]> Alexander D. Diehl Thomas Todd Rebecca Racz Ryan R. Brinkman Alan Ruttenburg Barry Smith Bjoern Peters Samantha G. Sayers (SGS) en Richard H. Scheuermann Melanie Courtot Chris Mungall An ontology for the annotation of the vaccine domain. Lindsay Cowell December 24, 2012 OWL-DL The Vaccine Ontology (VO) is a biomedical ontology in the domain of vaccine. VO aims to standardize vaccine annotation, integrate various vaccine data, and support computer-assisted reasoning. VO supports basic vaccine R&D and clincal vaccine usage. VO is primarily developed by Dr. Yongqun "Oliver" He at the University of Michigan Medical School. VO is being developed as a community-based ontology with support and collaborations from the vaccine and bio-ontology communities. Vaccine Ontology Vision Release; 1.0.658 Yongqun "Oliver" He (YH) Yu Lin (YL) Zuoshuang "Allen" Xiang definition editor note has curation status definition source definition editor alternative term editor preferred term example of usage participates_in has_vaccine_contraindication has_vaccine_contraindication is a relation that specifies contraindication of a vaccine. YH This relation may be replaced by has_vaccine_allergen. We need to determine if any vaccine contraindicator is not a vaccine allergen. infection_of The relation 'infection_of' is introduced to represent an infection caused by an infectious pathogen. A pathogen infection is a disorder. Since the number of pathogens is large, there are numerous infections. To make the description of a specific infection simple, the shortcut term 'infection_of' is defined: infection_of X = infection and has_part some (organism X and has_disposition some infectious disposition) YH, XZ, MC, BP, AR infection_of is a relation between a disorder and an infectious pathogen. vaccinates "A vaccinates B" means that the vaccine A is used for vaccinating the host B (e.g., human). A relationship between a vaccine instance and an organism type such that if the vaccine instance is given to an instance of the organism by the process vaccination, then it changes the organism's disposition to have an immune response against a disease. YH, AR, ZX, MC has_vaccine_allergen has_vaccine_allegen is a relation that specifies an allegen to a vaccine. YH has_gene_mutation_of YH is_distributed_by YH, ZX is_distributed_by is a relation that specifies a company that distributes a product (e.g., vaccine). The company is very likely not the manufacturer of the product. vaccine immunization for host YL Yongqun He a shortcut relation that equals to: processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some ('vaccine host role' and (role_of some 'organism')))))))). The domain of this relation is a vaccine. The range of this relation is a organism. has_vaccine_target YL is a short relation: 'vaccine' has_vaccine_target 'Y' equal to: 'vaccine' is_output_of ('vaccine preparation and (realizes some ('vaccine target specification' and is_about some 'Y'))) Y is the union of organism and disease. vaccine immunization against microbe a shortcut relation that equals to: processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some ('immunization target role' and (role_of some 'MICROBE')))))))) The domain of this relation is a vaccine. The range of this relation is a microbe (a bacterium, a virus, a fungus, and a parasite) Yongqun He influenza Feline viral rhinotracheitis virus VEE virus Birds chicken horse pig independent variable specification dependent variable specification live part of pathogen organism in vaccine YH 'part of organism in vaccine' is a pathogen component in vaccine that contains only a part of the pathogen organism instead of the whole organism. vaccine Many vaccines are developed to protect against infectious pathogens. Many vaccines are also being developed against some diseases such as cancer and autoimmune diseases. Vaccine is developed against a disease. Allergy. YH, BP, BS, MC, LC, XZ, RS A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine. MeSH: D014612 vaccination YH, BP a process of administering substance in vivo that involves in adding a vaccine into a host (e.g., human) in vivo with the intent to invoke a protective or therapeutic adaptive immune response. vaccine administration ACAM2000 Smallpox (Vaccinia) Vaccine, Live CVX: 75 YH Trade Name: ACAM2000 ActHIB Product Name: Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate) PMID: 1735812 YH Trade Name: ActHIB PMID: 1517908 CVX: 48 PMID: Preparation: The vaccine consists of the Haemophilus b capsular polysaccharide (polyribosyl-ribitol-phosphate, PRP), a high molecular weight polymer prepared from the Haemophilus influenzae type b (HiB) strain 1482 grown in a semi-synthetic medium, covalently bound to tetanus toxoid. The tetanus toxoid is prepared by extraction, ammonium sulfate purification, and formalin inactivation of the toxin from cultures of Clostridium tetani (Harvard strain) grown in a modified Mueller and Miller medium. The toxoid is filter sterilized prior to the conjugation process. When ActHIB vaccine is reconstituted with saline diluent, each single dose of 0.5 mL is formulated to contain 10 mu g of purified capsular polysaccharide conjugated to 24 mu g of inactivated tetanus toxoid, and 8.5% of sucrose (ActHIB 2005). Reference: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=157&keywords= Adacel Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed Trade Name: Adacel CVX: 115 CVX: 20 YH Afluria Product Name: Influenza Virus Vaccine YH Trade Name: Afluria CVX: 141 CVX: 140 Attenuvax Product Name: Measles Virus Vaccine, Live Trade Name: Attenuvax YH vaccine-induced lymphocyte activation YH vaccine-induced B cell antigen processing and presentation YH vaccine-induced B cell cytokine production YH B cell epitope in vaccine YH vaccine-induced B cell mediated immunity YH Bacillus anthracis vaccine anthrax vaccine A vaccine that protects against Bacillus anthrax that causes anthrax. MeSH: D022122 YH Biothrax Product Name: Anthrax Vaccine Adsorbed CVX: 24 YH Trade Name: Biothrax Boostrix Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed Trade Name: Boostrix CVX: 115 CVX: 20 YH inactivated pathogen organism as vaccine component YH, YL killed vaccine YL whole organism vaccine that uses killed pathogen organism as its component. Brucella abortus DNA vaccine pcDNA-SOD PMID: 15039330 YH A Brucella abortus vaccine that expresses Cu/Zn SOD with DNA plasmid pcDNA. PMID: 15039330. pVAX DNA vaccine plasmid YH, ZX Brucella abortus strain RB51 as vaccine vector YH Brucella abortus RB51 Brucella abortus vaccine RB51 is a Brucella abortus vaccine that is licensed in the USA since 1992. Brucella abortus vaccine RB51 is a live attenuated cattle vaccine against brucellosis that is currently used in the USA and many other coutries. PMID: 11504226 PMID: 12438380 B. abortus RB51 PMID: 12704101 Brucella RB51 PMID: 8890203 PMID: 12119140 Brucella RB-51 PMID: 7806364 PMID: 10534009 YH SRB51 PMID: 11768128 PMID: 17894637 WEB: http://rb51.com PMID: 11504238 PMID: 19362381 PMID: 8740701 PMID: 7622248 PMID: 1439207 PMID: 11500423 PMID: 16713034 PMID: 17653832 PMID: 11193615 PMID: 18836016 PMID: 11553603 PMID: 8039890 PMID: 1908158 PMID: 19439382 PMID: 7927779 Brucella abortus strain 19 Brucella strain-19 Brucella S19 YH PMID: 8039890 PMID: 11058778 A live attenuated Brucella abortus vaccine that is licensed and used in many countries. Invitrogen YH, ZX http://www.invitrogen.com pVAX1 DNA vaccine plasmid YH, ZX Brucella vaccine YH MeSH: D002004 brucellosis vaccine A vaccine that protects against Brucella that causes brucellosis in animals and humans. pCMV4 DNA vaccine plasmid YH, ZX pAp031 DNA vaccine plasmid YH, ZX Comvax Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant) PMID: Trade Name: Comvax CVX: 51 YH Daptacel Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed YH CVX: 106 CVX: 20 Vaccine components see http://www.vaccinesafety.edu/components-DTaP.htm Trade Name: DAPTACEL DECAVAC Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use Trade Name: DECAVAC CVX: 113 YH DNA of pathogen organism as vaccine component YH DNA from protective protein that is used as vaccine component. This is usually used for preparation of DNA vaccine. DNA vaccine synonym: naked DNA vaccine genetic vaccine nucleic acid vaccine DNA vaccine is a vaccine that is composed of a plasmid vaccine vector (a circular double stranded DNA molecule) containing genes encoding one or more proteins of a pathogen. YH naked DNA vaccine Diphtheria and Tetanus Toxoids Adsorbed USP by Sanofi Pasteur Inc Product Name: Diphtheria & Tetanus Toxoids Adsorbed CVX: 28 YH Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Ltd Product Name: Diphtheria & Tetanus Toxoids Adsorbed YH Dryvax Product Name: Smallpox Vaccine, Dried, Calf Lymph Type Dryvax is a freeze-dried calf lymph smallpox vaccine. It is the world's oldest smallpox vaccine, created in the late 19th century by American Home Products, a predecessor of Wyeth. By the 1940s, Wyeth was the leading US manufacturer of the vaccine and the only manufacturer by the 1960s. After world health authorities declared smallpox had been eradicated from nature in 1980, Wyeth stopped making the vaccine. Trade Name: Dryvax http://en.wikipedia.org/wiki/Dryvax YH CVX: 75 ETEC vaccine ACAM2010 YH PMID: 17566016 ACAM2007 is a vaccine candidate expressing CFA/II. Adenovirus vaccine A viral vaccine that protects against infection of an adenovirus. YH, SGS vaccine persistence assay YH An assay that measures the persistent survival of live vaccine in a host in vivo. pBacPAK9 DNA vaccine plasmid YH, ZX pBC12/CMV DNA vaccine plasmid YH, ZX Escherichia coli vaccine A bacterial vaccine that prevents against Escherichia coli infection. E. coli vaccine YH MeSH: D022361 pBHT DNA vaccine plasmid YH, ZX FluLaval Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: FluLaval YH CVX: 141 FluMist Product Name: Influenza Virus Vaccine, Live, Intranasal Trade Name: FluMist CVX: 111 YH Fluarix Product Name: Influenza Virus Vaccine, Trivalent, Types A and B CVX: 140 YH Trade Name: Fluarix Fluvirin Product Name: Influenza Virus Vaccine, Trivalent, Types A and B YH CVX: 140 CVX: 141 Trade Name: Fluvirin Fluzone Product Name: Influenza Virus Vaccine, Trivalent, Types A and B CVX: 144 Trade Name: Fluzone CVX: 140 YH CVX: 141 virmugen a gene that once deleted, would make an attenuated microbe that can be used as a live attenuated vaccine against virulent pathogen. YH, YL, ZX Gardasil Product Name: Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine Trade Name: Gardasil YH CVX: 62 Gardasil is a quadrivalent vaccine meaning it protects against 4 strains of virus (types 6, 11, 16, and 18). The vaccine was made using genetic engineering techniques. The genes that encode a specific protein from each of these strains are expressed in yeast in large-scale fermentation cultures. Protein purification methods are then used to isolate the proteins and make the vaccine. Cited from: http://biotech.about.com/b/2008/09/03/gardasil-safety-of-genetically-engineered-hpv-vaccine-still-in-question.htm HIV based lentivirus vaccine vector YH Balb/c mouse YH Havrix Product Name: Hepatitis A Vaccine, Inactivated YH Trade Name: Havrix CVX: 52 CVX: 83 Neisseria meningitidis vaccine MeSH: D022401 YH A bacterial vaccine that prevents Neisseria meningitidis infection. Meningococcal vaccine IPOL Product Name: Poliovirus Vaccine Inactivated (Monkey Kidney Cell) YH PMID: Trade Name: IPOL CVX: 10 vaccine related journal article YL The jourmal article that mentions a vaccine, which was retrieved from PubMed and annotated using VO-SciMinner.(Hur J, Xiang Z, Feldman EL, He Y. Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network. BMC Immunology. 12(1):49 2011 Aug 26. PMID: 21871085.) United Vaccines, Inc http://www.unitedvaccines.com/ Heska Corporation Texas Vet lab, Inc SolidTech Animal Health, Inc MVP Laboratories, Inc http://www.mvplabs.com/ Addison Biological Laboratory, Inc www.addisonlabs.com/ Neotech, LLC neotechvaccines.com/ Imovax Rabies Product Name: Rabies Vaccine Trade Name: Imovax CVX: 18 YH Infanrix Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed CVX: 20 Trade Name: Infanrix YH Influenza Virus Vaccine H5N1 (Sanofi Pasteur Inc) Product Name: Influenza Virus Vaccine, H5N1 (for National Stockpile) WEB: http://atomicnewsreview.org/2009/10/22/approval-for-the-arepanrix%E2%84%A2-gsk-vaccine-in-canada/ YH JE-Vax Product Name: Japanese Encephalitis Virus Vaccine Inactivated CVX: 39 Trade Name: JE-Vax YH Kinrix Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine CVX: 130 Trade Name: KINRIX YH Listeria monocytogenes as vaccine vector YH M-M-R II Product Name: Measles, Mumps, and Rubella Virus Vaccine, Live CVX: 03 Trade Name: M-M-R II YH M-M-Vax Product Name: Measles and Mumps Virus Vaccine, Live YH Trade Name: M-M-Vax Menactra Product Name: Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine WEB: http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm176044.htm CVX: 114 Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine Trade Name: Menactra YH Menomune A C Y W135 Product Name: Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined CVX: 32 YH Trade Name: Menomune-A/C/Y/W-135 Meruvax II Product Name: Rubella Virus Vaccine Live CVX: 06 YH Trade Name: Meruvax II Mumpsvax Product Name: Mumps Virus Vaccine Live YH CVX: 07 Trade Name: Mumpsvax pBI/tTA DNA vaccine plasmid YH, ZX pBISIA DNA vaccine plasmid YH, ZX Mycobacterium tuberculosis vaccine YH MeSH: D032581 tuberculosis vaccine A vaccine that protects against Mycobacterium tuberculosis. Mycobax Mycobax is a BCG vaccine that is made by Sanofi Pasteur, Ltd. Ref: http://www.biopharma.com/cgi/full6.lasso?Key=412.65916 Product Name: BCG Vaccine CVX: 19 Trade Name: Mycobax YH O antigen of pathogen organism as vaccine compent YH pBK-SFV DNA vaccine plasmid YH, ZX Influenza A (H1N1) 2009 Monovalent Vaccine (Novartis) Pediarix Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Hepatitis B (recombinant) and Inactivated Poliovirus Vaccine Combined YH Trade Name: Pediarix CVX: 110 PedvaxHIB Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) CVX: 49 YH PMID: Trade Name: PedvaxHIB PMID: 2791073 Pentacel Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine CVX: 120 YH Trade Name: Pentacel Plague Vaccine by Greer Laboratories Inc Product Name: Plague Vaccine CVX: 23 YH pBudCE4.1 DNA vaccine plasmid YH, ZX Plasmodium falciparum vaccine a malaria vaccine that protects against malaria caused by Plasmodium falciparum. YH Pneumovax 23 Product Name: Pneumococcal Vaccine, Polyvalent CVX: 33 YH Trade Name: Pneumovax 23 Poliovax Product Name: Poliovirus Vaccine Inactivated (Human Diploid Cell) Trade Name: Poliovax YH Prevnar Product Name: Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) CVX: 100 Trade Name: Prevnar YH ProQuad Product Name: Measles, Mumps, Rubella and Varicella Virus Vaccine Live CVX: 94 Trade Name: ProQuad YH RNA of pathogen organism as vaccine component YH RNA from protective protein that is used as vaccine component. This is usually used for preparation of RNA vaccine. mineral salt vaccine adjuvant CVX: 119 SGS, YH a vaccine adjuvant that is formed as a mineral salt. RabAvert Product Name: Rabies Vaccine YH CVX: 18 Trade Name: RabAvert Rabies Vaccine Adsorbed by BioPort Corp Product Name: Rabies Vaccine Adsorbed YH Adenovirus Type 4 and Type 7 Vaccine, Live, Oral CVX: 143 YH, SGS RotaTeq Product Name: Rotavirus Vaccine, Live, Oral, Pentavalent Trade Name: RotaTeq YH CVX: 116 SIV based lentivirus vaccine vector YH Pcaggs DNA vaccine plasmid YH, ZX vaccine-induced T-helper 1 type immune response YH vaccine-induced T-helper 2 type immune response YH TENIVAC Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Trade Name: TENIVAC TICE BCG Intravesical TICE BCG has been used as a therapy for, and to prevent recurrence of, tumors in patients with carcinoma in situ (CIS) of the urinary bladder, and to prevent recurrence of Stage Ta T1 papillary tumors of the bladder at high risk of recurrence. Refernce URL: http://www.ticebcg.com/Consumer/aboutTice/index.asp Product Name: BCG Vaccine CVX: 19 Trade Name: TICE BCG YH TYPHIM Vi Product Name: Typhoid Vi Polysaccharide Vaccine YH CVX: 101 Trade Name: TYPHIM Vi T cell epitope in vaccine YH vaccine-induced T cell mediated immunity YH T cell vaccine antigen processing and presentation YH Brucella abortus vaccine YH Tetanus Toxoid Adsorbed by Sanofi Pasteur Inc Product Name: Tetanus Toxoid Adsorbed YH CVX: 35 E. coli O157:H7 intimin vaccine PMID: 11500434 YH E. coli Int280a has been found to be a protective antigen. This subunit vaccine uses E. coli Int280a combined with adjuvant. This antigen can be used for development of type-specific EPEC or EHEC vaccine. Tetanus and Diphtheria Toxoids Adsorbed for Adult Use by Massachusetts Public Health Biologic Lab Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Tripedia Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed CVX: 20 YH Trade Name: Tripedia Twinrix Product Name: Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine YH Trade Name: Twinrix CVX: 104 pCAGGST7 DNA vaccine plasmid YH, ZX vaccine-induced T cell activation pCBINT DNA vaccine plasmid YH, ZX pCdm7 DNA vaccine plasmid YH, ZX microbial derivative vaccine adjuvant CVX: 52 a vaccine adjuvant that contains microbial derived material. YH, SGS CVX: 83 Varivax Product Name: Varicella Virus Vaccine Live CVX: 21 YH Trade Name: Varivax Vivotif Product Name: Typhoid Vaccine Live Oral Ty21a Trade Name: Vivotif CVX: 25 YH YF-Vax Product Name: Yellow Fever Vaccine YH CVX: 37 Trade Name: YF-Vax Yellow fever 17D as vaccine vector YH Yellow fever virus vaccine A viral vaccine that protects against infection with Yellow fever virus. YH MeSH: D022341 Zostavax Product Name: Zoster Vaccine, Live, (Oka/Merck) YH CVX: 121 Trade Name: Zostavax licensed turkey vaccine YH live attenuated pathogen as vaccine component YH aluminum hydroxide vaccine adjuvant an aluminum vaccine adjuvant that contains aluminum hydroxide. alum YH aluminum phosphate vaccine adjuvant Al(PO)4 Adju-Phos® an aluminum vaccine adjuvant that is aluminum phosphate. YH, SGS vaccination frequency YH Vaccination frequency is a qualitative term that represents how many times vaccination has occurred. pcDNA I/Amp DNA vaccine plasmid YH, ZX calcium phosphate vaccine adjuvant YH, SGS a mineral salt vaccine adjuvant composed of calcium phosphate. CaHPO4 pcDNA3 DNA vaccine plasmid YH, ZX Freund's emulsified oil adjuvant YH, SGS an emulsion vaccine adjuvant that consists of a water-in-oil emulsion of aqueous antigen in paraffin (mineral) oil of low specific gravity and low viscosity. It is named after Jules T. Freund (1890-1960), Hungarian-born American immunologist. It is a water in oil emulsion. vaccine-induced T cell proliferation vaccine-induced adaptive immune response YH adenovirus vaccine vector YH adjuvant role YH,YL The Latin "adjuvans" means to help, particularly to reach a goal. Adjuvant therapy for cancer