]> Richard H. Scheuermann Melanie Courtot Bjoern Peters Alan Ruttenburg Alexander D. Diehl An ontology for the annotation of the vaccine domain. Draft version Ryan R. Brinkman Lindsay Cowell en Chris Mungall Thomas Todd 2010-06-17 Barry Smith OWL-DL The Vaccine Ontology (VO) is a biomedical ontology in the domain of vaccine. VO aims to standardize vaccine annotation, integrate various vaccine data, and support computer-assisted reasoning. VO supports basic vaccine R&D and clincal vaccine usage. VO is primarily developed by Dr. Yongqun "Oliver" He at the University of Michigan Medical School. VO is being developed as a community-based ontology with support and collaborations from the vaccine and bio-ontology communities. Vaccine Ontology Vision Release; 1.0.419 Yongqun "Oliver" He (YH) Zuoshuang "Allen" Xiang has_dose_specification has_dose_specification is a relation that specifies the dose of a vaccine used for a specific vaccination process. YH, XZ has_vaccine_contraindication This relation may be replaced by has_vaccine_allergen. We need to determine if any vaccine contraindicator is not a vaccine allergen. has_vaccine_contraindication is a relation that specifies contraindication of a vaccine. YH has_adverse_event_disposition has_adverse_event_disposition is a relation that specifies some adverse event disposition that a vaccine may have. YH, XZ infection_of The relation 'infection_of' is introduced to represent an infection caused by an infectious pathogen. A pathogen infection is a disorder. Since the number of pathogens is large, there are numerous infections. To make the description of a specific infection simple, the shortcut term 'infection_of' is defined: infection_of X = infection and has_part some (organism X and has_disposition some infectious disposition) YH, XZ, MC, BP, AR infection_of is a relation between a disorder and an infectious pathogen. administered_to_ameliorate YH, XZ administered_to_ameliorate is a relationship between a material entity (eg., vaccine) instance and an instance of a disorder which the material is developed with the function to ameliorate in a host organism (e.g., human). disease_caused_by YH administered_to_prevent "Vaccine A administered_to_prevent some 'HIV infection'": means that Vaccine A is administered to prevent HIV infection. administered_to_prevent is a relationship between a material entity (eg., vaccine) instance and an instance of a disorder against which the material is developed with the function to induce protection (prevention) in a host organism (e.g., human). YH vaccinates "A vaccinates B" means that the vaccine A is used for vaccinating the host B (e.g., human). YH, AR, ZX, MC A relationship between a vaccine instance and an organism type such that if the vaccine instance is given to an instance of the organism by the process vaccination, then it changes the organism's disposition to have an immune response against a disease. has_route_specification YH has_vaccination_route is a relation that specifies the route of a vaccine. has_vaccine_allergen has_vaccine_allegen is a relation that specifies an allegen to a vaccine. YH has_gene_mutation_of YH is_distributed_by is_distributed_by is a relation that specifies a company that distributes a product (e.g., vaccine). The company is very likely not the manufacturer of the product. YH, ZX participates_in independent variable specification dependent variable specification AE: CSF protein increased AE: CSF protein increased is an abnormal cerebrospinal fluid production that results in and increase in blood level CSF protein SS, YH AE: CSF test abnormal SS, YH This should be inferred as a "AE: lab test abnormal". AE: CSF test abnormal is a lab test abnormal that results in abnormal result in the Cerebrospinal fluid (CSF) collection test to look at the fluid that surrounds the brain and spinal cord. WEB: www.nlm.nih.gov/medlineplus/ency/article/003428.htm AE: Henoch-Schonlein purpura WEB: http://en.wikipedia.org/wiki/Henoch-Schonlein_purpura SS, YH AE: Henoch-Schonlein purpura is purpura that is a systemic vasculitis (inflammation of blood vessels) characterized by deposition of immune complexes containing the antibody IgA in the skin and kidney. This results from some allergic response, allergic purpura, anaphylactoid purpura, vascular purpura AE: abasia WEB: http://en.wikipedia.org/wiki/Abasia SS, YH AE: abasia is a movement disorder that results in and inability to walk due to impaired muscle coordination AE: abdominal pain upper AE: abdominal pain upper is an abdominal pain that results in an upper stomach ache SS, YH AE: ageusia SS, YH WEB: http://en.wikipedia.org/wiki/Ageusia AE: ageusia is an abnormal behavior AE that results in loss of taste functions of the tongue, particularly the inability to detect sweetness, sourness, bitterness, saltiness, and umami (the taste of monosodium glutamate). AE: alanine aminotransferase increased SS, YH AE: alanine aminotransferase increased is a lab test abnormal that results in an increase in blood level alanine aminotransferase AE: anosmia AE: anosmia is an abnormal behavior AE that results in a lack of functioning olfaction , an inability to perceive odors WEB: http://en.wikipedia.org/wiki/Olfaction SS, YH AE: anxiety AE: anxiety is an abnormal behavior AE that results in a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components.[2] These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry SS, YH WEB: http://en.wikipedia.org/wiki/Anxiety AE: aspartate aminotransferase increased SS, YH AE: aspartate aminotransferase increased is a lab test abnormal that results in an increase in blood level aspartate aminotransferase AE: balance disorder SS, YH WEB: http://en.wikipedia.org/wiki/Balance_disorder AE: balance disorder is an abnormal behavior AE that results in a disturbance that causes an individual to feel unsteady, giddy, woozy, or have a sensation of movement, spinning, or floating AE: blister WEB: http://en.wikipedia.org/wiki/Blister SS, YH AE: blister is a skin adverse event that results in a small pocket of fluid within the upper layers of the skin AE: cellulitis WEB: http://en.wikipedia.org/wiki/Cellulitis AE: cellulitis is a diffuse inflammation of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin SS, YH AE: cold sweat WEB: http://en.wikipedia.org/wiki/Cold_sweat SS, YH AE: cold sweat is an abnormal behavior AE that results in a type of perspiration usually associated with anxiety or fear AE: convulsion AE: convulsion is a muscle adverse event that results in a medical condition where body muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body SS, YH WEB: http://en.wikipedia.org/wiki/Convulsion AE: difficulty in walking AE: difficulty in walking is a movement disorder that results in inability to walk properly SS, YH AE: dysgeusia SS, YH WEB: http://en.wikipedia.org/wiki/Dysgeusia AE: dysgeusia is an abnormal behavior AE that results in distortion of the sense of taste AE: dyskinesia WEB: http://en.wikipedia.org/wiki/Dyskinesia AE: dyskinesia is a movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements SS, YH AE: dyspnoea AE: dyspnoea is an abnormal respiration debilitating symptom that is the experience of unpleasant or uncomfortable respiratory sensations, shortness of breath, air hunger SS, YH AE: dyspnea WEB: http://en.wikipedia.org/wiki/Dyspnoea AE: electromyogram abnormal WEB: http://en.wikipedia.org/wiki/Electromyography SS, YH AE: electromyogram abnormal is a lab test abnormal that results in abnormal activity in skeletal muscles evaluted and measured by electromyography AE: eye irritation WEB: http://www.freemd.com/eye-irritation/ SS, YH AE: eye irritation is an eye disorder that results in mild eye redness, itching, or tearing AE: eye pruritus SS, YH AE: eye pruritus is a pruritus (an unpleasant sensation that evokes the desire or reflex to scratch) at the eye area AE: glomerulonephritis WEB: http://en.wikipedia.org/wiki/Glomerulonephritis SS, YH AE: glomerulonephritis is a kidney disorder that results in a renal disease that is characterized by inflammation of the glomeruli, or small blood vessels in the kidneys. AE: glomerular nephritis AE: haematocrit decreased AE: hematocrit decreased AE: haematocrit decreased is a lab test abnormal that results in decrease in the proportion of blood volume that is occupied by red blood cells SS, YH WEB: http://en.wikipedia.org/wiki/Hematocrit AE: haemoglobin decreased SS, YH AE: hemoglobin decreased AE: haemoglobin decreased is a lab test abnormal that results in a decrease in blood level hemoglobin AE: hypoaesthesia AE: hypoaesthesia is a sensory capability AE that skin loses some of its sensitivity to pain or touch SS, YH AE: hypoesthesia WEB:http://medguides.medicines.org.uk/document.aspx?name=hypoaesthesia AE: hypoaesthesia oral SS, YH AE: hypoaesthesia oral is a nervous system AE that results in a reduced sense of touch or sensation, or a partial loss of sensitivity to sensory stimuli in the oral area AE: hypoesthesia oral WEB: http://en.wikipedia.org/wiki/Hypoesthesia AE: influenza SS, YH AE: influenza is a respiratory system AE that results in an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses), that affects birds and mammals WEB: http://en.wikipedia.org/wiki/Influenza AE: influenza like illness SS, YH WEB: http://en.wikipedia.org/wiki/Influenza-like_illness