]> Alexander D. Diehl Thomas Todd Rebecca Racz Ryan R. Brinkman Alan Ruttenburg Barry Smith Bjoern Peters Samantha G. Sayers (SGS) en Richard H. Scheuermann Melanie Courtot Chris Mungall Lindsay Cowell An ontology for the annotation of the vaccine domain. May 17, 2012 OWL-DL The Vaccine Ontology (VO) is a biomedical ontology in the domain of vaccine. VO aims to standardize vaccine annotation, integrate various vaccine data, and support computer-assisted reasoning. VO supports basic vaccine R&D and clincal vaccine usage. VO is primarily developed by Dr. Yongqun "Oliver" He at the University of Michigan Medical School. VO is being developed as a community-based ontology with support and collaborations from the vaccine and bio-ontology communities. Vaccine Ontology Vision Release; 1.0.615 Yongqun "Oliver" He (YH) Yu Lin (YL) Zuoshuang "Allen" Xiang definition editor note has curation status definition source definition editor alternative term editor preferred term example of usage participates_in has_vaccine_contraindication has_vaccine_contraindication is a relation that specifies contraindication of a vaccine. YH This relation may be replaced by has_vaccine_allergen. We need to determine if any vaccine contraindicator is not a vaccine allergen. infection_of The relation 'infection_of' is introduced to represent an infection caused by an infectious pathogen. A pathogen infection is a disorder. Since the number of pathogens is large, there are numerous infections. To make the description of a specific infection simple, the shortcut term 'infection_of' is defined: infection_of X = infection and has_part some (organism X and has_disposition some infectious disposition) infection_of is a relation between a disorder and an infectious pathogen. YH, XZ, MC, BP, AR vaccinates "A vaccinates B" means that the vaccine A is used for vaccinating the host B (e.g., human). A relationship between a vaccine instance and an organism type such that if the vaccine instance is given to an instance of the organism by the process vaccination, then it changes the organism's disposition to have an immune response against a disease. YH, AR, ZX, MC has_vaccine_allergen has_vaccine_allegen is a relation that specifies an allegen to a vaccine. YH has_gene_mutation_of YH is_distributed_by YH, ZX is_distributed_by is a relation that specifies a company that distributes a product (e.g., vaccine). The company is very likely not the manufacturer of the product. vaccine immunization for host a shortcut relation that equals to: processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some ('vaccine host role' and (role_of some 'HOST')))))))). The domain of this relation is a vaccine. The range of this relation is a host. Yongqun He has_vaccine_target YL is a short relation: 'vaccine' has_vaccine_target 'Y' equal to: 'vaccine' is_output_of ('vaccine preparation and (realizes some ('vaccine target specification' and is_about some 'Y'))) Y is the union of organism and disease. vaccine immunization against microbe a shortcut relation that equals to: processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some ('immunization target role' and (role_of some 'MICROBE')))))))) The domain of this relation is a vaccine. The range of this relation is a microbe (a bacterium, a virus, a fungus, and a parasite) Yongqun He influenza Feline viral rhinotracheitis virus VEE virus Birds chicken horse pig independent variable specification dependent variable specification live part of pathogen organism in vaccine YH 'part of organism in vaccine' is a pathogen component in vaccine that contains only a part of the pathogen organism instead of the whole organism. vaccine Many vaccines are developed to protect against infectious pathogens. Many vaccines are also being developed against some diseases such as cancer and autoimmune diseases. Vaccine is developed against a disease. Allergy. YH, BP, BS, MC, LC, XZ, RS A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine. MeSH: D014612 vaccination YH, BP Vaccination is: an 'administering substance in vivo' that involves in adding vaccine into a host (e.g., human, mouse) in vivo with the intent to invoke a protective immune response. vaccine administration ACAM2000 Smallpox (Vaccinia) Vaccine, Live CVX: 75 YH Trade Name: ACAM2000 ActHIB Product Name: Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate) PMID: 1735812 YH Trade Name: ActHIB PMID: 1517908 CVX: 48 PMID: Preparation: The vaccine consists of the Haemophilus b capsular polysaccharide (polyribosyl-ribitol-phosphate, PRP), a high molecular weight polymer prepared from the Haemophilus influenzae type b (HiB) strain 1482 grown in a semi-synthetic medium, covalently bound to tetanus toxoid. The tetanus toxoid is prepared by extraction, ammonium sulfate purification, and formalin inactivation of the toxin from cultures of Clostridium tetani (Harvard strain) grown in a modified Mueller and Miller medium. The toxoid is filter sterilized prior to the conjugation process. When ActHIB vaccine is reconstituted with saline diluent, each single dose of 0.5 mL is formulated to contain 10 mu g of purified capsular polysaccharide conjugated to 24 mu g of inactivated tetanus toxoid, and 8.5% of sucrose (ActHIB 2005). Reference: http://www.violinet.org/vaxquery/vaccine_detail.php?c_vaccine_id=157&keywords= Adacel Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed Trade Name: Adacel CVX: 115 CVX: 20 YH Afluria Product Name: Influenza Virus Vaccine YH Trade Name: Afluria CVX: 141 CVX: 140 Attenuvax Product Name: Measles Virus Vaccine, Live Trade Name: Attenuvax YH vaccine-induced lymphocyte activation YH vaccine-induced B cell antigen processing and presentation YH vaccine-induced B cell cytokine production YH B cell epitope in vaccine YH vaccine-induced B cell mediated immunity YH Bacillus anthracis vaccine anthrax vaccine A vaccine that protects against Bacillus anthrax that causes anthrax. MeSH: D022122 YH Biothrax Product Name: Anthrax Vaccine Adsorbed CVX: 24 YH Trade Name: Biothrax Boostrix Product Name: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed Trade Name: Boostrix CVX: 115 CVX: 20 YH AE: fever AE: pyrexia Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1-2 degree C (1.8-3.6 degree F). YH, SS febrile response AE: body temperature increased AE: rash AE:rash is a vaccine induced skin adverse event. A rash is a change of the skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. This term is a COSTART term but not a MP term (3/17/2009). YH Brucella abortus DNA vaccine pcDNA-SOD PMID: 15039330 YH A Brucella abortus vaccine that expresses Cu/Zn SOD with DNA plasmid pcDNA. PMID: 15039330. AE: infection This term is a COSTART term but not a MP term (3/17/2009). YH Brucella abortus strain RB51 as vaccine vector YH Brucella abortus RB51 Brucella abortus vaccine RB51 is a Brucella abortus vaccine that is licensed in the USA since 1992. Brucella abortus vaccine RB51 is a live attenuated cattle vaccine against brucellosis that is currently used in the USA and many other coutries. PMID: 11504226 PMID: 12438380 B. abortus RB51 PMID: 12704101 Brucella RB51 PMID: 8890203 PMID: 12119140 Brucella RB-51 PMID: 7806364 PMID: 10534009 YH PMID: 11768128 SRB51 PMID: 17894637 WEB: http://rb51.com PMID: 11504238 PMID: 19362381 PMID: 8740701 PMID: 7622248 PMID: 1439207 PMID: 11500423 PMID: 16713034 PMID: 17653832 PMID: 11193615 PMID: 8039890 PMID: 11553603 PMID: 18836016 PMID: 1908158 PMID: 19439382 PMID: 7927779 Brucella abortus strain 19 Brucella strain-19 Brucella S19 PMID: 8039890 YH PMID: 11058778 A live attenuated Brucella abortus vaccine that is licensed and used in many countries. AE: syndrome This term is a COSTART term but not a MP term (3/17/2009). YH syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. AE: agitation YH emotional state of excitement or restlessness This term is a COSTART term but not a MP term (3/17/2009). Brucella vaccine YH MeSH: D002004 brucellosis vaccine A vaccine that protects against Brucella that causes brucellosis in animals and humans. injection-site AE This term is a COSTART term but not a MP term (3/17/2009). injection-site reaction YH AE: injection-site hypersensitivity This term is a COSTART term but not a MP term (3/17/2009). YH Comvax Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant) PMID: Trade Name: Comvax YH CVX: 51 Daptacel Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed YH CVX: 106 CVX: 20 Vaccine components see http://www.vaccinesafety.edu/components-DTaP.htm Trade Name: DAPTACEL DECAVAC Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use Trade Name: DECAVAC YH CVX: 113 DNA of pathogen organism as vaccine component YH DNA from protective protein that is used as vaccine component. This is usually used for preparation of DNA vaccine. DNA vaccine synonym: naked DNA vaccine genetic vaccine nucleic acid vaccine DNA vaccine is a vaccine that is composed of a plasmid vaccine vector (a circular double stranded DNA molecule) containing genes encoding one or more proteins of a pathogen. YH naked DNA vaccine Diphtheria and Tetanus Toxoids Adsorbed USP by Sanofi Pasteur Inc Product Name: Diphtheria & Tetanus Toxoids Adsorbed CVX: 28 YH Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Ltd Product Name: Diphtheria & Tetanus Toxoids Adsorbed YH Dryvax Product Name: Smallpox Vaccine, Dried, Calf Lymph Type Dryvax is a freeze-dried calf lymph smallpox vaccine. It is the world's oldest smallpox vaccine, created in the late 19th century by American Home Products, a predecessor of Wyeth. By the 1940s, Wyeth was the leading US manufacturer of the vaccine and the only manufacturer by the 1960s. After world health authorities declared smallpox had been eradicated from nature in 1980, Wyeth stopped making the vaccine. Trade Name: Dryvax YH http://en.wikipedia.org/wiki/Dryvax CVX: 75 ETEC vaccine ACAM2010 YH PMID: 17566016 ACAM2007 is a vaccine candidate expressing CFA/II. Adenovirus vaccine A viral vaccine that protects against infection of an adenovirus. YH, SGS vaccine persistence assay YH An assay that measures the persistent survival of live vaccine in a host in vivo. AE: injection-site edema YH AE: injection-site oedema This term is a COSTART term but not a MP term (3/17/2009). AE: injection-site pain YH This term is a COSTART term but not a MP term (3/17/2009). Escherichia coli vaccine A bacterial vaccine that prevents against Escherichia coli infection. E. coli vaccine YH MeSH: D022361 AE: injection-site inflammation YH This term is a COSTART term but not a MP term (3/17/2009). FluLaval Product Name: Influenza Virus Vaccine, Trivalent, Types A and B Trade Name: FluLaval YH CVX: 141 FluMist Product Name: Influenza Virus Vaccine, Live, Intranasal Trade Name: FluMist CVX: 111 YH Fluarix Product Name: Influenza Virus Vaccine, Trivalent, Types A and B CVX: 140 YH Trade Name: Fluarix Fluvirin Product Name: Influenza Virus Vaccine, Trivalent, Types A and B YH CVX: 140 CVX: 141 Trade Name: Fluvirin Fluzone Product Name: Influenza Virus Vaccine, Trivalent, Types A and B CVX: 144 Trade Name: Fluzone CVX: 140 YH CVX: 141 virmugen a gene that once deleted, would make an attenuated microbe that can be used as a live attenuated vaccine against virulent pathogen. YH, YL, ZX Gardasil Product Name: Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine Trade Name: Gardasil CVX: 62 YH Gardasil is a quadrivalent vaccine meaning it protects against 4 strains of virus (types 6, 11, 16, and 18). The vaccine was made using genetic engineering techniques. The genes that encode a specific protein from each of these strains are expressed in yeast in large-scale fermentation cultures. Protein purification methods are then used to isolate the proteins and make the vaccine. Cited from: http://biotech.about.com/b/2008/09/03/gardasil-safety-of-genetically-engineered-hpv-vaccine-still-in-question.htm HIV based lentivirus vaccine vector YH Balb/c mouse YH Havrix Product Name: Hepatitis A Vaccine, Inactivated YH Trade Name: Havrix CVX: 52 CVX: 83 Neisseria meningitidis vaccine MeSH: D022401 YH A bacterial vaccine that prevents Neisseria meningitidis infection. Meningococcal vaccine IPOL Product Name: Poliovirus Vaccine Inactivated (Monkey Kidney Cell) YH PMID: Trade Name: IPOL CVX: 10 vaccine related journal article YL The jourmal article that mentions a vaccine, which was retrieved from PubMed and annotated using VO-SciMinner.(Hur J, Xiang Z, Feldman EL, He Y. Ontology-based Brucella vaccine literature indexing and systematic analysis of gene-vaccine association network. BMC Immunology. 12(1):49 2011 Aug 26. PMID: 21871085.) United Vaccines, Inc http://www.unitedvaccines.com/ Heska Corporation Texas Vet lab, Inc SolidTech Animal Health, Inc MVP Laboratories, Inc http://www.mvplabs.com/ Addison Biological Laboratory, Inc www.addisonlabs.com/ Neotech, LLC neotechvaccines.com/ Imovax Rabies Product Name: Rabies Vaccine Trade Name: Imovax CVX: 18 YH Infanrix Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed CVX: 20 Trade Name: Infanrix YH Influenza Virus Vaccine H5N1 (Sanofi Pasteur Inc) Product Name: Influenza Virus Vaccine, H5N1 (for National Stockpile) WEB: http://atomicnewsreview.org/2009/10/22/approval-for-the-arepanrix%E2%84%A2-gsk-vaccine-in-canada/ YH JE-Vax Product Name: Japanese Encephalitis Virus Vaccine Inactivated CVX: 39 Trade Name: JE-Vax YH Kinrix Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine CVX: 130 Trade Name: KINRIX YH Listeria monocytogenes as vaccine vector YH M-M-R II Product Name: Measles, Mumps, and Rubella Virus Vaccine, Live CVX: 03 Trade Name: M-M-R II YH M-M-Vax Product Name: Measles and Mumps Virus Vaccine, Live YH Trade Name: M-M-Vax Menactra Product Name: Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine WEB: http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm176044.htm Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine CVX: 114 Trade Name: Menactra YH Menomune A C Y W135 Product Name: Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined YH CVX: 32 Trade Name: Menomune-A/C/Y/W-135 Meruvax II Product Name: Rubella Virus Vaccine Live CVX: 06 YH Trade Name: Meruvax II Mumpsvax Product Name: Mumps Virus Vaccine Live YH Trade Name: Mumpsvax CVX: 07 AE: injection-site hemorrhage This term is a COSTART term but not a MP term (3/17/2009). YH AE: injection-site mass This term is a COSTART term but not a MP term (3/17/2009). Not sure where to put "mass", which requires more discussion. AE: injection-site mass is a mass at physical injection site YH, SS Mycobacterium tuberculosis vaccine YH MeSH: D032581 tuberculosis vaccine A vaccine that protects against Mycobacterium tuberculosis. Mycobax Mycobax is a BCG vaccine that is made by Sanofi Pasteur, Ltd. Ref: http://www.biopharma.com/cgi/full6.lasso?Key=412.65916 Product Name: BCG Vaccine CVX: 19 Trade Name: Mycobax YH O antigen of pathogen organism as vaccine compent YH AE: pruritus AE: pruritus generalised itch Itch (Latin: pruritus) is an unpleasant sensation that evokes the desire or reflex to scratch. itching YH, SS This term is a COSTART term but not a MP term (3/17/2009). WEB: http://www.ncbi.nlm.nih.gov/sites/entrez?db=mesh&cmd=DetailsSearch&term=pruritus+generalised&log$=activity Influenza A (H1N1) 2009 Monovalent Vaccine (Novartis) Pediarix Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Hepatitis B (recombinant) and Inactivated Poliovirus Vaccine Combined YH Trade Name: Pediarix CVX: 110 PedvaxHIB Product Name: Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) CVX: 49 YH PMID: Trade Name: PedvaxHIB PMID: 2791073 Pentacel Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine CVX: 120 YH Trade Name: Pentacel Plague Vaccine by Greer Laboratories Inc Product Name: Plague Vaccine CVX: 23 YH AE: pain This term is a COSTART term but not a MP term (3/17/2009). YH Plasmodium falciparum vaccine a malaria vaccine that protects against malaria caused by Plasmodium falciparum. YH Pneumovax 23 Product Name: Pneumococcal Vaccine, Polyvalent CVX: 33 YH Trade Name: Pneumovax 23 Poliovax Product Name: Poliovirus Vaccine Inactivated (Human Diploid Cell) Trade Name: Poliovax YH Prevnar Product Name: Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) CVX: 100 Trade Name: Prevnar YH ProQuad Product Name: Measles, Mumps, Rubella and Varicella Virus Vaccine Live CVX: 94 Trade Name: ProQuad YH RNA of pathogen organism as vaccine component YH RNA from protective protein that is used as vaccine component. This is usually used for preparation of RNA