is surgery followed by chemotherapy or radiation to help decrease the risk of the cancer recurring (coming back). An adjuvant is a substance that helps and enhances the pharmacological effect of a drug or increases the ability of an antigen to stimulate the immune system. A role that inheres in a material entity that helps or enhances the effect of other agents, such as a drug or vaccine. live virulent pathogen as vaccine component YH complete Freund's adjuvant is a Freund's emulsfied oil adjuvant that contains inactivated and dried mycobacteria, usually Mycobacterium tuberculosis (the pathogenic agent of tuberculosis). YH agglutinating antibody role YH virulence factor YH incomplete Freund's adjuvant a Freud's adjuvant that does not contain the mycobacterial components. YH cholera toxin CT A microbial derivative vaccine adjuvant consisting of cholera toxin (CT) from Vibrio cholerae. YH, SGS alphavirus vaccine vector YH vaccine vector role YH,YL a biological vector role that is realized by the process of transmitting genetic material encoding vaccine antigen to the vaccinee, when introduced into the vaccinee, it results in the in situ production of antigen in the vaccinee Corynebacterium-derived P40 vaccine adjuvant A microbial derivative vaccine adjuvant that is the P40 particulate fraction isolated from Corynebacterium. YH, SGS PMID: 8447157 vaccine adjuvant role YH an adjuvant role that inheres in a material entity which is added as part of a vaccine and induces enhanced adaptive immune response to the vaccine antigen. antibody role YH Aceto Pharma Corp antibody titer Antibody titer is a titer of antibody that shows how much antibody an organism has produced that recognizes a particular epitope, expressed as the greatest dilution ratio (or its reciprocal) that still gives a positive result. ELISA is a common means of determining antibody titers. YH WEB: http://en.wikipedia.org/wiki/Antibody_titer immunized an organismal quality that indicates an organism (e.g., human) is immunized against a disease. To assign the state of ‘immunized’, we will need to do some assay to measure indicators of immunity, e.g., antibody titers in serum samples. YH, YL Francisella tularensis vaccine YH preparation of toxoid vaccine YH A vaccine preparation that results in the generation of a toxoid vaccine sodC from B. abortus strain 2308 YH NCBI Gene GI: 3827840; NCBITaxon: 234 A Brucella abortus gene that has the name sodC and comes from strain 2308. IMMUNOGENICITY: The SodC protein induces antigen-specific Th1 immune response, as indicated by the specific induction of serum IgG2a, but not IgG1, antibodies and by the secretion of IFN-alpha but not IL-4, by the Cu/Zn SOD-stimulated splenocytes. This gene has been used for vaccine development [PubMed: 10816475][PubMed: 11953393][PubMed: 12933826]. MUTATION: An isogenic sodC mutant constructed from B abortus 2308 by gene replacement exhibited much greater susceptibility to killing by exogenous O(2)(-) than the parental 2308 strain, supporting a role for SodC in protecting this bacterium from O(2)(-) stress. The B abortus sodC mutant was much more sensitive to killing by cultured resident peritoneal macrophages from C57BL6J mice than 2308, and its attenuation in cultured murine macrophages was enhanced when these phagocytes were treated with gamma interferon. The attenuation of the B abortus sodC mutant in both resting and IFN-gamma-activated macrophages was alleviated in the presence of the NADPH oxidase inhibitor apocynin. Consistently, the B abortus sodC mutant also displayed significant attenuation in infected C57BL6J mice compared to the parental strain. These findings suggest that SodC protects B abortus 2308 from the respiratory burst of host macrophages [PubMed: 15845493]. bacterial gene YH viral gene YH HIV gene YH pcDNA3.1 DNA vaccine plasmid YH, ZX preparation of live attenuated vaccine by serial passages in vitro Brucella abortus cattle vaccine RB51 was developed by serial passages of virulent B. abortus strain 2308 in vitro in rifampin agar plates (Reference: PMID: 1908158). A live attenuated vaccine prepraration process that is performed by serial passages in vitro for pathogen attenuation. YH Influenza A (H1N1) 2009 Monovalent Vaccine (Sanofi Pasteur) Escherichia coli gene E. coli gene YH avirulent YH vaccine-induced gene up-regulation controlling intracellular bacterial replication Mycobacterium tuberculosis gene YH bacterial vaccine YH A vaccine that protects against some bacterial disease. MeSH: D001428 bacterial vaccine vector YH pcDNA3.1V5HisTOPO/TA DNA vaccine plasmid YH, ZX Salmonella gene YH Shigella gene YH protozoan gene YH Plasmodium gene YH Plasmodium falciparum gene YH attenuated YH Leishmania gene YH pCEP4 DNA vaccine plasmid YH, ZX vaccine-induced T cell differentiation cancer vaccine neoplasm vaccine tumor vaccine A vaccine that prevents or treats cancer. It is produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced. MeSH: D019496 YH inactivated vaccine preparation A vaccine preparation that results in the generation of a inactivated vaccine YH vaccine component YH cardinal part of vaccine a processed material that is output of the vaccine preparation and part of a vaccine. vaccine ingredient vaccine-induced cell activation YH lipopolysaccharide vaccine adjuvant LPS vaccine adjuvant A microbial derivative vaccine adjuvant made from bacterial lipopolysaccharide (LPS) of gram-negative bacteria. YH, SGS vaccine-induced antibacterial agglutination antibody response YH Japanese encephalitis virus gene YH Ebola virus gene YH Influenza virus gene YH RNA vaccine Using RNA may eliminate the problem of having to tailor a vaccine for each individual patient with their specific immunity. The advantage of RNA is that it can be used for all immunity types and can be taken from a single cell. DNA vaccines need to produce RNA which then prompts the manufacture of proteins. However, RNA vaccine eliminates the step from DNA to RNA. A vaccine that uses RNA(s) derived from a pathogen organism. YH muramyl dipeptide a synthetic vaccine adjuvant formulated to correspond to a component found in a water-soluble extract of cell walls of mycobacteria used in complete Freund's adjuvant (CFA). YH, SGS PMID: 344799 MDP Dengue virus gene YH colony forming unit CFU WEB: http://en.wikipedia.org/wiki/Colony-forming_unit YH Colony-forming unit (CFU) is a titer measurement of viable bacterial or fungal numbers. Unlike in direct microscopic counts where all cells, dead and living, are counted, CFU measures viable cells. By convenience the results are given as CFU/mL (colony-forming units per milliliter) for water, and CFU/g (colony-forming units per gram) for soil or other porous material. squalene YH, SGS an emulsion vaccine adjuvant that contains an organic polymer with some antigenic epitopes which might be shared with other organic polymers acting as immunostimulators. arlacel A a synthetic vaccine adjuvant that is an emulsifier called Arlacel A. PMID: 2042393 YH, SGS Montanide 103 YH a montanide vaccine adjuvant that is Montanide 103. Bordetella pertussis component vaccine adjuvant a microbial derivitive vaccine adjuvant that contains components from killed Bordetella pertussis. The killed B. pertussis has a strong adjuvant effect on the diphtheria and tetanus toxoids in the DPT vaccines. YH PCV2 vaccine YH conjugate vaccine Conjugate vaccine is vaccine that conjugates/links antigens to the molecules that form the outer coat of disease-causing bacteria to promote an immune response. YH A conjugate vaccine is created by covalently attaching a poor (polysaccharide organism) antigen to a carrier protein (preferably from the same microorganism), thereby conferring the immunological attributes of the carrier on the attached antigen. --from wikipedia. preparation of recombinant vector vaccine YH A vaccine preparation that results in the generation of a recombinant vector vaccine West Nile virus gene YH chickenpox virus gene YH Rubella virus gene YH Hepatitis B virus gene YH Porcilis-PCV2 YH Characteristics: Inactivated baculovirus expressed PCV2 ORF2 protein; adjuvanted Hepatitis A virus gene YH Suvaxyn PCV2 Characteristics: Inactivated PCD1-2 chimera; adjuvanted YH Intervet YH Intervet has merged with Schering-Plough Animal Health and become Intervet/Schering-Plough Animal Health™ (YL.) http://www.intervet.com/ Fort Dodge YH http://www.wyeth.com/divisions/fort_dodge.asp licensed pig vaccine YH contraindication YH a contraindication is a condition or factor that increases the risks involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity. vaccine in research role YH vaccine in research role is a 'regulation-assigned roleof a vaccine that is not licensed or in clinical trial; instead, it is currently in laboratory research. pHIS64 DNA vaccine plasmid YH, ZX hemagglutination-inhibition assay an immune response detection assay that detects specific antiviral antibodies in a test serum. The serum, usually a twofold dilution series, is mixed with a standard number, usually 4 to 8 HA units, of virus and incubated prior to the addition of a standard suspension of erythrocytes. The highest dilution of serum that inhibits hemagglutination is the HI titer of the serum. For example, influenza (AI) viruses agglutinate erythrocytes through the interaction of the virus surface glycoprotein, the hemagglutinin (HA), with receptors on the surface of the erythrocyte. Inhibition of the agglutination reaction by HA subtype-specific antisera is the basis of the hemagglutination-inhibition (HI) assay. YH HI assay inactivated YH behavioural inactive (PATO:0001706) pcI DNA vaccine plasmid YH, ZX hypersensitivity to chicken product YH pCI-neo DNA vaccine plasmid YH, ZX pCMV DNA vaccine plasmid YH, ZX pCMV-1 DNA vaccine plasmid YH, ZX pCMV4 DNA vaccine plasmid YH, ZX hypersensitivity to chicken egg YH vaccine solvent vaccine diluent vaccine liquid diluent a vaccine component that is used to dissolve vaccine powder into liquid. The vaccine in a powder form has to be reconstituted by mixing vaccine powder with vaccine solvent before administered. YH pCMVI.UBF3/2 DNA vaccine plasmid YH, ZX pCMV-3FUB DNA vaccine plasmid YH, ZX pCMV-int DNA vaccine plasmid YH, ZX pCMV-LacZ DNA vaccine plasmid YH, ZX hypersensitivity to antibiotic YH hypersensitivity to neomycin YH hypersensitivity to polymyxin YH reaction to previous vaccination YH vaccine powder a vaccine component that contains the solid form of all vaccine components. A vaccine can be reconstituted by mixing vaccine powder with vaccine solvent. YH bacterial vaccine preparation A vaccine preparation that results in the generation of a bacterial vaccine YH, ZX pCMV-LIC DNA vaccine plasmid YH, ZX pCMVLuc DNA vaccine plasmid YH, ZX pCR3 DNA vaccine plasmid YH, ZX life-threatening reaction to previous vaccination YH pCR3.1 DNA vaccine plasmid YH, ZX life-threatening reaction to previous influenza vaccination YH pCR4-TOPO DNA vaccine plasmid YH, ZX hypersensitivity to gentamicin YH dominant epitope in vaccine YH vaccine-induced down-regulated gene expression YH hypersensitity to gelatin YH preparation of vaccine using heat inactivation YH A vaccine prepraration process that is performed by heat inactivation of virulent pathogen. CFU reduction assay CFU reduction assay is an assay that measures the reduction of the colony forming units of infected pathogens in vaccine-vaccinated animals compared to nonvaccinated animals. YH assay of CFU reduction in spleen YH assay of CFU reduction in spleen is a CFU reduction assay that is measured using the extracted spleen as the tissue for isolation of infected pathogens. hypersensitity to arginine Arginine is a conditionally essential amino acid, meaning most of the time it can be manufactured by the human body, and does not need to be obtained directly through the diet. The biosynthetic pathway however does not produce sufficient arginine, and some must still be consumed through diet. Individuals who have poor nutrition or certain physical conditions may be advised to increase their intake of foods containing arginine. Infants are unable to meet their requirements and thus arginine is nutritionally essential for infants. YH edibility YH, MC Melanie has submitted this term and its two subclasses to obo: http://sourceforge.net/tracker/?func=detail&aid=2873643&group_id=76834&atid=595654 A physical quality inhering in a bearer by virtue of the bearer being fit to be eaten. edible This term may be submitted to PATO. A quality of edibility that inheres in a bearer by virtue of the bearer being suitable for oral ingestion as food, drug, or vaccine. YH vaccine efficacy Vaccine efficacy is an efficacy of a vaccine in induction of protective immune response in vivo or protection against infection of a virulent pathogen. Specifically, vaccine efficacy (VE) is the percentage reduction in disease incidence attributable to vaccination, calculated by means of the following equation: VE(%) = (U - V)/U x 100 where U = the incidence in unvaccinated people and V = the incidence in vaccinated people. Ref: Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. YH history of asthma YH vaccine-induced antiviral neutralizing antibody response YH pcREV DNA vaccine plasmid YH, ZX peptide of pathogen organism as vaccine component YH peptide of pathogen that is used as vaccine component. This peptide may function as epitope to stimulate protective immunity. pDRVISV1.0 DNA vaccine plasmid YH, ZX pECK DNA vaccine plasmid YH, ZX vaccination with a licensed cattle vaccine YH usage of bronchodilator YH pET21a DNA vaccine plasmid YH, ZX pET-28a DNA vaccine plasmid YH, ZX pGA DNA vaccine plasmid YH, ZX pGEX-3X DNA vaccine plasmid YH, ZX vaccine-induced follicular dendritic cell activation YH usage of steroid YH pIRES DNA vaccine plasmid YH, ZX sodB(Ft) PMID: 16923916 sodBFt is a live vaccine strain mutant of Francisella tularensis with reduced Fe-superoxide dismutase gene expression. Ref: PMID: 18692537. YH PMID: 18692537 ProtaTek International, Inc www.protatek.com/ Arko Laboratories Ltd www.arkolabs.com/ fungal disease YH fungal vaccine MeSH: D005657 A vaccine that protects against infection with some fungus. YH Newport Laboratories, Inc www.newportlabs.com Texas Agricultural Experiment Station F. tularensis vaccine LVS PMID: 16912944 YH A live attenuated Francisella tularensis vaccine. It is available in American Type Culture Collection with ATCC ID: 29684. PMID: 8757866 pIRES2 DsRed2 DNA vaccine plasmid YH, ZX vaccine-induced T cell interferon-gamma production pING DNA vaccine plasmid YH, ZX pJW24 DNA vaccine plasmid YH, ZX pJW4303 DNA vaccine plasmid YH, ZX pK0 DNA vaccine plasmid YH, ZX vaccine function YH, MC, XZ, and AR PERSPN: Oliver He: There has been hot discussion about whether we use 'vaccine function' or 'vaccine role'. Vaccine role may not be the good term to use. Vaccine is designed to be 'vaccine', so it should be vaccine function. One special case is cowpox virus. The cowpox virus can be mixed with some liquid like water and used as a smallpox vaccine. In this case, people often say: the cowpox virus has a 'vaccine role'. However, the cowpox virus vaccine is a processed material of a mix of the virus with water. The virus is a virus, it is not a vaccine per se. Therefore, vaccine role may not be an accurate term. vaccine function is a function that inheres in a vaccine that induces protective immune response against a disease. It is realized in the immunization process in the host. pK3 DNA vaccine plasmid YH, ZX pMV60 DNA vaccine plasmid YH, ZX heat killed pathogen organism as vaccine component YH pMAMneoBlue DNA vaccine plasmid YH, ZX herpesvirus vaccine vector YH pMASIA DNA vaccine plasmid YH, ZX pND DNA vaccine plasmid YH, ZX vaccine-induced host gene response YH vaccine-induced host immune response The definition of this term is based on the definition of 'immune response (GO:0006955)' . It is a child term of this GO term. Y.H. Any immune system process that functions in the calibrated response of the host to a vaccine. Y.L. vaccine-induced host response a processual entity that specifies host response to a vaccine. YH host response to vaccine adjuvant a process that specifies host response to a vaccine adjuvant. YH host response to vaccine component a processual entity that specifies host response to a vaccine component. YH host response to vaccine antigen a process that specifies host response to a vaccine antigen. YH host response to vaccine vaccine vector a process that specifies host response to a vaccine vector. YH pND2 DNA vaccine plasmid YH, ZX pNGVL DNA vaccine plasmid YH, ZX human immunodeficiency virus vaccine AIDS vaccine YH MeSH: D016915 HIV vaccine A viral vaccine that protects against infection with human immunodeficiency virus that causes AIDS. Brinton Laboratories Inc pNL3-gal DNA vaccine plasmid YH, ZX pN4a-gal DNA vaccine plasmid YH, ZX company YH Brucella melitensis strain VTRM1 YH pRc/CMV DNA vaccine plasmid YH, ZX pRc/CMV2 DNA vaccine plasmid YH, ZX Brucella suis strain VTRS1 YH PMID: 17428946 B. suis VTRS1 pRK DNA vaccine plasmid YH, ZX pRSV DNA vaccine plasmid YH, ZX pRSV0 DNA vaccine plasmid YH, ZX KKF24 YH PMID: 16552035 KKF24 is a recombinant strain of Francisella novicida U112 with iglC mutation (F. novicida delta-iglC::ermC). PMID: 14680699. F. tularensis vaccine LVS LPS YH F. tularensis vaccine LVS lipopolysaccharide PMID: 10722593 vaccine-induced antibody mediated immune response immunoglobulin mediated immune response to vaccine YH vaccine emulsifier WEB: http://www.ncbi.nlm.nih.gov/pubmed/16337664 a vaccine additive that stabilizes the vaccine emulsification manufacturing process and makes emulsion of the vaccine easier. Emulsifiers help bind ingredients together and keep them from separating, most commonly with oil and water. An emulsifier is also a surfactant that reduces the surface tension of a liquid and results in an easier, smoother spread. Reference: http://www.wisegeek.org/what-is-polysorbate-80.htm YH, YL B. melitensis lipopolysaccharide vaccine YH B. melitensis LPS-GBOMP noncovalent complex vaccine PMID: 8723881 B. melitensis LPS-GBOMP subunit vaccine YH pSC65 DNA vaccine plasmid YH, ZX pSG2 DNA vaccine plasmid YH, ZX inactivated vaccine killed vaccine YH A whole organism vaccine that uses an inativated pathogen organism as its component. inactivated organism vaccine pSG5 DNA vaccine plasmid YH, ZX Psin DNA vaccine plasmid YH, ZX pTARGET DNA vaccine plasmid YH, ZX pTH DNA vaccine plasmid YH, ZX pTHamp DNA vaccine plasmid YH, ZX Brucella abortus DNA vaccine encoding BCSP31, SOD and L7/L12 YH B. abortus DNA vaccine expressing BCSP31, SOD and L7/L12 PMID: 17570767 pTR600 DNA vaccine plasmid YH, ZX Brucella abortus subunit vaccine using L7/L12 YH PMID: 8873388 recombinant B. abortus L7/L12 vaccine pTVG4 DNA vaccine plasmid YH, ZX B. melitensis DNA vaccine encoding Omp31 PMID: 17428946 YH pUC18 DNA vaccine plasmid YH, ZX pUC19 DNA vaccine plasmid YH, ZX pV1J DNA vaccine plasmid YH, ZX Mycoplasma hyopneumoniae vaccine YL bacterial vaccine that protect against Mycoplasma hyopneumoniae infection inedible YH, MC A quality of edibility that inheres in a bearer by virtue of the bearer being not suitable for oral ingestion. pVCL(pCXN2-mVIN) DNA vaccine plasmid YH, ZX tertiary vaccination YH, Thom Todd tertiary vaccination is a vaccination that is performed at the third time in a row. Protozoa YL Protozoa are a diverse group of unicellular eukaryotic organisms,[1] many of which are motile. Originally, protozoa had been defined as unicellular protists with animal-like behavior, e.g., movement. Protozoa were regarded as the partner group of protists to protophyta, which have plant-like behaviour, e.g., photosynthesis.