acute respiratory infection, ARI, flu-like syndrome AE: influenza like illness is a respiratory system AE that results in a medical diagnosis of possible influenza or other illness causing a set of common symptoms AE: injected limb mobility decreased AE: injected limb mobility decreased is a mobility decreased that occurs in the limb in which injection is administered SS, YH AE: injection-site haematoma AE: injection-site haematoma is an injection-site AE that results in a collection of blood outside the blood vessels at the physical area of injection http://en.wikipedia.org/wiki/Hematoma AE: injection-site hematoma SS, YH AE: injection-site induration WEB: http://wordnetweb.princeton.edu/perl/webwn?s=induration AE: injection-site induration is an injection-site AE that results in hardening or thickening of tissue at the physical injection site SS, YH AE: injection-site pruritus AE: injection-site pruritus is an injection-site AE that results in an unpleasant sensation that evokes the desire or reflex to scratch at the physical area of injection WEB: http://en.wikipedia.org/wiki/Itch SS, YH AE: injection-site rash WEB: http://en.wikipedia.org/wiki/Rash SS, YH AE: injection-site rash is a rash that results in a change of the skin which affects its color, appearance or texture at the physical injection site AE: injection-site warmth SS, YH AE: injection-site warmth is an injection-site AE that results in feeling of warmth at the physical injection site AE: joint swelling SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003262.htm AE: joint swelling is a joint disorder that results in a buildup of fluid in the soft tissue surrounding the joint AE: kidney disorder AE: kidney disorder is an adverse event that results in disease or disorder that affects the functions of the kidneys. SS, YH AE: lacrimation increased WEB: http://www.medterms.com/script/main/art.asp?articlekey=6199 SS, YH AE: lacrimation increased is a crying abnormal that results in an increase in production, secretion, and shedding of tears AE: lip swelling SS, YH AE: lip swelling is an edema (swelling) that results in enlargement or protuberance in the lip WEB: http://en.wikipedia.org/wiki/Swelling_%28medical%29 AE: lymphadenopathy WEB: http://en.wikipedia.org/wiki/Lymphadenopathy SS, YH AE: lymphadenopathy is an immune system disorder that results in swollen/enlarged lymph nodes AE: mobility decreased AE: mobility decreased is a nervous system AE that results in difficulty in movement leading to less ability to move part(s) of body SS, YH AE: muscular weakness AE: muscular weakness is a muscle adverse event that results in lack of muscle strength WEB: http://en.wikipedia.org/wiki/Muscular_weakness SS, YH AE: musculoskeletal stiffness AE: musculoskeletal stiffness is a sensory capability AE that results in a sensation of stiffness in muscles and skeleton SS, YH AE: nasal congestion AE: nasal congestion is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels WEB: http://en.wikipedia.org/wiki/Nasal_congestion SS, YH AE: nasopharyngitis AE: common cold SS, YH AE: nasopharyngitis is a respiratory system inflammation that results in common cold, a contagious, viral infectious disease of the upper respiratory system WEB: http://en.wikipedia.org/wiki/Nasopharyngitis AE: neuropathy peripheral AE: neuropathy peripheral is an AE: neuropathy that results in a damage to the peripheral nervous system, the vast communication network that transmits information from the brain and the spinal cord (the central nervous system) to every other part of the body WEB: http://www.ninds.nih.gov/disorders/peripheralneuropathy/detail_peripheralneuropathy.htm SS, YH AE: ocular hyperaemia AE: ocular hyperemia AE: ocular hyperaemia is an eye disorder that results in severe redness and irritation of the eyes SS, YH WEB: http://www.med.miami.edu/news/view.asp?id=259 AE: oropharyngeal pain AE: oropharyngeal pain is a pain in oral airway SS, YH WEB: http://en.wikipedia.org/wiki/Oropharyngeal_airway AE: otitis media SS, YH AE: otitis media is an ear disorder that results in inflammation of the middle ear, or middle ear infection WEB: http://en.wikipedia.org/wiki/Otitis_media AE: pericarditis AE: pericarditis is a cardiovascular disorder that results in a condition in which the sac-like covering around the heart (pericardium) becomes inflamed SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/000182.htm AE: pharyngeal edema SS, YH AE: pharyngeal oedema WEB: http://www.ncbi.nlm.nih.gov/mesh/68004487?ordinalpos=1&itool=EntrezSystem2.PEntrez.Mesh.Mesh_ResultsPanel.Mesh_RVDocSum AE: pharyngeal edema is an edema that results in an bbnormal fluid accumulation in TISSUES or body cavities in pharynx (throat swelling). AE: pharyngitis AE: pharyngitis is a digestive system AE that results in an inflammation of the throat or pharynx WEB: http://en.wikipedia.org/wiki/Pharyngitis SS, YH AE: pharyngolaryngeal pain AE: pharyngolaryngeal pain is a pain in sinus and throat SS, YH WEB: http://www.wordinfo.info/words/index/info/view_unit/1631/ AE: rash macular WEB: http://medical-dictionary.thefreedictionary.com/macular+rash AE: rash macular is a rash that results in a skin eruption in which the lesions are flat and less than 1 cm in diameter SS, YH AE: rash papular AE: rash papular is a skin adverse event that results in a change of the skin which affects its color, appearance or texture to a form similar to a papule WEB: http://en.wikipedia.org/wiki/Rash SS, YH AE: respiratory distress WEB: http://en.wikipedia.org/wiki/Acute_respiratory_distress_syndrome SS, YH AE: respiratory distress is a respiratory system AE that results in a severe lung disease caused by a variety of direct and indirect issues. It is characterized by inflammation of the lung parenchyma leading to impaired gas exchange with concomitant systemic release of inflammatory mediators causing inflammation, hypoxemia and frequently resulting in multiple organ failure. AE: respiratory tract congestion SS, YH AE: respiratory tract congestion is a respiratory system AE that results in congestion in respiratory tract AE: retching WEB: http://en.wikipedia.org/wiki/Retching SS, YH AE: retching is a gustatory system AE that results in a process in the human body where gastric (and sometimes duodenal) contents are forced into the esophagus, but do not enter the pharynx AE: rhinitis SS, YH WEB: http://en.wikipedia.org/wiki/Rhinitis runny nose AE: rhinitis is a respiratory system inflammation that is characterized by runny nose,irritation and inflammation of some internal areas of the nose AE: rhinorrhoea AE: rhinorrhoea is a respiratory system AE that results in runny nose, an unusually significant amount of nasal fluid AE: rhinorrhea SS, YH WEB: http://en.wikipedia.org/wiki/Rhinorrhoea AE: shoulder pain SS, YH WEB: http://www.nlm.nih.gov/medlineplus/ency/article/003171.htm AE: shoulder pain is a pain iin or around the shoulder joint AE: sinus congestion WEB: http://en.wikipedia.org/wiki/Sinus_%28anatomy%29, http://en.wikipedia.org/wiki/Nasal_congestion SS, YH AE: sinus congestion is a respiratory system AE that results in blockage of the air cavities in the cranial bones or nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels AE: sneezing SS, YH sternutation AE: sneezing is an adverse event that results in sternutation, a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa WEB: http://en.wikipedia.org/wiki/Sneezing AE: tachycardia SS, YH WEB: http://en.wikipedia.org/wiki/Tachycardia AE: tachycardia is an increased heart rate that exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual) AE: tendonitis WEB: http://en.wikipedia.org/wiki/Tendinitis AE: tendonitis is a tendon disorder that results in an inflammation of a tendon SS, YH AE: tendinitis AE: throat tightness AE: throat tightness is a sensory capability AE that results in a sensation of tightness in the throat AE: upper respiratory tract infection URI, URTI WEB: http://en.wikipedia.org/wiki/Upper_respiratory_tract_infection SS, YH AE: upper respiratory tract infection is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx AE: varicella SS, YH AE: chicken pox WEB: http://wordnetweb.princeton.edu/perl/webwn?s=varicella AE: varicella is an AE: infect viral that results in an acute contagious diseased caused by herpes varicella zoster virus; causes a rash of vesicles on the face and body. AE: paraesthesia oral http://www.answers.com/topic/oral-paresthesia SS, YH AE: paresthesia oral paraesthesia oral is a paresthesia that results in a numbness or tingling that occurs in the mucosa or tissues of the oral cavity. part of organism in vaccine YH 'part of organism in vaccine' is a pathogen component in vaccine that contains only a part of the pathogen organism instead of the whole organism. vaccine Many vaccines are developed to protect against infectious pathogens. Many vaccines are also being developed against some diseases such as cancer and autoimmune diseases. Vaccine is developed against a disease. Allergy. A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine. MeSH: D014612 YH, BP, BS, MC, LC, XZ, RS vaccination Vaccination is: an 'administering substance in vivo' that involves in adding vaccine into a host (e.g., human, mouse) in vivo with the intend to invoke a protective immune response. vaccine administration YH, BP