VIOLIN: Vaccine Investigation and Online Information Network

Virugen: Virulent Genes for Vaccine Development

"Virugen" is coined here to represent a gene that encodes for a virulent factor of a pathogen and has been proven feasible to make a live attenuated vaccine by knocking out this gene. Not all virulence factors can be used for vaccine development. Currently, VIOLIN includes 3 virugens that have been verified to be valuable for vaccine development against 73 pathogens. See detailed curated data:

Index	Pathogen Name	Disease	No. of Virugens
1	Actinobacillus pleuropneumoniae		0
2	Aeromonas salmonicida		0
3	Babesia bovis		0
4	Babesia canis		0
5	Bacillus anthracis	Anthrax	0
6	Bordetella avium		0
7	Bovine herpesvirus 1	infectious bovine rhinotracheitis	0
8	Brucella spp.	Brucellosis	1
9	Campylobacter jejuni	Campylobacterosis	0
10	Cancer	Cancer	0
11	Canine coronavirus		0
12	Canine distemper virus	Canine distemper	0
13	Canine parvovirus	Canine parvovirus infection	0
14	Chlamydophila abortus		0
15	Classical swine fever virus	Classical swine fever	0
16	Clostridium botulinum	Botulism	0
17	Clostridium tetani	Tetanus	0
18	Corynebacterium diphtheriae	Diphtheria	0
19	Coxiella burnetii	Q fever	0
20	Ebola virus	Ebola hemorrhagic fever	0
21	Eimeria maxima		0
22	Eimeria spp.		0
23	Eimeria tenella		0
24	Escherichia coli	Hemorrhagic colitis	0
25	Feline leukemia virus	Feline leukemia virus infection	0
26	Francisella tularensis	Tularemia	2
27	Giardia duodenalis		0
28	Haemophilus influenzae	Meningitis	0
29	Hantavirus	Hantavirus Pulmonary Syndrome	0
30	Hepatitis A virus	Hepatitis A	0
31	Hepatitis B virus	Hepatitis B	0
32	Human Immunodeficiency Virus	Acquired Immunodeficiency Syndrome (AIDS)	0
33	Human papillomavirus	HPV infection	0
34	Infectious Hematopoietic Necrosis Virus		0
35	Influenza virus	Influenza (flu)	0
36	Japanese encephalitis virus	Japanese encephalitis	0
37	Lassa Fever Virus	Lassa fever	0
38	Lawsonia intracellularis	Lawsonia intracellularis infection	0
39	Leishmania donovani		0
40	Marburg Virus	Hemorrhagic fever	0
41	Marek’s disease virus	Marek's disease	0
42	Measles virus	Measles	0
43	Mumps virus	Mumps	0
44	Mycobacterium tuberculosis	Tuberculosis	0
45	Mycoplasma gallisepticum		0
46	Mycoplasma synoviae		0
47	Neisseria meningitidis	Meningitis	0
48	Neospora caninum		0
49	Newcastle disease virus	Newcastle disease	0
50	Plasmodium spp.	Malaria	0
51	Poliovirus	Polio	0
52	Porcine circovirus 2	postweaning multisystemic wasting syndrome	0
53	Porphyromonas gulae		0
54	Pseudorabies virus	Aujeszky's disease	0
55	Rabies virus	Rabies	0
56	Rotavirus	Gastroenteritis	0
57	Rubella virus	Rubella	0
58	Salmonella spp.	Salmonellosis	0
59	Sarcocystis neurona		0
60	Shigella	Shigellosis	0
61	Streptococcus equi		0
62	Streptococcus pneumoniae	Pneumonia	0
63	Theileria annulata		0
64	Theileria parva		0
65	Toxoplasma gondii		0
66	Varicella-zoster virus	chickenpox / shingles	0
67	Variola virus	Smallpox	0
68	VEE Virus	Venezuelan equine encephalitis	0
69	Vibrio anguillarum		0
70	West Nile virus	West Nile fever	0
71	Yellow fever virus	Yellow fever	0
72	Yersinia pestis	Plague	0
73	Yersinia ruckeri		0
Total	73		3

NOTE: This page is still under development.