(http://en.wikipedia.org/wiki/Protozoa) pVR1012 DNA vaccine plasmid YH, ZX vaccine injection site a vaccination site that is used for injection of a vaccine. YH, YL pVR1012x/s DNA vaccine plasmid YH, ZX pWRG1644 DNA vaccine plasmid YH, ZX Brucella melitensis bp26 deletion vaccine Brucella CGV26 PMID: 16519974 CGV26 YH A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the bp26 deletion. It has similar vaccien efficacy to Rev. 1. Its advantage compared to Rev. 1 is that this feature of bp26 deletion promotes diagnosis. PMID: 17070627. F. tularensis vaccine FSC043 A spontaneous mutant of the SCHU S4 strain that protects against virulent F. tularensis infection. PMID: 16299332. PMID: 16299332 YH intramuscular route intramuscular injection route YH,YL I.M. a route of administration that inject the material(such as vaccines, allergens) directly into a muscle. intranasal route rounte of administration that located in nose. I.N. YH intranasal route by drop YH intranasal route by spray YH intraperitoneal route YH YL a route of administration that located in the peritoneum. Brucella melitensis WR201 YH pWRG7077 DNA vaccine plasmid YH, ZX Brucella abortus bacA mutant YH PMID: 17196866 B. abortus bacA mutant Influenza A (H1N1) 2009 Monovalent Vaccine (CSL Limited) Influenza A (H1N1) 2009 Monovalent Vaccine ( MedImmune LLC) Arepanrix MC, YH Adjumer PCPP salt SGS A synthetic vaccine adjuvant that is PCPP salt. polyidi (carboxylatophenoxy) lphosphazene PMID: 75551218 polyphosphazene Megan Egg WEB: http://www.fda.gov/ohrms/dockets/dockets/00n0504/00N-0504_emc-001650-02.pdf Megan Egg is a Salmonella vaccine that that consists of a double gene-deleted S. enterica serovar Typhimurium strain and is formulated fro immunization of pullets. Megan Egg contains the same Megan Vac1 organism but Megan Vac1 is used for younger birds (broilers). YH pWRM DNA vaccine plasmid YH, ZX B. ovis microparticle subunit vaccine PMID: 16481077 YH pzz DNA vaccine plasmid YH, ZX pME18100 DNA vaccine plasmid YH, ZX pVIVO2 DNA vaccine plasmid YH, ZX Brucella recombinant SurA protein vaccine Brucella rSurA protein vaccine Brucella recombinant SurA protein YH PMID: 17686554 lentivirus vaccine vector YH pcDNA1.1/Amp DNA vaccine plasmid YH, ZX vaccine-induced leukocyte activation YH USA licensed human vaccine YH a licensed human vaccine that is licensed in the USA. licensed vaccine A vaccine that is licensed for commercial use. YH pRK7 DNA vaccine plasmid YH, ZX lipopolysaccharide of pathogen organism as vaccine component YH liposome-based vaccine adjuvant YH a vaccine adjuvant that contains particles made up of concentric lipid membranes containing phospholipids and other lipids in a bilayer configuration separated by aqueous compartments. It is a relatively stable but non-covalently-bound complex of saponin adjuvant Quil-A, cholesterol and amphipathic antigen in a molar ratio of approximately 1:1:1. The spectrum of viral capsid antigens and non-viral amphipathic antigens of relevance for human vaccination, incorporated into ISCOMs, comprises influenza, measles, rabies, gp340 from EB-virus, gp120 from HIV, Plasmodium falciparum and Trypanosoma cruzi. Ref: http://www.vaccination.inoz.com/adjuvants.html. live attenuated vaccine A live vaccine that is made from microbes that have been attenuated (weakened) in the laboratory so that they can't cause disease. attenuated vaccine YH live pathogen organism as vaccine component YH live vaccine A whole organism vaccine that uses live pathogen oragnism as its component. YH live virulent vaccine YH quaternary vaccination quaternary vaccination is a vaccination that is performed at the fourth time in a row. YH, Thom Todd profertility vaccine YH A vaccine that is used to improve conception. Brucella recombinant DnaK protein vaccine YH PMID: 17686554 divalent DNA B. abortus vaccine using L7/L12 and Omp16 PMID: 16622210 YH preparation of gene mutant vaccine YH, YL, ZX A live attenuated vaccine prepraration process that is performed by mutation of a gene(s) from a virulent pathogen. 'Mycobacterium avium relA mutant vaccine' includes a gene mutation of relA from virulent Mycobacterium avium. subtenon route http://ncim.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI%20MetaThesaurus&code=CL426248 Y.L. a route of administration that is through the membrane covering the muscles and nerves at the back of the eyeball sublingual route http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38300 an oral route of administration that is underneath the tongue. intravaginal route Y.L. intravaginal vaccination subtenon vaccination sublingual vaccination pharyngeal mucosal vaccination vaccine-induced, adjuvant boosted T cell interferon-gramm production YH a vaccine-induced T cell interferon-gramm production that results from the addition of a vaccine adjuvant IL-15 plasmid vaccine adjuvant PMID: 18472194 YH Brucella abortus DNA vaccine encoding L7/L12 and P39 PMID: 16537031 B. abortus DNA vaccine encoding L7/L12 and P39 YH attenuated Brucella abortus with deletion of znuA PMID: 16790759 YH mucosal immune response to vaccine YH E. coli LT toxin derived vaccine adjuvant a microbial derivative vaccine adjuvant that is derived from E. coli heat labile toxin LT. YH, SGS Feline panleukopenia virus vaccine generated using OntoRat YL viral vaccine that is used to protect against Feline panleukopenia virus infection birds vaccine Vaccine that used for immunizing birds. YL Leptospira spp. vaccine bacterial vaccine that is used to protect against Leptospira spp. infection YL generated using OntoRat Campylobacter fetus vaccine bacterial vaccine that is used to protect against Campylobacter fetus infection generated using OntoRat YL Pseudomonas aeruginosa vaccine bacterial vaccine that is used to protect against Pseudomonas aeruginosa infection YL generated using OntoRat Bordetella bronchiseptica vaccine bacterial vaccine that is used to protect against Bordetella bronchiseptica infection generated using OntoRat YL killed pathogen organism as vaccine component YH, YL, ZX licensed rabbit vaccine neutralizing antibody role YH microencapsulated B. melitensis mutant vaccine YH A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant vjbR::Tn5 (BMEII1116) delivered using alginate microspheres that is coated with a protein of the parasite Fasciola hepatica (vitelline protein B [VpB]). PMID: 18362129. A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant delivered using a microsphere delivery system. PMID: 18362129 vaccine-induced T cell interferon-gramm production boosted by IL-15 vaccine adjuvant a vaccine-induced adjuvant boosted T cell interferon-gramm production that results from the addition of a IL-15 vaccine adjuvant YH PMID: 18472194 prime-boost vaccine a vaccine that contains one vaccine for priming and at least one other vaccine for boosting. YH, RR prime-boost vaccine with DNA vaccine priming YH, RR a vaccine that contains one DNA vaccine for priming and at least one other vaccine for boosting. AIDSVAX http://en.wikipedia.org/wiki/AIDSVAX a prophylactic vaccine developed by VaxGen company to against HIV-1 consisting of two recombinant gp120 surface protein from different HIV-1 strains. PMID: 12848591 porin-S-LPS from B. abortus strain 2308 YH complex of porin and S-LPS from B. abortus strain 2308 PMID: 2844673 Brucella abortus RB51WboA PMID: 15327798 B. abortus RB51WboA YH AIDSVAX B/B link to another well-known study: VAX004 The AIDSVAX that is bicovalent vaccine including two kinds of gp120 protein: MN rgp120/HIV-1 and GNE8 rgp120/HIV-1 (MN and GNE8 are strain names). Resource: ClinicalTrials.gov linkto the clinical trail database by : ClinicalTrials.gov Identifier: NCT00002441 AIDSVAX B/E recombinant O. anthropi 49237SOD YH PMID: 11953393 organ or tissue specific immune response to vaccine YH licensed horse vaccine YH B. melitensis Bp26 and Tf protein vaccine YH PMID: 17239499 B. melitensis Bp26 and trigger factor B. melitensis P39 recombinant protein vaccine PMID: 11447155 YH A Brucella subunit vaccine that uses recombinant Brucella melitensis 16M P39, a putative periplasmic binding protein. PMID: 11447155. recombinant chimera BLSOmp31 YH PMID: 17442465 rBLSOmp31 Panvax Panvax is an H1N1 unadjuvanted monovalent vaccine. MC, YH WEB: http://www.infowars.com/h1n1-panvax-training-powerpoint-received-by-health-care-workers-in-australia/ vaccine additive role YL,YH Page 73, Chapter 6, Vaccine, 5th Edition. EXPERT CONSULT by Plotkin SA., et. al. 2008 a role inheres in a material entity, that has been added into a vaccine's formulation by the manufacture for a specific purpose. For example: adjuvant to enhance the effect of immunogen, perservatives, stablizers and those materials added for affecting PH and isotonicity. intravenous route route of administration that is located in the vein YH, Thom Todd i.v. protozoan vaccine A vaccine that protects against some protozoan disease. parasitic vaccine parasite vaccine MeSH: D016052 YH pathogen organism component in vaccine YH a vaccine component that originates from an organism such as a pathogen or a modified organism. Brucella abortus pcDNA-BLS B. abortus pcDNA-BLS YH escheriosome-mediated delivery of B. abortus L7/L12 escheriosome-encapsulated B. abortus L7/L12 YH PMID: 17931756 period of persistence of vaccine induced immune response period of persistence of vaccine induced immune response is a temporal interval during which a vaccine-induced immune response continuously exists. This term is related to the process 'persistence of vaccine induced immune response'. YH, MC phase 1 vaccine trial YH A vaccine clinical trial that investigates the safety profile of a vaccine in a small group (10-50) of healthy volunteers. phase 2 vaccine trial YH A vaccine clinical trial that studies vaccine efficacy with a target population (numbering 50-100). Different dosage levels will also be explored at this stage to determine the optimum dose. phase 3 vaccine trial YH A vaccine clinical trial that takes the trial to a large-scale safety and efficacy study in a relevant patient population, usually in excess of 3,000. phase 4 vaccine trial YH The final stage of vaccine clinical evaluation. Phase IV occurs after a vaccine or therapy is licensed and is being used by large numbers of people. These studies are not always required or completed. rLm/iglC Seven F. tularensis proteins including IglC (rLm/iglC) were expressed in recombinant L. monocytogenes (rLm) vaccines. These 7 F. tularensis proteins are: AcpA, Bfr, DnaK, GroEL, IglC, Pld and KatG from SchuS4 strain. YH nontypeable H. influenzae Hap Protein Vaccine PMID: 15557618 YH A subunit nontypeable H. influenzae vaccine that uses Hap protein. DNA vaccine plasmid vector a vaccine vector that is composed of a plasmid and used in the generation of a DNA vaccine. YH B. melitensis DNA vaccine encoding Omp31 boosted with Omp31 pCIBLSOmp31 YH Salmonella spp. vaccine generated using OntoRat YL bacterial vaccine that is used to protect against Salmonella spp. infection vaccine approval process WEB: http://www.examiner.com/x-7707-Infectious-Disease-Examiner~y2009m9d15-News-Release-H1N1-vaccines-get-FDA-approval-expected-to-be-available-in-4-weeks @2009/10/06. H1N1 vaccines get FDA approval. Food and Drug Administration announced today that it has approved four vaccines against the 2009 H1N1 influenza virus. Obtaining FDA licensure of this vaccine for A (H1N1) pandemic response is a key milestone that will enable Sanofi Pasteur to provide a licensed vaccine to the U.S. government to support pandemic immunization efforts YH, ZX, AR, and MC vaccine product approval process WEB: http://energycommerce.house.gov/images/stories/Documents/PDF/publications/109_health.pdf @2009/10/06. This is the US Health Law which includes a section about vaccine. WEB: http://news.prnewswire.com/ViewContent.aspx?ACCT=109&STORY=/www/story/09-15-2009/0005094621&EDATE @2009/10/06 vaccine approval process is a processual entity that involves approval of a vaccine. WEB: http://www.hhs.gov/nvpo/factsheets/fs_tableII_doc2.htm @2009/10/06 #Following the FDA's review of a license application, the sponsor and the FDA may present their findings to the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC). This non-FDA expert committee (scientists, physicians, biostatisticians, and a consumer representative) provides advice to the Agency regarding the safety and efficacy of the vaccine for the proposed indication. vaccine candidate role BP, YH This role should be a subclass of 'test substance role', which will be mireoted from OBI by OntoFox. vaccine candidate role is the role of a material entity in an investigation, which is tested for its capability to serve as a vaccine. CFU measurement assay CFU measurement assay is an assay that measures the colony forming unit (CFU) of a bacterium in a specific location (e.g., spleen of a mouse). YH, MC vaccine effectiveness rate vaccine effectiveness rate is a measurement datum that measues the vaccine effectiveness. It is assessed with respect to prevention of the disease against which the vaccine is given. One simple method to estimate vaccine effectiveness is to use routine data on notifications of disease cases in vaccinated and unvaccinatted children and to compare the porportion of cases vaccinated with the vaccine covervage among the same age group in the general population. If p is the proportion vaccinated in the population and c is the proportion of cases reported to be vaccinated, then VE = (p-c)/p(1-c) x 100%. Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. YH, MC WEB: http://en.wikipedia.org/wiki/Influenza_vaccine vaccine licensing YH, ZX vaccine licensing is a vaccine approval process that involves in licensing a vaccine. licensed chicken vaccine YH, XZ poxvirus vaccine vector YH NPAP Brucella vaccine Brucella vaccine using nonpathogenic alphaproteobacteria PMID: 17715332 YH preventive vaccine function preventive vaccine function is a vaccine function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which protects against a specific disorder. YH prophylactic vaccine function prime boost regimen YH APEC vaccine using GST-Iss fusion protein YH Colibacillosis, caused by avian pathogenic Escherichia coli (APEC), is a major problem for the poultry industry in the world. prophylactic vaccine a vaccine that is used for prevention against a disease. YH protection efficacy Protection efficacy is an efficiency that is associated with protection by a biological product (e.g., vaccine) against a disease. YH protective antigen role YH Protective antigen is an antigen that stimulates protective immunity when used in vivo. E. coli LB-T vaccine E. coli heat-labile enterotoxin B-subunit (LB-T) vaccine PMID: 11500434 YH E. coli O157:H7 subunit vaccine expressing Esps and Tir PMID: 14670317 YH protein of pathogen organism as vaccine component YH soybean-expressed E. coli LTB vaccine YH PMID: 17188785 nontypeable H. influenzae vaccine YH nontypeable Haemophilus influenzae NTHi Nontypeable Haemophilus influenzae (NTHi) is a nonencapsulated Haemophilus influenzae (a gram-negative bacterium). It is the cause of a number of human respiratory tract diseases, such as otitis media, sinusitis, bronchitis, and pneumonia. YH non-typeable H. influenzae rLP4/rLP6 and Moraxella catarrhalis UspA2 protein vaccine YH rLP4/rLP6/UspA2 PMID: 15308371 killed nontypeable H. influenzae whole-cell vaccine PMID: 1953532 PMID: 2867396 YH PMID: 2184330 PMID: 1859055 radiation-inactivated pathogen organism as vaccine component YH E. coli vaccine using intimin polypeptide YH PMID: 14688094 PMID: 17258324 nontypeable H. influenzae cell membrane vaccine (CM-Hi) YH PMID: 10353870 nontypeable H. influenzae LOS-TT conjugate vaccine YH PMID: 12706701 Nontypeable H. influenzae lipooligosaccharide-tetanus toxoid conjugate vaccine PMID: 9353024 E. coli subunit vaccine using IroN YH PMID: 17145948 preparation of recombinant protein vaccine YH A vaccine preparation process that uses recombinant molecular technology to prepare recombinant protein. protein subunit vaccine A subunit vaccine that is made using recombinant DNA technology to engineer the antigen molecules of the particular microbe. YH recombinant vector vaccine A vaccine that uses a modified virus or bacterium to deliver genes that code for microbial antigens to cells of the body. YH E. coli subunit vaccine using CO393 YH PMID: 17145948 vaccination with a licensed pig vaccine YH E. coli subunit vaccine using FyuA PMID: 17258324 YH PMID: 14688094 vaccination with a licensed horse vaccine YH immunization WEB: http://en.wikipedia.org/wiki/Immunization immunization is a processual entity that primes or modifies an adaptivie immune response to some antigens. YH, XZ, BP active immunization WEB: http://en.wikipedia.org/wiki/Immunization Active immunization entails the introduction of a foreign molecule into the body, which causes the body itself to generate immunity against the target. This immunity comes from the T cells and the B cells with their antibodies. Active immunization can occur naturally when a person comes in contact with, for example, a microbe. If the person has not yet come into contact with the microbe and has no pre-made antibodies for defense (like in passive immunization), the person becomes immunized. The immune system will eventually create antibodies and other defenses against the microbe. The next time, the immune response against this microbe can be very efficient; this is the case in many of the childhood infections that a person only contracts once, but then is immune. Artificial active immunization is where the microbe, or parts of it, are injected into the person before they are able to take it in naturally. If whole microbes are used, they are pre-treated, Attenuated vaccine. (Wikipedia) Active immunization is an immunization process that entails the introduction of a foreign molecule into the body, which causes the body itself to generate adaptive immunity against the target. YH, XZ passive immunization WEB: http://en.wikipedia.org/wiki/Immunization YH, XZ Currently, antibodies can be used for passive immunization. This method of immunization works very quickly. However, it is short lasting. The antibodies are naturally broken down. If