ACAM2000 ACAM2000 Smallpox (Vaccinia) Vaccine, Live YH ActHIB ActHIB Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate) PMID: 1517908 YH PMID: PMID: 1735812 Adacel Adacel Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed YH Afluria Afluria Influenza Virus Vaccine YH Attenuvax Attenuvax Measles Virus Vaccine, Live YH vaccine-induced lymphocyte activation YH vaccine-induced B cell antigen processing and presentation YH vaccine-induced B cell cytokine production YH B cell epitope in vaccine YH vaccine-induced B cell mediated immunity YH Bacillus anthracis vaccine MeSH: D022122 YH anthrax vaccine A vaccine that protects against Bacillus anthrax that causes anthrax. Biothrax Anthrax Vaccine Adsorbed Biothrax YH Boostrix Boostrix Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed YH AE: fever YH, SS AE: pyrexia AE: body temperature increased febrile response Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 °C (1.8-3.6 °F). AE: rash YH AE:rash is a vaccine induced skin adverse event. A rash is a change of the skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. This term is a COSTART term but not a MP term (3/17/2009). Brucella abortus DNA vaccine pcDNA-SOD PMID: 15039330 YH A Brucella abortus vaccine that expresses Cu/Zn SOD with DNA plasmid pcDNA. PMID: 15039330. AE: infection This term is a COSTART term but not a MP term (3/17/2009). YH Brucella abortus strain RB51 as vaccine vector YH Brucella abortus RB51 Brucella abortus vaccine RB51 is a Brucella abortus vaccine that is licensed in the USA since 1992. Brucella abortus vaccine RB51 is a live attenuated cattle vaccine against brucellosis that is currently used in the USA and many other coutries. PMID: 11768128 PMID: 11504238 B. abortus RB51 WEB: http://rb51.com PMID: 19439382 PMID: 19362381 PMID: 11193615 PMID: 1439207 PMID: 11500423 PMID: 16713034 SRB51 PMID: 1908158 PMID: 12704101 PMID: 11553603 PMID: 7806364 PMID: 18836016 PMID: 8890203 PMID: 17894637 PMID: 10534009 PMID: 7927779 PMID: 8740701 PMID: 12119140 Brucella RB51 PMID: 8039890 PMID: 12438380 PMID: 17653832 PMID: 11504226 Brucella RB-51 YH PMID: 7622248 Brucella abortus strain 19 PMID: 8039890 A live attenuated Brucella abortus vaccine that is licensed and used in many countries. Brucella strain-19 YH Brucella S19 PMID: 11058778 AE: syndrome YH syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. This term is a COSTART term but not a MP term (3/17/2009). AE: agitation emotional state of excitement or restlessness YH This term is a COSTART term but not a MP term (3/17/2009). Brucella vaccine brucellosis vaccine MeSH: D002004 A vaccine that protects against Brucella spp. that causes brucellosis in animals and humans. YH injection-site AE This term is a COSTART term but not a MP term (3/17/2009). injection-site reaction YH AE: injection-site hypersensitivity YH This term is a COSTART term but not a MP term (3/17/2009). Comvax Comvax Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant) YH PMID: DAPTACEL DAPTACEL Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed YH DECAVAC DECAVAC Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH DNA of pathogen organism as vaccine component YH DNA from protective protein that is used as vaccine component. This is usually used for preparation of DNA vaccine. DNA vaccine synonym: naked DNA vaccine YH nucleic acid vaccine genetic vaccine naked DNA vaccine DNA vaccine is a vaccine that is composed of a plasmid vaccine vector (a circular double stranded DNA molecule) containing genes encoding one or more proteins of a pathogen. Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Inc Diphtheria & Tetanus Toxoids Adsorbed YH Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Ltd Diphtheria & Tetanus Toxoids Adsorbed YH Dryvax Dryvax Smallpox Vaccine, Dried, Calf Lymph Type YH ETEC vaccine ACAM2010 PMID: 17566016 ACAM2007 is a vaccine candidate expressing CFA/II. YH Engerix-B Engerix-B Hepatitis B Vaccine (Recombinant) YH vaccine persistence assay YH An assay that measures the persistent survival of live vaccine in a host in vivo. AE: injection-site edema YH AE: injection-site oedema This term is a COSTART term but not a MP term (3/17/2009). AE: injection-site pain YH This term is a COSTART term but not a MP term (3/17/2009). Escherichia coli vaccine MeSH: D022361 E. coli vaccine YH A bacterial vaccine that prevents against Escherichia coli infection. AE: injection-site inflammation YH This term is a COSTART term but not a MP term (3/17/2009). FluLaval FluLaval Influenza Virus Vaccine, Trivalent, Types A and B YH FluMist FluMist Influenza Virus Vaccine, Live, Intranasal YH Fluarix Fluarix Influenza Virus Vaccine, Trivalent, Types A and B YH Fluvirin Fluvirin Influenza Virus Vaccine, Trivalent, Types A and B YH Fluzone Fluzone Influenza Virus Vaccine, Trivalent, Types A and B YH intramuscular injection YH Gardasil Gardasil Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine YH HIV based lentivirus vaccine vector YH Balb/c mouse YH Havrix Havrix Hepatitis A Vaccine, Inactivated YH Neisseria meningitidis vaccine A bacterial vaccine that prevents Neisseria meningitidis infection. YH Meningococcal vaccine MeSH: D022401 IPOL IPOL Poliovirus Vaccine Inactivated (Monkey Kidney Cell) PMID: YH IgA YH IgE YH IgG YH IgG1 YH IgG2a YH IgG2b YH IgG3 YH IgM YH Imovax Rabies Imovax Rabies Vaccine YH Infanrix Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed Infanrix YH Influenza Virus Vaccine H5N1 by Sanofi Pasteur Inc Influenza Virus Vaccine, H5N1 (for National Stockpile) YH WEB: http://atomicnewsreview.org/2009/10/22/approval-for-the-arepanrix%E2%84%A2-gsk-vaccine-in-canada/ JE-Vax JE-Vax Japanese Encephalitis Virus Vaccine Inactivated YH KINRIX Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine KINRIX YH Listeria monocytogenes as vaccine vector YH M-M-R II M-M-R II Measles, Mumps, and Rubella Virus Vaccine, Live YH M-M-Vax M-M-Vax Measles and Mumps Virus Vaccine, Live YH Menactra Menactra Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine YH Menomune A C Y W135 Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined Menomune-A/C/Y/W-135 YH Meruvax II Meruvax II Rubella Virus Vaccine Live YH Mumpsvax Mumps Virus Vaccine Live Mumpsvax YH AE: injection-site hemorrhage This term is a COSTART term but not a MP term (3/17/2009). YH AE: injection-site mass This term is a COSTART term but not a MP term (3/17/2009). Not sure where to put "mass", which requires more discussion. AE: injection-site mass is a mass at physical injection site YH, SS Mycobacterium tuberculosis vaccine YH tuberculosis vaccine MeSH: D032581 A vaccine that protects against Mycobacterium tuberculosis. Mycobax BCG Vaccine Mycobax Mycobax is a BCG vaccine that is made by Sanofi Pasteur, Ltd. Ref: http://www.biopharma.com/cgi/full6.lasso?Key=412.65916 YH O antigen of pathogen organism as vaccine compent YH AE: pruritus AE: pruritus generalised itch Itch (Latin: pruritus) is an unpleasant sensation that evokes the desire or reflex to scratch. YH, SS itching WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity This term is a COSTART term but not a MP term (3/17/2009). Influenza A (H1N1) 2009 Monovalent Vaccine by Novartis Pediarix Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Hepatitis B (recombinant) and Inactivated Poliovirus Vaccine Combined Pediarix YH PedvaxHIB Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) PedvaxHIB YH PMID: PMID: 2791073 Pentacel Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine Pentacel YH Plague Vaccine by Greer Laboratories Inc Plague Vaccine YH AE: pain This term is a COSTART term but not a MP term (3/17/2009). YH Plasmodium falciparum vaccine a malaria vaccine that protects against malaria caused by Plasmodium falciparum. YH Pneumovax 23 Pneumococcal Vaccine, Polyvalent Pneumovax 23 YH Poliovax Poliovax Poliovirus Vaccine Inactivated (Human Diploid Cell) YH Prevnar Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) Prevnar YH ProQuad Measles, Mumps, Rubella and Varicella Virus Vaccine Live ProQuad YH RNA of pathogen organism as vaccine component RNA from protective protein that is used as vaccine component. This is usually used for preparation of RNA vaccine. YH ROTARIX ROTARIX Rotavirus Vaccine, Live, Oral YH RabAvert RabAvert Rabies Vaccine YH Rabies Vaccine Adsorbed by BioPort Corp Rabies Vaccine Adsorbed YH Recombivax HB Hepatitis B Vaccine (Recombinant) Recombivax HB YH RotaTeq RotaTeq Rotavirus Vaccine, Live, Oral, Pentavalent YH SIV based lentivirus vaccine vector YH AE: myalgia YH Myalgia means "muscle pain" and is a symptom of many diseases and disorders. This term is a COSTART term but not a MP term (3/17/2009). muscle pain vaccine-induced T-helper 1 type immune response YH vaccine-induced T-helper 2 type immune response YH TENIVAC TENIVAC Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH TICE BCG BCG Vaccine Intravesical TICE® BCG has been used as a therapy for, and to prevent recurrence of, tumors in patients with carcinoma in situ (CIS) of the urinary bladder, and to prevent recurrence of Stage Ta T1 papillary tumors of the bladder at high risk of recurrence. Refernce URL: http://www.ticebcg.com/Consumer/aboutTice/index.asp TICE BCG YH TYPHIM Vi TYPHIM Vi Typhoid Vi Polysaccharide Vaccine YH T cell epitope in vaccine YH vaccine-induced T cell mediated immunity YH T cell vaccine