vaccine. mineral salt vaccine adjuvant CVX: 119 SGS, YH a vaccine adjuvant that is formed as a mineral salt. RabAvert Product Name: Rabies Vaccine YH CVX: 18 Trade Name: RabAvert Rabies Vaccine Adsorbed by BioPort Corp Product Name: Rabies Vaccine Adsorbed YH Adenovirus Type 4 and Type 7 Vaccine, Live, Oral CVX: 143 YH, SGS RotaTeq Product Name: Rotavirus Vaccine, Live, Oral, Pentavalent Trade Name: RotaTeq YH CVX: 116 SIV based lentivirus vaccine vector YH AE: myalgia This term is a COSTART term but not a MP term (3/17/2009). YH Myalgia means "muscle pain" and is a symptom of many diseases and disorders. muscle pain vaccine-induced T-helper 1 type immune response YH vaccine-induced T-helper 2 type immune response YH TENIVAC Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Trade Name: TENIVAC TICE BCG Intravesical TICE BCG has been used as a therapy for, and to prevent recurrence of, tumors in patients with carcinoma in situ (CIS) of the urinary bladder, and to prevent recurrence of Stage Ta T1 papillary tumors of the bladder at high risk of recurrence. Refernce URL: http://www.ticebcg.com/Consumer/aboutTice/index.asp Product Name: BCG Vaccine CVX: 19 Trade Name: TICE BCG YH TYPHIM Vi Product Name: Typhoid Vi Polysaccharide Vaccine YH CVX: 101 Trade Name: TYPHIM Vi T cell epitope in vaccine YH vaccine-induced T cell mediated immunity YH T cell vaccine antigen processing and presentation YH Brucella abortus vaccine YH Tetanus Toxoid Adsorbed by Sanofi Pasteur Inc Product Name: Tetanus Toxoid Adsorbed YH CVX: 35 E. coli O157:H7 intimin vaccine PMID: 11500434 YH E. coli Int280a has been found to be a protective antigen. This subunit vaccine uses E. coli Int280a combined with adjuvant. This antigen can be used for development of type-specific EPEC or EHEC vaccine. Tetanus and Diphtheria Toxoids Adsorbed for Adult Use by Massachusetts Public Health Biologic Lab Product Name: Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Tripedia Product Name: Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed CVX: 20 YH Trade Name: Tripedia Twinrix Product Name: Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine YH Trade Name: Twinrix CVX: 104 AE: urticaria This term is a COSTART term but not a MP term (3/17/2009). Urticaria is a kind of skin rash notable for dark red, raised, itchy bumps. YH hives vaccine-induced T cell activation AE: headache This term is a COSTART term but not a MP term (3/17/2009). YH respiratory system AE YH I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He microbial derivative vaccine adjuvant CVX: 52 a vaccine adjuvant that contains microbial derived material. YH, SGS CVX: 83 Varivax Product Name: Varicella Virus Vaccine Live CVX: 21 YH Trade Name: Varivax Vivotif Product Name: Typhoid Vaccine Live Oral Ty21a Trade Name: Vivotif CVX: 25 YH YF-Vax Product Name: Yellow Fever Vaccine YH CVX: 37 Trade Name: YF-Vax Yellow fever 17D as vaccine vector YH Yellow fever virus vaccine A viral vaccine that protects against infection with Yellow fever virus. YH MeSH: D022341 Zostavax Product Name: Zoster Vaccine, Live, (Oka/Merck) YH CVX: 121 Trade Name: Zostavax licensed turkey vaccine YH live attenuated pathogen as vaccine component YH aluminum hydroxide vaccine adjuvant an aluminum vaccine adjuvant that contains aluminum hydroxide. alum YH aluminum phosphate vaccine adjuvant Adju-Phos® Al(PO)4 an aluminum vaccine adjuvant that is aluminum phosphate. YH, SGS vaccination frequency YH Vaccination frequency is a qualitative term that represents how many times vaccination has occurred. AE: increased leukocyte cell number SS, YH MP: MP_0000218 According to the Vaccine Adverse Event Reporting System (VAERS), 'leukocytosis' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). AE: white blood cell count increased greater than normal number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue calcium phosphate vaccine adjuvant YH, SGS a mineral salt vaccine adjuvant composed of calcium phosphate. CaHPO4 AE: decreased leukocyte cell number According to the Vaccine Adverse Event Reporting System (VAERS), 'leukopenia' is an adverse event that was mentioned in 417 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000221 reduction in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue Freund's emulsified oil adjuvant YH, SGS an emulsion vaccine adjuvant that consists of a water-in-oil emulsion of aqueous antigen in paraffin (mineral) oil of low specific gravity and low viscosity. It is named after Jules T. Freund (1890-1960), Hungarian-born American immunologist. It is a water in oil emulsion. vaccine-induced T cell proliferation vaccine-induced adaptive immune response YH adenovirus vaccine vector YH adjuvant role A role inherens in a material entity that helps or enhances the effect of other agents, such as a drug or vaccine. YH,YL The Latin "adjuvans" means to help, particularly to reach a goal. Adjuvant therapy for cancer is surgery followed by chemotherapy or radiation to help decrease the risk of the cancer recurring (coming back). An adjuvant is a substance that helps and enhances the pharmacological effect of a drug or increases the ability of an antigen to stimulate the immune system. live virulent pathogen as vaccine component YH complete Freund's adjuvant is a Freund's emulsfied oil adjuvant that contains inactivated and dried mycobacteria, usually Mycobacterium tuberculosis (the pathogenic agent of tuberculosis). YH agglutinating antibody role YH virulence factor YH incomplete Freund's adjuvant a Freud's adjuvant that does not contain the mycobacterial components. YH cholera toxin CT A microbial derivative vaccine adjuvant consisting of cholera toxin (CT) from Vibrio cholerae. YH, SGS alphavirus vaccine vector YH vaccine vector role YH,YL a biological vector role that is realized by the process of transmitting genetic material encoding vaccine antigen to the vaccinee, when introduced into the vaccinee, it results in the in situ production of antigen in the vaccinee Corynebacterium-derived P40 vaccine adjuvant A microbial derivative vaccine adjuvant that is the P40 particulate fraction isolated from Corynebacterium. YH, SGS PMID: 8447157 vaccine adjuvant role YH an adjuvant role that inheres in a material entity when added to vaccine, it will induce stronger immune response than using vaccine without adjuvant. But don not in itself confer immunity. antibody role YH Aceto Pharma Corp antibody titer Antibody titer is a titer of antibody that shows how much antibody an organism has produced that recognizes a particular epitope, expressed as the greatest dilution ratio (or its reciprocal) that still gives a positive result. ELISA is a common means of determining antibody titers. YH WEB: http://en.wikipedia.org/wiki/Antibody_titer immunized an organismal quality that indicates an organism (e.g., human) is immunized against a disease. To assign the state of ‘immunized’, we will need to do some assay to measure indicators of immunity, e.g., antibody titers in serum samples. YH, YL Francisella tularensis vaccine YH preparation of toxoid vaccine YH A vaccine preparation that results in the generation of a toxoid vaccine Brucella abortus sodC YH bacterial gene YH viral gene YH HIV gene YH AE: abnormal blood pressure MP: MP_0000230 altered tension of the blood within the systemic arteries preparation of live attenuated vaccine by serial passages in vitro Brucella abortus cattle vaccine RB51 was developed by serial passages of virulent B. abortus strain 2308 in vitro in rifampin agar plates (Reference: PMID: 1908158). A live attenuated vaccine prepraration process that is performed by serial passages in vitro for pathogen attenuation. YH Influenza A (H1N1) 2009 Monovalent Vaccine (Sanofi Pasteur) Escherichia coli gene YH E. coli gene avirulent YH vaccine-induced gene up-regulation controlling intracellular bacterial replication Mycobacterium tuberculosis gene YH bacterial vaccine YH A vaccine that protects against some bacterial disease. MeSH: D001428 bacterial vaccine vector YH AE: asthenia YH This term is a COSTART term but not a MP term (3/17/2009). Asthenia is a medical term denoting symptoms of physical weakness and loss of strength. Asthenia is a side effect of vaccines such as the HPV vaccine Gardasil. Salmonella gene YH Shigella gene YH protozoan gene YH Plasmodium gene YH Plasmodium falciparum gene YH attenuated YH Leishmania gene YH AE: muscle ache muscle pain YH vaccine-induced T cell differentiation cancer vaccine neoplasm vaccine tumor vaccine A vaccine that prevents or treats cancer. It is produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced. MeSH: D019496 YH inactivated vaccine preparation A vaccine preparation that results in the generation of a inactivated vaccine YH vaccine component YH cardinal part of vaccine a processed material that is output of the vaccine preparation and part of a vaccine. vaccine ingredient vaccine-induced cell activation YH lipopolysaccharide vaccine adjuvant A microbial derivative vaccine adjuvant made from bacterial lipopolysaccharide (LPS) of gram-negative bacteria. LPS vaccine adjuvant YH, SGS vaccine-induced antibacterial agglutination antibody response YH Japanese encephalitis virus gene YH Ebola virus gene YH Influenza virus gene YH RNA vaccine Using RNA may eliminate the problem of having to tailor a vaccine for each individual patient with their specific immunity. The advantage of RNA is that it can be used for all immunity types and can be taken from a single cell. DNA vaccines need to produce RNA which then prompts the manufacture of proteins. However, RNA vaccine eliminates the step from DNA to RNA. A vaccine that uses RNA(s) derived from a pathogen organism. YH muramyl dipeptide a synthetic vaccine adjuvant formulated to correspond to a component found in a water-soluble extract of cell walls of mycobacteria used in complete Freund's adjuvant (CFA). YH, SGS PMID: 344799 MDP Dengue virus gene YH colony forming unit CFU WEB: http://en.wikipedia.org/wiki/Colony-forming_unit YH Colony-forming unit (CFU) is a titer measurement of viable bacterial or fungal numbers. Unlike in direct microscopic counts where all cells, dead and living, are counted, CFU measures viable cells. By convenience the results are given as CFU/mL (colony-forming units per milliliter) for water, and CFU/g (colony-forming units per gram) for soil or other porous material. squalene YH, SGS an emulsion vaccine adjuvant that contains an organic polymer with some antigenic epitopes which might be shared with other organic polymers acting as immunostimulators. arlacel A a synthetic vaccine adjuvant that is an emulsifier called Arlacel A. PMID: 2042393 YH, SGS Montanide 103 YH a montanide vaccine adjuvant that is Montanide 103. Bordetella pertussis component vaccine adjuvant a microbial derivitive vaccine adjuvant that contains components from killed Bordetella pertussis. The killed B. pertussis has a strong adjuvant effect on the diphtheria and tetanus toxoids in the DPT vaccines. YH PCV2 vaccine YH conjugate vaccine Conjugate vaccine is vaccine that conjugates/links antigens to the molecules that form the outer coat of disease-causing bacteria to promote an immune response. YH A conjugate vaccine is created by covalently attaching a poor (polysaccharide organism) antigen to a carrier protein (preferably from the same microorganism), thereby conferring the immunological attributes of the carrier on the attached antigen. --from wikipedia. preparation of recombinant vector vaccine YH A vaccine preparation that results in the generation of a recombinant vector vaccine West Nile virus gene YH chickenpox virus gene YH Rubella virus gene YH Hepatitis B virus gene YH Porcilis-PCV2 YH Characteristics: Inactivated baculovirus expressed PCV2 ORF2 protein; adjuvanted Hepatitis A virus gene YH Suvaxyn PCV2 Characteristics: Inactivated PCD1-2 chimera; adjuvanted YH Intervet YH Intervet has merged with Schering-Plough Animal Health and become Intervet/Schering-Plough Animal Health™ (YL.) http://www.intervet.com/ Fort Dodge YH http://www.wyeth.com/divisions/fort_dodge.asp licensed pig vaccine YH contraindication YH a contraindication is a condition or factor that increases the risks involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity. vaccine in research role YH vaccine in research role is a 'regulation-assigned roleof a vaccine that is not licensed or in clinical trial; instead, it is currently in laboratory research. AE: maculopapular rash YH A maculopapular rash is a rash with flat, red area on the skin that is covered with small confluent bumps. This term is a COSTART term but not a MP term (3/17/2009). hemagglutination-inhibition assay an immune response detection assay that detects specific antiviral antibodies in a test serum. The serum, usually a twofold dilution series, is mixed with a standard number, usually 4 to 8 HA units, of virus and incubated prior to the addition of a standard suspension of erythrocytes. The highest dilution of serum that inhibits hemagglutination is the HI titer of the serum. For example, influenza (AI) viruses agglutinate erythrocytes through the interaction of the virus surface glycoprotein, the hemagglutinin (HA), with receptors on the surface of the erythrocyte. Inhibition of the agglutination reaction by HA subtype-specific antisera is the basis of the hemagglutination-inhibition (HI) assay. YH HI assay inactivated YH behavioural inactive (PATO:0001706) AE: arthralgia This term is a COSTART term but not a MP term (3/17/2009). Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. YH hypersensitivity to chicken product YH AE: vesiculobullous rash This term is a COSTART term but not a MP term (3/17/2009). vesiculobullous rash is a blistering rash characterized by serous-fluid-filled vesicles (blisters) YH AE: screaming syndrome YH This term is a COSTART term but not a MP term (3/17/2009). AE: dizziness YH, SS This term is a COSTART term but not a MP term (3/17/2009). Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs. AE: peripheral edema AE: oedema peripheral AE: peripheral edema is an edema thatresults in swelling of tissues, usually in the lower limbs, due to the accumulation of fluids This term is a COSTART term but not a MP term (3/17/2009). YH, SS WEB: http://en.wikipedia.org/wiki/Peripheral_edema AE: edema peripheral hypersensitivity to chicken egg YH vaccine solvent A vaccine solvent is a vaccine component that dissolve vaccine powder into liquid. The vaccine in a powder form has to be reconstituted by mixing vaccine powder with vaccine solvent before administrated. vaccine diluent vaccine liquid diluent YH AE: malaise This term is a COSTART term but not a MP term (3/17/2009). YH Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. AE: somnolence This term is a COSTART term but not a MP term (3/17/2009). drowsiness YH, SS Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia). AE: paresthesia Paresthesia is a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect. It is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic. YH This term is a COSTART term but not a MP term (3/17/2009). AE: paraesthesia AE: crying abnormal This term is a COSTART term but not a MP term (3/17/2009). YH hypersensitivity to antibiotic YH hypersensitivity to neomycin YH hypersensitivity to polymyxin YH reaction to previous vaccination YH vaccine powder vaccine powder is a part of vaccine that contains all vaccine components in solid form. A vaccine can be reconstituted by mixing vaccine powder with vaccine solvent. YH bacterial vaccine preparation YH, ZX A vaccine preparation that results in the generation of a bacterial vaccine chills YH Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold. This term is a COSTART term but not a MP term (3/17/2009). AE: stupor This term is a COSTART term but not a MP term (3/17/2009). Stupor is the lack of critical cognitive function and level of consciousness wherein a sufferer is almost entirely unresponsive and only responds to base stimuli such as pain. The word derives from the Latin stupure, meaning insensible. Being characterised by impairments of reactions to external stimuli, in this case, vaccine immunization. YH AE: anorexia AE: decreased appetite Anorexia is the decreased sensation of appetite. This term is a COSTART term but not a MP term (3/17/2009). anorexia nervosa YH life-threatening reaction to previous vaccination YH AE: face edema AE: face oedema WEB:http://www.nlm.nih.gov/medlineplus/ency/article/003105.htm