Click Here.
  • znuC gene engineering:
    • Type: Gene mutation
    • Description: This znuABC mutant is from Salmonella Typhimurium (Pesciaroli et al., 2011).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oral immunization
References
Pesciaroli et al., 2011: Pesciaroli M, Aloisio F, Ammendola S, Pistoia C, Petrucci P, Tarantino M, Francia M, Battistoni A, Pasquali P. An attenuated Salmonella enterica serovar Typhimurium strain lacking the ZnuABC transporter induces protection in a mouse intestinal model of Salmonella infection. Vaccine. 2011; ; . [PubMed: 21219981].