antigen processing and presentation YH Brucella abortus vaccine YH Tetanus Toxoid Adsorbed by Sanofi Pasteur Inc Tetanus Toxoid Adsorbed YH E. coli O157:H7 intimin vaccine E. coli Int280a has been found to be a protective antigen. This subunit vaccine uses E. coli Int280a combined with adjuvant. This antigen can be used for development of type-specific EPEC or EHEC vaccine. YH PMID: 11500434 Tetanus and Diphtheria Toxoids Adsorbed for Adult Use by Massachusetts Public Health Biologic Lab Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Tripedia Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed Tripedia YH Twinrix Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine Twinrix YH AE: urticaria hives This term is a COSTART term but not a MP term (3/17/2009). Urticaria is a kind of skin rash notable for dark red, raised, itchy bumps. YH vaccine-induced T cell activation AE: headache This term is a COSTART term but not a MP term (3/17/2009). YH respiratory system AE I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He YH VAQTA Hepatitis A Vaccine, Inactivated VAQTA YH Varivax Varicella Virus Vaccine Live Varivax YH Vivotif Typhoid Vaccine Live Oral Ty21a Vivotif YH YF-Vax YF-Vax Yellow Fever Vaccine YH Yellow fever 17D as vaccine vector YH Yellow fever virus vaccine A viral vaccine that protects against infection with Yellow fever virus. MeSH: D022341 YH Zostavax Zostavax Zoster Vaccine, Live, (Oka/Merck) YH licensed turkey vaccine YH live attenuated pathogen as vaccine component YH aluminum hydroxide vaccine adjuvant alum YH aluminium phosphate vaccine adjuvant YH vaccination frequency Vaccination frequency is a qualitative term that represents how many times vaccination has occurred. YH AE: increased leukocyte cell number AE: white blood cell count increased According to the Vaccine Adverse Event Reporting System (VAERS), 'leukocytosis' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000218 SS, YH greater than normal number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue calcium phosphate vaccine adjuvant YH AE: decreased leukocyte cell number MP: MP_0000221 According to the Vaccine Adverse Event Reporting System (VAERS), 'leukopenia' is an adverse event that was mentioned in 417 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). reduction in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue Freund's emulsified oil adjuvant a vaccine adjuvant that consists of a water-in-oil emulsion of aqueous antigen in paraffin (mineral) oil of low specific gravity and low viscosity. It is named after Jules T. Freund (1890-1960), Hungarian-born American immunologist. It is a water in oil emulsion. YH vaccine-induced T cell proliferation vaccine-induced adaptive immune response YH adenovirus vaccine vector YH adjuvant role YH live virulent pathogen as vaccine component YH complete Freund's adjuvant is a Freund's emulsfied oil adjuvant that contains inactivated and dried mycobacteria, usually Mycobacterium tuberculosis (the pathogenic agent of tuberculosis). YH agglutinating antibody YH virulence factor YH incomplete Freund's adjuvant YH a Freud's adjuvant that does not contain the mycobacterial components. cholera toxin YH alphavirus vaccine vector YH vaccine vector role YH Corynebacterium-derived P40 vaccine adjuvant YH vaccine adjuvant role YH antibody YH antibody isotype YH antibody titer WEB: http://en.wikipedia.org/wiki/Antibody_titer YH Antibody titer is a titer of antibody that shows how much antibody an organism has produced that recognizes a particular epitope, expressed as the greatest dilution ratio (or its reciprocal) that still gives a positive result. ELISA is a common means of determining antibody titers. antigen YH Francisella tularensis vaccine YH toxoid vaccine preparation YH Brucella abortus sodC YH bacterial gene YH viral gene YH HIV gene YH AE: abnormal blood pressure MP: MP_0000230 altered tension of the blood within the systemic arteries live attenuated vaccine preparation by serial passages in vitro Brucella abortus cattle vaccine RB51 was developed by serial passages of virulent B. abortus strain 2308 in vitro in rifampin agar plates (Reference: PMID: 1908158). YH A live attenuated vaccine prepraration process that is performed by serial passages in vitro for pathogen attenuation. Influenza A (H1N1) 2009 Monovalent Vaccine by Sanofi Pasteur E. coli gene YH avirulent YH M. tuberculosis gene YH bacterial vaccine MeSH: D001428 YH A vaccine that protects against some bacterial disease. bacterial vaccine vector YH AE: asthenia This term is a COSTART term but not a MP term (3/17/2009). Asthenia is a medical term denoting symptoms of physical weakness and loss of strength. Asthenia is a side effect of vaccines such as the HPV vaccine Gardasil. YH Salmonella gene YH Shigella gene YH protozoan gene YH Plasmodium gene YH Plasmodium falciparum gene YH attenuated YH Leishmania gene YH AE: muscle ache muscle pain YH vaccine-induced T cell differentiation cancer vaccine MeSH: D019496 tumor vaccine neoplasm vaccine YH A vaccine that prevents or treats cancer. It is produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced. inactivated vaccine preparation YH Preparation of inactivated vaccine. part of vaccine vaccine component A 'part of vaccine' is a material entity that is a part or component of a vaccine. YH cardinal part of vaccine vaccine-induced cell activation YH lipopolysaccharide vaccine adjuvant YH vaccine-induced antibacterial agglutination antibody response YH Japanese encephalitis virus gene YH Ebola virus gene YH Influenza virus gene YH RNA vaccine YH Using RNA may eliminate the problem of having to tailor a vaccine for each individual patient with their specific immunity. The advantage of RNA is that it can be used for all immunity types and can be taken from a single cell. DNA vaccines need to produce RNA which then prompts the manufacture of proteins. However, RNA vaccine eliminates the step from DNA to RNA. A vaccine that uses RNA(s) derived from a pathogen organism. muramyl dipeptide MDP YH Dengue virus gene YH colony forming unit CFU YH WEB: http://en.wikipedia.org/wiki/Colony-forming_unit Colony-forming unit (CFU) is a titer measurement of viable bacterial or fungal numbers. Unlike in direct microscopic counts where all cells, dead and living, are counted, CFU measures viable cells. By convenience the results are given as CFU/mL (colony-forming units per milliliter) for water, and CFU/g (colony-forming units per gram) for soil or other porous material. squalene a vaccine adjuvant that contains an organic polymer with some antigenic epitopes which might be shared with other organic polymers acting as immunostimulators. YH arlacel A YH Montanide 103 YH Bordetella pertussis component vaccine adjuvant YH a vaccine adjuvant that contains components from killed Bordetella pertussis. The killed B. pertussis has a strong adjuvant effect on the diphtheria and tetanus toxoids in the DPT vaccines. PCV2 vaccine YH conjugate vaccine Conjugate vaccine is vaccine that conjugates/links antigens to the molecules that form the outer coat of disease-causing bacteria to promote an immune response. Conjugate vaccines are designed primarily for very young children because their immune systems can not recognize the outer coats of certain bacteria. YH recombinant vector vaccine preparation YH Preparation of recombinant vector vaccine West Nile virus gene YH chickenpox virus gene YH Rubella virus gene YH Hepatitis B virus gene YH Porcilis-PCV2 Characteristics: Inactivated baculovirus expressed PCV2 ORF2 protein; adjuvanted YH Hepatitis A virus gene YH Suvaxyn PCV2 Characteristics: Inactivated PCD1-2 chimera; adjuvanted YH Intervet http://www.intervet.com/ YH Fort Dodge YH http://www.wyeth.com/divisions/fort_dodge.asp licensed pig vaccine YH contraindication a contraindication is a condition or factor that increases the risks involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity. YH vaccine in research role YH vaccine in research role is a 'regulation-assigned roleof a vaccine that is not licensed or in clinical trial; instead, it is currently in laboratory research. AE: maculopapular rash This term is a COSTART term but not a MP term (3/17/2009). A maculopapular rash is a rash with flat, red area on the skin that is covered with small confluent bumps. YH hemagglutination-inhibition assay an immune response detection assay that detects specific antiviral antibodies in a test serum. The serum, usually a twofold dilution series, is mixed with a standard number, usually 4 to 8 HA units, of virus and incubated prior to the addition of a standard suspension of erythrocytes. The highest dilution of serum that inhibits hemagglutination is the HI titer of the serum. For example, influenza (AI) viruses agglutinate erythrocytes through the interaction of the virus surface glycoprotein, the hemagglutinin (HA), with receptors on the surface of the erythrocyte. Inhibition of the agglutination reaction by HA subtype-specific antisera is the basis of the hemagglutination-inhibition (HI) assay. HI assay YH inactivated YH AE: arthralgia This term is a COSTART term but not a MP term (3/17/2009). Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. YH hypersensitivity to chicken product YH AE: vesiculobullous rash vesiculobullous rash is a blistering rash characterized by serous-fluid-filled vesicles (blisters) This term is a COSTART term but not a MP term (3/17/2009). YH AE: screaming syndrome This term is a COSTART term but not a MP term (3/17/2009). YH AE: dizziness This term is a COSTART term but not a MP term (3/17/2009). YH, SS Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs. AE: peripheral edema AE: peripheral edema is an edema thatresults in swelling of tissues, usually in the lower limbs, due to the accumulation of fluids This term is a COSTART term but not a MP term (3/17/2009). YH, SS AE: oedema peripheral WEB: http://en.wikipedia.org/wiki/Peripheral_edema AE: edema peripheral hypersensitivity to chicken egg YH vaccine solvent solution YH A vaccine solvent solution is a vaccine additive that helps to dissolve all vaccine components in liquid. malaise This term is a COSTART term but not a MP term (3/17/2009). YH Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. AE: somnolence drowsiness This term is a COSTART term but not a MP term (3/17/2009). Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia). YH, SS AE: paresthesia AE: paraesthesia Paresthesia is a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect. It is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic. This term is a COSTART term but not a MP term (3/17/2009). YH AE: crying abnormal YH This term is a COSTART term but not a MP term (3/17/2009). hypersensitivity to antibiotic YH hypersensitivity to neomycin YH hypersensitivity to polymyxin YH reaction to previous vaccination YH chills Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold. YH This term is a COSTART term but not a MP term (3/17/2009). AE: stupor This term is a COSTART term but not a MP term (3/17/2009). YH Stupor is the lack of critical cognitive function and level of consciousness wherein a sufferer is almost entirely unresponsive and only responds to base stimuli such as pain. The word derives from the Latin stupure, meaning insensible. Being characterised by impairments of reactions to external stimuli, in this case, vaccine immunization. AE: anorexia AE: decreased appetite This term is a COSTART term but not a MP term (3/17/2009). anorexia nervosa Anorexia is the decreased sensation of appetite. YH life-threatening reaction to previous vaccination YH AE: face edema WEB:http://www.nlm.nih.gov/medlineplus/ency/article/003105.htm AE: face oedema This term is a COSTART term but not a MP term (3/17/2009). YH, SS AE: face edema is an edema that results in facial swelling, the build-up of fluid in the tissues of the face. Swelling may also affect the neck and upper arms life-threatening reaction to previous influenza vaccination YH AE: cough increased YH, SS This term is a COSTART term but not a MP term (3/17/2009). cough AE: cough increased is an abnormal respiration that results in a reflex that keeps your throat and airways clear WEB: http://www.nlm.nih.gov/medlineplus/cough.html hypersensitivity to gentamicin YH dominant epitope in vaccine YH vaccine-induced down-regulated gene expression YH hypersensitity to gelatin YH vaccine preparation using heat inactivation YH A vaccine prepraration process that is performed by heat inactivation of virulent pathogen. CFU reduction assay CFU reduction assay is an assay that measures the reduction of the colony forming units of infected pathogens in vaccine-vaccinated animals compared to nonvaccinated animals. YH assay of CFU reduction in spleen YH assay of CFU reduction in spleen is a CFU reduction assay that is measured using the extracted spleen as the tissue for isolation of infected pathogens. hypersensitity to arginine Arginine is a conditionally essential amino acid, meaning most of the time it can be manufactured by the human body, and does not need to be obtained directly through the diet. The biosynthetic pathway however does not produce sufficient arginine, and some must still be consumed through diet. Individuals who have poor nutrition or certain physical conditions may be advised to increase their intake of foods containing arginine. Infants are unable to meet their requirements and thus arginine is nutritionally essential for infants. YH edibility Melanie has submitted this term and its two subclasses to PATO: http://sourceforge.net/tracker/?func=detail&aid=2873643&group_id=76834&atid=595654 YH, MC A physical quality inhering in a bearer by virtue of the bearer being fit to be eaten. edible This term may be submitted to PATO. A quality of edibility that inheres in a bearer by virtue of the bearer being suitable for oral ingestion as food, drug, or vaccine. YH vaccine efficacy YH Vaccine efficacy is an efficacy of a vaccine in induction of protective immune response in vivo or protection against infection of a virulent pathogen. Specifically, vaccine efficacy (VE) is the percentage reduction in disease incidence attributable to vaccination, calculated by means of the following equation: VE(%) = (U - V)/U x 100 where U = the incidence in unvaccinated people and V = the incidence in vaccinated people. Ref: Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. history of asthma YH vaccine-induced antiviral neutralizing antibody response YH AE: flu syndrome This term is a COSTART term but not a MP term (3/17/2009). YH peptide of pathogen organism as vaccine component YH peptide of pathogen that is used as vaccine component. This peptide may function as epitope to stimulate protective immunity. AE: syncope YH, SS fainting Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. This term is a COSTART term but not a MP term (3/17/2009). WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29 AE: syncope is a sensory capability AE that results in loss of consciousness, fainting AE: sweating According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,301 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). YH vaccination with a licensed cattle vaccine YH usage of bronchodilator YH AE: abdominal pain AE: abdominal pain is a pain in abdominal cavity, stomach ache YH, SS WEB: http://en.wikipedia.org/wiki/Abdominal_pain This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). AE: hypertension YH, SS MP: MP_0000231 According to the Vaccine Adverse Event Reporting System (VAERS), 'hypertension' is an adverse event that was mentioned in 1,038 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). blood pressure increased hypertension sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states AE: lab test abnormal According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,056 VAERS reports (1.6%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH Intially, 'adverse event' and (is_specified_output_of some 'laboratory test') However, it cannot be inferred right. The reason appears that the is_specified_output_of cannot be another process (here, the AE is defined as a process.) We will think it over. AE: myasthenia According to the Vaccine Adverse Event Reporting System (VAERS), 'myasthenia' is an adverse event that was mentioned in 1,812 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). Myasthenia represenats myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. YH myasthenia gravis vaccine-induced follicular dendritic cell activation YH usage of steroid YH AE: chest pain YH According to the Vaccine Adverse Event Reporting System (VAERS), 'chest pain' is an adverse event that was mentioned in 1,752 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). sodB(Ft) PMID: 18692537 PMID: 16923916 YH sodBFt is a live vaccine strain mutant of Francisella tularensis with reduced Fe-superoxide dismutase gene expression. Ref: PMID: 18692537. licensed human vaccine role Oliver He: The previous OWL definition includes: contained_in some 'homo sapiens' However, the contained_in relation is not right. On the other hand, we have not found an appropriate way to define it by including the species name like 'homo sapiens'. We will look into it later. YH, ZX licensed human vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for human use. licensed cattle vaccine role YH licensed cattle vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for cattle use. fungal disease YH fungal vaccine A vaccine that protects against infection with some fungus. YH MeSH: D005657 licensed dog vaccine role YH, XZ licensed dog vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for dog use. licensed pig vaccine role YH, XZ licensed pig vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for pig use. F. tularensis vaccine LVS YH PMID: 16912944 A live attenuated Francisella tularensis vaccine. It is available in American Type Culture Collection with ATCC ID: 29684. PMID: 8757866 AE: exacerbation of underlying condition This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'exacerbation of underlying condition' is an adverse event that was mentioned in 1,606 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). AE: insomnia Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity. Insomnia is a symptom, not a stand-alone diagnosis or a disease. According to the Vaccine Adverse Event Reporting System (VAERS), 'insomnia' is an adverse event that was mentioned in 1,526 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: twitching According to the Vaccine Adverse Event Reporting System (VAERS), 'twitching' is an adverse event that was mentioned in 1,511 