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GSK1437173A |
| Vaccine Information |
- Product Name: Herpes Zoster vaccine GSK1437173A
- Vaccine Ontology ID: VO_0004598
- Type: Subunit vaccine
- Status: Clinical trial
- Antigen: Glycoprotein E (gE) (Chlibek et al., 2013)
- US8
gene engineering:
- Type: Recombinant protein preparation
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Chlibek et al., 2013: Chlibek R, Bayas JM, Collins H, de la Pinta ML, Ledent E, Mols JF, Heineman TC. Safety and Immunogenicity of an AS01-adjuvanted Varicella-zoster Virus Subunit Candidate Vaccine Against Herpes Zoster in Adults >=50 Years of Age. The Journal of infectious diseases. 2013; ; . [PubMed: 23904292].
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Herpes simplex virus 1 gD mutant vaccine |
| Vaccine Information |
- Product Name: KOS-gDA3C
- Vaccine Ontology ID: VO_0002970
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- gD
gene engineering:
- Type: Gene mutation
- Description: This gD mutant is from human herpesvirus 1 (Awasthi et al., 2008).
- Detailed Gene Information: Click Here.
- Immunization Route: Flank scratch
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| References |
Awasthi et al., 2008: Awasthi S, Lubinski JM, Eisenberg RJ, Cohen GH, Friedman HM. An HSV-1 gD mutant virus as an entry-impaired live virus vaccine. Vaccine. 2008; 26(9); 1195-1203. [PubMed: 18243431].
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Herpes simplex virus 1 gH mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002971
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- gH
gene engineering:
- Type: Gene mutation
- Description: This gH mutant is from Herpes simplex virus type 1 (Farrell et al., 1994).
- Detailed Gene Information: Click Here.
- Immunization Route: Ear pinna
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| References |
Farrell et al., 1994: Farrell HE, McLean CS, Harley C, Efstathiou S, Inglis S, Minson AC. Vaccine potential of a herpes simplex virus type 1 mutant with an essential glycoprotein deleted. Journal of virology. 1994; 68(2); 927-932. [PubMed: 8289395].
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Herpes simplex virus 1 TK mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002973
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- TK
gene engineering:
- Type: Gene mutation
- Description: This TK mutant is from human herpesvirus type 1 (Field and Wildy, 1978).
- Detailed Gene Information: Click Here.
- Immunization Route: Intracerebral immunization
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| References |
Field and Wildy, 1978: Field HJ, Wildy P. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. The Journal of hygiene. 1978; 81(2); 267-277. [PubMed: 212476].
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Herpes simplex virus 1 UL29 mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002974
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- UL29
gene engineering:
- Type: Gene mutation
- Description: This UL29 mutant is from human herpesvirus type 1 (Morrison and Knipe, 1994).
- Detailed Gene Information: Click Here.
- Immunization Route: subcutaneous injection
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| References |
Morrison and Knipe, 1994: Morrison LA, Knipe DM. Immunization with replication-defective mutants of herpes simplex virus type 1: sites of immune intervention in pathogenesis of challenge virus infection. Journal of virology. 1994; 68(2); 689-696. [PubMed: 8289372].
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Herpes simplex virus 2 ICP0 mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002972
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- ICP0
gene engineering:
- Type: Gene mutation
- Description: This ICP0 mutant is from Human herpesvirus type 2 (Halford et al., 2011).
- Detailed Gene Information: Click Here.
- Immunization Route: Vaginal immunization
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| References |
Halford et al., 2011: Halford WP, Püschel R, Gershburg E, Wilber A, Gershburg S, Rakowski B. A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccine. PloS one. 2011; 6(3); e17748. [PubMed: 21412438].
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Herpes Simplex Virus Type 1 DNA Vaccine encoding 5gP |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004520
- Type: DNA vaccine
- Status: Research
- UL27 from Herpes simplex virus type 1
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- UL44 from HSV-1
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- gD
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- US8
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- US7
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- Vector: VR-1055 (Osorio et al., 2004)
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Osorio et al., 2004: Osorio Y, Cohen J, Ghiasi H. Improved protection from primary ocular HSV-1 infection and establishment of latency using multigenic DNA vaccines. Investigative ophthalmology & visual science. 2004; 45(2); 506-514. [PubMed: 14744892].
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Herpes simplex virus type 1 DNA vaccine encoding GE |
| Vaccine Information |
- Vaccine Ontology ID: VO_0011423
- Type: DNA vaccine
- Status: Research
- Antigen: Herpes simplex virus type 1 glycoprotein E
- US8
gene engineering:
- Type: DNA vaccine construction
- Description: The HSV-1 KOS gE gene was isolated by PCR. Each gene was initially cloned into a TA cloning vector and then into a eukaryotic plasmic expression vector that uses the cytomegalovirus immediate-early promoter for expression (pRc/CMV for gE) (Nass et al., 1998).
- Detailed Gene Information: Click Here.
- Vector: pRc/CMV
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| References |
Nass et al., 1998: Nass PH, Elkins KL, Weir JP. Antibody response and protective capacity of plasmid vaccines expressing three different herpes simplex virus glycoproteins. The Journal of infectious diseases. 1998; 178(3); 611-617. [PubMed: 9728527].
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Herpes Simplex Virus Type 1 DNA Vaccine pRSC-gD-IL-21 |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004519
- Type: DNA vaccine
- Status: Research
- gD
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- Immunization Route: Eye-drop immunization
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| References |
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