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Vaccine Comparison

Classical Swine Fever Virus DNA Vaccine pcDNA/E2 with TRIF
Vaccine Information
  • Vaccine Ontology ID: VO_0004524
  • Type: DNA vaccine
  • Status: Research
  • E2 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pRK-TRIF (Wan et al., 2010)
  • Immunization Route: Intramuscular injection (i.m.)
References
Wan et al., 2010: Wan C, Yi L, Yang Z, Yang J, Shao H, Zhang C, Pan Z. The Toll-like receptor adaptor molecule TRIF enhances DNA vaccination against classical swine fever. Veterinary immunology and immunopathology. 2010; 137(1-2); 47-53. [PubMed: 20466439].
Classical swine fever virus DNA vaccine pCI-gp55
Vaccine Information
  • Vaccine Ontology ID: VO_0004340
  • Type: DNA vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • E2 gene engineering:
    • Type: DNA vaccine construction
    • Description: Vector pCI expressed the gp55/E2 gene from classical swine fever virus (CSFV) (Hammond et al., 2001).
    • Detailed Gene Information: Click Here.
  • Vector: pCI (Hammond et al., 2001)
  • Immunization Route: Intramuscular injection (i.m.)
References
Hammond et al., 2001: Hammond JM, Jansen ES, Morrissy CJ, Goff WV, Meehan GC, Williamson MM, Lenghaus C, Sproat KW, Andrew ME, Coupar BE, Johnson MA. A prime-boost vaccination strategy using naked DNA followed by recombinant porcine adenovirus protects pigs from classical swine fever. Veterinary microbiology. 2001; 80(2); 101-119. [PubMed: 11295331].
Classical swine fever virus E(rns) mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002952
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • E(rns) gene engineering:
    • Type: Gene mutation
    • Description: This E(rns) mutant is from Classical swine fever virus (Sainz et al., 2008).
    • Detailed Gene Information: Click Here.
  • Immunization Route: intranasal immunization
References
Sainz et al., 2008: Sainz IF, Holinka LG, Lu Z, Risatti GR, Borca MV. Removal of a N-linked glycosylation site of classical swine fever virus strain Brescia Erns glycoprotein affects virulence in swine. Virology. 2008; 370(1); 122-129. [PubMed: 17904607].
Classical swine fever virus E1 mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002953
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • E1 gene engineering:
  • Immunization Route: intranasal immunization
References
Fernandez-Sainz et al., 2009: Fernandez-Sainz I, Holinka LG, Gavrilov BK, Prarat MV, Gladue D, Lu Z, Jia W, Risatti GR, Borca MV. Alteration of the N-linked glycosylation condition in E1 glycoprotein of Classical Swine Fever Virus strain Brescia alters virulence in swine. Virology. 2009; 386(1); 210-216. [PubMed: 19203774].
Classical swine fever virus E2 mutant vaccine
Vaccine Information
  • Vaccine Ontology ID: VO_0002954
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Pig
  • E2 gene engineering:
    • Type: Gene mutation
    • Description: This E2 mutant is from Classical swine fever virus (Maurer et al., 2005).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Oronasal immunization
References
Maurer et al., 2005: Maurer R, Stettler P, Ruggli N, Hofmann MA, Tratschin JD. Oronasal vaccination with classical swine fever virus (CSFV) replicon particles with either partial or complete deletion of the E2 gene induces partial protection against lethal challenge with highly virulent CSFV. Vaccine. 2005; 23(25); 3318-3328. [PubMed: 15837238].
DNA vaccine expressing the E2 protein
Vaccine Information
  • Vaccine Ontology ID: VO_0004514
  • Type: Live, attenuated vaccine
  • Status: Licensed
  • E2 gene engineering:
    • Type: DNA vaccine construction
    • Detailed Gene Information: Click Here.
  • Vector: pcDNA3.1+ (Tarradas et al., 2011)
  • Immunization Route: Intramuscular injection (i.m.)
References
Tarradas et al., 2011: Tarradas J, Álvarez B, Fraile L, Rosell R, Muñoz M, Galindo-Cardiel I, Domingo M, Dominguez J, Ezquerra A, Sobrino F, Ganges L. Immunomodulatory effect of swine CCL20 chemokine in DNA vaccination against CSFV. Veterinary immunology and immunopathology. 2011; 142(3-4); 243-251. [PubMed: 21684019].
rORFV-CSFV-E2
Vaccine Information
  • Vaccine Ontology ID: VO_0004768
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • E2 gene engineering:
    • Type: Recombinant vector construction
    • Description: Using the new recombinant parapoxvirus (PPV) Orf virus (ORFV) as a vaccine expressing the CSFV E. (Voigt et al., 2007).
    • Detailed Gene Information: Click Here.
  • Preparation: (Voigt et al., 2007) the recombinant parapoxvirus (PPV) Orf virus (ORFV) as a vaccine expressing the CSFV E2 glycoprotein to protect CSFV chellange.
  • Immunization Route: Intramuscular injection (i.m.)
References
Voigt et al., 2007: Voigt H, Merant C, Wienhold D, Braun A, Hutet E, Le Potier MF, Saalmüller A, Pfaff E, Büttner M. Efficient priming against classical swine fever with a safe glycoprotein E2 expressing Orf virus recombinant (ORFV VrV-E2). Vaccine. 2007; 25(31); 5915-5926. [PubMed: 17600594].