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). YH Involuntary sudden movement of part of the body. This term is a COSTART term but not a MP term (3/17/2009). AE: febrile seizure According to the Vaccine Adverse Event Reporting System (VAERS), 'febrile seizure' is an adverse event that was mentioned in 1,490 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: asthma This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'asthma' is an adverse event that was mentioned in 1,373 VAERS reports (1.1%) during1991-2001 (Reference: PMID: 12825543). Asthma is a common chronic lung disease. It has been defined by the National Heart, Lung and Blood Institute as a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm), and an underlying inflammation. YH vaccine function YH, MC, XZ, and AR vaccine function is a function that enheres in a vaccine that induces protective immune response against a disease. It is realized in the vaccination process in the host. PERSPN: Oliver He: There has been hot discussion about whether we use 'vaccine function' or 'vaccine role'. Vaccine role may not be the good term to use. Vaccine is designed to be 'vaccine', so it should be vaccine function. One special case is cowpox virus. The cowpox virus can be mixed with some liquid like water and used as a smallpox vaccine. In this case, people often say: the cowpox virus has a 'vaccine role'. However, the cowpox virus vaccine is a processed material of a mix of the virus with water. The virus is a virus, it is not a vaccine per se. Therefore, vaccine role may not be an accurate term. AE: neck pain According to the Vaccine Adverse Event Reporting System (VAERS), 'neck pain' is an adverse event that was mentioned in 1,323 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: positive rechallenge According to the Vaccine Adverse Event Reporting System (VAERS), 'positive rechallenge' is an adverse event that was mentioned in 1,292 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). In contrast, positive dechallenge occurs when the adverse reaction disappears once the drug is stopped. This term is a COSTART term but not a MP term (3/17/2009). Positive rechallenge occurs when the adverse reaction re-emerges once a drug (e.g., vaccine) is restrarted. YH heat killed pathogen in vaccine YH AE: back pain This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'back pain' is an adverse event that was mentioned in 1,277 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH herpesvirus vaccine vector YH AE: alopecia VAE MP: MP_0000414 According to the Vaccine Adverse Event Reporting System (VAERS), 'alopecia'; is an adverse event that was mentioned in 260 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition alopecia AE: gastrointestinal hemorrhage According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal hemorrhage'; is an adverse event that was mentioned in 183 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000465 bleeding in the stomach and/or the intestines vaccine-induced host gene response YH vaccine-induced host immune response YH vaccine-induced host response YH a processual entity that specifies host response to a vaccine. host response to vaccine adjuvant a process that specifies host response to a vaccine adjuvant. YH host response to vaccine component YH a processual entity that specifies host response to a vaccine component. host response to vaccine antigen a process that specifies host response to a vaccine antigen. YH host response to vaccine vaccine vector a process that specifies host response to a vaccine vector. YH AE: eyes gaze upward YH According to the Vaccine Adverse Event Reporting System (VAERS), 'eyes gaze upward' is an adverse event that was mentioned in 1,249 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). AE: neuropathy This term is a COSTART term but not a MP term (3/17/2009). Neuropathy is a medical term describing disorders of the nerves of the peripheral nervous system (specifically excluding encephalopathy and myelopathy, which refer to the central nervous system.) It is usually considered equivalent to peripheral neuropathy. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'neuropathy' is an adverse event that was mentioned in 1,154 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). peripheral neuropathy human immunodeficiency virus vaccine A viral vaccine that protects against infection with human immunodeficiency virus that causes AIDS. MeSH: D016915 AIDS vaccine HIV vaccine YH licensed horse vaccine role licensed horse vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for horse use. YH, XZ AE: skin nodule This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' is an adverse event that was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). YH AE: arthrosis A degenerative disease of a joint. Arthrosis is an articular illness that produces fibrosis or degeneration of the cartilage. According to the Vaccine Adverse Event Reporting System (VAERS), 'arthrosis' is an adverse event that was mentioned in 1,129 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH company YH Brucella melitensis strain VTRM1 YH AE: hypokinesia Hypokinesia refers to slow or diminished movement of body musculature. YH AE: muscle twitching muscle contraction YH muscle fasciculation Brucella suis strain VTRS1 B. suis VTRS1 PMID: 17428946 YH AE: skin discoloration AE: skin discolouration AE: skin discoloration is a skin adverse event that results in change in color of skin or mucus membranes According to the Vaccine Adverse Event Reporting System (VAERS), 'skin discoloration' is an adverse event that was mentioned in 909 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH, SS AE: herpes zoster According to the Vaccine Adverse Event Reporting System (VAERS), 'herpes zoster' is an adverse event that was mentioned in 892 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). Herpes zoster is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox, and generally occurs in children and young people. Once an episode of chickenpox has resolved, the virus is not eliminated from the body but can go on to cause shingles (an illness with very different symptoms) often many years after the initial infection. YH This term is a COSTART term but not a MP term (3/17/2009). zoster shingles AE: laryngismus YH According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngismus' is an adverse event that was mentioned in 881 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). laryngospasm sudden laryngeal spasm with crowing inhalation and cyanosis. It is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. KKF24 YH PMID: 16552035 KKF24 is a recombinant strain of Francisella novicida U112 with iglC mutation (F. novicida delta-iglC::ermC). PMID: 14680699. F. tularensis vaccine LVS LPS YH PMID: 10722593 F. tularensis vaccine LVS lipopolysaccharide vaccine-induced antibody mediated immune response YH immunoglobulin mediated immune response to vaccine immunologic adjuvant YH B. melitensis lipopolysaccharide vaccine YH B. melitensis LPS-GBOMP noncovalent complex vaccine B. melitensis LPS-GBOMP subunit vaccine PMID: 8723881 YH AE: speech disorder This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'speech disorder' is an adverse event that was mentioned in 848 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH AE: hemorrhage According to the Vaccine Adverse Event Reporting System (VAERS), 'hemorrhage' is an adverse event that was mentioned in 338 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001914 hemorrhage loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels inactivated vaccine killed vaccine A vaccine that is made from whole viruses or bacteria that have been inactivated with chemicals or heat. inactivated organism vaccine YH AE: neck rigidity According to the Vaccine Adverse Event Reporting System (VAERS), 'Neck rigidity' is an adverse event that was mentioned in 829 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: Guillain-Barré syndrome According to the Vaccine Adverse Event Reporting System (VAERS), 'Guillain-Barré syndrome' is an adverse event that was mentioned in 820 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). AE: GBS Guillain-Barré syndrome is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances, the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until the muscles cannot be used at all and the patient is almost totally paralyzed. In these cases, the disorder is life-threatening and is considered a medical emergency. Usually Guillain-Barré occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. Reference: http://www.ninds.nih.gov/disorders/gbs/gbs.htm. This term is a COSTART term but not a MP term (3/17/2009). YH, SS AE: nausea and vomiting This term is a COSTART term but not a MP term (3/17/2009). This term will most likely removed since it is just a combination of nausea and vomiting. According to the Vaccine Adverse Event Reporting System (VAERS), 'nausea and vomiting' is an adverse event that was mentioned in 812 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). YH AE: sudden infant death YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). AE: fever with chills This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'chills and fever' is an adverse event that was mentioned in 722 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). successive