there are no B cells to produce more antibodies, they will disappear. Passive immunization is an immunization process where pre-synthesized elements of the immune system are transferred to an organism so that the body does not need to produce these elements itself. natural active immunization YH, XZ WEB: http://en.wikipedia.org/wiki/Immunization natural active immunization is an active immunization that occur naturally when a person or animal comes in contact with antigens includeing microbes. vaccine immunization YH, XZ WEB: http://en.wikipedia.org/wiki/Immunization artificial active immunization artificial active immunization is an active immunization that occurs when a person or animal is vaccinated with a specific vaccine. induction of adaptive immune response to antigen induction of adaptive immune response to antigen is an active immunization process that results in induction of adaptive immune response to some antigens, for example, in a vaccine. YH, XZ disorder prevention disorder prevention is a processual entity that prevents a disorder that is the physical basis of a disease. YH, XZ disorder treatment disorder treatment is a processual entity that leads to treat a disorder that is the physical basis of a disease. YH, XZ modification of adaptive immune response to antigen modification of adaptive immune response to antigen is an active immunization process that results in modification of an adaptive immune response to some antigens, for example, in a therapeutic vaccine. YH, XZ preventive infectious disease vaccine function YH, XZ infection disorder prevention YH, XZ infection disorder prevention is a process that prevents a disorder that is the physical basis of an infectious disease. E. coli vaccine using verocytotoxin toxoid PMID: 17145948 YH Inactivated ETEC expressing expressing CFA/I and CFA/II PMID: 1612730 YH EHEC O157 subunit vaccine using his-tagged N-terminal intimin YH PMID: 1612730 nontypeable H. influenzae P5 peptide MVF/H3 vaccine YH PMID: 10603411 nontypeable H. influenzae rTbpB vaccine YH PMID: 10225866 ETEC vaccine ACAM2007 ACAM2007 is a vaccine candidate expressing CFA/II. YH rough phenotype YH ETEC vaccine ACAM2017 ACAM2017 was derived from ACAM2007. Genes aroC, ompC, and ompF were deleted, while CS1 and pStrep were added. YH PMID: 17566016 B. anthracis DNA vaccine encoding PA63 YH This DNA vaccine contains the gene fragment encoding AAs 173-764 of PA. PMID: 9987172 B. anthracis DNA vaccine encoding PA83 and LF YH PMID: 15342913 DAAV using PA and PGA PMID: 12960361 YH smooth phenotype YH rPA with adjuvant Nanoemulsion YH PMID: 17502384 M. tuberculosis arabinomannan-protein conjugate PMID: 12922145 Xref: VIOLIN vaccine ID: 223. YH subcutaneous route YH YL S.C. a route of administration that is loacted in the hypodermis (subcutaneous tissue) region. subdominant epitope in vaccine YH subunit vaccine A vaccine that is composed of a purified protein(s) or other antigenic determinant(s) from a disease-causing organism. A subunit vaccine does not include pathogen nucleic acids. The subunits have less risk of causing adverse reactions. YH recombinant S. typhimurium secreting M. tuberculosis ESAT-6 Xref: VIOLIN vaccineID: 176. PMID: 11427279 YH Ag85B and ESAT-6 fusion protein PMID: YH time of survival of live vaccine inside host YH, MC time of survival of live vaccine inside host is a temporal interval during which a live vaccine survives inside a host organism. This entity is related to the process survival of live vaccine inside host. attenuated M. bovis strain WAg539 PMID: 15784584 YH target YH bacterial phenotype YH therapeutic vaccine A vaccine that is used for treatment for a disease. YH vaccination with a licensed vaccine YH, BP, XZ licensed use of vaccine is a vaccination process that follows a protocol for a licensed vaccine. attenuated M. bovis strain WAg520 PMID: 10225931 YH titer WEB:http://en.wikipedia.org/wiki/Titer A titer (or titre) is a measure of concentration. Titer testing employs serial dilution to obtain approximate quantitative information from an analytical procedure that inherently only evaluates as positive or negative. The titer corresponds to the highest dilution factor that still yields a positive reading; for example, positive readings in the first 8 serial twofold dilutions translate into a titer of 1:256. YH vaccination with a licensed human vaccine licensed use of vaccine is a vaccination process that involves the vaccination of a licensed human vaccine. YH, XZ attenuated M. bovis strain WAg522 PMID: 10225931 YH recombinant nontypeable H. influenzae protein P6 with AdDP YH PMID: 15031801 adamantylamide dipeptide vaccine adjuvant a synthetic vaccine adjuvant, adamantylamide dipeptide (AdDP) is the desmuramyl analog of MDP. PMID: 8375945 YH, SGS AdDP toxin YH A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous substance produced within living cells or organisms; man-made substances created by artificial processes are thus excluded. The term was first used by organic chemist Ludwig Brieger (1849–1919).[3] For a toxic substance not produced within living organisms, "toxicant" and "toxics" are also sometimes used.[citation needed]. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their severity, ranging from usually minor and acute (as in a bee sting) to almost immediately deadly (as in botulinum toxin).-- from Wikipedia. toxoid vaccine A vaccine containing a toxoid, used to protect against toxins produced by certain bacteria. A toxoid (also called inactivated toxin) is a processed toxin that has been treated by chemical means, heat, or irradiation and is no longer capable of causing disease. YH therapeutic vaccine function YH The therapeutic vaccine function is a function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which ameliorates a specific disorder. M. tuberculosis secA2 mutant PMID: 17671656 YH rBCG-Ag85A[Tokyo] YH PMID: 17720625 DNA vaccine Rv1806-1807 YH PMID: 16520093 vaccine-induced up-regulated gene expression YH Novartis Animal Health US, Inc. http://www.petwellness.com/ YL AAV vaccine vector YH vaccination protocol vaccination protocol is the protocol of a vaccination procedure. YH vaccination schedule route of administration http://en.wikipedia.org/wiki/Route_of_administration http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38114 a path that is located in gross anatomical part of an organism (e.g., human) and is used for administering a vaccine, a drug, fluid, poison, or other substance into the body. YH,YL http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66729 CDISC has a codelist: Rout of Administration. Desription from CDISC: The course by which a substance was administered in order to reach the site of action in the body. CDISC_SDTM_Route_of_Administration_Terminology vaccine candidate During our call, we decided not to say vaccine candidate is an output of vaccine preparation, which may be reserved for vaccine alone. -- Aug 4, 2009. YH, AR, BP, LC, MC, and ZX vaccine candidate is a processed material that is designed to prevent or ameliorate a disorder in a target organism by modulating adaptive immune responses in that organism by administrating the vaccine. thimerosal vaccine preservative vaccine preservative that has thimerosal as part. YH peptide vaccine Peptide vaccine is a subunit vaccine that uses small peptide(s) as immunoepitopes. YH H1N1 Influenza vaccine YH H1N1 Influenza vaccine is an Influenza virus vaccine that is used to vaccinate against H1N1 Influenza subtype vaccine. Haemophilus somnus vaccine YL generated using OntoRat bacterial vaccine that is used to protect against Haemophilus somnus infection vaccine adjuvant YH a vaccine component that is chemical substance added to vaccine and enhance and direct immune response to protective antigen. Many of vaccine adjuvants cause a range of serious side-effects. H. influenzae gene YH vaccine license application A vaccine regulatory process that is for vaccine producer to apply for vaccine license. YH nontypeable H. influenzae gene hel (encoding P4) YH Encodes for protein P4 immune response detection assay An assay that is used to detect the immune response of a host to vaccination of a vaccine. YH immunization objective WEB: http://en.wikipedia.org/wiki/Immunization YH, XZ immunization objective is the specification of an objective to achieve immunization. vaccination with a licensed dog vaccine YH M. tuberculosis phoP mutant SO2 YH PMID: 16564606 PMID: 17084814 vaccine preparation vaccine production YH, BP vaccine preparation is a manufacturing process to produce a vaccine. vaccine generation vaccine protection assay An assay that is used to detect if a vaccine protects a host against infection of virulent pathogen after vaccine immunization. YH vaccine challenge experiment vaccine specific T cell cytokine production YH vaccine specific T cell mediated cytotoxicity YH vaccine dose YH, MC vaccine dose is a dose of vaccine specified by the vaccine manufacturer, distributor, or a regulatory agent. vaccine clinical trial A processual entity by which a vaccine is tested clinically for safety and effectiveness. Clinical trials are conducted in phases. Classically, clinical trials unfold in three phases in order to gather data and information about a vaccine and its performance. This will form the basis of a dossier submitted to regulatory authorities by way of an application for licensure. After a vaccine is licensed and is being used by large numbers of people, a Phase IV study may or may not be taken for vaccine clinical evaluation. Most vaccines against a pathogen (e.g., HIV) are not tested by vaccinating people and then deliberately exposing them to virulent pathogen (e.g., HIV). This strategy is never for a vaccine against a disease as serious as HIV. The best way to determine if a vaccine is effective is to test it in a randomized, controlled, double-blind clinical trial. This type of trial is often referred to as the gold standard in medical research and provides the strongest evidence for the efficacy of a vaccine. YH vaccine using part of organism A vaccine that uses part of pathogen organism. YH whole organism vaccine WEB: http://onlinelibrary.wiley.com/doi/10.1038/npg.els.0000491/full YH A vaccine that uses whole organism as its component vaccine vector a vaccine component that functions as a vector that carries an inserted antigen (protein recognized by the body as foreign) from a disease causing agent to the vaccinee. YH vaccinia virus vector YH BCG mutant secreting listeriolysin YH delta ureC hly+ rBCG YH PMID: 16110326 Intercell Biomedical viral vaccine A vaccine that protects against some viral disease. YH MeSH: D014765 viral vaccine vector YH Haemophilus parasuis vaccine YL generated using OntoRat bacterial vaccine that is used to protect against Haemophilus parasuis infection virulent YH Nontypeable H. influenzae protein P6 with cholera toxin PMID: 15297063 YH animal model of vaccine research YH Animal model of vaccine research is a role played by some organism (e.g., mouse) that is used for vaccine research. vaccination with a licensed turkey vaccine YH Pasteurella multocida vaccine generated using OntoRat bacterial vaccine that is used to protect against Pasteurella multocida infection YL laboratory animal model of vaccine research Animal model of vaccine research is a role played by some organism (e.g., mouse) that is used for vaccine research in the laboratory. YH whole pathogen organism as vaccine component whole organism in vaccine is a organism component in vaccine that includes the whole organism such as a whole live attenuated organism. YH survival assessment Need to point out more specifically that survival / death is measured. Survival assessment is an assay that measures the occurence of death events in one or more organisms that are monitored over time. YH H. influenzae Type b capsular polysaccharide vaccine PMID: 335348 YH PMID: 6387614 vaccination with a licensed rabbit vaccine YH B. anthracis recombinant vaccine using PA domain 4 YH PMID: 11854261 PMID: 15935874 licensed vaccine role YH licensed vaccine role is a regulation-assigned role that indicates that a vaccine obtains official approval for commercial production and selling on the market. vaccine in clinical trial role In medical research, clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. YH vaccine in clinical trial role is a regulation-assigned role that inheres in a vaccine that is currently in clinical trial. vaccine-induced humoral immune response YL Vaccine induced immue response mediated hrough a body fluid Brucella melitensis Rev. 1 with P39 deletion YH PMID: 9784574 A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the p39 gene deletion. B. melitensis Rev. 1 P39 deletion mutant intravenous vaccination YL licensed human vaccine YH a vaccine with license that is for human use. Flavobacterium columnare vaccine bacterial vaccine that is used to protect against Flavobacterium columnare infection generated using OntoRat YL Clostridium vaccine A bacterial vaccine that protects against infection with Clostridium spp. YH Clostridium tetani vaccine tetanus vaccine YH a Clostridium vaccine that protects against infection with Clostridium tetani that causes tenanus. combination vaccine 2 Combination vaccine is a vaccine that induces protection against multiple infectious diseases or several different serotypes of the same organism. The anitgens contained in combination vaccines are either formulated together by the manufacturer or physically mixed by a health care provider just prior to administration. Both approaches require licensure. Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1624. combo vaccine YH MeSH: D017778 Influenza virus vaccine A viral vaccine that protects against infection with influenza virus. YH MeSH: D007252 Influenza vaccine licensed cattle vaccine a vaccine with license that is used for cattle. YH Hepatitis B virus vaccine A viral vaccine that protects against infection with Hepatitis B virus. YH MeSH: D017325 licensed fish vaccine YH Hepatitis A virus vaccine A viral vaccine that protects against infection with Hepatitis A virus. YH MeSH: D022362 licensed goat and sheep vaccine YH Yersinia pestis vaccine A bacteria vaccine that prevents against Yersinia pestis infection that causes plague. MeSH: D010931 YH Plague vaccine licensed dog vaccine YH Rabies virus vaccine MeSH: D011819 A viral vaccine that protects against infection with Rabies virus. YH Smallpox virus vaccine YH MeSH: D012900 A viral vaccine that protects against infection with Smallpox virus. licensed cat vaccine YH licensed ferret vaccine YH Measles virus vaccine A viral vaccine that protects against infection with Measles virus. MeSH: D008458 Measles vaccine YH licensed deer vaccine YH Mumps virus vaccine A viral vaccine that protects against infection with Mumps virus. YH MeSH: D009108 licensed bird vaccine YH Rotavirus vaccine MeSH: D022243 A viral vaccine that protects against infection with Rotavirus. YH HIBTITER PMID: In most cases HibTITER was administered concomitantly with other vaccines including DTP, DTaP, hepatitis B vaccine, IPV, OPV, pneumococcal 7-valent conjugate vaccine, MMR, and/or meningococcal group C conjugate vaccine (not licensed in the US). YH PMID: 9353019 PMID: 2057256 ProHIBiT PMID: 2057256 Ref: http://www.rxlist.com/prohibit-drug.htm YH Haemophilus vaccine YH A bacterial vaccine that protects against infection with Haemophilus. MeSH: D018073 Haemophilus influenzae serotype b vaccine Haemophilus b vaccine YH SC602 A live attenuated Shigella flexneri 2a vaccine that carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding aerobactin). PMID: 10377124. YH PMID: 10377124 Poliovirus vaccine A viral vaccine that protects against infection with Poliovirus. MeSH: D023321 YH Japanese encephalitis virus vaccine A viral vaccine that protects against infection with Japanese encephalitis virus. YH MeSH: D022321 Japanese encephalitis vaccine CVD 1208 CVD 1208 is derived from wild type Shigella flexneri 2a strain 2457T and has defined deletions in four genes: (1) the guaBA chromosomal operon that encodes two enzymes (inositol 5'-monophosphate dehydrogenase and guanosine 5'synthase) essential for de novo purine biosynthesis; (2) set, a locus in a chromosomal pathogenicity island that encodes Shigella enterotoxin (ShET); (3) Pic, an autotransporter mucinase encoded on the opposite strand from set; and (4) sen, an invasiveness plasmid gene encoding ShET. PMID: 15499528 YH human papillomavirus vaccine YH CVD 1208S PMID: 17938573 YH CVD 1208S is the same thing as CVD 1208, but CVD 1208S was prepared using animal-free media. PMID: 17938573. Varicella-zoster virus vaccine YH EcSf2a-2 YH PMID: 1587589 This vaccine is an aro-D mutant derivative of EcSf2a-1. PMID: 1587589. Salmonella typhi vaccine YH heat-killed virulent Shigella flexneri 2a PMID: 10102148 YH Shigella Sfl 124 vaccine PMID: 1937767 YH Recombinant SFL124-27 expressing S. dysenteriae type 1 O antigen YH PMID: 9169740 Streptococcus pneumoniae vaccine YH S. dysenteriae 1 strain WRSd1 PMID: 12010984 YH S. flexneri 2a strain CVD 1207 A live attenuated Shigella flexneri 2a vaccine with specific deletion mutations in virG, sen, set, and guaBA. YH PMID: 10678904 S. sonnei strain WRSS1 PMID: 9712824 A stable attenuated Shigella sonnei strain with virG mutation. PMID: 9712824. YH PMID: 11895966 Shigella sonnei vaccine YH Shigella flexneri vaccine YH Shigella dysenteriae vaccine YH S. flexneri 2a LPS vaccine complexed with N. meningitidis proteosomes YH PMID: 8500877 vaccine regulation A processual entity that regulates vaccine-related processes, such as vaccine trial, vaccine license application. YH vaccine transportation A processual entity of transporting vaccine from one place to another place. YH Acambis, Inc YH http://www.acambis.com/ Berna Biotech, Ltd YH http://www.crucell.com/ BioPort Corp http://www.bioport.com/ YH CSL Limited YH http://www.csl.com.au/ GlaxoSmithKline Biologicals YH http://www.gsk-bio.com/english/index.html Greer Laboratories Inc http://www.greerlabs.com/ YH ID Biomedical Corp of Quebec http://www.ctidirectory.com/search/company.cfm?company=129584 YH Massachusetts Public Health Biologic Lab YH MedImmune Vaccines, Inc YH http://www.medimmune.com/ Merck & Co, Inc http://www.merck.com/ YH Merck Sharp & Dohme Corp. Novartis Vaccines and Diagnostics YH http://www.novartis.com/about-novartis/our-businesses/vaccines-diagnostic.shtml Organon Teknika Corp LLC 100 Rodolphe Street Building 1300 Durham, NC 27712 YH Research Foundation for Microbial Diseases of Osaka University YH http://read.jst.go.jp/public/cs_kkn_004EventAction.do?action5=event&lang_act5=E&kcd1_act5=9535000000&judge_act5=2 Sanofi Pasteur Limited http://www.sanofipasteur.com YH Sanofi Pasteur, Inc YH http://www.sanofipasteur.us Wyeth Pharmaceuticals Inc YH http://www.wyeth.com/ Sanofi Pasteur, SA http://www.sanofipasteur.co.za/ YH antibiotics vaccine residual a vaccine residual that is from