This term is a COSTART term but not a MP term (3/17/2009). AE: face edema is an edema that results in facial swelling, the build-up of fluid in the tissues of the face. Swelling may also affect the neck and upper arms YH, SS life-threatening reaction to previous influenza vaccination YH AE: cough increased WEB: http://www.nlm.nih.gov/medlineplus/cough.html This term is a COSTART term but not a MP term (3/17/2009). AE: cough increased is an abnormal respiration that results in a reflex that keeps your throat and airways clear YH, SS cough hypersensitivity to gentamicin YH dominant epitope in vaccine YH vaccine-induced down-regulated gene expression YH hypersensitity to gelatin YH preparation of vaccine using heat inactivation YH A vaccine prepraration process that is performed by heat inactivation of virulent pathogen. CFU reduction assay CFU reduction assay is an assay that measures the reduction of the colony forming units of infected pathogens in vaccine-vaccinated animals compared to nonvaccinated animals. YH assay of CFU reduction in spleen YH assay of CFU reduction in spleen is a CFU reduction assay that is measured using the extracted spleen as the tissue for isolation of infected pathogens. hypersensitity to arginine Arginine is a conditionally essential amino acid, meaning most of the time it can be manufactured by the human body, and does not need to be obtained directly through the diet. The biosynthetic pathway however does not produce sufficient arginine, and some must still be consumed through diet. Individuals who have poor nutrition or certain physical conditions may be advised to increase their intake of foods containing arginine. Infants are unable to meet their requirements and thus arginine is nutritionally essential for infants. YH edibility YH, MC Melanie has submitted this term and its two subclasses to obo: http://sourceforge.net/tracker/?func=detail&aid=2873643&group_id=76834&atid=595654 A physical quality inhering in a bearer by virtue of the bearer being fit to be eaten. edible This term may be submitted to PATO. A quality of edibility that inheres in a bearer by virtue of the bearer being suitable for oral ingestion as food, drug, or vaccine. YH vaccine efficacy Vaccine efficacy is an efficacy of a vaccine in induction of protective immune response in vivo or protection against infection of a virulent pathogen. Specifically, vaccine efficacy (VE) is the percentage reduction in disease incidence attributable to vaccination, calculated by means of the following equation: VE(%) = (U - V)/U x 100 where U = the incidence in unvaccinated people and V = the incidence in vaccinated people. Ref: Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. YH history of asthma YH vaccine-induced antiviral neutralizing antibody response YH AE: flu syndrome This term is a COSTART term but not a MP term (3/17/2009). YH peptide of pathogen organism as vaccine component YH peptide of pathogen that is used as vaccine component. This peptide may function as epitope to stimulate protective immunity. AE: syncope This term is a COSTART term but not a MP term (3/17/2009). Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. YH, SS AE: syncope is a sensory capability AE that results in loss of consciousness, fainting fainting WEB: http://en.wikipedia.org/wiki/Syncope_%28medicine%29 AE: sweating According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,301 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). YH vaccination with a licensed cattle vaccine YH usage of bronchodilator YH AE: abdominal pain According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). YH, SS AE: abdominal pain is a pain in abdominal cavity, stomach ache WEB: http://en.wikipedia.org/wiki/Abdominal_pain This term is a COSTART term but not a MP term (3/17/2009). AE: hypertension According to the Vaccine Adverse Event Reporting System (VAERS), 'hypertension' is an adverse event that was mentioned in 1,038 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). blood pressure increased YH, SS MP: MP_0000231 hypertension sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states AE: lab test abnormal YH Intially, 'adverse event' and (is_specified_output_of some 'laboratory test') However, it cannot be inferred right. The reason appears that the is_specified_output_of cannot be another process (here, the AE is defined as a process.) We will think it over. According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,056 VAERS reports (1.6%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: myasthenia myasthenia gravis This term is a COSTART term but not a MP term (3/17/2009). Myasthenia represenats myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'myasthenia' is an adverse event that was mentioned in 1,812 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). vaccine-induced follicular dendritic cell activation YH usage of steroid YH AE: chest pain This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'chest pain' is an adverse event that was mentioned in 1,752 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). sodB(Ft) PMID: 16923916 sodBFt is a live vaccine strain mutant of Francisella tularensis with reduced Fe-superoxide dismutase gene expression. Ref: PMID: 18692537. YH PMID: 18692537 ProtaTek International, Inc www.protatek.com/ Arko Laboratories Ltd www.arkolabs.com/ fungal disease YH fungal vaccine MeSH: D005657 A vaccine that protects against infection with some fungus. YH Newport Laboratories, Inc www.newportlabs.com Texas Agricultural Experiment Station F. tularensis vaccine LVS PMID: 16912944 YH A live attenuated Francisella tularensis vaccine. It is available in American Type Culture Collection with ATCC ID: 29684. PMID: 8757866 AE: exacerbation of underlying condition According to the Vaccine Adverse Event Reporting System (VAERS), 'exacerbation of underlying condition' is an adverse event that was mentioned in 1,606 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH vaccine-induced T cell interferon-gamma production AE: insomnia Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity. Insomnia is a symptom, not a stand-alone diagnosis or a disease. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'insomnia' is an adverse event that was mentioned in 1,526 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: twitching Involuntary sudden movement of part of the body. According to the Vaccine Adverse Event Reporting System (VAERS), 'twitching' is an adverse event that was mentioned in 1,511 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: febrile seizure According to the Vaccine Adverse Event Reporting System (VAERS), 'febrile seizure' is an adverse event that was mentioned in 1,490 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: asthma Asthma is a common chronic lung disease. It has been defined by the National Heart, Lung and Blood Institute as a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm), and an underlying inflammation. According to the Vaccine Adverse Event Reporting System (VAERS), 'asthma' is an adverse event that was mentioned in 1,373 VAERS reports (1.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH vaccine function YH, MC, XZ, and AR PERSPN: Oliver He: There has been hot discussion about whether we use 'vaccine function' or 'vaccine role'. Vaccine role may not be the good term to use. Vaccine is designed to be 'vaccine', so it should be vaccine function. One special case is cowpox virus. The cowpox virus can be mixed with some liquid like water and used as a smallpox vaccine. In this case, people often say: the cowpox virus has a 'vaccine role'. However, the cowpox virus vaccine is a processed material of a mix of the virus with water. The virus is a virus, it is not a vaccine per se. Therefore, vaccine role may not be an accurate term. vaccine function is a function that inheres in a vaccine that induces protective immune response against a disease. It is realized in the immunization process in the host. AE: neck pain This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'neck pain' is an adverse event that was mentioned in 1,323 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). AE: positive rechallenge In contrast, positive dechallenge occurs when the adverse reaction disappears once the drug is stopped. Positive rechallenge occurs when the adverse reaction re-emerges once a drug (e.g., vaccine) is restrarted. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'positive rechallenge' is an adverse event that was mentioned in 1,292 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH heat killed pathogen in vaccine YH AE: back pain YH According to the Vaccine Adverse Event Reporting System (VAERS), 'back pain' is an adverse event that was mentioned in 1,277 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). herpesvirus vaccine vector YH AE: alopecia MP: MP_0000414 VAE According to the Vaccine Adverse Event Reporting System (VAERS), 'alopecia'; is an adverse event that was mentioned in 260 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition alopecia AE: gastrointestinal hemorrhage According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal hemorrhage'; is an adverse event that was mentioned in 183 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000465 bleeding in the stomach and/or the intestines vaccine-induced host gene response YH vaccine-induced host immune response YH vaccine-induced host response a processual entity that specifies host response to a vaccine. YH host response to vaccine adjuvant YH a process that specifies host response to a vaccine adjuvant. host response to vaccine component a processual entity that specifies host response to a vaccine component. YH host response to vaccine antigen a process that specifies host response to a vaccine antigen. YH host response to vaccine vaccine vector a process that specifies host response to a vaccine vector. YH AE: eyes gaze upward According to the Vaccine Adverse Event Reporting System (VAERS), 'eyes gaze upward' is an adverse event that was mentioned in 1,249 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH AE: neuropathy This term is a COSTART term but not a MP term (3/17/2009). peripheral neuropathy Neuropathy is a medical term describing disorders of the nerves of the peripheral nervous system (specifically excluding encephalopathy and myelopathy, which refer to the central nervous system.) It is usually considered equivalent to peripheral neuropathy. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'neuropathy' is an adverse event that was mentioned in 1,154 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). human immunodeficiency virus vaccine AIDS vaccine YH MeSH: D016915 HIV vaccine A viral vaccine that protects against infection with human immunodeficiency virus that causes AIDS. Brinton Laboratories Inc AE: skin nodule According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' is an adverse event that was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: arthrosis According to the Vaccine Adverse Event Reporting System (VAERS), 'arthrosis' is an adverse event that was mentioned in 1,129 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). A degenerative disease of a joint. Arthrosis is an articular illness that produces fibrosis or degeneration of the cartilage. YH company YH Brucella melitensis strain VTRM1 YH AE: hypokinesia YH Hypokinesia refers to slow or diminished movement of body musculature. AE: muscle twitching muscle contraction muscle fasciculation YH Brucella suis strain VTRS1 YH PMID: 17428946 B. suis VTRS1 AE: skin discoloration AE: skin discoloration is a skin adverse event that results in change in color of skin or mucus membranes According to the Vaccine Adverse Event Reporting System (VAERS), 'skin discoloration' is an adverse event that was mentioned in 909 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH, SS AE: skin discolouration AE: herpes zoster This term is a COSTART term but not a MP term (3/17/2009). zoster shingles Herpes zoster is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox, and generally occurs in children and young people. Once an episode of chickenpox has resolved, the virus is not eliminated from the body but can go on to cause shingles (an illness with very different symptoms) often many years after the initial infection. According to the Vaccine Adverse Event Reporting System (VAERS), 'herpes zoster' is an adverse event that was mentioned in 892 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH AE: laryngismus This term is a COSTART term but not a MP term (3/17/2009). YH sudden laryngeal spasm with crowing inhalation and cyanosis. It is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. laryngospasm According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngismus' is an adverse event that was mentioned in 881 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). KKF24 YH PMID: 16552035 KKF24 is a recombinant strain of Francisella novicida U112 with iglC mutation (F. novicida delta-iglC::ermC). PMID: 14680699. F. tularensis vaccine LVS LPS YH F. tularensis vaccine LVS lipopolysaccharide PMID: 10722593 vaccine-induced antibody mediated immune response immunoglobulin mediated immune response to vaccine YH vaccine emulsifier a vaccine additive that serves as an emulsifier, i.e., a chemical additives that encourages the suspension of vaccine substances in a solution. WEB: http://www.ncbi.nlm.nih.gov/pubmed/15246616 YH, YL B. melitensis lipopolysaccharide vaccine YH B. melitensis LPS-GBOMP noncovalent complex vaccine PMID: 8723881 B. melitensis LPS-GBOMP subunit vaccine YH AE: speech disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'speech disorder' is an adverse event that was mentioned in 848 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: hemorrhage MP: MP_0001914 According to the Vaccine Adverse Event Reporting System (VAERS), 'hemorrhage' is an adverse event that was mentioned in 338 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). hemorrhage loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels inactivated vaccine killed vaccine A whole organism vaccine that is inactivated with chemicals or heat. YH inactivated organism vaccine AE: neck rigidity YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'Neck rigidity' is an adverse event that was mentioned in 829 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). AE: Guillain-Barre syndrome AE: GBS YH, SS This term is a COSTART term but not a MP term (3/17/2009). Guillain-Barre syndrome is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances, the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until the muscles cannot be used at all and the patient is almost totally paralyzed. In these cases, the disorder is life-threatening and is considered a medical emergency. Usually Guillain-Barre occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. Reference: http://www.ninds.nih.gov/disorders/gbs/gbs.htm. According to the Vaccine Adverse Event Reporting System (VAERS), Guillain-Barre yndrome is an adverse event that was mentioned in 820 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). AE: nausea and vomiting This term will most likely removed since it is just a combination of nausea and vomiting. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'nausea and vomiting' is an adverse event that was mentioned in 812 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: sudden infant death This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). AE: fever with chills This term is a COSTART term but not a MP term (3/17/2009). AE: chills and fever successive stages of chills and fever. This is a symptom of malaria. According to the Vaccine Adverse Event Reporting System (VAERS), 'chills and fever' is an adverse event that was mentioned in 722 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). YH Brucella abortus DNA vaccine encoding BCSP31, SOD and L7/L12 YH B. abortus DNA vaccine expressing BCSP31, SOD and L7/L12 PMID: 17570767 AE: personality disorder YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'personality disorder' is an adverse event that was mentioned in 678 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). Brucella abortus subunit vaccine using L7/L12 YH PMID: 8873388 recombinant B. abortus L7/L12 vaccine AE: lung disorder YH According to the Vaccine Adverse Event Reporting System (VAERS), 'lung disorder' is an adverse event that was mentioned in 614 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). B. melitensis DNA vaccine encoding Omp31 PMID: 17428946 YH muscle adverse event YH AE: liver/biliary system disorder YH AE: enlarged liver MP: MP_0000599 According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatomegaly'; is an adverse event that was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). enlarged liver larger than average size of the liver Mycoplasma hyopneumoniae vaccine YL bacterial vaccine that protect against Mycoplasma hyopneumoniae infection inedible YH, MC A quality of edibility that inheres in a bearer by virtue of the bearer being not suitable for oral ingestion. AE: meningitis Meningitis is a medical condition caused by inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases. According to the Vaccine Adverse Event Reporting System (VAERS), 'meningitis' is an adverse event that was mentioned in 592 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH tertiary vaccination YH, Thom Todd tertiary vaccination is a vaccination that is performed at the third time in a row. Protozoa YL Protozoa are a diverse group of unicellular eukaryotic organisms,[1] many of which are motile. Originally, protozoa had been defined as unicellular protists with animal-like behavior, e.g., movement. Protozoa were regarded as the partner group of protists to protophyta, which have plant-like behaviour, e.g., photosynthesis.(http://en.wikipedia.org/wiki/Protozoa) digestive system AE YH vaccine injection site YH AE: facial paralysis YH According to the Vaccine Adverse Event Reporting System (VAERS), 'facial paralysis' is an adverse event that was mentioned in 580 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). AE: confusion According to the Vaccine Adverse Event Reporting System (VAERS), 'confusion' is an adverse event that was mentioned in 579 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH Brucella melitensis bp26 deletion vaccine Brucella CGV26 PMID: 16519974 CGV26 YH A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the bp26 deletion. It has similar vaccien efficacy to Rev. 1. Its advantage compared to Rev. 1 is that this feature of bp26 deletion promotes diagnosis. PMID: 17070627. F. tularensis vaccine FSC043 A spontaneous mutant of the SCHU S4 strain that protects against virulent F. tularensis infection. PMID: 16299332. PMID: 16299332 YH intramuscular route intramuscular injection route YH,YL I.M. a route of administration that inject the material(such as vaccines, allergens) directly into a muscle. intranasal route rounte of administration that located in nose. I.N. YH intranasal route by drop YH intranasal route by spray YH intraperitoneal route YL YH a route of administration that located in the peritoneum. Brucella melitensis WR201 YH AE: joint disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'joint disorder' is an adverse event that was mentioned in 562 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). Brucella abortus bacA mutant YH PMID: 17196866 B. abortus bacA mutant Influenza A (H1N1) 2009 Monovalent Vaccine (CSL Limited) Influenza A (H1N1) 2009 Monovalent Vaccine ( MedImmune LLC) Arepanrix MC, YH Adjumer PCPP salt SGS A synthetic vaccine adjuvant that is PCPP salt. polyidi (carboxylatophenoxy) lphosphazene PMID: 75551218 polyphosphazene Megan Egg WEB: http://www.fda.gov/ohrms/dockets/dockets/00n0504/00N-0504_emc-001650-02.pdf Megan Egg is a Salmonella vaccine that that consists of a double gene-deleted S. enterica serovar Typhimurium strain and is formulated fro immunization of pullets. Megan Egg contains the same Megan Vac1 organism but Megan Vac1 is used for younger birds (broilers). YH AE: eye disorder YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'eye disorder' is an adverse event that was mentioned in 543 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). B. ovis microparticle subunit vaccine PMID: 16481077 YH AE: autism This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'autism' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Autism is a brain development disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. AE: sedimentation rate increased erythrocyte sedimentation rate ESR Sedimentation rate is a diagnostic test for inflammation. The test measures the rate at which red blood cells fall to the bottom of a tube over time. An increased sedimentation rate corresponds to increased non-specific inflammation in the body. It is often called "sedrate" for short. YH This term should be inferred to lab test abnormal. sedrate According to the Vaccine Adverse Event Reporting System (VAERS), 'sedimentation rate increased' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). AE: red blood cell sedimentation rate increased AE: red blood cell sedimentation rate increased is an AE: sedimentation rate increased that has an increase in rate at which red blood cells precipitate in a period of 1 hour. This term is a COSTART term but not a MP term (3/17/2009). AE: accidental injury According to the Vaccine Adverse Event Reporting System (VAERS), 'accidental injury' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH an injury that occurs accidentally. Brucella recombinant SurA protein vaccine Brucella rSurA protein vaccine Brucella recombinant SurA protein YH PMID: 17686554 lentivirus vaccine vector YH AE: amblyopia According to the Vaccine Adverse Event Reporting System (VAERS), 'amblyopia' is an adverse event that was mentioned in 507 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH vaccine-induced leukocyte activation YH USA licensed human vaccine YH a human vaccine with license that is commercially used in the USA. licensed vaccine A vaccine that is licensed for commercial use. YH AE: mental retardation YH According to the Vaccine Adverse Event Reporting System (VAERS), 'mental retardation' is an adverse event that was mentioned in 498 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). lipopolysaccharide of pathogen organism as vaccine component YH liposome-based vaccine adjuvant YH a vaccine adjuvant that contains particles made up of concentric lipid membranes containing phospholipids and other lipids in a bilayer configuration separated by aqueous compartments. It is a relatively stable but non-covalently-bound complex of saponin adjuvant Quil-A, cholesterol and amphipathic antigen in a molar ratio of approximately 1:1:1. The spectrum of viral capsid antigens and non-viral amphipathic antigens of relevance for human vaccination, incorporated into ISCOMs, comprises influenza, measles, rabies, gp340 from EB-virus, gp120 from HIV, Plasmodium falciparum and Trypanosoma cruzi. Ref: http://www.vaccination.inoz.com/adjuvants.html. live attenuated vaccine A live vaccine that is made from microbes that have been attenuated (weakened) in the laboratory so that they can't cause disease. attenuated vaccine YH live pathogen organism as vaccine component YH live vaccine A whole organism vaccine that is liive. YH live virulent vaccine YH quaternary vaccination quaternary vaccination is a vaccination that is performed at the fourth time in a row. YH, Thom Todd AE: erythema multiforme YH brain inflammation local accumulation of fluid, plasma proteins, and leukocytes in the brain According to the Vaccine Adverse Event Reporting System (VAERS), 'erythema multiforme' is an adverse event that was mentioned in 483 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). Brucella recombinant DnaK protein vaccine YH PMID: 17686554 divalent DNA B. abortus vaccine using L7/L12 and Omp16 PMID: 16622210 YH AE: SGOT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGOT increased' is an adverse event that was mentioned in 477 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). Increased level of SGOT. SGOT respresents serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. SGOT is also called aspartate aminotransferase (AST). AE: SGPT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGPT increased' is an adverse event that was mentioned in 459 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH Increased level of SGPT. SGPT represents serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. SGPT is also called alanine aminotransferase (ALT). AE: thinking abnormality YH According to the Vaccine Adverse Event Reporting System (VAERS), 'thinking abnormality' is an adverse event that was mentioned in 457 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: dyspepsia This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'dyspepsia' is an adverse event that was mentioned in 454 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Dyspepsia is popularly known as indigestion, meaning hard or difficult digestion. It is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating. AE: anaphylactoid reaction This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'anaphylactoid reaction' is an adverse event that was mentioned in 452 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). is an acute systemic (multi-system) and very severe Type I Hypersensitivity allergic reaction in humans and other mammals. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. AE: gastrointestinal disorder YH According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: previous reaction This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'previous reaction' is an adverse event that was mentioned in 442 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH AE: serum sickness Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'serum sickness' is an adverse event that was mentioned in 428 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). AE: injection-site abscess YH According to the Vaccine Adverse Event Reporting System (VAERS), 'injection-site abscess' is an adverse event that was mentioned in 426 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: abnormal electroencephalogram YH According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal electroencephalogram' is an adverse event that was mentioned in 420 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). Abnormal results of electroencephalography (EEG). EEG is the recording of electrical activity along the scalp produced by the firing of neurons within the brain. In clinical contexts, EEG refers to the recording of the brain's spontaneous electrical activity over a short period of time, usually 20-40 minutes, as recorded from multiple electrodes placed on the scalp. In neurology, the main diagnostic application of EEG is in the case of epilepsy, as epileptic activity can create clear abnormalities on a standard EEG study. A secondary clinical use of EEG is in the diagnosis of coma and encephalopathies. EEG used to be a first-line method for the diagnosis of tumors, stroke and other focal brain disorders, but this use has decreased with the advent of anatomical imaging techniques such as MRI and CT. Brucella abortus DNA vaccine encoding L7/L12 and P39 PMID: 16537031 B. abortus DNA vaccine encoding L7/L12 and P39 YH attenuated Brucella abortus with deletion of znuA PMID: 16790759 YH mucosal immune response to vaccine YH E. coli LT toxin derived vaccine adjuvant a microbial derivative vaccine adjuvant that is derived from E. coli heat labile toxin LT. YH, SGS Feline panleukopenia virus vaccine generated using OntoRat YL viral vaccine that is used to protect against Feline panleukopenia virus infection birds vaccine Vaccine that used for immunizing birds. YL Leptospira spp. vaccine bacterial vaccine that is used to protect against Leptospira spp. infection YL generated using OntoRat Campylobacter fetus vaccine bacterial vaccine that is used to protect against Campylobacter fetus infection generated using OntoRat YL Pseudomonas aeruginosa vaccine bacterial vaccine that is used to protect against Pseudomonas aeruginosa infection YL generated using OntoRat Bordetella bronchiseptica vaccine bacterial vaccine that is used to protect against Bordetella bronchiseptica infection generated using OntoRat YL inactive or killed pathogen organism in vaccine licensed rabbit vaccine neutralizing antibody role YH microencapsulated B. melitensis mutant vaccine A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant vjbR::Tn5 (BMEII1116) delivered using alginate microspheres that is coated with a protein of the parasite Fasciola hepatica (vitelline protein B [VpB]). PMID: 18362129. YH A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant delivered using a microsphere delivery system. PMID: 18362129 AE: vertigo Vertigo is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings. The effects of vertigo may be slight. It can cause nausea and vomiting and, in severe cases, it may give rise to difficulties with standing and walking. This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'vertigo' is an adverse event that was mentioned in 412 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). AE: heart arrest According to the Vaccine Adverse Event Reporting System (VAERS), 'heart arrest' is an adverse event that was mentioned in 410 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). cardiac arrest cardiopulmonary arrest asystole This term is a COSTART term but not a MP term (3/17/2009). heart arrest is the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole. YH circulatory arrest AE: bronchitis Bronchitis is an inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes. YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'bronchitis' is an adverse event that was mentioned in 407 VAERS reports 0.3%) during1991-2001 (Reference: PMID: 12825543). AE: grand malconvulsion According to the Vaccine Adverse Event Reporting System (VAERS), 'grand malconvulsion' is an adverse event that was mentioned in 402 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). This term is a COSTART term but not a MP term (3/17/2009). porin-S-LPS from B. abortus strain 2308 YH complex of porin and S-LPS from B. abortus strain 2308 PMID: 2844673 Brucella abortus RB51WboA PMID: 15327798 B. abortus RB51WboA YH AE: liver function tests abnormal According to the Vaccine Adverse Event Reporting System (VAERS), 'liver function tests abnormal' is an adverse event that was mentioned in 717 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000609 aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage AE: ear disorder This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'ear disorder' is an adverse event that was mentioned in 362 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH recombinant O. anthropi 49237SOD YH PMID: 11953393 organ or tissue specific immune response to vaccine YH licensed horse vaccine YH AE: infect viral viral infection This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'infect viral' is an adverse event that was mentioned in 358 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH, SS WEB: http://en.wikipedia.org/wiki/Viral_infection AE: infect viral is an infection that results in detrimental colonization of a host organism by virus B. melitensis Bp26 and Tf protein vaccine YH PMID: 17239499 B. melitensis Bp26 and trigger factor B. melitensis P39 recombinant protein vaccine PMID: 11447155 YH A Brucella subunit vaccine that uses recombinant Brucella melitensis 16M P39, a putative periplasmic binding protein. PMID: 11447155. recombinant chimera BLSOmp31 YH PMID: 17442465 rBLSOmp31 Panvax Panvax is an H1N1 unadjuvanted monovalent vaccine. MC, YH WEB: http://www.infowars.com/h1n1-panvax-training-powerpoint-received-by-health-care-workers-in-australia/ vaccine additive role YL,YH Page 73, Chapter 6, Vaccine, 5th Edition. EXPERT CONSULT by Plotkin SA., et. al. 2008 a role inheres in a material entity, that has been added into a vaccine's formulation by the manufacture for a specific purpose. For example: adjuvant to enhance the effect of immunogen, perservatives, stablizers and those materials added for affecting PH and isotonicity. intravenous route route of administration that is located in the vein YH, Thom Todd i.v. protozoan vaccine A vaccine that protects against some protozoan disease. parasitic vaccine parasite vaccine MeSH: D016052 YH AE: lacrimation disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'lacrimation disorder' is an adverse event that was mentioned in 334 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). Disorder of lacrimation. Lacrimation is the production, secretion, and shedding of tears. YH This term is a COSTART term but not a MP term (3/17/2009). AE: jaundice AE: icterus