stages of chills and fever. This is a symptom of malaria. YH AE: chills and fever Brucella abortus DNA vaccine encoding BCSP31, SOD and L7/L12 YH B. abortus DNA vaccine expressing BCSP31, SOD and L7/L12 PMID: 17570767 AE: personality disorder This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'personality disorder' is an adverse event that was mentioned in 678 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). Brucella abortus subunit vaccine using L7/L12 recombinant B. abortus L7/L12 vaccine PMID: 8873388 YH AE: lung disorder YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'lung disorder' is an adverse event that was mentioned in 614 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). B. melitensis DNA vaccine encoding Omp31 PMID: 17428946 YH muscle adverse event YH AE: liver/biliary system disorder YH AE: enlarged liver MP: MP_0000599 According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatomegaly'; is an adverse event that was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). enlarged liver larger than average size of the liver licensed goat and sheep vaccine role YH licensed goat and sheep vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for goat and sheep use. inedible YH, MC A quality of edibility that inheres in a bearer by virtue of the bearer being not suitable for oral ingestion. AE: meningitis According to the Vaccine Adverse Event Reporting System (VAERS), 'meningitis' is an adverse event that was mentioned in 592 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). Meningitis is a medical condition caused by inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases. This term is a COSTART term but not a MP term (3/17/2009). YH tertiary vaccination YH, Thom Todd tertiary vaccination is a vaccination that is performed at the third time in a row. licensed cat vaccine role licensed cat vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for cat use. YH, XZ digestive system AE YH vaccine injection site YH AE: facial paralysis YH According to the Vaccine Adverse Event Reporting System (VAERS), 'facial paralysis' is an adverse event that was mentioned in 580 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). AE: confusion YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'confusion' is an adverse event that was mentioned in 579 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Brucella melitensis bp26 deletion vaccine A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the bp26 deletion. It has similar vaccien efficacy to Rev. 1. Its advantage compared to Rev. 1 is that this feature of bp26 deletion promotes diagnosis. PMID: 17070627. CGV26 PMID: 16519974 Brucella CGV26 YH F. tularensis vaccine FSC043 YH A spontaneous mutant of the SCHU S4 strain that protects against virulent F. tularensis infection. PMID: 16299332. PMID: 16299332 intramuscular route YH intranasal route YH intranasal route by drop YH intranasal route by spray YH intraperitoneal route YH Brucella melitensis WR201 YH AE: joint disorder YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'joint disorder' is an adverse event that was mentioned in 562 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Brucella abortus bacA mutant B. abortus bacA mutant YH PMID: 17196866 Influenza A (H1N1) 2009 Monovalent Vaccine by CSL Limited Influenza A (H1N1) 2009 Monovalent Vaccine from MedImmune LLC Arepanrix MC, YH vaccine host a vaccine host is a role that inheres in an organism that is the target of a vaccine administration (vaccination process). Megan Egg WEB: http://www.fda.gov/ohrms/dockets/dockets/00n0504/00N-0504_emc-001650-02.pdf Megan Egg is a Salmonella vaccine that that consists of a double gene-deleted S. enterica serovar Typhimurium strain and is formulated fro immunization of pullets. Megan Egg contains the same Megan Vac1 organism but Megan Vac1 is used for younger birds (broilers). YH AE: eye disorder This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'eye disorder' is an adverse event that was mentioned in 543 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). B. ovis microparticle subunit vaccine PMID: 16481077 YH AE: autism According to the Vaccine Adverse Event Reporting System (VAERS), 'autism' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH Autism is a brain development disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. This term is a COSTART term but not a MP term (3/17/2009). AE: sedimentation rate increased YH AE: red blood cell sedimentation rate increased Sedimentation rate is a diagnostic test for inflammation. The test measures the rate at which red blood cells fall to the bottom of a tube over time. An increased sedimentation rate corresponds to increased non-specific inflammation in the body. It is often called "sedrate" for short. ESR erythrocyte sedimentation rate This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'sedimentation rate increased' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term should be inferred to lab test abnormal. AE: red blood cell sedimentation rate increased is an AE: sedimentation rate increased that has an increase in rate at which red blood cells precipitate in a period of 1 hour. sedrate AE: accidental injury an injury that occurs accidentally. According to the Vaccine Adverse Event Reporting System (VAERS), 'accidental injury' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). Brucella recombinant SurA protein vaccine PMID: 17686554 YH lentivirus vaccine vector YH AE: amblyopia YH According to the Vaccine Adverse Event Reporting System (VAERS), 'amblyopia' is an adverse event that was mentioned in 507 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). vaccine-induced leukocyte activation YH licensed human vaccine in USA a human vaccine with license that is commercially used in the USA. YH licensed vaccine YH A vaccine that is licensed for commercial use. AE: mental retardation This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'mental retardation' is an adverse event that was mentioned in 498 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). lipopolysaccharide of pathogen organism as vaccine component YH liposome-based vaccine adjuvant a vaccine adjuvant that contains particles made up of concentric lipid membranes containing phospholipids and other lipids in a bilayer configuration separated by aqueous compartments. It is a relatively stable but non-covalently-bound complex of saponin adjuvant Quil-A, cholesterol and amphipathic antigen in a molar ratio of approximately 1:1:1. The spectrum of viral capsid antigens and non-viral amphipathic antigens of relevance for human vaccination, incorporated into ISCOMs, comprises influenza, measles, rabies, gp340 from EB-virus, gp120 from HIV, Plasmodium falciparum and Trypanosoma cruzi. Ref: http://www.vaccination.inoz.com/adjuvants.html. YH live attenuated vaccine attenuated vaccine YH A live vaccine that is made from microbes that have been attenuated (weakened) in the laboratory so that they can't cause disease. live pathogen organism as vaccine component YH live vaccine A vaccine that is made of live whole organism. YH live virulent vaccine YH quaternary vaccination quaternary vaccination is a vaccination that is performed at the fourth time in a row. YH, Thom Todd AE: erythema multiforme This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'erythema multiforme' is an adverse event that was mentioned in 483 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH local accumulation of fluid, plasma proteins, and leukocytes in the brain brain inflammation Brucella recombinant DnaK protein vaccine YH PMID: 17686554 divalent DNA B. abortus vaccine using L7/L12 and Omp16 PMID: 16622210 YH AE: SGOT increased YH According to the Vaccine Adverse Event Reporting System (VAERS), 'SGOT increased' is an adverse event that was mentioned in 477 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Increased level of SGOT. SGOT respresents serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. SGOT is also called aspartate aminotransferase (AST). This term is a COSTART term but not a MP term (3/17/2009). AE: SGPT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGPT increased' is an adverse event that was mentioned in 459 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). Increased level of SGPT. SGPT represents serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. SGPT is also called alanine aminotransferase (ALT). YH AE: thinking abnormality YH According to the Vaccine Adverse Event Reporting System (VAERS), 'thinking abnormality' is an adverse event that was mentioned in 457 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: dyspepsia According to the Vaccine Adverse Event Reporting System (VAERS), 'dyspepsia' is an adverse event that was mentioned in 454 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH Dyspepsia is popularly known as indigestion, meaning hard or difficult digestion. It is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating. AE: anaphylactoid reaction YH This term is a COSTART term but not a MP term (3/17/2009). is an acute systemic (multi-system) and very severe Type I Hypersensitivity allergic reaction in humans and other mammals. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. According to the Vaccine Adverse Event Reporting System (VAERS), 'anaphylactoid reaction' is an adverse event that was mentioned in 452 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). AE: gastrointestinal disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: previous reaction According to the Vaccine Adverse Event Reporting System (VAERS), 'previous reaction' is an adverse event that was mentioned in 442 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: serum sickness YH This term is a COSTART term but not a MP term (3/17/2009). Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). According to the Vaccine Adverse Event Reporting System (VAERS), 'serum sickness' is an adverse event that was mentioned in 428 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). AE: injection-site abscess YH According to the Vaccine Adverse Event Reporting System (VAERS), 'injection-site abscess' is an adverse event that was mentioned in 426 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: abnormal electroencephalogram Abnormal results of electroencephalography (EEG). EEG is the recording of electrical activity along the scalp produced by the firing of neurons within the brain. In clinical contexts, EEG refers to the recording of the brain's spontaneous electrical activity over a short period of time, usually 20-40 minutes, as recorded from multiple electrodes placed on the scalp. In neurology, the main diagnostic application of EEG is in the case of epilepsy, as epileptic activity can create clear abnormalities on a standard EEG study. A secondary clinical use of EEG is in the diagnosis of coma and encephalopathies. EEG used to be a first-line method for the diagnosis of tumors, stroke and other focal brain disorders, but this use has decreased with the advent of anatomical imaging techniques such as MRI and CT. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal electroencephalogram' is an adverse event that was mentioned in 420 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). Brucella abortus DNA vaccine encoding L7/L12 and P39 PMID: 16537031 B. abortus DNA vaccine encoding L7/L12 and P39 YH attenuated Brucella abortus with deletion of znuA YH PMID: 16790759 mucosal immune response to vaccine YH nanoparticle vaccine adjuvant YH licensed fish vaccine role licensed fish vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for fish use. YH, XZ licensed bird vaccine role YH, XZ licensed bird vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for bird use. licensed rabbit vaccine role licensed rabbit vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for rabbit use. YH, XZ licensed ferret vaccine role YH, XZ licensed ferret vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for ferret use. licensed turkey vaccine role YH, XZ licensed turkey vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for turkey use. licensed chicken vaccine role YH, XZ licensed chicken vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for chicken use. licensed deer vaccine role licensed deer vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for deer use. YH, XZ licensed rabbit vaccine neutralizing antibody YH microencapsulated B. melitensis mutant vaccine YH A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant delivered using a microsphere delivery system. PMID: 18362129 A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant vjbR::Tn5 (BMEII1116) delivered using alginate microspheres that is coated with a protein of the parasite Fasciola hepatica (vitelline protein B [VpB]). PMID: 18362129. AE: vertigo According to the Vaccine Adverse Event Reporting System (VAERS), 'vertigo' is an adverse event that was mentioned in 412 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). Vertigo is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings. The effects of vertigo may be slight. It can cause nausea and vomiting and, in severe cases, it may give rise to difficulties with standing and walking. YH This term is a COSTART term but not a MP term (3/17/2009). AE: heart arrest According to the Vaccine Adverse Event Reporting System (VAERS), 'heart arrest' is an adverse event that was mentioned in 410 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH heart arrest is the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole. circulatory arrest cardiopulmonary arrest asystole cardiac arrest AE: bronchitis This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'bronchitis' is an adverse event that was mentioned in 407 VAERS reports 0.3%) during1991-2001 (Reference: PMID: 12825543). Bronchitis is an inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes. YH AE: grand malconvulsion A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). According to the Vaccine Adverse Event Reporting System (VAERS), 'grand malconvulsion' is an adverse event that was mentioned in 402 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). porin-S-LPS from B. abortus strain 2308 PMID: 2844673 complex of porin and S-LPS from B. abortus strain 2308 YH Brucella abortus RB51WboA B. abortus RB51WboA PMID: 15327798 YH AE: liver function tests abnormal MP: MP_0000609 According to the Vaccine Adverse Event Reporting System (VAERS), 'liver function tests abnormal' is an adverse event that was mentioned in 717 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage AE: ear disorder This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'ear disorder' is an adverse event that was mentioned in 362 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH recombinant O. anthropi 49237SOD PMID: 11953393 YH organ or tissue specific immune response to vaccine YH licensed horse vaccine YH AE: infect viral YH, SS This term is a COSTART term but not a MP term (3/17/2009). AE: infect viral is an infection that results in detrimental colonization of a host organism by virus According to the Vaccine Adverse Event Reporting System (VAERS), 'infect viral' is an adverse event that was mentioned in 358 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). WEB: http://en.wikipedia.org/wiki/Viral_infection viral infection B. melitensis Bp26 and Tf vaccine YH B. melitensis P39 recombinant protein vaccine PMID: 11447155 YH A Brucella subunit vaccine that uses recombinant Brucella melitensis 16M P39, a putative periplasmic binding protein. PMID: 11447155. recombinant chimera BLSOmp31 rBLSOmp31 YH PMID: 17442465 Panvax MC, YH Panvax is an H1N1 unadjuvanted monovalent vaccine. WEB: http://www.infowars.com/h1n1-panvax-training-powerpoint-received-by-health-care-workers-in-australia/ parasite YH intravenous route YH, Thom Todd protozoan vaccine A vaccine that protects against some protozoan disease. YH MeSH: D016052 parasitic vaccine AE: lacrimation disorder YH Disorder of lacrimation. Lacrimation is the production, secretion, and shedding of tears. According to the Vaccine Adverse Event Reporting System (VAERS), 'lacrimation disorder' is an adverse event that was mentioned in 334 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: jaundice MP: MP_0000611 According to the Vaccine Adverse Event Reporting System (VAERS), 'jaundice' is an adverse event that was mentioned in 317 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). SS, YH WEB: http://en.wikipedia.org/wiki/Jaundice AE: icterus clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes jaundice organism component in vaccine YH a part of vaccine that originates from an organism such as a pathogen or an attenuated organism. Brucella abortus pcDNA-BLS YH B. abortus pcDNA-BLS AE: abscess YH This term is a COSTART term but not a MP term (3/17/2009). abscessus According to the Vaccine Adverse Event Reporting System (VAERS), 'abscess' is an adverse event that was mentioned in 318 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). An abscess is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue on the basis of an infectious process (usually caused by bacteria or parasites) or other foreign materials (e.g. splinters, bullet wounds, or injecting needles). It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body. escheriosome-mediated delivery of B. abortus L7/L12 YH PMID: 17931756 escheriosome-encapsulated B. abortus L7/L12 AE: eye pain This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'eye pain' is an adverse event that was mentioned in 316 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH palpitation This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'palpitations' is an adverse event that was mentioned in 313 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). A palpitation is an abnormal awareness of the beating of the heart, whether it is too slow, too fast, irregular, or at its normal frequency. YH period of persistence of vaccine induced immune response YH, MC period of persistence of vaccine induced immune response is a temporal interval during which a vaccine-induced immune response continuously exists. This term is related to the process 'persistence of vaccine induced immune response'. phase 1 vaccine trial A vaccine clinical trial that investigates the safety profile of a vaccine in a small group (10-50) of healthy volunteers. YH phase 2 vaccine trial A vaccine clinical trial that studies vaccine efficacy with a target population (numbering 50-100). Different dosage levels will also be explored at this stage to determine the optimum dose. YH phase 3 vaccine trial