antibiotics used during the manufacture process. YL, YH vaccine specific antibody test YH vaccine trial regulation A vaccine regulation process for vaccine clinical trials. YH primary vaccination A vaccination process that occurs at the first time to a host organization in a specified period. prime vaccination YH boost vaccination A vaccination process that occurs after the primer vaccination with a purpose to boost host immune response to vaccine antigen. YH Brucella melitensis vaccine YH Brucella melitensis strain Rev. 1 YH Brucella melitensis Rev. 1 PMID: 13416171 Brucella melitensis Rev 1 inactivated viral vaccine killed viral vaccine vaccine allergen disposition YH Canada licensed human vaccine a licensed human vaccine that is licensed in Canada YH preparation of DNA vaccine YH A vaccine preparation that results in the generation of a DNA vaccine preparation of conjugate vaccine A vaccine preparation that results in the generation of a conjugate vaccine YH subunit vaccine preparation A vaccine preparation that results in the generation of a subunit vaccine YH live attenuated vaccine preparation YH A vaccine preparation that results in the generation of a live attenuated vaccine preparation of RNA vaccine YH A vaccine preparation that results in the generation of a RNA vaccine Brucella abortus strain RB51SOD PMID: 10816475 YH B. abortus strain RB51SOD Brucella suis vaccine YH Brucella suis strain 2 Brucella suis S2 YH An orally administrable brucellosis vaccine that was was developed in China. It is effective for oral vaccination of sheep, goats, cattle and pigsPMID: 3541425. Brucella abortus strain 45/20 B. abortus strain 45/20 YH PMID: 8236802 cytomegalovirus vaccine YH Dengue virus vaccine A viral vaccine that protects against infection with Dengue virus. MeSH: D053059 Dengue vaccine YH Ebola virus vaccine YH A viral vaccine that protects against infection with Ebola virus. MeSH: D046129 Ebola vaccine Herpesvirus vaccine A viral vaccine that protects against infection with Herpesvirus. MeSH: D022283 YH chickenpox virus vaccine YH Herpes simplex virus vaccine YH Marek disease vaccine YH Measles-Mumps-Rubella vaccine YH Diphtheria-Tetanus vaccine YH A combination vaccine that is used to vaccinate against infections with both Clostridium tetani and Corynebacterium diphtheriae. CVD 1204(pGA1-CS2) PMID: 11292735 YH CVD 1204(pGA1-CS3) YH PMID: 11292735 Corynebacterium diphtheriae vaccine A bacterial vaccine that protects against infection with Corynebacterium diphtheriae that causes Diphtheria. YH diphtheria vaccine Measles-Mumps vaccine YH Measles-Mumps-Rubella-Vericella vaccine YH Diphtheria-Tetanus-Pertussis vaccine YH DTaP vaccine Shigella ribosome-based Vaccine (SRB) YH PMID: 17507120 P. falciparum vaccine Combination B YH PMID: 14604568 A malaria vaccine that comprises recombinant Plasmodium falciparum (P. falciparum) blood-stage proteins MSP1, MSP2 and RESA, formulated with the adjuvant Montanide ISA 720. PMID: 14604568. Haemophilus influenzae serotype b YH Diphtheria-Tetanus-Pertussis-Poliovirus vaccine YH Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine YH Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine YH Hepatitis A&B vaccine YH Haemophilus b and Hepatitis B vaccine YH DNA and MVA encoding ME-TRAP YH A vaccine that contains DNA and modified vaccinia virus Ankara (MVA) encoding thrombospondin-related adhesion protein (TRAP) with a multiple-epitope string ME (ME-TRAP). This vaccine is used with a prime-boost regime by DNA priming and MVA boosting. PMID: 16988273. PMID: 16988273 Papillomavirus vaccine A viral vaccine that protects against infection with Papillomavirus. MeSH: D053918 YH Parainfluenza virus vaccine parainfluenza vaccine A viral vaccine that protects against infection with Parainfluenza virus. MeSH: D022241 YH Pseudorabies virus vaccine MeSH: D022421 pseudorabies vaccine A viral vaccine that protects against infection with Pseudorabies virus. YH Simian immunodeficiency virus vaccine SAIDS vaccine MeSH: D018449 A viral vaccine that prevents against infection with Simian immunodeficiency virus. YH West Nile virus vaccine A viral vaccine that protects against West Nile virus infection. MeSH: D053060 YH Respiratory syncytial virus vaccine YH A viral vaccine that prevents infection with Respiratory syncytial virus. MeSH: D022261 marker vaccine A vaccine that is used in conjunction with diagnostic tests to differentiate vaccinated animals from carrier animals. It can be a subunit or a gene-deleted vaccine. MeSH: D022581 YH edible vaccine YH MeSH: D022462 A vaccine that is edible and derived from an edible plant. The transgenic plant is used as recombinant protein production system. The edible plant tissue functions as an oral vaccine. acellular vaccine YH acellular vaccine is a subunit vaccine that is produced by using only the antigenic part of the disease causing organism. It often requires a "booster" every few years to maintain their effectiveness. MeSH term: D20.215.894.860.900. ISCOM The immunostimulating complex YH A particulate antigen delivery system, ISCOM is a vaccine adjuvant that consists of an assembly of antigens in multimeric form and presents an antigen to induce specific immunologic responses. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines. MeSH term: D20.215.894.860.449. Plasmodium vivax vaccine YH contraceptive vaccine antifertility vaccine MeSH: D022642 YH A vaccine that is used to prevent conception. Alzheimer vaccine A vaccine that prevents or treats Alzheimer disease. MeSH: D023582 YH malaria vaccine Plasmodium vaccine MeSH: D017780 Plasmodium vaccine is a vaccine that prevents against Plasmodium species causing malaria. It is made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents. malarial Vaccine YH Leishmania vaccine YH Leishmaniasis vaccine MeSH: D054332 a protozoan vaccine that prevents against infection with Leishmania. Vibrio cholerae vaccine YH A bacterial vaccine that prevents infection with Vibrio cholera. MeSH: D022121 Lyme disease vaccine YH MeSH: D022123 A vaccine that prevents Lyme disease caused by Borrelia burgdorferi. Borrelia burgdorferi vaccine Bordetella pertussis vaccine A bacterial vaccine that prevents against Bordetella pertussis infection that causes pertussis or whooping cough. MeSH: D010567 YH Pertussis vaccine Pseudomonas vaccine MeSH: D054406 A bacterial vaccine that protects against infection with Pseudomonas. YH Rickettsial vaccine YH A bacterial vaccine that protects against diseases caused by various species of Rickettsia. MeSH: D012290 Salmonella vaccine A bacterial vaccine that protects against infections by various Salmonella species. MeSH: D022562 YH Shigella vaccine A bacterial vaccine that protects against infections with Shigella species. YH MeSH: D022281 Staphylococcal vaccine A bacterial vaccine that protects against infection with Staphylococcus. YH Staphylococcus vaccine MeSH: D013209 Staph vaccine BCG vaccine YH CVX: 19 Bacillus Calmette Guerin BCG Vaccine is a Mycobacterium tuberculosis vaccine that is a live attenuated strain of Mycobacterium bovis (Bacillus Calmette Guerin; BCG). Streptococcal vaccine A bacterial vaccine that prevents streptococcal infections. Streptococcus vaccine YH MeSH: D022541 MSP3-LSP with aluminium hydroxide PMID: 17280744 YH RTS,S/AS02A PMID: 15488216 YH RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. PMID: 15488216. P. falciparum MSP1 from transgenic mice with Freund's adjuvant YH PMID: 11752405 P. vivax PVS25 with Montanide ISA-720 YH PMID: 16291764 FMP1/AS02A FMP2.1/AS02A is a recombinant E. coli-expressed protein based upon the apical membrane antigen-1 (AMA-1) of the 3D7 clone formulated with the AS02A adjuvant. PMID: 17442466. YH PMID: 17442466 recombinant ABRA protein vaccine PMID: 11489167 YH PMID: 9400530 NP-VRP YH An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus NP protein. GP-VRP An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus GP protein. YH VRP expressing VP24 PMID: 11485406 YH An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP24 protein. alphavirus replicon expressing VP24 VRP expressing VP30 PMID: 11485406 YH alphavirus replicon expressing VP30 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP30 protein. VRP expressing VP35 alphavirus replicon expressing VP35 YH PMID: 11485406 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP35 protein. VRP expressing VP40 PMID: 11485406 alphavirus replicon expressing VP40 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP40 protein. YH DNA vaccine expressing sGP PMID: 9427604 A DNA vaccine that encodes for a secreted form of Ebola virus GP protein. YH DNA and adenoviral vector Ad5 expressing SIV gag protein A vaccine combination that includes a DNA vaccine and a recombinant adenovirus Ad5 expressing the same codon-optimized SIV gag gene. The DNA vaccine is used for priming, and the Ad5 vaccine is used for boosting. PMID: 11797011. PMID: 11797011 YH gene YH A gene that is a pathogen gene used for vaccine preparation or a host gene encoding for an immune factor important in induction of protective immunity. a vaccine-associated gene that exists in a pathogen and has been engineered for vaccine develoment. This gene can encode for protective antigen that is overexpressed for vaccine development. This gene can also be a virulence factor that is mutated to attenuate a virulent pathogen with the purpose of making attenuated vaccine. The term 'gene' has appears in several ontologies, such as Sequence Ontology (SO) and Protein Ontology (PRO). We may choose to use a 'gene' term from other ontologies. The 'gene' term in SO has ID: SO:0000704. adenoviral vector Ad5 expressing SIV gag protein PMID: 11797011 A recombinant adenovirus (Ad5) expressing the codon-optimized SIV gag gene. PMID: 11797011. YH DNA and Ad5/35 vector expressing HIV gp160 protein PMID: 16079886 A vaccine combination that includes a DNA vaccine and a replication-defective chimeric Ad5 vector with the Ad35 fiber (Ad5/35) that express the same codon-optimized SIV gag gene. The DNA vaccine is used for priming, and the Ad5/35 vaccine is used for boosting. PMID: 16079886. YH Brucella gene YH human gene YH mouse gene YH Brucella abortus gene YH A Brucella gene that is from B. abortus. wboA from B. abortus strain 2308 YH A Brucella abortus gene that has the name wboA and comes from strain 2308. Brucella abortus gene wboA is interrupted in Brucella abortus cattle vaccine RB51. mouse Ifng YH Interferon-gamma (IFN-g) is an indicative of Th1 immune response. It is produced in host immunized by vaccines such as Brucella abortus cattle vaccine RB51. human ifng YH Interferon-gamma (IFN-g) is an indicative of Th1 immune response. cattle gene YH cattle Ifng YH Interferon-gamma (IFN-g) is an indicative of Th1 immune response. It is produced in host immunized by vaccines such as Brucella abortus cattle vaccine RB51. vaccine storage YH a storage process that is specifically for vaccine. vaccine storage at room temperature a vaccine storage that is execuated at room temperature. Room temperature is also referred to as ambient temperature. Room temperature denotes a certain temperature within enclosed space at which humans are accustomed. Room temperature is usually indicated by general human comfort, with the common range of 10 degree C (50 degree F) to 28 degree C (82.4 degree F). YH vaccine storage in refrigerator vaccine storage that is executed in refrigerator, usually 0-10^C. YH vaccine storage in freezer YH vaccine storage that is executed in freezer under 0^C. effectiveness YH Effectiveness is physical quality that represents the capability of a single physical entity (e.g., vaccine) producing an effect (e.g, protection against a disease). effective YH ineffective YH rapid vaccination A vaccination process that is implemented fast. vaccine rapid implementation YH vaccination coverage YH, MC WEB: http://www.who.int/immunization_monitoring/routine/immunization_coverage/en/ WEB: http://www.sanofipasteur.com/sanofi-pasteur2/front/index.jsp?siteCode=SP_CORP&codeRubrique=19 A measure datum that measures the coverage of vaccination in a specific area during a specific time period. immunization coverage DNA/MVA prime-boost HIV vaccine YH PMID: 17328232 An HIVA.DNA/modified vaccinia Ankara (MVA) prime-boost vaccine for the potential prevention of infection with HIV subtype A. The vaccination strategy consists of priming with a DNA vaccine made from HIV-1 clade A gag p24/p17 consensus sequence (pTHr.HIVA) then boosting with a MVA virus expressing HIVA (MVA.HIVA). PMID: 2152500. epitope YH USA licensed vaccine role YH a licensed vaccine role that indicates the vaccine occurs in USA. USA licensed cattle vaccine YH a cattle vaccine with license that is used in USA. vaccination dose vaccination dose is a dose of vaccine that is used in a vaccination. Vaccination dose may be and may be not the same as the vaccine dose. YH monthly YH biweekly YH DNA vaccine expressing multiple HIV epitopes YH A HIV vaccine that is composed of a DNA vaccine expressing conserved, multiple HIV epitopes. PMID: 16359234. PMID: 16359234 recombinant HIV gp120 with adjuvant NanoEmulsion PMID: 18260780 YH A HIV vaccine that is made of recombinant HIV gp120 protein adjuvanted with the adjuvant NanoEmulsion. PMID: 18260780. Aeromonas salmonicida vaccine YH bacterial vaccine that is used to protect against Aeromonas salmonicida infection Vetech Labs http://www.vetechinc.com/ YH Gag-VRPs Gag-VRPs is a cocktail vaccine of V3014-packaged VRPs expressing the SIVsm H-4i nonmyristylated matrix-capsid region, full-length gp160, and a secreted form of gp160 (gp140). PMID: 12120997. YH PMID: 10462249 PMID: 12120997 Vibrio anguillarum vaccine YH MVA expressing HIV Gag, Pol and Env proteins A recombinant modified vaccinia Ankara (MVA) expressing HIV Gag, Pol, and Env proteins. PMID: 16472543. PMID: 16472543 YH DNA and poxvirus priming-boosting SIV vaccine A SIV vaccine that is composed of a DNA vaccine and a poxvirus vector expressing the same SIV antigens. PMID: 15258286. PMID: 15258286 YH Brucella abortus S19 with P39 deletion A B. abortus vaccine that is recombinant B. abortus strain 19 vaccine with the p39 gene deletion. B. abortus S19 P39 deletion mutant PMID: 9784574 YH AdsecV PMID: 17041851 A Yersinia pestis vaccine that uses a recombinant Ad5-based vector (E1a, partial E1b, and partial E3 deletion) to express Y. pestis V antigen. YH Yersinia EV76 YH PMID: 4988692 A Yersinia pestis vaccine that is a pigmentation negative mutant of Y. pestis derived from a fully virulent strain. Yersinia EV-76 PMID: 8578841 Y. pestis F1 protein vaccine A Yersinia pestis subunit vaccine that uses Y. pestis F1 protein as antigen. PMID: 8675324 YH PMID: 312163 rF1 + rV vaccine PMID: 10930691 YH PMID: 15908389 A Y. pestis subunit vaccine that uses recombinant F1 and V antigens. PMID: 312163. PMID: 12922126 Recombinant Y. pestis V antigen vaccine PMID: 7622205 YH A Y. pestis subunit vaccine that uses recombinant Y. pestis V antigen. PMID: 7622205. modified Y. pestis with TLR4-stimulating LPS PMID: 16980981 YH Yersinia PAV YH A Yersinia pestis subunit vaccine that contains staphylococcal protein A-V antigen fusion peptide (PAV). PMID: 7622225. PMID: 7622225 recombinant Y. pestis YopD protein vaccine PMID: 10024607 PMID: 8890210 YH Epm vaccine In vitro-cultured merozoites, chemically inactivated YH Y. pestis YscF subunit vaccine YH A Y. pestis subunit vaccine that uses Y. pestis YscF protein as antigen. PMID: 15978133. PMID: 15978133 microencapsulated Caf1 and LcrV vaccine YH PMID: 16546306 Ovilis Enzovax Live temperature-sensitive mutant strain for subcutaneous or intramuscular injection YH Trovac AI H5 YH Fowlpox virus-vectored H5 recombinant Yersinia rV10 vaccine YH PMID: 16861680 A Y. pestis vaccine that uses the recombinant V10 (rV10), a variant (lacking residues 271 to 300) of Yersinia pestis LcrV. PMID: 16861680. Pfizer Animal Health http://www.pfizerah.com/ YH AquaVac ERM YH Killed oral vaccine Feline leukemia virus vaccine YH Art Vax YH Live temperature-sensitive mutant strain; spray inhalation or drinking water VSV vector expressing Y. pestis lcrV YH PMID: 16959385 BIOPHARM YH Plague vaccine USP A formalin-inactivated preparation that was manufactured by Cutter Biologicals (a division of Miles Laboratories, Inc.). It is now available only from Greer Laboratories, Inc. The killed or inactivated plague vaccine is prepared from Y. pestis organisms grown in artificial media and then inactivated in formaldehyde. URL: http://www.cdc.gov/mmwr/preview/mmwrhtml/00044836.htm YH PMID: 8578841 Cutter Biological YH Improvac YH Peptide-protein conjugate and water-miscible adjuvant; control of boar taint IMPROVAC is a vaccine that stimulates the pig’s own immune system to produce specific antibodies against GnRF. This temporarily inhibits testes function and thus stops the production and accumulation of boar taint-causing compounds. WEB: http://www.improvac.co.nz/sites/improvac/en-nz/Pages/productoverview.aspx vaccine additive Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. a vaccine component that is added to the immunogen by the vaccine manufacturer for a specific purpose. Additives include adjuvants, preservatives and stablizers, as well as materials that are added to affect pH and isotonicity. YH vaccine preservative antimicrobial agent in vaccine vaccine preservative is an vaccine additive that is added to a vaccine formulation to prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during use. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. YH Periovac YH Killed vaccine against periodontitis vaccine stabilizer YH Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 75. a vaccine additive that helps to protect the vaccine from adverse conditions such as the freeze-drying process (for those vaccines that are freeze-dried) or heat. vaccine residual Although no all manufacturing residuals may be identified and quantified, their presence and quantity is assumed to be constant because of the constancy of the manufacturing process. Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. YH a vaccine component that remains from the vaccine manufacturing process. inactivation residual in vaccine YH a vaccine residual that is used to inactivate bacteria and viruses or to detoxify bacterial toxins. For example, formaldehyde is a frequently used inactivation agent in vaccine preparation. Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78. cell culture residual in vaccine YH a vaccine residual that is generatead from cell culture for vaccine preparation. Examples include: antibiotics, sensitizing substances, bacterial and cellular residuals, and adventitious agents. Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78-81. vaccine-induced immune correlate of protection Immune correlate of protection is a host immune response to vaccine that correlates with protective induced by the vaccine. YH serologic correlate of protection YH Serological correlate of protection is an immune correlate of protection that is reflected by serologic antibody levels. cell mediated immune correlate of protection YH A cell mediated immune correlate of protection is an immune correlate of protection that is reflected by a cell mediated immune response. vaccine effectiveness YH Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. Vaccine effectiveness is an effectiveness associated with a vaccine. Bioproperties YH http://www.bioproperties.com.au/ Canada Canada is a country that exists in north America. YH Pirodog YH In vitro-cultured supernatant antigens, reduce clinical disease Canada licensed vaccine role a licensed status that occurs in Canada. YH Porphyromonas gulae vaccine YH Fluviral S/F YH Influvac Influvac is an Influenza virus vaccine that is manufactured by Solvay Pharma. YH Vaxigrip Vaxigrip is an Influenza virus vaccine that is manufactured by 'Sanofi Pasteur Limited. YH, Melanie Solvay Pharmaceuticals YH Babesia bigemina vaccine by local veterinary institutes YH Purevax Feline Rabies Canarypox virus-vectored vaccine YH Babesia bovis vaccine by local veterinary institutes YH PGA/ME YH pGPA-incorporated microemulsion PMID: 16730934 Anthrax Spore Vaccine Anthrax Spore Vaccine is a B. anthracis vaccine that is prepared with a relatively nonpathogenic, noncapsulated variant strain of B. anthracis, originally developed at the Onderstepoort Laboratory, Pretoria, South Africa. Further work was conducted in England, India and in many other countries. Vaccine Strain is Sterne 34F2. The vaccine is a suspension of viable Bacillus anthracis spores in saponin. YH B. anthracis Sterne strain spore vaccine PMID: 3084385 pSecTag-PA83 YH PMID: 15293452 pCMV/ER-PA83 PMID: 15293452 YH Websters Animal Health https://www.webstervet.com/app.aspx YH RECOMBITEKEquine WNV Canarypox virus-vectored vaccine YH Porphyromonas denticanis YH pCLF4 YH PMID: 11401993 PMID: 15068841 pCLF4 is a Bacillus anthracis vaccine that contains the N-terminal region (amino acids [aa] 10-254) of Bacillus anthracis LF cloned into the pCI expression plasmid. Equity YH Equity Oestrus Control Vaccine for Horses is prepared from an analogue of gonadotropin releasing factor (GnRF) linked to a carrier protein. It has an adjuvant that enhances the level and duration of the immune response to GnRF with minimal injection site reactivity. It is used as an aid in the control of oestrus and oestrus-related behaviour in fillies and mares not intended for breeding. WEB: https://www.pfizeranimalhealth.com.au/products/352/equityreg-oestrus-control-vaccine.aspx Equity Oestrus Control Vaccine for Horses Peptide-protein conjugate and proprietary adjuvant (immunostimulating complex); control of estrus and estrus-related behavior single-dose Vaxigrip multi-dose Vaxigrip YH, Melanie, and Allen We still have not made it defined class since we still need to figure out how to represent multi-dose vs. single dose. The previous method discussed brief needs vetting. --YH The difference between single-dose and multi-dose Vaxigrip is that multi-dose Vaxigrip contains preservative thimoseral. aluminum vaccine adjuvant a mineral salt vaccine adjuvant that is composed of aluminum salt. Aluminum vaccine adjuvant is a vaccine adjuvant that is composed of some aluminum compound. YH vaccine preservative role a role inhers in a vaccine component that when added into a vccine formmulation, it can prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during administrating process or the manufacturing process. P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al. YH,YL The CFR requires that, with certain defined exceptions, preservatives must be added to mulitdose vials of vaccine. (P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al.) oral route a route of administration that located in the mouth YH intradermal route a route of administration that inject the material(such as vaccines, allergens) into the skin itself. YH,YL intradermal injection route I.D. phenol vaccine preservative YH PleuroStar APP YH Recombinant ApxII, TbpB, CysL, OmlA(1), and OmlA(2) proteins Colorado Serum Company CZ Veterinaria http://www.colorado-serum.com/ YH phenoxy ethanol vaccine preservative YH Biken YH, ZX Schering-Plough http://www.schering-plough.com/ YH BHV-1 vaccine YH Baxter Healthcare Corporation YH, ZX http://www.baxter.com/ Merck Frosst YH, ZX http://www.merckfrosst.ca/ age at vaccination YH Age at vaccination is the age of an experiment animal at the time of vaccination. Theileria annulata vaccine by local veterinary institutes Culture-derived schizonts YH dose dose is a measurement data that measures the quantity of something that may be eaten by or administered to an organism, or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses. WEB: http://en.wikipedia.org/wiki/Dose_%28biochemistry%29 YH, MC challenge dose challenge dose is a dose of a virulent pathogen used for a vaccine challenge process. YH Boehringer-Ingelheim Vetmedica, Inc http://www.bi-vetmedica.com/ YH PROTEQ-FLU (European Union) Recombitek (United States) YH Canarypox virus-vectored vaccine secondary vaccination YH, Thom Todd Secondary vaccination is a vaccination that is performed immediately after the primary or the first vaccination. SBL Vaccine YH, ZX Wyeth Canada http://www.wyeth.ca/ YH, ZX Eimeria vaccine YH surface antigens from the zona pellucida YH Theileria annulata vaccine YH vaccine allergen YH, ZX vaccine allergen is a material entity that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals who has been vaccinated with a vaccine. passive immunization using natural maternal antibody 09-26-2011 YL http://pathmicro.med.sc.edu/ghaffar/immunization-ver2.htm passive immunization that Immunity is transferred from mother to fetus through placental transfer of IgG or colostral transfer of IgA. chicken egg protein allergen YH, ZX, MC Eegg protein may come from NCIS thesaurus egg - poultry, combination of minimal anatomy terminology and NCBI taxonomy... Eventually, this term chicken egg protein allergen may become a cross product of sevreal ontology terms. chicken egg protein allergen is a vaccine allergen that is composed of chicken egg protein. latex vaccine allergen YH, ZX Virbac YH http://www.virbac.com/ gelatin vaccine allergen YH, ZX protamine sulfate vaccine allergen YH, ZX polymyxin B vaccine allergen YH, ZX EURIFEL FeLV YH Canarypox virus-vectored vaccine vaccine antigen To create this term for cover some other vaccines such as cancer vaccine and so on. vaccine antigenic component YL, YH the vaccine component that is used as antigen to produce an immune responce protect against the specific pathogen or disease. This is a modified or partial form of the virus, bacteria or the toxin that causes the disease against which the vaccine protects. The vaccine antigen is altered from its original form so it no longer causes disease but it can produce an immune response.(Vaccine components FactSheet of NCIRS) bovine albumin cell culture residual in vaccine a cell culture residual in vaccine that is bovine albumin. YH, ZX bovine serum cell culture residual in vaccine a cell culture residual in vaccine that is bovine serum. YH monosodium glutamate stabliizer YL,YH http://www.novaccine.com/vaccine-ingredients/results.asp?sc=13 a vaccine stablizer that is based on monosodium glutamate. C5H8NNaO4 RECOMBITEK Corona MLV YH Modified live virus glutaraldehyde vaccine additive Babesia bovis vaccine YH Infected blood from splenectomized calves human albumin cell culture residual in vaccine YH a cell culture residual in vaccine that is human albumin. human serum cell culture residual in vaccine YH a cell culture residual in vaccine that is human serum. Raboral Vaccinia virus recombinant YH Reference: http://www.raboral.com/ polysorbate 20 vaccine stabilizer Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Reference: http://www.sciencelab.com/msds.php?msdsId=9926640 YH, YL a vaccine stabilizer that is a polysorbate 20. It encourages the suspension of one liquid in another and has mild toxicity. http://www.novaccine.com/vaccine-ingredients/results.asp?sc=95 polysorbate 80 vaccine emulsifier Tween 80 is an amber-colored, viscous liquid with a slightly bitter taste. The product is a derivative of sorbitol and oleic acid. a vaccine emulsifier that uses polysorbate 80, also known as polyoxyethylene sorbitan monooleate or Tween™ 80. Tween 80 vaccine emulsifier YH,YL WEB: http://www.wisegeek.org/what-is-polysorbate-80.htm vaccine residual protein from cell culture a cell culture residual in vaccine that is residual protein from cell culture. YH Canine coronavirus vaccine YH ActHIB intramuscular vaccination sorbitol vaccine stabilizer a vaccine stabilizer that is specifically made by sorbitol. glucitol Sorbitol, also known as glucitol, is a sugar alcohol that the human body metabolizes slowly. It can be obtained by reduction of glucose, changing the aldehyde group to a hydroxyl group. Sorbitol is found in apples, pears, peaches, and prunes. It is synthesized by sorbitol-6-phosphate dehydrogenase, and converted to fructose by succinate dehydrogenase and sorbitol dehydrogenase. Succinate dehydrogenase is an enzyme complex that participates in the citric acid cycle. (wikipedia) YH, YL Sarcocystis neurona vaccine YH Suvaxyn Aujeszky YH gE- and thymidine kinase-deleted marker vaccine A vaccine that is made of a TK-negative (TK -) and gI/gE-negative (gI/gE -) pseudorabies virus (PRV) mutant to protect pigs against Aujeszky's disease. Aujeszky's disease is also known as pseudorabies. It is a disease primarily of pigs and is caused by porcine herpesvirus 1. This disease is characterized by respiratory, reproductive and nervous signs. sucrose albumin cell culture residual in vaccine a cell culture residual in vaccine that is sucrose albumin. YH xanthan gum vaccine ajuvant PMID: 19608270 "XG is derived from Xanthomonas campestris, has a pentasaccharide repeating unit structure, and its terminus contains a mannose moiety which acts as a toll-like receptor 2 agonist." REF: Mucoadhesive liposomes for intranasal immunization with an avian influenza virus vaccine in chickens, by Chiou C. et al. Biomaterials, Volume 30, Issue 29, October 2009, Pages 5862-5868, ISSN 0142-9612, 10.1016/j.biomaterials.2009.06.046. (http://www.sciencedirect.com/science/article/pii/S0142961209006371) YL yeast extract cell culture residual in vaccine a cell culture residual in vaccine that is from yeast extract. YH yeast protein cell culture residual in vaccine YH a cell culture residual in vaccine that is yeast protein. Apex-IHN YH DNA vaccine Diphtheria-Tetanus-Pertussis-Haemophilus b vaccine Diphtheria-Tetanus-Poliovirus vaccine Vibro-E.coli vaccine Measles-Rubella vaccine Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b-Hepatitis B vaccine PreveNile Live flavivirus chimera vaccine YH Streptococcus equi vaccine YH Mycoplasma gallisepticum vaccine YH Salmonella typhi-Hepatitis A vaccine Bayovac CSF E2 YH Baculovirus recombinant E2 protein without emulsion Dhori virus vaccine Tick-borne virus vaccine pharyngeal mucosal route Pharyngeal mucosal route is an oral route of administration. TT, YH Intervet Avian Influenza virus vaccine YH Chimera virus on NDV backbone; field trials in 2007 host survival to pathogen challenge after vaccination Embrex http://www.embrex.com/ YH Novartis Animal Health YH http://www.ah.novartis.com/ Novartis http://www.novartis.com/ YH Aqua Health LHRH YH luteinizing hormone-releasing hormone Bovilis IBR Marker Live or inactivated gE-deleted marker vaccine YH Porcilis Pesti YH Baculovirus recombinant E2 protein without emulsion Theileria parva vaccine by local veterinary institutes YH Infection followed by drug treatment Novus International http://www.novusint.com/ YH Toxoplasma gondii vaccine YH SpayVac SpayVac is a contraceptive vaccine that has proven highly effective in deer and can be used to control populations. Refernce: http://terramar.bc.ca/. YH no longer available Crude ZPA preparation; supplied to research groups only Biomune http://www.biomunecompany.com/ YH Giardiavax Cultured trophozoites, reduces disease and cyst shedding YH plant-based Newcastle disease virus vaccine The plant-based Newcastle disease virus vaccine is a Newcastle disease virus vaccine that is developed by Dow AgroSciences LLC. It uses technology discovered at Washington University. It is the first plant-made animal vaccine approved for sale in the United States. HN recombinant produced in plant cell lines (registered but not on market) YH Classical swine fever virus vaccine YH Vectormune FP-ND YH Fowlpox virus vectored Immucox Paracox Coccivac Advent Nobilis Cox ATM YH Sporulated oocysts of several or all of the avian species Megan Vac1 WEB: http://www.fda.gov/ohrms/dockets/dockets/00n0504/00N-0504_emc-001650-02.pdf YH Megan Vac1 is a Salmoneela vaccine that consists of a double gene-deleted S. enterica serovar Typhimurium strain and is designed for protection of broilers to reduce Salmonella contamination. AquaVac Furuvac Killed oral vaccine YH Lohman Animal Health International YH http://www.lahinternational.com/ Babesia bigemina vaccine YH Yersinia ruckeri vaccine YH Vaxsafe MS YH Live temperature-sensitive mutant strain; eye drop administration Nobivac Piro YH In vitro-cultured supernatant antigens, reduce clinical disease Equilis StrepE YH Live submucosal vaccine; deletions in aroA gene Centre for Ticks and Tickborne Disease, Malawi YH Theileria parva vaccine YH Neospora caninum vaccine YH ImmunoVaccine Technologies, Canada http://www.immunovaccine.com YH AquaVac Vibrio YH Killed oral vaccine Reference: http://www.spaquaculture.com/default.aspx?pageid=553 Babesia canis vaccine YH vaccination with a licensed goat and sheep vaccine YH Mycoplasma synoviae vaccine YH vaccination with a licensed fish vaccine YH Local veterinary institutes YH Androstenedione YH vaccination with a licensed cat vaccine YH vaccination with a licensed ferret vaccine YH Giardia duodenalis vaccine protozoan vaccine that is used to protect against Giardia intestinalis infection YH vaccination with a licensed bird vaccine YH Chlamydophila abortus vaccine YH vaccination with a licensed deer vaccine YH vaccination with a licensed chicken vaccine YH 2009 H1N1 vaccine protocol YH CDC recommendation of the use of Influenza A (h1N1) 2009 vaccine YH, XZ WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm vaccination target group vaccination target group is a population group that have priority for vaccination when a vaccine is first available. YH, XZ Poulvac FluFend I AI H5N3 RG YH Chimera H5N3 virus, inactivated in oil-based adjuvant USDA YH 2009 H1N1 Influenza A vaccine target group YH, XZ WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm a vaccination target group for 2009 H1N1 Influenza monovalent vaccine. pregnant women XY, XZ WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm passive immunization by injecting pre-made immune element 09-26-2011 YL passive immunization by injecting a recipient with pre-made antibody, antitoxin, epitope, etc. Ovastim Increased ovulation/twinning YH A vaccine used to increase the fecundity in breeding ewes. Ovastim increases the number of multiple ovulations and therefore the number of multiple births. WEB: http://www.virbac.co.nz/p-virbacnzpuben/display.aspx?srv=p-virbacnz&typ=pub&lang=en&cmd=view&style=styles/specie.xsl&select=PRODUCT[@ID$eq$PRODUCT_264]&affp=& RECOMBITEK rDistemper YH Canarypox virus-vectored vaccine (HA and F antigens) persons living with or providing care for infants aged <6 months WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm XY, XZ health-care and emergency medical services personnel WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm XY, XZ persons aged 6 months--24 years XY, XZ WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm persons aged 25--64 years with medical conditions at higher risk for influenza-related complications WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm XY, XZ vaccination target role vaccination target role is a regulation-assigned role to a group of population with priority of getting some vaccination (e.g., 2009 H1N1 Influenza vaccine). YH inactivation YH, MC, and XZ inactivation is a processual entity that produces inactive material. Lawsonia intracellularis vaccine YH Fecundin Linked to human serum albumin; increased ovulation/twinning YH withdrawn WEB: http://www.journals.elsevierhealth.com/periodicals/anirep/article/PII0378432093901125/abstract a fertility vaccine that enhance fertility in sheep. CoxAbic YH Gametocyte antigen(s); transmission blocking through maternal antibody transfer Bordetella avium vaccine YH survival of live vaccine inside host YH survival of live vaccine inside host is a processual entity that represents the survival of a live vaccine inside its host. The time of the survival is often important for the success of the live vaccine. persistence of vaccine induced immune response YH persistence of vaccine induced immune response is a processual entity that indicates the persistence of an immune reponse induced by a vaccine in a vaccinated host. Merial, Inc http://www.merial.com/ YH Bovilis Neoguard YH Killed tachyzoites, reduces abortion RECOMBITEK Canine Parvo Modified live virus YH Eimeria maxima vaccine YH Agriflu YH CVX: 140 live attenuated Brucella vaccine CVX: 135 live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella infection. YH Actinobacillus pleuropneumoniae vaccine YH assay of CFU reduction in liver assay of CFU reduction in liver is a CFU reduction assay that is measured using the extracted liver as the tissue for isolation of infected pathogens. YH assay of CFU reduction in lung YH assay of CFU reduction in lung is a CFU reduction assay that is measured using the extracted lung as the tissue for isolation of infected pathogens. live attenuated Brucella abortus vaccine live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella abortus infection. YH live attenuated Brucella melitensis vaccine YH live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella melitensis infection. live attenuated Brucella suis vaccine live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella melitensis infection. YH Eimeria tenella vaccine YH Ovilis Toxovax S48 strain with a lost ability to form cysts after passages in mice YH vaccine viability YH, ZX vaccine viability is a viability of a vaccine. West Nile-Innovator DNA YH DNA vaccine Brucella DNA vaccine Brucella DNA vaccine is a DNA vaccine that protects against a Brucella infection. YH Leishmania donovani vaccine YH DNA encoding pathogen protein as vaccine component YH Brucella DNA vaccine encoding chimera BLSOmp31 pCIBLSOmp31 PMID: 17600596 YH vaccine being viable vaccine being viable is a vaccine viability that indicates a vaccine uses live organism. YH, ZX vaccine being dead vaccine being dead is a vaccine viability that indicates a vaccine uses dead or killed organism. YH, ZX IL-12 vacince adjuvant a cytokine vaccine adjuvant