MP: MP_0000611 SS, YH WEB: http://en.wikipedia.org/wiki/Jaundice According to the Vaccine Adverse Event Reporting System (VAERS), 'jaundice' is an adverse event that was mentioned in 317 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes jaundice pathogen organism component in vaccine YH a vaccine component that originates from an organism such as a pathogen or a modified organism. Brucella abortus pcDNA-BLS B. abortus pcDNA-BLS YH AE: abscess An abscess is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue on the basis of an infectious process (usually caused by bacteria or parasites) or other foreign materials (e.g. splinters, bullet wounds, or injecting needles). It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body. YH This term is a COSTART term but not a MP term (3/17/2009). abscessus According to the Vaccine Adverse Event Reporting System (VAERS), 'abscess' is an adverse event that was mentioned in 318 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). escheriosome-mediated delivery of B. abortus L7/L12 escheriosome-encapsulated B. abortus L7/L12 YH PMID: 17931756 AE: eye pain This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'eye pain' is an adverse event that was mentioned in 316 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). palpitation YH According to the Vaccine Adverse Event Reporting System (VAERS), 'palpitations' is an adverse event that was mentioned in 313 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). A palpitation is an abnormal awareness of the beating of the heart, whether it is too slow, too fast, irregular, or at its normal frequency. This term is a COSTART term but not a MP term (3/17/2009). period of persistence of vaccine induced immune response period of persistence of vaccine induced immune response is a temporal interval during which a vaccine-induced immune response continuously exists. This term is related to the process 'persistence of vaccine induced immune response'. YH, MC phase 1 vaccine trial YH A vaccine clinical trial that investigates the safety profile of a vaccine in a small group (10-50) of healthy volunteers. phase 2 vaccine trial YH A vaccine clinical trial that studies vaccine efficacy with a target population (numbering 50-100). Different dosage levels will also be explored at this stage to determine the optimum dose. phase 3 vaccine trial YH A vaccine clinical trial that takes the trial to a large-scale safety and efficacy study in a relevant patient population, usually in excess of 3,000. phase 4 vaccine trial YH The final stage of vaccine clinical evaluation. Phase IV occurs after a vaccine or therapy is licensed and is being used by large numbers of people. These studies are not always required or completed. rLm/iglC Seven F. tularensis proteins including IglC (rLm/iglC) were expressed in recombinant L. monocytogenes (rLm) vaccines. These 7 F. tularensis proteins are: AcpA, Bfr, DnaK, GroEL, IglC, Pld and KatG from SchuS4 strain. YH nontypeable H. influenzae Hap Protein Vaccine PMID: 15557618 YH A subunit nontypeable H. influenzae vaccine that uses Hap protein. AE: tongue edema AE: tongue oedema According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue edema'; is an adverse event that was mentioned in 310 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: ear pain According to the Vaccine Adverse Event Reporting System (VAERS), 'ear pain'; is an adverse event that was mentioned in 302 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). plasmid vaccine vector YH B. melitensis DNA vaccine encoding Omp31 boosted with Omp31 pCIBLSOmp31 YH AE: angioedema This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'angioedema'; is an adverse event that was mentioned in 296 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). Angioedema is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermis. AE: rheumatoid arthritis According to the Vaccine Adverse Event Reporting System (VAERS), 'rheumatoid arthritis'; is an adverse event that was mentioned in 295 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body YH Salmonella spp. vaccine generated using OntoRat YL bacterial vaccine that is used to protect against Salmonella spp. infection vaccine approval process WEB: http://www.examiner.com/x-7707-Infectious-Disease-Examiner~y2009m9d15-News-Release-H1N1-vaccines-get-FDA-approval-expected-to-be-available-in-4-weeks @2009/10/06. H1N1 vaccines get FDA approval. Food and Drug Administration announced today that it has approved four vaccines against the 2009 H1N1 influenza virus. Obtaining FDA licensure of this vaccine for A (H1N1) pandemic response is a key milestone that will enable Sanofi Pasteur to provide a licensed vaccine to the U.S. government to support pandemic immunization efforts YH, ZX, AR, and MC WEB: http://energycommerce.house.gov/images/stories/Documents/PDF/publications/109_health.pdf @2009/10/06. This is the US Health Law which includes a section about vaccine. vaccine product approval process WEB: http://news.prnewswire.com/ViewContent.aspx?ACCT=109&STORY=/www/story/09-15-2009/0005094621&EDATE @2009/10/06 vaccine approval process is a processual entity that involves approval of a vaccine. WEB: http://www.hhs.gov/nvpo/factsheets/fs_tableII_doc2.htm @2009/10/06 #Following the FDA's review of a license application, the sponsor and the FDA may present their findings to the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC). This non-FDA expert committee (scientists, physicians, biostatisticians, and a consumer representative) provides advice to the Agency regarding the safety and efficacy of the vaccine for the proposed indication. vaccine candidate role BP, YH vaccine candidate role is the role of a material entity in an investigation, which is tested for its capability to serve as a vaccine. This role should be a subclass of 'test substance role', which will be mireoted from OBI by OntoFox. CFU measurement assay CFU measurement assay is an assay that measures the colony forming unit (CFU) of a bacterium in a specific location (e.g., spleen of a mouse). YH, MC vaccine effectiveness rate vaccine effectiveness rate is a measurement datum that measues the vaccine effectiveness. It is assessed with respect to prevention of the disease against which the vaccine is given. One simple method to estimate vaccine effectiveness is to use routine data on notifications of disease cases in vaccinated and unvaccinatted children and to compare the porportion of cases vaccinated with the vaccine covervage among the same age group in the general population. If p is the proportion vaccinated in the population and c is the proportion of cases reported to be vaccinated, then VE = (p-c)/p(1-c) x 100%. Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. YH, MC WEB: http://en.wikipedia.org/wiki/Influenza_vaccine vaccine licensing YH, ZX vaccine licensing is a vaccine approval process that involves in licensing a vaccine. licensed chicken vaccine YH, XZ poxvirus vaccine vector YH AE: immune system disorder YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder'; is an adverse event that was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: antinuclear antibody present This term is a COSTART term but not a MP term (3/17/2009). anti-nuclear factor present YH The presence of anti-nuclear antibodies (ANAs) that are antibodies directed against contents of the cell nucleus. ANAs are present in higher than normal numbers in autoimmune disease. The ANA test measures the pattern and amount of autoantibody which can attack the body's tissues as if they were foreign material. Autoantibodies are present in low titers in the general population, but in about 5% of the population, their concentration is increased, and about half of this 5% have an autoimmune disease. According to the Vaccine Adverse Event Reporting System (VAERS), 'antinuclear antibody present'; is an adverse event that was mentioned in 288 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). NPAP Brucella vaccine Brucella vaccine using nonpathogenic alphaproteobacteria PMID: 17715332 YH AE: myelitis This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'myelitis'; is an adverse event that was mentioned in 280 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). Myelitis is a disease involving inflammation of the spinal cord, which disrupts central nervous system functions linking the brain and limbs. YH preventive vaccine function preventive vaccine function is a vaccine function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which protects against a specific disorder. YH prophylactic vaccine function prime boost regimen YH APEC vaccine using GST-Iss fusion protein YH Colibacillosis, caused by avian pathogenic Escherichia coli (APEC), is a major problem for the poultry industry in the world. prophylactic vaccine a vaccine that is used for prevention against a disease. YH protection efficacy Protection efficacy is an efficiency that is associated with protection by a biological product (e.g., vaccine) against a disease. YH protective antigen role YH Protective antigen is an antigen that stimulates protective immunity when used in vivo. E. coli LB-T vaccine E. coli heat-labile enterotoxin B-subunit (LB-T) vaccine PMID: 11500434 YH E. coli O157:H7 subunit vaccine expressing Esps and Tir PMID: 14670317 YH AE: migraine A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit. This term is a COSTART term but not a MP term (3/17/2009). migraine headache According to the Vaccine Adverse Event Reporting System (VAERS), 'migraine'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH AE: thrombocytopenic purpura Thrombocytopenic purpura are purpura associated with a reduction in circulating blood platelets which can result from a variety of causes. YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenic purpura'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: multiple sclerosis Multiple sclerosis is an autoimmune condition in which the immune system attacks the central nervous system, leading to demyelination. YH MS This term is a COSTART term but not a MP term (3/17/2009). encephalomyelitis disseminata disseminated sclerosis According to the Vaccine Adverse Event Reporting System (VAERS), 'multiple sclerosis'; is an adverse event that was mentioned in 264 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: amnesia Amnesia is a short term memory condition in which memory is disturbed. In simple terms it is the loss of memory. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'amnesia'; is an adverse event that was mentioned in 262 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH protein of pathogen organism as vaccine component YH AE: incoordination YH a lack of normal adjustment of muscular action so that the intended movement of the limb or other part is not made smoothly and harmoniously, and does not accurately achieve its objective. If the abnormality is hypermetric, the condition is referred to as ataxia. If it is inclined to weakness, e.g. knuckling at the turn, stumbling, failure to flex limbs properly, or to misdirection as in a proprioceptive deficit, it is called incoordination. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'incoordination'; is an adverse event that was mentioned in 261 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). soybean-expressed E. coli LTB vaccine YH PMID: 17188785 AE: voice alteration This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'voice alteration'; is an adverse event that was mentioned in 259 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH AE: abortion WEB: http://en.wikipedia.org/wiki/Abortion This term is a COSTART term but not a MP term (3/17/2009). AE: abortion is a reproductive system AE that is the termination of a pregnancyby the removal or expulsion from the uterus of a fetus or embryo, resulting in or caused by its death. YH, SS According to the Vaccine Adverse Event Reporting System (VAERS), 'abortion'; is an adverse event that was mentioned in 257 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: shock According to the Vaccine Adverse Event Reporting System (VAERS), 'shock'; is an adverse event that was mentioned in 253 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). mental shock acute stress reaction psychological shock Mental shock (or shock) is a psychological condition arising in response to a terrifying event. It should not be confused with the unrelated circulatory condition of shock. This term is a COSTART term but not a MP term (3/17/2009). acute stress disorder YH AE: purpura YH Purpura is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This is common with typhus and can be present with meningitis caused by meningococcal meningitis or septicaemia. Reference: http://en.wikipedia.org/wiki/Purpura. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'purpura'; is an adverse event that was mentioned in 251 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). nontypeable H. influenzae vaccine YH nontypeable Haemophilus influenzae NTHi Nontypeable Haemophilus influenzae (NTHi) is a nonencapsulated Haemophilus influenzae (a gram-negative bacterium). It is the cause of a number of human respiratory tract diseases, such as otitis media, sinusitis, bronchitis, and pneumonia. YH non-typeable H. influenzae rLP4/rLP6 and Moraxella catarrhalis UspA2 protein vaccine YH rLP4/rLP6/UspA2 PMID: 15308371 killed nontypeable H. influenzae whole-cell vaccine PMID: 1953532 PMID: 2867396 YH PMID: 2184330 PMID: 1859055 AE: bacterial infection event AE: bacterial infection event is an infection that results in detrimental colonization of a host organism by bacteria AE: bacterial infection This term is a COSTART term but not a MP term (3/17/2009). WEB: http://en.wikipedia.org/wiki/Bacterial_infection According to the Vaccine Adverse Event Reporting System (VAERS), 'bacterial infection'; is an adverse event that was mentioned in 250 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH, SS radiated pathogen as vaccine component YH AE: skin striae Skin striae are irregular areas of skin that look like bands, stripes, or lines. Striae are seen when a person grows or gains weight rapidly or has certain diseases or conditions. striae distensae YH According to the Vaccine Adverse Event Reporting System (VAERS), 'skin striae'; is an adverse event that was mentioned in 247 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). stretch marks E. coli vaccine using intimin polypeptide YH PMID: 14688094 PMID: 17258324 nontypeable H. influenzae cell membrane vaccine (CM-Hi) PMID: 10353870 YH nontypeable H. influenzae LOS-TT conjugate vaccine YH PMID: 12706701 Nontypeable H. influenzae lipooligosaccharide-tetanus toxoid conjugate vaccine PMID: 9353024 E. coli subunit vaccine using IroN PMID: 17145948 YH preparation of recombinant protein vaccine A vaccine preparation process that uses recombinant molecular technology to prepare recombinant protein. YH protein subunit vaccine A subunit vaccine that is made using recombinant DNA technology to engineer the antigen molecules of the particular microbe. YH recombinant vector vaccine A vaccine that uses a modified virus or bacterium to deliver genes that code for microbial antigens to cells of the body. YH E. coli subunit vaccine using CO393 YH PMID: 17145948 vaccination with a licensed pig vaccine YH AE: acute brain syndrome According to the Vaccine Adverse Event Reporting System (VAERS), 'acute brain syndrome'; is an adverse event that was mentioned in 240 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). E. coli subunit vaccine using FyuA PMID: 17258324 PMID: 14688094 YH vaccination with a licensed horse vaccine YH immunization WEB: http://en.wikipedia.org/wiki/Immunization immunization is a processual entity that primes or modifies an adaptivie immune response to some antigens. YH, XZ, BP active immunization WEB: http://en.wikipedia.org/wiki/Immunization Active immunization is an immunization process that entails the introduction of a foreign molecule into the body, which causes the body itself to generate adaptive immunity against the target. Active immunization entails the introduction of a foreign molecule into the body, which causes the body itself to generate immunity against the target. This immunity comes from the T cells and the B cells with their antibodies. Active immunization can occur naturally when a person comes in contact with, for example, a microbe. If the person has not yet come into contact