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Vaccine Comparison
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P. berghei p36p mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0003008
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- P36p
gene engineering:
- Type: Gene mutation
- Description: This p36p mutant is from Plasmodium berghei (Douradinha et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| References |
Douradinha et al., 2007: Douradinha B, van Dijk MR, Ataide R, van Gemert GJ, Thompson J, Franetich JF, Mazier D, Luty AJ, Sauerwein R, Janse CJ, Waters AP, Mota MM. Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection. International journal for parasitology. 2007; 37(13); 1511-1519. [PubMed: 17604034].
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P. yoelii p36/p52 mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0003009
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Py36
gene engineering:
- Type: Gene mutation
- Description: This p36/p52 mutant is from Plasmodium yoelii (Labaied et al., 2007).
- Detailed Gene Information: Click Here.
- Py52
gene engineering:
- Type: Gene mutation
- Description: This p36/p52 mutant is from Plasmodium yoelii (Labaied et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| References |
Labaied et al., 2007: Labaied M, Harupa A, Dumpit RF, Coppens I, Mikolajczak SA, Kappe SH. Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection. Infection and immunity. 2007; 75(8); 3758-3768. [PubMed: 17517871].
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P. yoelii UIS3 mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0003011
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- Antigen: UIS3(Tarun et al., 2007)
- UIS3
gene engineering:
- Type: Gene mutation
- Description: This UIS3 mutant is from Plasmodium yoelii (Tarun et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| References |
Tarun et al., 2007: Tarun AS, Dumpit RF, Camargo N, Labaied M, Liu P, Takagi A, Wang R, Kappe SH. Protracted sterile protection with Plasmodium yoelii pre-erythrocytic genetically attenuated parasite malaria vaccines is independent of significant liver-stage persistence and is mediated by CD8+ T cells. The Journal of infectious diseases. 2007; 196(4); 608-616. [PubMed: 17624848].
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Plasmodium FabB/FabF mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0003007
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- FabB/FabF
gene engineering:
- Type: Gene mutation
- Description: This FabB/FabF mutant is from Plasmodium (Butler et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| References |
Butler et al., 2011: Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell host & microbe. 2011; 9(6); 451-462. [PubMed: 21669394].
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