that includes IL-12. IL-12 vaccine adjuvant is a vaccine adjuvant that contains IL-12. YH, ZX no vaccine protection YH, ZX significant vaccine protection YH, ZX enhanced significant protection YH, ZX Piscirickettsia salmonis vaccine YL bacterial vaccine that is used to protect against Piscirickettsia salmonis infection generated using OntoRat Androvax Increased ovulation/twinning YH B. abortus HSA-L7/L12 YH Brucella abortus Human serum albumin (HAS)-L7/L12 B. abortus L7/L12 is a B. abortus subunit vaccine using L7/L12 that is formed by recombinant Human Serum Albumin (HAS)-L7/L12 fusion protein. PMID: 19293473 Porcilis APP Extracted ApxI, ApxII, ApxIII, and outer membrane proteins YH PUREVAX Ferret Distemper Canarypox virus-vectored vaccine YH PUREVAX Ferret Distemper is a lyophilized ferret vaccine of a recombinant canarypox vector expressing the HA and F glycoproteins of canine distemper virus. Reference: http://www.drugs.com/vet/purevax-ferret-distemper.html. vaccination dose sepcification YH, ZX challenge dose specification YH, ZX specification of vaccination-challenge interval YH, ZX specification of time interval after vaccination for challenge is a plan specification that specifies the time interval after vacciation for challenge pathogen challenge protocol YH, ZX pathogen challenge protocol is a protocol that is used for a pathogen challenge process. reduction of colony forming unit reduction of colony-forming unit (CFU) is a titer measurement of viable bacterial or fungal numbers. It equals to a reduction of a CFU count from another CFU count. This term is often used as a measurement of a vaccine protection study. YH, ZX intraperitoneal pathogen challenge YH, ZX intraperitoneal pathogen challenge is a pathogen challenge process that occurs in the intraperitoneal site of a host. intraperitoneal vaccination a vaccination process that occurs in the intraperitoneal route YH, ZX E. coli DNA vaccine E. coli DNA vaccine is a DNA vaccine that protects against an E. coli infection. YH Brucella subunit vaccine YH Brucella subunit vaccine is a subunit vaccine that protects against a Brucella infection. B. melitensis Rev. 1 with bp26 and omp31 deletions PMID: 17070627 YH CGV2631 B. melitensis bp26 and omp31 deletion vaccine is a Brucella melitensis vaccine that has double deletions of bp26 and omp31. pCIOmp31 YH pCIOmp31 is a B. melitensis DNA vaccine expressing Omp31 that uses the pCI plasmid. PMID: 16177328 pTargeTomp31 YH PMID: 17014873 pTargeTomp31 is a B. melitensis DNA vaccine expressing Omp31 that uses the pTargeT mammalian expression system vector (Promega, USA). Schering-Plough Animal Health YH http://www.intervet.com/ Intervet has merged with Schering-Plough Animal Health and become Intervet/Schering-Plough Animal Health™ (YL.) B. abortus L7/L12 fused to MBP B. abortus L7/L12 fused to MBP is a B. abortus subunit vaccine using L7/L12 that uses recombinant L7/L12 fused on maltose binding protein MBP. PMID: 8873388 YH inactivated influenza vaccine YH inactivated influenza vaccine is an inactivated viral vaccine that targets at influenza viral infections. Livacox YH Precocious and egg-passaged lines live attenuated influenza vaccine live attenuated influenza vaccine is a live attenuated vaccine that protects against influenza viral infection. YH Bayer Leverkusen http://www.bayer.com/ YH laboratory test Vaxsafe MG YH Live temperature-sensitive mutant strain; eye drop administration ANOVA Oliver: It's temporary. We will get this term from OBI eventually. GonaCon YH registration reported to be in progress WEB: http://www.aphis.usda.gov/wildlife_damage/nwrc/research/reproductive_control/gonacon.shtml a contraceptive vaccine that is used in wildlife population Peptide conjugated to keyhole limpet hemocyanin in mycobacterium-oil adjuvant (AdjuVac); contraceptive vaccine to control wildlife vaccine protection ANOVA Inovocox YH In ovo delivery using proprietary platform injection system vaccine protection data set YH intramuscular vaccination YH, YL a vaccination that occurs in the intramuscular route. vaccine strain data set YH vaccine viability data set YH IL-12 vaccine adjuvant data set YH vaccine protective antigen data set YH mutated gene in vaccine strain data set YH vaccination mouse strain data set YH biological sex data set YH vaccination route data set YH vaccination dose data set YH animal age at vaccination data set YH pathogen strain for challenge data set YH pathogen challenge data set YH Leishmune Native fucose-mannose-ligand antigen complex YH Enterisol Ileitis Live oral vaccine YH challenge dose data set YH vaccination-challenge interval data set YH CFU per volume data set YH CFU reduction data set YH vaccine protection efficacy data set YH p-value data set B. abortus BLS-L7/L12 YH B. abortus BLS-L7/L12 is a B. abortus subunit vaccine using L7/L12 that is made as a recombinant BLS-L7/L12 fusion protein vaccine. recombinant Brucella BLS-L7/L12 fusion protein vaccine PMID: 19596411 recombinant Brucella lumazine synthase and L7/L12 fusion protein vaccine vaccine protection efficacy measurement YH vaccine protection efficacy measurement is an assay that measures the protection efficayc of a vaccine. lipopolysaccharide subunit vaccine YH recombinant bacterial vector vaccine YH, XZ Coopers Animal Health YH http://www.coopersanimalhealth.com.au/ recombinant viral vector vaccine YH, ZX inactivated bacterial vaccine YH Vaxstrate WEB: http://www.ncbi.nlm.nih.gov/pubmed/1370000 LHRH peptide conjugated to ovalbumin; oil emulsion adjuvant an anti-reproductive vaccine for cattle. The vaccine is based on the established principle that antibodies to the hypothalamic releasing hormone, gonadotrophin releasing hormone (GnRH) block the action of GnRH on pituitary secretion of luteinizing hormone and follicle stimulating hormone, leading to gonadal atrophy in mammals. The vaccine comprises an immunogenic GnRH:ovalbumin conjugate formulated in a novel double adjuvant system and is administered in a two-dose treatment regimen. withdrawn in 1996 YH inactivated Brucella vaccine YH live attenuated bacterial vaccine YH veterinary vaccine YH Veterinary vaccine is a vaccine that is used for animals (excluding humans), for example, pet, domestic, wildlife, and livestock animals. Dow AgroSciences YH http://www.dowagro.com/homepage/index.htm?DCSext.das=dowagro.com live attenuated viral vaccine YH Brucella abortus subunit vaccine YH Newcastle disease virus vaccine YH Brucella melitensis subunit vaccine YH Brucella suis subunit vaccine YH Brucella abortus DNA vaccine YH Brucella melitensis DNA vaccine YH Brucella suis DNA vaccine YH inactivated Brucella abortus vaccine recombinant bacterial vector vaccine for Brucella recombinant bacterial vector vaccine for Brucella abortus human vaccine Human vaccine is a vaccine that is used for human. YH protective antigen YH, ZX viral vaccine preparation A vaccine preparation that results in the generation of a viral vaccine YH, ZX protozoan vaccine preparation YH, ZX A vaccine preparation that results in the generation of a protozoan vaccine fungal vaccine preparation A vaccine preparation that results in the generation of a fungal vaccine YH, ZX preparation of cancer vaccine A vaccine preparation that results in the generation of a cancer vaccine CpG DNA vaccine adjuvant YH A microbial derivative vaccine adjuvant compsed of CpG DNA. PMID: 12899580 Ribi vaccine adjuvant Ribi vaccine adjuvant is an emulsion vaccine adjuvant that is a stable oil-in-water emulsion. http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=M6661%7CSIGMA&N25=0&QS=ON&F=SPEC SGS RC529 vaccine adjuvant a synthetic vaccine adjuvant named RC529 that is a lipid A mimetic. PMID: 16204643 SGS aluminum potassium sulfate adjuvant An aluminum vaccine adjuvant that is aluminum potassium sulfate (AlK(SO4)2). ZX, SGS Alhydrogel ZX, SGS An aluminum hydroxide vaccine adjuvant that is a gel that is made by precipitation of aluminum hydroxide Al(OH)3 under alkaline conditions. PMID: 7551218 cholera toxin B subunit CTB SGS A microbial derivative vaccine adjuvant made of the B subunit of the cholera toxin from Vibrio cholerae. Prevnar 13 ZX VIOLIN Vaccine ID: 1114 CVX: 133 Synflorix ZX VIOLIN Vaccine ID: 1115 Menveo VIOLIN Vaccine ID: 1113 CVX: 136 AREPANRIX H1N1 VIOLIN Vaccine ID: 1116 Intanza VIOLIN Vaccine ID: 1117 RC529-AF vaccine adjuvant RC529-AF can be obtained from Corixa Corporation (Seattle, WA). Reference: PMID: 15308371 RC529 vaccine adjuvant in an aqueour formulation an aqueous formula of the synthetic vaccine adjuvant RC529. MPL vaccine adjuvant PMID: 7551218 SGS 3D-MLA A microbial derivative vaccine adjuvant derived from the lipopolysaccharide (LPS) of Salmonella minnesota R595. PMID: 10768940 3-O-deacylated monophosphoryl lipid A vaccine adjuvant LTK63 vaccine mutant PMID: 10790422; PMID: 17920733 A microbial derivative vaccine adjuvant that is a mutant form of LT containing a Ser-Lys substitution in position 63 which has been shown to be totally devoid of toxicity stable to protease treatment and able to act as mucosal adjuvant. PMID: 9607006 LTK63 is an enzymatically inactive mutant of the heat-labile enterotoxin of Escherichia coli. It can be used as a potent mucosal adjuvant. SGS toxoid YH WEB: http://en.wikipedia.org/wiki/Toxoid is a bacterial toxin (usually an exotoxin) whose toxicity has been weakened or suppressed either by chemical (formalin) or heat treatment, while other properties, typically immunogenicity, are maintained. capsular polysaccharide subunit vaccine YH capsular polysaccharide of pathogen organism as vaccine component YH polysaccharide subunit vaccine YH polysaccharide of pathogen organism as vaccine component YH prevention of disorder objective YH is the specification of an objective to prevent a disorder. amelioration of disorder objective is the specification of an objective to ameliorate a disorder. YH killed Corynebacterium parvum vaccine adjuvant SGS PMID: 4596278; PMID: 7591056 PMID: 5483667 A microbial derivative vaccine adjuvant derived from heat-killed Corynebacterium parvum. Titermax Gold URL: http://www.titermax.com/i_gold4.htm Titermax Gold is an emulsion vaccine adjuvant which is a water-in-oil adjuvant with CRL-8300 (a block copolymer), squalene, and sorbitan monooleate. SGS It's a water-in-oil emulsion adjuvant. Reference: http://www.titermax.com/i_gold4.htm. DDA vaccine adjuvant PMID: 1439129 a synthetic vaccine adjuvant that is dimethyldioctadecylammonium bromide (DDA), a lipophilic quaternary ammonium salt known as a good adjuvant when co-administered systemically or nasally with an antigen. SGS Dimethyl dioctadecyl ammonium bromide cationic liposomal vaccine adjuvant DDA:TDB SGS A liposome-based vaccine adjuvant that have a positive surface charge. PMID: 19874860 QuilA vaccine adjuvant a tenosactive compound vaccine adjuvant that contains purified extract from the bark of the South American tree Quillaja saponaria Molina. SGS PMID: 7551218 AS02 vaccine adjuvant monophosphoryl lipid A (MPL), QS21 and an oil in water emulsion. PMID: 15780441; PMID: 15187142 SGS A combination vaccine adjuvant comprised of monophosphoryl lipid A (MPL), QS21 and an oil in water emulsion. AS04 vaccine adjuvant AS04 is a combination vaccine adjuvant that is a combination of 50 μg of the immunoenhancer MPL (3-O-desacyl-4′-monophosphoryl lipid A) with 500 μg of aluminium salt. SGS PMID: 21527299 VSA-3 VSA-3 is an emulsion vaccine adjuvant which is an emulsion plus DDA. PMID:16187717 Emulsigen D SGS saponin vaccine adjuvant a tensoactive compound vaccine adjuvant that is derived from saponin, a compound that is an immunostimulator found in the plant P. senega. Montanide ISA 720 PMID: 15752840 A Montanide vaccine adjuvant that is formulated as water-in-oil emulsions and induces high antibody titers in several animal species. It is a vaccine adjuvant composed of metabolizable oil and a surfactant system designed to make a water-in-oil emulsion. It has been used since 1992 in more than 50 clinical trials related to therapeutic vaccines against various diseases such as cancer and malaria. WEB: http://www.seppic.com/human-health/vaccine-adjuvant/montanide-isa-720-@/view-1044-seproduit.html?menuid=,979,&lang=en YH, SGS Montanide ISA 720 VG Montanide incomplete Seppic adjuvant a montanide vaccine adjuvant that is a mineral oil adjuvant. Montanide ISA51 A montanide vaccine adjuvant that is a vaccine adjuvant composed of a light mineral oil and a surfactant system designed to make a water-in-oil emulsion. WEB: http://www.seppic.com/human-health/vaccine-adjuvant/montanide-isa-51-@/view-1042-seproduit.html?menuid=,979,&lang=en SGS Montanide vaccine adjuvant An emulsion vaccine adjuvant developed by Montanide (http://www.montanide.com/). YH, SS EtxB vaccine adjuvant B subunit of E. coli heat-labile enterotoxin YH, SS A microbial derivative vaccine adjuvant composed of the B subunit of E. coli heat-labile toxin. Polygen vaccine adjuvant A synthetic vaccine adjuvant with the tradename Polygen. YH, SS URL: http://www.mvp-technologies.com/adjuvants/Polygen%20Final%20Technical%20Bulletin.pdf vaccine host role YH, ZX a role of host that contains vaccine. It is a role that inheres in an organism that is the target of a vaccine administration (vaccination process). immunization target role a role that represents a target (i.e., some disorder) of immunization. YH, ZX bacterial vaccine immunization YH, ZX viral vaccine immunization YH, ZX cancer vaccine immunization YH, ZX parasite vaccine immunization YH, ZX immunization target role of pathogen immunization target role of bacterial pathogen YH, ZX immunization target role of viral pathogen YH, ZX immunization target role of parasite pathogen YH, ZX immunization target role of fungal pathogen YH, ZX Algal Glucan vaccine adjuvant SGS A nonantigenic carbohydrate adjuvant, which enhances both humoral and cell-mediated immunity to oligopeptides in experimental animal models. PMID: 7551218 Algammulin vaccine adjuvant PMID:1887671 SGS A suspension of 1-2μm ovoids of immune stimulant gamma inulin (g-IN) in which alum is embedded as a carrier for protein or other anionic antigens. BAY R1005 a synthetic vaccine adjuvant that is Bay R1005 (N-(2-Deoxy-2-L-leucylamino β-D-glucopyranosyl)-N-octadecyldodecanoylamide hydroacetate ). N-( 2-Deoxy-2-L-leucylamino-β-D-glucopyranosyl)-N-octadecyldodecanoylamide hydroacetate SGS PMID: 7551218 Avridine SGS N, N-dioctadecyl-N′, N′-bis( 2-hydroxyethyl) propanediamine CP20,96 PMID:7551218 A synthetic vaccine adjuvant that is N, N-dioctadecyl-N′, N′-bis( 2-hydroxyethyl) propanediamine (Avridine). calcium phosphate gel SGS PMID: 7551218 a calcium phosphate vaccine adjuvant that is a gel prepared by precipitating soluable calcium and phosphate salts. Cholera toxin A1-subunit-ProteinA D-fragment fusion protein SGS CTA1-DD gene fusion protein PMID: 7551218 A microbial derivative vaccine adjuvant composed of the CTA1-DD fusion protein. DOC/Alum Complex SGS A mineral salt vaccine adjuvant that is composed of Deoxycholic acid sodium salt (DOC) complexed with aluminum hydroxide. PMID:7551218 gamma Inulin vaccine adjuvant PMID: 3265692; PMID: 7551218 SGS gamma inulin is a carbohydrate adjuvant that is a highly specific activator of the alternative pathway of complement in vitro and in vivo, and is composed of linear (unbranched) b-D-(2-1) polyfructofuranosyl-a-D-glucose. Gerbu vaccine adjuvant Gerbu adjuvant is a combination vaccine adjuvant that is comprised of a mixture of GMDP, DDA, and Zinc L-proline salt complex (ZnPro8). SGS PMID: 7551218 PMID: 15953835 GM-CSF vaccine adjuvant a cytokine vaccine adjuvant that includes GM-CSF. YH, SGS GMDP N-acetylglucosaminyl-(b1-4)-N-acetylmuramyl-L-alanyl-D-isoglutamine PMID: 7551218 SGS A synthetic vaccine adjuvant containing GMDP, a higly effective primary adjuvant. recombinant hIFN-gamma/Interferon-g vaccine adjuvant an IFN-gamma vaccine adjuvant that is composed of recombinant hIFN-gamma. YH, SGS interleukin-1b vaccine adjuvant a cytokine vaccine adjuvant that includes IL-1b. YH, SGS interleukin-2 YH, SGS a cytokine vaccine adjuvant that includes IL-2. interleukin-7 YH, SGS a cytokine vaccine adjuvant that includes IL-7. Loxoribine 7-allyl-8-oxoguanosine SGS a synthetic vaccine adjuvant loxoribine is a guanosine analog derivatized at position N7 and C8, and activates TLR-7. PMID: 7551218 MF59 PMID: 20488726 An emulsion vaccine adjuvant consisting of an oil (squalene)-in-water nano emulsion. SGS MTP-PE Liposomes MTP-PE liposomes are a liposome-based vaccine adjuvant that consists of liposomes containing the synthetic lipophilic analog of muramyl dipeptide, muramyl tripeptide phosphatidylethanolamine (MTP-PE). PMID: 1431559 SGS MTP-PE Murametide SGS PMID: 7551218 a synthetic vaccine adjuvant made of murametide that has adjuvant activity similar to MDP. Nac-Mur-L-Ala-D-Gln-OCH3 Murapalmitine PMID: 7551218 Nac-Mur-L-Thr-D-isoGIn-sn-glyceroI dipalmitoyl SGS a synthetic vaccine adjuvant called murapalmitine. D-Murapalmitine Nac-Mur-D-Ala-D-isoGln-sn-glycerol dipalmitoyl PMID: 7551218 SGS a synthetic adjuvant that is an MDP analog called D-Murapalmitine. NAGO SGS PMID: 7551218 a synthetic vaccine adjuvant that is composed of neuraminidase-galactose oxidase (NAGO) a mixture of mixture of the two enzymes-neuraminidase and galactose oxidase. Neuraminidase-galactose oxidase non-ionic surfactant vesicles a synthetic vaccine adjuvant consisting of multi-lamellar vesicles comprising a mixture of non-ionic surfactant (e.g., 1-monopalmitoyl-rac-glycerol), cholesterol and dicetyl phosphate used as a primary vaccine adjuvant for entrapped antigen. SGS PMID: 7551218 NISV PMMA PMID: 7551218 a synthetic vaccine adjuvant made from the emulsion polymerization of methyl methacrylate. Polymethyl methacrylate SGS protein cochleates PMID: 7551218 SGS a synthetic vaccine adjuvant synthesized from stable protein phospholipid-calcium precipitates. QS-21 SGS a tensoactive compound vaccine adjuvant that is composed of extracts from the bark of the Quillaja saponaria Molina tree. PMID: 7551218 Stimulon™ QS-21 Adjuvant Rehydragel HPA PMID: 7551218 SGS An aluminum vaccine adjuvant that is a synthetic oxyhydroxide of aluminum (aluminum hydroxide) prepared by acid-base precipitation. Rehydragel LV An aluminum hydroxide vaccine adjuvant that is a low visosity aluminum hydroxide gel. PMID: 7551218 SGS Sclavo peptide IL-1β 163-171 peptide YH, SGS a cytokine vaccine adjuvant that contains the 163-171 peptide of IL-1β. Specol SGS PMID: 1439130 Specon is an emulsion vaccine adjuvant that is a water-in-oil emulsion that is used as an adjuvant and has immunostimulating properties similar to Freund's complete adjuvant (FCA). SPT (Antigen Formulation) SPT is an emulsion vaccine adjuvant that is an emulsion of squalane (5%), Tween 80( 0.2%), Pluronic L121( 1.25%), phosphate-buffered saline pH 7.4, and antigen. PMID: 7551218 SGS stearyl tyrosine a synthetic vaccine adjuvant stearyl tyrosine is considered an "organic equivelant" of aluminum hydroxide. SGS PMID: 7551218 Theramide PMID: 7551218 a synthetic vaccine adjuvant called Theramide that is composed of N-acetylglucosaminyl-N-acetylinuramyl-L-Ala-D-isoGlu-L-Ala-dipalmitoxy propylamide (DTP-DPP). SGS CRL1005 PMID: 10717336 a synthetic vaccine adjuvant that is a copolymer (CRL1005), based on a 12 kDa polyoxypropylene (POP) core with 5% POE. SGS nanoemulsion vaccine adjuvant SGS Nanoemulsion vaccine adjuvant is an emulsion vaccine adjuvant and is made from non-toxic lipid droplets a few hundred nanometers in diameter and made from surfactants approved for human consumption and common food substances that are 'Generally Recognized as Safe' (GRAS) by the FDA. http://nano.med.umich.edu/platforms/Nanoemulsions.html AS03 PMID: 21256188 SGS AS03 is an emusion vaccine adjuvant that contains α-tocopherol and squalene, two biodegradable polyprenyls, in an oil-in-water emulsion. LTR192G PMID: 11803061 A microbial deriviative vaccine adjuvant that is a mutant form of E.coli heat-labile toxin. SGS E. coli heat-labile toxin, LT LT Oral Adjuvant A microbial derivative vaccine adjuvant containing E. coli heat-labile toxin. PMID: 7551218 SGS LT-OA amorphous aluminum hydroxyphosphate sulfate adjuvant (AAHSA) AAHSA Merck Aluminum Adjuvant PMID: 17581283 An aluminum vaccine adjuvant that is a a proprietary aluminum hydroxyphosphate sulfate formulation that is both physically and functionally distinct from traditional aluminum phosphate and aluminum hydroxide adjuvants. SGS Matrix-S Brucella abortus subunit vaccine using Bfr PMID: 11447155 recombinant Brucella abortus Bfr protein vaccine Brucella BFR antigen vaccine Brucella abortus subunit vaccine using Omp16 PMID: 18981242 Brucella abortus Omp16 vaccine B. melitensis DNA vaccine encoding Bp26 and Tf imiquimod vaccine adjuvant S26308 a synthetic vaccine adjuvant contiaing imiquimod a imidazoquinoline. 