with the microbe and has no pre-made antibodies for defense (like in passive immunization), the person becomes immunized. The immune system will eventually create antibodies and other defenses against the microbe. The next time, the immune response against this microbe can be very efficient; this is the case in many of the childhood infections that a person only contracts once, but then is immune. Artificial active immunization is where the microbe, or parts of it, are injected into the person before they are able to take it in naturally. If whole microbes are used, they are pre-treated, Attenuated vaccine. (Wikipedia) YH, XZ passive immunization WEB: http://en.wikipedia.org/wiki/Immunization YH, XZ Currently, antibodies can be used for passive immunization. This method of immunization works very quickly. However, it is short lasting. The antibodies are naturally broken down. If there are no B cells to produce more antibodies, they will disappear. Passive immunization is an immunization process where pre-synthesized elements of the immune system are transferred to an organism so that the body does not need to produce these elements itself. natural active immunization YH, XZ WEB: http://en.wikipedia.org/wiki/Immunization natural active immunization is an active immunization that occur naturally when a person or animal comes in contact with antigens includeing microbes. vaccine immunization YH, XZ WEB: http://en.wikipedia.org/wiki/Immunization artificial active immunization artificial active immunization is an active immunization that occurs when a person or animal is vaccinated with a specific vaccine. induction of adaptive immune response to antigen induction of adaptive immune response to antigen is an active immunization process that results in induction of adaptive immune response to some antigens, for example, in a vaccine. YH, XZ disorder prevention disorder prevention is a processual entity that prevents a disorder that is the physical basis of a disease. YH, XZ disorder treatment disorder treatment is a processual entity that leads to treat a disorder that is the physical basis of a disease. YH, XZ modification of adaptive immune response to antigen modification of adaptive immune response to antigen is an active immunization process that results in modification of an adaptive immune response to some antigens, for example, in a therapeutic vaccine. YH, XZ preventive infectious disease vaccine function YH, XZ infection disorder prevention YH, XZ infection disorder prevention is a process that prevents a disorder that is the physical basis of an infectious disease. E. coli vaccine using verocytotoxin toxoid PMID: 17145948 YH Inactivated ETEC expressing expressing CFA/I and CFA/II YH PMID: 1612730 coma YH Coma is a profound state of unconsciousness. A comatose person cannot be awakened, fails to respond normally to pain or light, does not have sleep-wake cycles, and does not take voluntary actions. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'coma'; is an adverse event that was mentioned in 230 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: hyperkinesia YH Hyperkinesia is an abnormal increase in muscular activity. According to the Vaccine Adverse Event Reporting System (VAERS), 'hyperkinesia'; is an adverse event that was mentioned in 227 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). EHEC O157 subunit vaccine using his-tagged N-terminal intimin YH PMID: 1612730 AE: cardiovascular disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'cardiovascular disorder'; is an adverse event that was mentioned in 225 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: encephalopathy According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalopathy'; is an adverse event that was mentioned in 224 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). Encephalopathy is disorder or disease of the brain. YH This term is a COSTART term but not a MP term (3/17/2009). AE: urine abnormality This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'urine abnormality'; is an adverse event that was mentioned in 223 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH nontypeable H. influenzae P5 peptide MVF/H3 vaccine YH PMID: 10603411 nontypeable H. influenzae rTbpB vaccine YH PMID: 10225866 ETEC vaccine ACAM2007 ACAM2007 is a vaccine candidate expressing CFA/II. YH AE: gastroenteritis YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'gastroenteritis'; is an adverse event that was mentioned in 218 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: peripheral vascular disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'peripheral vascular disorder'; is an adverse event that was mentioned in 215 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: urinary tract infection According to the Vaccine Adverse Event Reporting System (VAERS), 'urinary tract infection'; is an adverse event that was mentioned in 213 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). rough phenotype YH AE: increased salivation According to the Vaccine Adverse Event Reporting System (VAERS), 'increased salivation' is an adverse event that was mentioned in 336 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000622 greater than normal amounts of flowing saliva ETEC vaccine ACAM2017 ACAM2017 was derived from ACAM2007. Genes aroC, ompC, and ompF were deleted, while CS1 and pStrep were added. YH PMID: 17566016 B. anthracis DNA vaccine encoding PA63 YH This DNA vaccine contains the gene fragment encoding AAs 173-764 of PA. PMID: 9987172 depression This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'depression'; is an adverse event that was mentioned in 196 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH AE: diabetes mellitus Diabetes mellitus, often referred to simply as diabetes, is a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'diabetes mellitus'; is an adverse event that was mentioned in 196 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). diabetes B. anthracis DNA vaccine encoding PA83 and LF YH PMID: 15342913 DAAV using PA and PGA PMID: 12960361 YH smooth phenotype YH AE: laryngitis Laryngitis is an inflammation of the larynx. It causes hoarse voice or the complete loss of the voice because of irritation to the vocal folds (vocal cords). This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngitis'; is an adverse event that was mentioned in 190 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). AE: generalized spasm YH This term is a COSTART term but not a MP term (3/17/2009). An involuntary contraction of a muscle or group of muscles. Spasms may involve skeletal muscle (MUSCLE, SKELETAL) or smooth muscle (MUSCLE, SMOOTH). According to the Vaccine Adverse Event Reporting System (VAERS), 'generalized spasm'; is an adverse event that was mentioned in 186 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). rPA with adjuvant Nanoemulsion YH PMID: 17502384 AE: reflexes decreased According to the Vaccine Adverse Event Reporting System (VAERS), 'reflexes decreased'; is an adverse event that was mentioned in 178 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH reflexes decreased is an abnormal movement that showed decrease in an involuntary response to a peripheral stimulus M. tuberculosis arabinomannan-protein conjugate PMID: 12922145 Xref: VIOLIN vaccine ID: 223. YH AE: dry mouth YH dryness of the mouth resulting from reduced salivary secretion According to the Vaccine Adverse Event Reporting System (VAERS), 'dry mouth'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). xerostomia AE: optic neuritis This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'optic neuritis'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). AE: thrombocythemia According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocythemia'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH Thrombocythemia (primary thrombocythemia) is a disorder in which excess platelets are produced, leading to abnormal blood clotting or bleeding. This term is a COSTART term but not a MP term (3/17/2009). subcutaneous route YH YL S.C. a route of administration that is loacted in the hypodermis (subcutaneous tissue) region. subdominant epitope in vaccine YH subunit vaccine A vaccine that is composed of a purified protein(s) or other antigenic determinant(s) from a disease-causing organism. A subunit vaccine does not include pathogen nucleic acids. The subunits have less risk of causing adverse reactions. YH recombinant S. typhimurium secreting M. tuberculosis ESAT-6 Xref: VIOLIN vaccineID: 176. PMID: 11427279 YH Ag85B and ESAT-6 fusion protein PMID: YH AE: epistaxis This term is a COSTART term but not a MP term (3/17/2009). nosebleed According to the Vaccine Adverse Event Reporting System (VAERS), 'epistaxis'; is an adverse event that was mentioned in 163 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). Epistaxis is the relatively common occurrence of hemorrhage from the nose, usually noticed when the blood drains out through the nostrils. YH AE: lupus syndrome YH According to the Vaccine Adverse Event Reporting System (VAERS), 'lupus syndrome'; is an adverse event that was mentioned in 163 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: photophobia YH According to the Vaccine Adverse Event Reporting System (VAERS), 'photophobia'; is an adverse event that was mentioned in 163 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). Photophobia is a symptom of excessive sensitivity to light and the aversion to sunlight or well-lit places. In medical terms it is not fear, but an experience of discomfort or pain to the eyes due to light exposure. This term is a COSTART term but not a MP term (3/17/2009). time of survival of live vaccine inside host YH, MC time of survival of live vaccine inside host is a temporal interval during which a live vaccine survives inside a host organism. This entity is related to the process survival of live vaccine inside host. AE: abnormal salivary gland physiology MP: MP_0005310 any functional anomaly of any of the glands in the mouth that secrete saliva hallucination This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'hallucinations'; is an adverse event that was mentioned in 157 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). A hallucination, in the broadest sense, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space. attenuated M. bovis strain WAg539 PMID: 15784584 YH tongue disorder YH According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue disorder'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: neuralgia Neuralgia or neuropathic pain can be defined most simply as non-nociceptive pain. Neuralgia is pain produced by a change in neurological structure or function. Unlike nociceptive pain, Neuralgia exists with no continuous nociceptive input. Neuralgia falls into two categories: central Neuralgia and peripheral Neuralgia. YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'neuralgia'; is an adverse event that was mentioned in 155 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). target YH AE: lung edema This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'lung edema'; is an adverse event that was mentioned in 152 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). AE: circumoral paresthesia This term is a COSTART term but not a MP term (3/17/2009). numbness around the mouth. According to the Vaccine Adverse Event Reporting System (VAERS), 'circumoral paresthesia'; is an adverse event that was mentioned in 152 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH bacterial phenotype YH therapeutic vaccine A vaccine that is used for treatment for a disease. YH vaccination with a licensed vaccine YH, BP, XZ licensed use of vaccine is a vaccination process that follows a protocol for a licensed vaccine. attenuated M. bovis strain WAg520 PMID: 10225931 YH AE: thirst Thirst is the craving for liquids, resulting in the basic instinct of humans or animals to drink. It is an essential mechanism involved in fluid balance. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'thirst'; is an adverse event that was mentioned in 148 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: bone disorder YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'bone disorder'; is an adverse event that was mentioned in 145 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). titer WEB:http://en.wikipedia.org/wiki/Titer A titer (or titre) is a measure of concentration. Titer testing employs serial dilution to obtain approximate quantitative information from an analytical procedure that inherently only evaluates as positive or negative. The titer corresponds to the highest dilution factor that still yields a positive reading; for example, positive readings in the first 8 serial twofold dilutions translate into a titer of 1:256. YH vaccination with a licensed human vaccine licensed use of vaccine is a vaccination process that involves the vaccination of a licensed human vaccine. YH, XZ attenuated M. bovis strain WAg522 PMID: 10225931 YH recombinant nontypeable H. influenzae protein P6 with AdDP YH PMID: 15031801 adamantylamide dipeptide vaccine adjuvant a synthetic vaccine adjuvant, adamantylamide dipeptide (AdDP) is the desmuramyl analog of MDP. PMID: 8375945 YH, SGS AdDP toxin YH A toxin (from Ancient Greek: τοξικόν toxikon) is a poisonous substance produced within living cells or organisms; man-made substances created by artificial processes are thus excluded. The term was first used by organic chemist Ludwig Brieger (1849–1919).[3] For a toxic substance not produced within living organisms, "toxicant" and "toxics" are also sometimes used.[citation needed]. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their severity, ranging from usually minor and acute (as in a bee sting) to almost immediately deadly (as in botulinum toxin).-- from Wikipedia. toxoid vaccine A vaccine containing a toxoid, used to protect against toxins produced by certain bacteria. A toxoid (also called inactivated toxin) is a processed toxin that has been treated by chemical means, heat, or irradiation and is no longer capable of causing disease. YH therapeutic vaccine function YH The therapeutic vaccine function is a function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which ameliorates a specific disorder. AE: fetal disorder YH According to the Vaccine Adverse Event Reporting System (VAERS), 'fetal disorder'; is an adverse event that was mentioned in 142 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). M. tuberculosis secA2 mutant PMID: 17671656 YH rBCG-Ag85A[Tokyo] YH PMID: 17720625 emotional liability This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'emotional liability'; is an adverse event that was mentioned in 138 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH DNA vaccine Rv1806-1807 YH PMID: 16520093 AE: muscle spasm SS, YH MP: MP_0000743 WEB: http://en.wikipedia.org/wiki/Spasm an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions muscle spasm vaccine-induced up-regulated gene expression YH Novartis Animal Health US, Inc. http://www.petwellness.com/ YL AAV vaccine vector YH vaccination protocol vaccination protocol is the protocol of a vaccination procedure. YH vaccination schedule AE: tendon disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'tendon disorder'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). A tendon (or sinew) is a tough band of fibrous connective tissue that usually connects muscle to bone and is capable of withstanding tension. This term is a COSTART term but not a MP term (3/17/2009). YH Tendon disorder is a medical condition that results in a tendon not functioning normally. route of administration http://en.wikipedia.org/wiki/Route_of_administration A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. [definition from wikipedia - YL] YH,YL vaccine candidate During our call, we decided not to say vaccine candidate is an output of vaccine preparation, which may be reserved for vaccine alone. -- Aug 4, 2009. YH, AR, BP, LC, MC, and ZX vaccine candidate is a processed material that is designed to prevent or ameliorate a disorder in a target organism by modulating adaptive immune responses in that organism by administrating the vaccine. thimerosal vaccine preservative vaccine preservative that has thimerosal as part. YH peptide vaccine Peptide vaccine is a subunit vaccine that uses small peptide(s) as immunoepitopes. YH H1N1 Influenza vaccine YH H1N1 Influenza vaccine is an Influenza virus vaccine that is used to vaccinate against H1N1 Influenza subtype vaccine. Haemophilus somnus vaccine YL generated using OntoRat bacterial vaccine that is used to protect against Haemophilus somnus infection vaccine adjuvant YH a vaccine component that is chemical substance added to vaccine and enhance and direct immune response to protective antigen. Many of vaccine adjuvants cause a range of serious side-effects. H. influenzae gene YH vaccine license application A vaccine regulatory process that is for vaccine producer to apply for vaccine license. YH nontypeable H. influenzae gene hel (encoding P4) YH Encodes for protein P4 immune response detection assay An assay that is used to detect the immune response of a host to vaccination of a vaccine. YH immunization objective WEB: http://en.wikipedia.org/wiki/Immunization YH, XZ immunization objective is the specification of an objective to achieve immunization. vaccination with a licensed dog vaccine YH AE: hostility This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'hostility'; is an adverse event that was mentioned in 136 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). M. tuberculosis phoP mutant SO2 YH PMID: 16564606 PMID: 17084814 AE: visual field defect According to the Vaccine Adverse Event Reporting System (VAERS), 'visual field defect'; is an adverse event that was mentioned in 131 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). AE: visual impairment SS, YH This term is a COSTART term but not a MP term (3/17/2009). vaccine preparation vaccine production YH, BP vaccine preparation is a manufacturing process to produce a vaccine. vaccine generation vaccine protection assay An assay that is used to detect if a vaccine protects a host against infection of virulent pathogen after vaccine immunization. YH vaccine challenge experiment AE: myopathy According to the Vaccine Adverse Event Reporting System (VAERS), 'myopathy'; is an adverse event that was mentioned in 199 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000751 any abnormal condition or disease of the skeletal muscle myopathy vaccine specific T cell cytokine production YH vaccine specific T cell mediated cytotoxicity YH vaccine dose YH, MC vaccine dose is a dose of vaccine specified by the vaccine manufacturer, distributor, or a regulatory agent. vaccine clinical trial A processual entity by which a vaccine is tested clinically for safety and effectiveness. Clinical trials are conducted in phases. Classically, clinical trials unfold in three phases in order to gather data and information about a vaccine and its performance. This will form the basis of a dossier submitted to regulatory authorities by way of an application for licensure. After a vaccine is licensed and is being used by large numbers of people, a Phase IV study may or may not be taken for vaccine clinical evaluation. Most vaccines against a pathogen (e.g., HIV) are not tested by vaccinating people and then deliberately exposing them to virulent pathogen (e.g., HIV). This strategy is never for a vaccine against a disease as serious as HIV. The best way to determine if a vaccine is effective is to test it in a randomized, controlled, double-blind clinical trial. This type of trial is often referred to as the gold standard in medical research and provides the strongest evidence for the efficacy of a vaccine. YH vaccine using part of organism A vaccine that uses part of pathogen organism. YH whole organism vaccine WEB: http://onlinelibrary.wiley.com/doi/10.1038/npg.els.0000491/full YH A vaccine that uses whole organism as its component vaccine vector a vaccine component that functions as a vector that carries an inserted antigen (protein recognized by the body as foreign) from a disease causing agent to the vaccinee. YH vaccinia virus vector YH AE: apathy impassivity Apathy is a state of indifference, or the suppression of emotions such as concern, excitement, motivation and passion. An apathetic individual has an absence of interest or concern to emotional, social, or physical life. They may also exhibit an insensibility or sluggishness. According to the Vaccine Adverse Event Reporting System (VAERS), 'apathy'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). perfunctoriness YH AE: hemiplegia YH Hemiplegia is total paralysis of the arm, leg, and trunk on the same side of the body. Hemiplegia is more severe than hemiparesis, wherein one half of the body is weakened but not paralysed. According to the Vaccine Adverse Event Reporting System (VAERS), 'hemiplegia'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). BCG mutant secreting listeriolysin YH AE: pustular rash YH This term is a COSTART term but not a MP term (3/17/2009). Pastular rash is a rash that is composed of pustular lesions. According to the Vaccine Adverse Event Reporting System (VAERS), 'pustular rash'; is an adverse event that was mentioned in 128 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). AE: creatine phosphokinase increased An abnormal lab test that has increased creatine phosphokinase. Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissue types. It catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). According to the Vaccine Adverse Event Reporting System (VAERS), 'creatine phosphokinase increased'; is an adverse event that was mentioned in 127 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH delta ureC hly+ rBCG YH PMID: 16110326 Intercell Biomedical AE: intracranial hypertension YH According to the Vaccine Adverse Event Reporting System (VAERS), 'intracranial hypertension'; is an adverse event that was mentioned in 118 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). viral vaccine A vaccine that protects against some viral disease. YH MeSH: D014765 viral vaccine vector YH Haemophilus parasuis vaccine YL generated using OntoRat bacterial vaccine that is used to protect against Haemophilus parasuis infection virulent YH AE: gamma glutamyl transpeptidase increased According to the Vaccine Adverse Event Reporting System (VAERS), 'gamma glutamyl transpeptidase increased'; is an adverse event that was mentioned in 117 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). Gamma-GT increased GGTP increased GGT increased This term is a COSTART term but not a MP term (3/17/2009). YH An abnormal lab test that has increased gamma glutamyl transpeptidase (GGT). GGT is involved in the transfer of amino acids across the cellular membrane. Nontypeable H. influenzae protein P6 with cholera toxin PMID: 15297063 YH AE: abnormal stool This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal stools'; is an adverse event that was mentioned in 111 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). animal model of vaccine research YH Animal model of vaccine research is a role played by some organism (e.g., mouse) that is used for vaccine research. AE: bone pain YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'bone pain'; is an adverse event that was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). AE: cerebrovascular accident Cerebrovascular accident: The sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A CVA is also referred to as a stroke. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'cerebrovascular accident'; is an adverse event that was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). stroke This term is a COSTART term but not a MP term (3/17/2009). vaccination with a licensed turkey vaccine YH Pasteurella multocida vaccine generated using OntoRat bacterial vaccine that is used to protect against Pasteurella multocida infection YL laboratory animal model of vaccine research Animal model of vaccine research is a role played by some organism (e.g., mouse) that is used for vaccine research in the laboratory. YH AE: parotid gland enlargement According to the Vaccine Adverse Event Reporting System (VAERS), 'parotid gland enlargement'; is an adverse event that was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH AE: flatulence Flatulence is the production of a mixture of gases in the digestive tract of mammals or other animals that are byproducts of the digestion process. Such a mixture of gases is known as flatus, and is expelled from the rectum in a process colloquially referred to as "passing gas" or "farting". According to the Vaccine Adverse Event Reporting System (VAERS), 'flatulence'; is an adverse event that was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH whole pathogen organism in vaccine whole organism in vaccine is a organism component in vaccine that includes the whole organism such as a whole live attenuated organism. YH AE: liver damage According to the Vaccine Adverse Event Reporting System (VAERS), 'liver damage'; is an adverse event that was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). survival assessment Need to point out more specifically that survival / death is measured. Survival assessment is an assay that measures the occurence of death events in one or more organisms that are monitored over time. YH H. influenzae Type b capsular polysaccharide vaccine PMID: 335348 YH PMID: 6387614 vaccination with a licensed rabbit vaccine YH B. anthracis recombinant vaccine using PA domain 4 YH PMID: 11854261 PMID: 15935874 licensed vaccine role YH licensed vaccine role is a regulation-assigned role that indicates that a vaccine obtains official approval for commercial production and selling on the market. vaccine in clinical trial role In medical research, clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. YH vaccine in clinical trial role is a regulation-assigned role that inheres in a vaccine that is currently in clinical trial. vaccine-induced humoral immune response YL Vaccine induced immue response mediated hrough a body fluid Brucella melitensis Rev. 1 with P39 deletion YH PMID: 9784574 A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the p39 gene deletion. B. melitensis Rev. 1 P39 deletion mutant intravenous vaccination YL licensed human vaccine YH a vaccine with license that is for human use. AE: sore throat YH Flavobacterium columnare vaccine bacterial vaccine that is used to protect against Flavobacterium columnare infection generated using OntoRat YL Clostridium vaccine A bacterial vaccine that protects against infection with Clostridium spp. YH Clostridium tetani vaccine tetanus vaccine YH a Clostridium vaccine that protects against infection with Clostridium tetani that causes tenanus. combination vaccine 2 Combination vaccine is a vaccine that induces protection against multiple infectious diseases or several different serotypes of the same organism. The anitgens contained in combination vaccines are either formulated together by the manufacturer or physically mixed by a health care provider just prior to administration. Both approaches require licensure. Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1624. combo vaccine YH MeSH: D017778 Influenza virus vaccine A viral vaccine that protects against infection with influenza virus. YH MeSH: D007252 Influenza vaccine licensed cattle vaccine a vaccine with license that is used for cattle. YH Hepatitis B virus vaccine A viral vaccine that protects against infection with Hepatitis B virus. YH MeSH: D017325 licensed fish vaccine YH Hepatitis A virus vaccine A viral vaccine that protects against infection with Hepatitis A virus. YH MeSH: D022362 licensed goat and sheep vaccine YH Yersinia pestis vaccine MeSH: D010931 A bacteria vaccine that prevents against Yersinia pestis infection that causes plague. YH Plague vaccine licensed dog vaccine YH Rabies virus vaccine MeSH: D011819 A viral vaccine that protects against infection with Rabies virus. YH Smallpox virus vaccine YH MeSH: D012900 A viral vaccine that protects against infection with Smallpox virus. licensed cat vaccine YH licensed ferret vaccine YH Measles virus vaccine A viral vaccine that protects against infection with Measles virus. MeSH: D008458 Measles vaccine YH licensed deer vaccine YH Mumps virus vaccine A viral vaccine that protects against infection with Mumps virus. YH MeSH: D009108 licensed bird vaccine YH Rotavirus vaccine MeSH: D022243 A viral vaccine that protects against infection with Rotavirus. YH HIBTITER PMID: In most cases HibTITER was administered concomitantly with other vaccines including DTP, DTaP, hepatitis B vaccine, IPV, OPV, pneumococcal 7-valent conjugate vaccine, MMR, and/or meningococcal group C conjugate vaccine (not licensed in the US). YH PMID: 9353019 PMID: 2057256 ProHIBiT PMID: 2057256 Ref: http://www.rxlist.com/prohibit-drug.htm YH Haemophilus vaccine YH A bacterial vaccine that protects against infection with Haemophilus. MeSH: D018073 Haemophilus influenzae serotype b vaccine Haemophilus b vaccine YH SC602 A live attenuated Shigella flexneri 2a vaccine that carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding aerobactin). PMID: 10377124. YH PMID: 10377124 Poliovirus vaccine A viral vaccine that protects against infection with Poliovirus. MeSH: D023321 YH Japanese encephalitis virus vaccine A viral vaccine that protects against infection with Japanese encephalitis virus. YH MeSH: D022321 Japanese encephalitis vaccine CVD 1208 CVD 1208 is derived from wild type Shigella flexneri 2a strain 2457T and has defined deletions in four genes: (1) the guaBA chromosomal operon that encodes two enzymes (inositol 5'-monophosphate dehydrogenase and guanosine 5'synthase) essential for de novo purine biosynthesis; (2) set, a locus in a chromosomal pathogenicity island that encodes Shigella enterotoxin (ShET); (3) Pic, an autotransporter mucinase encoded on the opposite strand from set; and (4) sen, an invasiveness plasmid gene encoding ShET. PMID: 15499528 YH human papillomavirus vaccine YH CVD 1208S PMID: 17938573 YH CVD 1208S is the same thing as CVD 1208, but CVD 1208S was prepared using animal-free media. PMID: 17938573. Varicella-zoster virus vaccine YH EcSf2a-2 YH This vaccine is an aro-D mutant derivative of EcSf2a-1. PMID: 1587589. PMID: 1587589 Salmonella typhi vaccine YH heat-killed virulent Shigella flexneri 2a PMID: 10102148 YH Shigella Sfl 124 vaccine PMID: 1937767 YH Recombinant SFL124-27 expressing S. dysenteriae type 1 O antigen YH PMID: 9169740 Streptococcus pneumoniae vaccine YH S. dysenteriae 1 strain WRSd1 PMID: 12010984 YH S. flexneri 2a strain CVD 1207 A live attenuated Shigella flexneri 2a vaccine with specific deletion mutations in virG, sen, set, and guaBA. YH PMID: 10678904 S. sonnei strain WRSS1 PMID: 9712824 A stable attenuated Shigella sonnei strain with virG mutation. PMID: 9712824. YH PMID: 11895966 Shigella sonnei vaccine YH Shigella flexneri vaccine YH Shigella dysenteriae vaccine YH S. flexneri 2a LPS vaccine complexed with N. meningitidis proteosomes YH PMID: 8500877 vaccine regulation A processual entity that regulates vaccine-related processes, such as vaccine trial, vaccine license application. YH vaccine transportation A processual entity of transporting vaccine from one place to another place. YH AE: paralysis According to the Vaccine Adverse Event Reporting System (VAERS), 'paralysis' is an adverse event that was mentioned in 574 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). SS, YH hemiplegia, palsy, paraplegia, quadiplegia MP: MP_0000753 loss of power of voluntary movement in a muscle through injury or disease of its nerve supply paralysis Acambis, Inc YH http://www.acambis.com/ Berna Biotech, Ltd YH http://www.crucell.com/ BioPort Corp http://www.bioport.com/ YH CSL Limited YH http://www.csl.com.au/ GlaxoSmithKline Biologicals YH http://www.gsk-bio.com/english/index.html Greer Laboratories Inc http://www.greerlabs.com/ YH ID Biomedical Corp of Quebec http://www.ctidirectory.com/search/company.cfm?company=129584 YH Massachusetts Public Health Biologic Lab YH MedImmune Vaccines, Inc YH http://www.medimmune.com/ Merck & Co, Inc http://www.merck.com/ YH Merck Sharp & Dohme Corp. Novartis Vaccines and Diagnostics YH http://www.novartis.com/about-novartis/our-businesses/vaccines-diagnostic.shtml Organon Teknika Corp LLC 100 Rodolphe Street Building 1300 Durham, NC 27712 YH Research Foundation for Microbial Diseases of Osaka University YH http://read.jst.go.jp/public/cs_kkn_004EventAction.do?action5=event&lang_act5=E&kcd1_act5=9535000000&judge_act5=2 Sanofi Pasteur Limited http://www.sanofipasteur.com YH Sanofi Pasteur, Inc YH http://www.sanofipasteur.us Wyeth Pharmaceuticals Inc YH http://www.wyeth.com/ Sanofi Pasteur, SA