1-(2-methypropyl)-IH-imidazo[4,5-c]quinolin-4-amine R-837 SGS Aldara™ PMID: 7551218, PMID: 18566444 resiquimod vaccine adjuvant a synthetic vaccine adjuvant, resiquimod is a chemical analog of imiquimod. SGS PMID: 15068862 AF03 vaccine adjuvant SGS PMID:20193791 An emulsion vaccine adjuvant containing 2.5% squalene. Flagellin vaccine adjuvant PMID: 16428759, PMID: 21048152 FliC SGS A microbial derivative vaccine adjuvant composed of flagellin from gram-negative bacteria. poly(I:C) vaccine adjuvant SGS a synthetic vaccine adjuvant containing Poly(I:C), a synthetic double stranded analog of RNA. WEB: http://en.wikipedia.org/wiki/Polyinosinic:polycytidylic_acid polyriboinosinic-polyribocytidylic acid ISCOMATRIX vaccine adjuvant ISCOMATRIX is identical to ISCOMs except that it does not contain antigen. Ref: PMID: 17336431. a particulate antigen delivery system that is a vaccine adjuvant comprising cholesterol, phospholipid and saponin but without antigen. SGS PMID: 19450632 Abisco-100 vaccine adjuvant SGS, YH WEB: http://www.isconova.com/products/abisco-research-reagent/abisco-100.aspx a tensoactive compound vaccine adjuvant that is made from highly purified saponins. albumin-heparin microparticles vaccine adjuvant a particulate antigen delivery system that is albumin-heparin microparticles vaccine adjuvant that is prepared from albumin and heparin stabilized by cross-linking reaction with EDC. PMID: 16734558 SGS AS-2 vaccine adjuvant http://www.pasteur.fr/applications/euroconf/vaccins/vaccins-abs.html SGS SmithKline Beecham adjuvant system 2 (AS-2) is a combination vaccine adjuvant and is based on the combination of Monophosphoryl Lipid A(MPL), QS21 (a purified fraction of Saponin extracted from Quillarja Saponaria), and a proprietary oil in water emulsion. B7-2 vaccine adjuvant a cytokine vaccine adjuvant that includes B7-2. YH, SGS Bupivacaine vaccine adjuvant a synthetic vaccine adjuvant that is a local anaesthetic drug belonging to the amino amide group, and is used as a vaccine adjuvant in DNA vaccines. PMID: 15246629, WEB: http://en.wikipedia.org/wiki/Bupivacaine SGS cationic liposome-DNA complex JVRS-100 PMID: 19285425 SGS A liposome-based vaccine adjuvant that is composed of virus sized liposomes that contain a DNA plasmid. DHEA vaccine adjuvant prasterone a synthetic vaccine adjuvant that is DHEA, which is relatively stable and can be directly incorporated into vaccine formulations. SGS transdehydroandrosterone DHA androstenolone 5-androsten-3β-ol-17-one Dehydroepiandrosterone PMID: 7551218 DL-PGL (Polyester poly (DL-lactide-co-glycolide)) vaccine adjuvant PLGA a synthetic vaccine adjuvant that is PLGA, which has been used in the controlled delivery of peptide drugs. PMID: 15560948 PLGA microspheres SGS Polyester poly (DL-lactide-co-glycolide) IL-15 vaccine adjuvant a cytokine vaccine adjuvant that uses the adjuvant effect of cytokine IL-15. YH, SGS immunoliposomes containing antibodies to costimulatory molecules SGS immunoliposomes containing antibodies to costimulatory molecules is a liposome-based vaccine adjuvant which is prepared from dehydration-rehydration vesicles (DRVs). PMID: 7551218 LTK72 vaccine adjuvant SGS A microbial derivative vaccine adjuvant that is a mutant form of heat-labile Escherichia coli enterotoxin (LT) that contains a substitution Ala → Arg in position 72 of the A subunit. PMID: 9529328 MPL-SE vaccine adjuvant SGS A microbial derivative vaccine adjuvant containing MPL and squalene. PMID: 12213399 formaldehyde vaccine preservative WEB: http://www.mja.com.au/public/issues/184_04_200206/eld10500_fm.pdf a vaccine preservative that contains formaldehyde. YH, SGS non-toxic mutant E112K of Cholera Toxin mCT-E112K A microbial derived vaccine adjuvant made of E112K mC, a mutated CT created by substituting a single amino acid in the ADP-ribosyltransferase active centre, glutamate to lysine at position 112. SGS mCT PMID: 11251876: cholera toxin derived vaccine adjuvant YH, SGS a microbial derivative vaccine adjuvant that is derived from cholera toxin. SAF-1 vaccine adjuvant PMID: 7551218 SAF-1 is a combination vaccine adjuvant that is composed of threonyl-MDP (0.05-1%) in an emulsion vehicle [5% squalane, 2.5% Pluronic® L121, 0.2% Polysorbate 80 and phosphate buffered saline (pH 7.4)]. SGS Sendai Proteoliposomes, Sendai-containing Lipid Matrices A liposome-based vaccine adjuvant that includes the glycoproteins of Sendai virus. SGS PMID: 7551218 threonyl muramyl dipeptide (TMDP) vaccine adjuvant [thr1 ]-MDP a synthetic vaccine adjuvant that is threonyl muramyl dipeptide (TMDP). Termurtide™ PMID: 7551218 N-acetyl muramyl-L-threonyl-D-isoglutamine SGS ty particles vaccine adjuvant PMID: 7551218 A microbial derivative vaccine adjuvant made of virus like particles (VLPS) containing the yeast retrotransposon Ty which has the amino acids 1-381 of the pI protein encoded. SGS Ty-VLPs cytokine vaccine adjuvant YH, SGS a vaccine adjuvant that contains active cytokine compound. combination vaccine adjuvant YH, SGS a vaccine adjuvant that is composed of differnt compounds under more than one category. emulsion vaccine adjuvant particulate antigen delivery system a vaccine adjuvant that serves as a particulate antigen delivery system. YH, SGS synthetic vaccine adjuvant YH, SGS A vaccine aduvant that contains synthetic material. tensoactive compound vaccine adjuvant a vaccine adjuvant that includes tensioactive material. Tensioactive materials, surfactants or active surface agents are chemical substances with a polar-non polar structure. These substances have a tendency to locate themselves at the surface creating an adsorbed monomolecular layer on the interface. WEB: http://www.citt.ufl.edu/team/sepulveda/html/en_tensioactivos.htm tensioactive compound vaccine adjuvant YH, SGS carbohydrate vaccine adjuvant YH, SGS a vaccine adjuvant that is primarily composed of carbohydrates. IFN-gamma vaccine adjuvant YH, SGS a cytokine vaccine adjuvant that includes IFN-gamma. virmugen role YH, YL a role that is inherenced in a gene that can be mutated in a virulent pathogen, leading to an attenuated strain serving as a live attenuated vaccine strain. allergy vaccine YL, YH YL,YH a vaccine that targets for allergy. Clostridium perfringens vaccine bacterial vaccine that is used to protect against Clostridium perfringens infection YL generated using OntoRat human immunization objective vaccine target role heat-inactivated vaccine an inactivation vaccine that is prepared by heat inactivation. YH, YL irradiation-inactivated vaccine an inactivation vaccine that is prepared by irradiation inactivation. YH, YL H2O2-inactivated vaccine YH, YL an inactivation vaccine that is prepared by H2O2 inactivation. formalin-inactivated vaccine an inactivation vaccine that is prepared by formalin inactivation. YH, YL preparation of vaccine using H2O2 inactivation YH A vaccine prepraration process that is performed by H2O2 inactivation of virulent pathogen. unimmunized an organismal quality that indicates an organism (e.g., human) is not yet immunized against a disease. YH immunized by vaccination with a licensed vaccine YH an organismal quality that indicates an organism (e.g., human) is immunized against a disease through vaccination with a licensed vaccine. vaccinated organism Vaccinee an organism that is vaccinated with a vaccine YH, YL, MC organism vaccinated with a licensed vaccine a vaccinated organism that is vaccinated with a licensed vaccine vaccinee YH, YL, MC vaccinated an organismal quality that indicates an organism (e.g., human) is vaccinated with a vaccine. YH unvaccinated YH an organismal quality that indicates an organism (e.g., human) is unvaccinated with any vaccine. vaccinated with a licensed vaccine a vaccinated quality that indicates an organism is vaccinated with a licensed vaccine. YH unvaccinated with a licensed vaccine YH a unvaccinated quality that indicates an organism has not been vaccinated with a licensed vaccine. B16 vaccine adjuvanted by loxoribine a cancer vaccine that protects mice against tumor growth following challenge with live B16 cells. YH PMID: 8306370 immunized organism an organism that is immunized for a disease YH, YL, MC organism immunized with a licensed vaccine YH, YL, MC an immunized organism that is immunized by vaccination with a licensed vaccine unvaccinated organism an organism that is unvaccinated with a vaccine YH, YL, MC Actinobacillus pleuropneumoniae gene a bacterial gene from Actinobacillus pleuropneumoniae. YH, RR Trypanosoma cruzi vaccine YH T. cruzi vaccine A vaccine that protects against Trypanosoma cruzi. T. cruzi DNA vaccine encoding CRP-10 YH A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi CRP-10 protein. VIOLIN Vaccine ID: 803 T. cruzi DNA vaccine encoding G2 A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi G2 protein. YH VIOLIN Vaccine ID: 807 T. cruzi DNA vaccine encoding G4 YH VIOLIN Vaccine ID: 809 A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi G4 protein. T. cruzi DNA vaccine encoding TSA-1 A T. cruzi DNA vaccine that uses a DNA plasmid expressing T. cruzi TSA-1 protein. VIOLIN Vaccine ID: 812 YH T. cruzi DNA vaccine pGFP-TSA1 YH A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi TSA-1 protein. VIOLIN Vaccine ID: 811 T. cruzi PAR1 protein vaccine VIOLIN Vaccine ID: 806 A T. cruzi subunit vaccine that uses T. cruzi PAR1 protein as protective antigen. YH T. cruzi PAR2 protein vaccine YH A T. cruzi subunit vaccine that uses T. cruzi PAR2 protein as protective antigen. VIOLIN Vaccine ID: 810 T. cruzi vaccine using attenuated Salmonella expressing T. cruzi Cruzipain A T. cruzi vaccine that uses attenuated Salmonella to express T. cruzi Cruzipain protein. VIOLIN Vaccine ID: 804 YH T. cruzi vaccine using Sendai virus vector expressing amastigote surface protein-2 YH A T. cruzi vaccine that uses Sendai virus vector to express T. cruzi amastigote surface protein-2. VIOLIN Vaccine ID: 802 cocktail vaccine a vaccine that contains two or more individual vaccines. YH cocktail vaccine containing subunit vaccine and inactivated whole organism vaccine YH a cocktail vaccine that contains both subunit vaccine and inactivated whole organism vaccines. vaccine containing DNA vaccine for priming and subunit vaccine for boosting a prime-boost vaccine with DNA vaccine priming that contains a subunit vaccine for boosting YH vaccine containing DNA vaccine for priming and Ad vector vaccine for boosting a prime-boost vaccine with a DNA vaccine priming that contains a Ad vector vaccine for boosting YH funsion protein vaccine An example of fusion protein vaccine is Mtb72f fusion protein vaccine. Reference: PubMed: 15187142. Funsion protein vaccine is a subunit vaccine that fuses more than one open reading frames of protective antigens. YH Brucella melitensis gene YH, RR A Brucella gene that is from B. melitensis. Brucella suis gene A Brucella gene that is from B. suis. YH Bacillus anthracis gene A bacterial gene that is from Bacillus anthracis. YH, RR Listeria monocytogenes gene YH, RR A bacterial gene that is from Listeria monocytogenes. Mycobacterium avium gene YH, RR A bacterial gene that is from Mycobacterium avium. Staphylococcus aureus gene A bacterial gene that is from Staphylococcus aureus. YH, RR Aeromonas hydrophila gene YH, RR A bacterial gene that is from Aeromonas hydrophila. Bordetella bronchiseptica gene YH, RR A bacterial gene that is from Bordetella bronchiseptica. Aeromonas salmonicida gene YH, RR A bacterial gene that is from Aeromonas salmonicida. Bordetella pertussis gene A bacterial gene that is from Bordetella pertussis. YH, RR Borrelia burgdorferi gene A bacterial gene that is from Borrelia burgdorferi. YH, RR Burkholderia pseudomallei gene YH, RR A bacterial gene that is from Burkholderia pseudomallei. Edwardsiella ictaluri gene A bacterial gene that is from Burkholderia pseudomallei. YH, RR Edwardsiella tarda gene YH, RR A bacterial gene that is from Edwardsiella tarda. Francisella tularensis gene A bacterial gene that is from Francisella tularensis. YH, RR Mannheimia haemolytica gene YH, RR A bacterial gene that is from Mannheimia haemolytica. Mycoplasma gallisepticum gene A bacterial gene that is from Mycoplasma gallisepticum. YH, RR Neisseria meningitidis gene YH, RR A bacterial gene that is from Neisseria meningitidis. Pasteurella multocida gene A bacterial gene that is from Pasteurella multocida. YH, RR Salmonella Typhi gene A bacterial gene that is from Salmonella Typhi. YH, RR Salmonella Gallinarum gene A bacterial gene that is from Salmonella Gallinarum. YH, RR 'Salmonella Typhimurium gene YH, RR A bacterial gene that is from Salmonella Typhimurium. Salmonella Enteritidis gene YH, RR A bacterial gene that is from Salmonella Enteritidis. Vibrio cholerae gene A bacterial gene that is from Vibrio cholerae. YH, RR Bovine herpesvirus 1 gene YH, RR A viral gene that is from Bovine herpesvirus 1. Yersinia enterocolitica gene A bacterial gene that is from Yersinia enterocolitica. YH, RR Yersinia pestis gene YH, RR A bacterial gene that is from Yersinia pestis. Yersinia pseudotuberculosis gene A bacterial gene that is from Yersinia pseudotuberculosis. YH, RR Yersinia ruckeri gene A bacterial gene that is from Yersinia ruckeri. YH, RR Bovine Respiratory Syncytial Virus gene A viral gene that is from Bovine Respiratory Syncytial Virus. YH, RR Classical swine fever virus gene YH, RR A viral gene that is from Classical swine fever virus. Equid herpesvirus gene A viral gene that is from Equid herpesvirus 1. YH, RR Feline herpesvirus 1 gene YH, RR A viral gene that is from Feline herpesvirus 1. Feline immunodeficiency virus gene YH, RR A viral gene that is from Feline immunodeficiency virus. Feline infectious peritonitis virus gene A viral gene that is from Feline infectious peritonitis virus. YH, RR Gallid herpesvirus 1 gene A viral gene that is from Gallid herpesvirus 1. YH, RR Hepatitis B virus gene A viral gene that is from Hepatitis B virus. YH, RR Human herpesvirus 1 gene A viral gene that is from Human herpesvirus 1. YH, RR Human metapneumovirus gene A viral gene that is from Human metapneumovirus. YH, RR Human Respiratory Syncytial Virus gene A viral gene that is from Human Respiratory Syncytial Virus. YH, RR Infectious Hematopoietic Necrosis Virus gene A viral gene that is from Infectious Hematopoietic Necrosis Virus. YH, RR Porcine respiratory and reproductive syndrome virus gene YH, RR A viral gene that is from Porcine respiratory and reproductive syndrome virus. Pseudorabies virus gene Suid herpesvirus 1 gene A viral gene that is from Pseudorabies virus. YH, RR Rabies virus gene A viral gene that is from Rabies virus. YH, RR SARS-CoV gene YH, RR A viral gene that is from SARS-CoV. Simian Immunodeficiency Virus gene A viral gene that is from Simian Immunodeficiency Virus. YH, RR Tick-borne Encephalitis Virus gene A viral gene that is from Tick-borne Encephalitis Virus. YH, RR VEE Virus gene YH, RR A viral gene that is from VEE Virus. West Nile virus gene YH, RR A viral gene that is from West Nile virus. Western equine encephalomyelitis virus gene YH, RR A viral gene that is from Western equine encephalomyelitis virus. Leishmania donovani gene A protozoan gene that is from Leishmania donovani. YH, RR Plasmodium berghei gene YH, RR A Plasmodium gene that is from Plasmodium berghei. Plasmodium yoelii gene A Plasmodium gene that is from Plasmodium yoelii. YH, RR Toxoplasma gondii gene YH, RR A protozoan gene that is from Toxoplasma gondii. 'Human herpesvirus 2 gene' A viral gene that is from Human herpesvirus 2. YH, RR vaccination with Afluria Erysipelothrix rhusiopathiae vaccine generated using OntoRat YL bacterial vaccine that is used to protect against Erysipelothrix rhusiopathiae infection Trichomonas foetus vaccine protozoan vaccine that is used to protect against Tritrichomonas suis infection YL generated using OntoRat International Duck Research Cooperative, Inc. YL http://www.duckhealth.com/idrc.html Eimeria spp. vaccine protozoan vaccine that is used to protect against Eimeria spp. (Eimeria) infection YL generated using OntoRat Orf Virus vaccine YL generated using OntoRat viral vaccine that is used to protect against Orf Virus infection Aves vaccine Vaccine that used for immunizing Aves. YL. fish vaccine YL. vaccine that used for immunizing fishes Fowlpox virus vaccine viral vaccine that is used to protect against Fowlpox virus infection generated using OntoRat YL carnivora vaccine YL vaccine that used for immunizing carnivora. cat vaccine vaccine that used for immunizing cat (felis catus) cattle vaccine dog vaccine chicken vaccine Ducks vaccine catfish vaccine gray wolf vaccine horse vaccine parrot vaccine pig vaccine sei whale vaccine sheep vaccine salmoninae vaccine YL vaccine that used for immunizing salmoninae (tourts, salmons & chars ) turkey vaccine vaccine target specification The objective that intends to produce vaccine via the vaccine preparation process. YH Pigeonpox virus vaccine generated using OntoRat YL viral vaccine that is used to protect against Pigeonpox virus infection Bovine herpesvirus 1 vaccine generated using OntoRat YL