http://www.sanofipasteur.co.za/ YH antibiotics vaccine residual YL The vaccine residual that is from antibiotics used during the manufacture process. vaccine specific antibody test YH vaccine trial regulation A vaccine regulation process for vaccine clinical trials. YH primary vaccination A vaccination process that occurs at the first time. prime vaccination YH boost vaccination A vaccination process that occurs after the primer vaccination with a purpose to boost host immune response to vaccine antigen. YH Brucella melitensis vaccine YH Brucella melitensis strain Rev. 1 YH Brucella melitensis Rev. 1 PMID: 13416171 Brucella melitensis Rev 1 inactivated viral vaccine killed viral vaccine vaccine allergen disposition YH Canada licensed human vaccine preparation of DNA vaccine YH A vaccine preparation that results in the generation of a DNA vaccine preparation of conjugate vaccine A vaccine preparation that results in the generation of a conjugate vaccine YH subunit vaccine preparation A vaccine preparation that results in the generation of a subunit vaccine YH live attenuated vaccine preparation YH A vaccine preparation that results in the generation of a live attenuated vaccine preparation of RNA vaccine YH A vaccine preparation that results in the generation of a RNA vaccine Brucella abortus strain RB51SOD PMID: 10816475 YH B. abortus strain RB51SOD Brucella suis vaccine YH Brucella suis strain 2 Brucella suis S2 YH An orally administrable brucellosis vaccine that was was developed in China. It is effective for oral vaccination of sheep, goats, cattle and pigsPMID: 3541425. Brucella abortus strain 45/20 B. abortus strain 45/20 YH PMID: 8236802 cytomegalovirus vaccine YH Dengue virus vaccine A viral vaccine that protects against infection with Dengue virus. MeSH: D053059 Dengue vaccine YH Ebola virus vaccine YH A viral vaccine that protects against infection with Ebola virus. MeSH: D046129 Ebola vaccine Herpesvirus vaccine A viral vaccine that protects against infection with Herpesvirus. MeSH: D022283 YH chickenpox virus vaccine YH Herpes simplex virus vaccine YH Marek disease vaccine YH Measles-Mumps-Rubella vaccine YH Diphtheria-Tetanus vaccine YH A combination vaccine that is used to vaccinate against infections with both Clostridium tetani and Corynebacterium diphtheriae. CVD 1204(pGA1-CS2) PMID: 11292735 YH CVD 1204(pGA1-CS3) YH PMID: 11292735 Corynebacterium diphtheriae vaccine A bacterial vaccine that protects against infection with Corynebacterium diphtheriae that causes Diphtheria. YH diphtheria vaccine Measles-Mumps vaccine YH Measles-Mumps-Rubella-Vericella vaccine YH Diphtheria-Tetanus-Pertussis vaccine YH DTaP vaccine Shigella ribosome-based Vaccine (SRB) YH PMID: 17507120 P. falciparum vaccine Combination B YH PMID: 14604568 A malaria vaccine that comprises recombinant Plasmodium falciparum (P. falciparum) blood-stage proteins MSP1, MSP2 and RESA, formulated with the adjuvant Montanide ISA 720. PMID: 14604568. Haemophilus influenzae serotype b YH Diphtheria-Tetanus-Pertussis-Poliovirus vaccine YH Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine YH Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine YH Hepatitis A&B vaccine YH Haemophilus b and Hepatitis B vaccine YH DNA and MVA encoding ME-TRAP YH A vaccine that contains DNA and modified vaccinia virus Ankara (MVA) encoding thrombospondin-related adhesion protein (TRAP) with a multiple-epitope string ME (ME-TRAP). This vaccine is used with a prime-boost regime by DNA priming and MVA boosting. PMID: 16988273. PMID: 16988273 Papillomavirus vaccine A viral vaccine that protects against infection with Papillomavirus. MeSH: D053918 YH Parainfluenza virus vaccine parainfluenza vaccine A viral vaccine that protects against infection with Parainfluenza virus. YH MeSH: D022241 Pseudorabies virus vaccine MeSH: D022421 pseudorabies vaccine A viral vaccine that protects against infection with Pseudorabies virus. YH Simian immunodeficiency virus vaccine SAIDS vaccine MeSH: D018449 A viral vaccine that prevents against infection with Simian immunodeficiency virus. YH West Nile virus vaccine A viral vaccine that protects against West Nile virus infection. MeSH: D053060 YH Respiratory syncytial virus vaccine YH A viral vaccine that prevents infection with Respiratory syncytial virus. MeSH: D022261 marker vaccine A vaccine that is used in conjunction with diagnostic tests to differentiate vaccinated animals from carrier animals. It can be a subunit or a gene-deleted vaccine. MeSH: D022581 YH edible vaccine YH MeSH: D022462 A vaccine that is edible and derived from an edible plant. The transgenic plant is used as recombinant protein production system. The edible plant tissue functions as an oral vaccine. acellular vaccine YH acellular vaccine is a subunit vaccine that is produced by using only the antigenic part of the disease causing organism. It often requires a "booster" every few years to maintain their effectiveness. MeSH term: D20.215.894.860.900. ISCOM The immunostimulating complex YH A particulate antigen delivery system, ISCOM is a vaccine adjuvant that consists of an assembly of antigens in multimeric form and presents an antigen to induce specific immunologic responses. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines. MeSH term: D20.215.894.860.449. Plasmodium vivax vaccine YH contraceptive vaccine antifertility vaccine MeSH: D022642 YH A vaccine that is used to prevent conception. Alzheimer vaccine A vaccine that prevents or treats Alzheimer disease. MeSH: D023582 YH malaria vaccine MeSH: D017780 Plasmodium vaccine Plasmodium vaccine is a vaccine that prevents against Plasmodium species causing malaria. It is made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents. malarial Vaccine YH Leishmania vaccine YH Leishmaniasis vaccine a protozoan vaccine that prevents against infection with Leishmania. MeSH: D054332 Vibrio cholerae vaccine YH A bacterial vaccine that prevents infection with Vibrio cholera. MeSH: D022121 Lyme disease vaccine YH MeSH: D022123 A vaccine that prevents Lyme disease caused by Borrelia burgdorferi. Borrelia burgdorferi vaccine Bordetella pertussis vaccine A bacterial vaccine that prevents against Bordetella pertussis infection that causes pertussis or whooping cough. MeSH: D010567 YH Pertussis vaccine Pseudomonas vaccine MeSH: D054406 A bacterial vaccine that protects against infection with Pseudomonas. YH Rickettsial vaccine YH A bacterial vaccine that protects against diseases caused by various species of Rickettsia. MeSH: D012290 Salmonella vaccine A bacterial vaccine that protects against infections by various Salmonella species. MeSH: D022562 YH Shigella vaccine A bacterial vaccine that protects against infections with Shigella species. YH MeSH: D022281 Staphylococcal vaccine A bacterial vaccine that protects against infection with Staphylococcus. Staphylococcus vaccine YH MeSH: D013209 Staph vaccine BCG vaccine YH CVX: 19 Bacillus Calmette Guerin BCG Vaccine is a Mycobacterium tuberculosis vaccine that is a live attenuated strain of Mycobacterium bovis (Bacillus Calmette Guerin; BCG). Streptococcal vaccine A bacterial vaccine that prevents streptococcal infections. Streptococcus vaccine YH MeSH: D022541 MSP3-LSP with aluminium hydroxide PMID: 17280744 YH RTS,S/AS02A PMID: 15488216 YH RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. PMID: 15488216. P. falciparum MSP1 from transgenic mice with Freund's adjuvant YH PMID: 11752405 P. vivax PVS25 with Montanide ISA-720 YH PMID: 16291764 FMP1/AS02A FMP2.1/AS02A is a recombinant E. coli-expressed protein based upon the apical membrane antigen-1 (AMA-1) of the 3D7 clone formulated with the AS02A adjuvant. PMID: 17442466. YH PMID: 17442466 recombinant ABRA protein vaccine PMID: 11489167 YH PMID: 9400530 NP-VRP YH An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus NP protein. GP-VRP An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus GP protein. YH VRP expressing VP24 PMID: 11485406 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP24 protein. YH alphavirus replicon expressing VP24 VRP expressing VP30 PMID: 11485406 YH alphavirus replicon expressing VP30 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP30 protein. VRP expressing VP35 alphavirus replicon expressing VP35 YH PMID: 11485406 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP35 protein. VRP expressing VP40 PMID: 11485406 alphavirus replicon expressing VP40 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP40 protein. YH DNA vaccine expressing sGP PMID: 9427604 A DNA vaccine that encodes for a secreted form of Ebola virus GP protein. YH DNA and adenoviral vector Ad5 expressing SIV gag protein A vaccine combination that includes a DNA vaccine and a recombinant adenovirus Ad5 expressing the same codon-optimized SIV gag gene. The DNA vaccine is used for priming, and the Ad5 vaccine is used for boosting. PMID: 11797011. PMID: 11797011 YH gene YH A gene that is a pathogen gene used for vaccine preparation or a host gene encoding for an immune factor important in induction of protective immunity. a vaccine-associated gene that exists in a pathogen and has been engineered for vaccine develoment. This gene can encode for protective antigen that is overexpressed for vaccine development. This gene can also be a virulence factor that is mutated to attenuate a virulent pathogen with the purpose of making attenuated vaccine. The term 'gene' has appears in several ontologies, such as Sequence Ontology (SO) and Protein Ontology (PRO). We may choose to use a 'gene' term from other ontologies. The 'gene' term in SO has ID: SO:0000704. adenoviral vector Ad5 expressing SIV gag protein PMID: 11797011 A recombinant adenovirus (Ad5) expressing the codon-optimized SIV gag gene. PMID: 11797011. YH DNA and Ad5/35 vector expressing HIV gp160 protein PMID: 16079886 A vaccine combination that includes a DNA vaccine and a replication-defective chimeric Ad5 vector with the Ad35 fiber (Ad5/35) that express the same codon-optimized SIV gag gene. The DNA vaccine is used for priming, and the Ad5/35 vaccine is used for boosting. PMID: 16079886. YH Brucella gene YH human gene YH mouse gene YH Brucella abortus gene YH A Brucella gene that is from B. abortus. Brucella abortus wboA YH Brucella abortus gene wboA is interrupted in Brucella abortus cattle vaccine RB51. mouse Ifng YH Interferon-gamma (IFN-g) is an indicative of Th1 immune response. It is produced in host immunized by vaccines such as Brucella abortus cattle vaccine RB51. human ifng YH Interferon-gamma (IFN-g) is an indicative of Th1 immune response. cattle gene YH cattle Ifng YH Interferon-gamma (IFN-g) is an indicative of Th1 immune response. It is produced in host immunized by vaccines such as Brucella abortus cattle vaccine RB51. vaccine storage YH a storage process that is specifically for vaccine. vaccine storage at room temperature a vaccine storage that is execuated at room temperature. Room temperature is also referred to as ambient temperature. Room temperature denotes a certain temperature within enclosed space at which humans are accustomed. Room temperature is usually indicated by general human comfort, with the common range of 10 degree C (50 degree F) to 28 degree C (82.4 degree F). YH vaccine storage in refrigerator vaccine storage that is executed in refrigerator, usually 0-10^C. YH vaccine storage in freezer YH vaccine storage that is executed in freezer under 0^C. effectiveness YH Effectiveness is physical quality that represents the capability of a single physical entity (e.g., vaccine) producing an effect (e.g, protection against a disease). effective YH ineffective YH adverse event induced by vaccination An adverse event is an unexpected or dangerous reaction followed by a vaccination process. YH, MC,YL The 'induced by' used in the term indicate that the causal relation between the vaccination and an adverse event given in the licensed vaccine's package insert. It is a subclass of causal adverse event of OAE ( http://purl.obolibrary.org/obo/OAE_0000003) rapid vaccination A vaccination process that is implemented fast. vaccine rapid implementation YH vaccination coverage YH, MC WEB: http://www.who.int/immunization_monitoring/routine/immunization_coverage/en/ WEB: http://www.sanofipasteur.com/sanofi-pasteur2/front/index.jsp?siteCode=SP_CORP&codeRubrique=19 A measure datum that measures the coverage of vaccination in a specific area during a specific time period. immunization coverage DNA/MVA prime-boost HIV vaccine YH PMID: 17328232 An HIVA.DNA/modified vaccinia Ankara (MVA) prime-boost vaccine for the potential prevention of infection with HIV subtype A. The vaccination strategy consists of priming with a DNA vaccine made from HIV-1 clade A gag p24/p17 consensus sequence (pTHr.HIVA) then boosting with a MVA virus expressing HIVA (MVA.HIVA). PMID: 2152500. epitope YH USA licensed vaccine role YH a licensed vaccine role that indicates the vaccine occurs in USA. USA licensed cattle vaccine YH a cattle vaccine with license that is used in USA. vaccination dose vaccination dose is a dose of vaccine that is used in a vaccination. Vaccination dose may be and may be not the same as the vaccine dose. YH monthly YH biweekly YH DNA vaccine expressing multiple HIV epitopes YH PMID: 16359234 A HIV vaccine that is composed of a DNA vaccine expressing conserved, multiple HIV epitopes. PMID: 16359234. AE: weight loss MP: MP_0001263 According to the Vaccine Adverse Event Reporting System (VAERS), 'weight loss' is an adverse event that was mentioned in 415 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). progressive reduction of body weight below normal average for age weight loss recombinant HIV gp120 with adjuvant NanoEmulsion PMID: 18260780 YH A HIV vaccine that is made of recombinant HIV gp120 protein adjuvanted with the adjuvant NanoEmulsion. PMID: 18260780. Aeromonas salmonicida vaccine YH bacterial vaccine that is used to protect against Aeromonas salmonicida infection Vetech Labs http://www.vetechinc.com/ YH Gag-VRPs Gag-VRPs is a cocktail vaccine of V3014-packaged VRPs expressing the SIVsm H-4i nonmyristylated matrix-capsid region, full-length gp160, and a secreted form of gp160 (gp140). PMID: 12120997. PMID: 10462249 YH PMID: 12120997 Vibrio anguillarum vaccine YH MVA expressing HIV Gag, Pol and Env proteins A recombinant modified vaccinia Ankara (MVA) expressing HIV Gag, Pol, and Env proteins. PMID: 16472543. PMID: 16472543 YH DNA and poxvirus priming-boosting SIV vaccine A SIV vaccine that is composed of a DNA vaccine and a poxvirus vector expressing the same SIV antigens. PMID: 15258286. PMID: 15258286 YH Brucella abortus S19 with P39 deletion A B. abortus vaccine that is recombinant B. abortus strain 19 vaccine with the p39 gene deletion. B. abortus S19 P39 deletion mutant PMID: 9784574 YH AdsecV PMID: 17041851 A Yersinia pestis vaccine that uses a recombinant Ad5-based vector (E1a, partial E1b, and partial E3 deletion) to express Y. pestis V antigen. YH Yersinia EV76 YH PMID: 4988692 A Yersinia pestis vaccine that is a pigmentation negative mutant of Y. pestis derived from a fully virulent strain. Yersinia EV-76 PMID: 8578841 Y. pestis F1 protein vaccine A Yersinia pestis subunit vaccine that uses Y. pestis F1 protein as antigen. PMID: 8675324 YH PMID: 312163 rF1 + rV vaccine PMID: 10930691 YH PMID: 15908389 A Y. pestis subunit vaccine that uses recombinant F1 and V antigens. PMID: 312163. PMID: 12922126 Recombinant Y. pestis V antigen vaccine PMID: 7622205 YH A Y. pestis subunit vaccine that uses recombinant Y. pestis V antigen. PMID: 7622205. modified Y. pestis with TLR4-stimulating LPS PMID: 16980981 YH Yersinia PAV YH A Yersinia pestis subunit vaccine that contains staphylococcal protein A-V antigen fusion peptide (PAV). PMID: 7622225. PMID: 7622225 recombinant Y. pestis YopD protein vaccine PMID: 10024607 PMID: 8890210 YH Epm vaccine In vitro-cultured merozoites, chemically inactivated YH Y. pestis YscF subunit vaccine YH A Y. pestis subunit vaccine that uses Y. pestis YscF protein as antigen. PMID: 15978133. PMID: 15978133 microencapsulated Caf1 and LcrV vaccine YH PMID: 16546306 Ovilis Enzovax Live temperature-sensitive mutant strain for subcutaneous or intramuscular injection YH Trovac AI H5 YH Fowlpox virus-vectored H5 recombinant Yersinia rV10 vaccine YH PMID: 16861680 A Y. pestis vaccine that uses the recombinant V10 (rV10), a variant (lacking residues 271 to 300) of Yersinia pestis LcrV. PMID: 16861680. Pfizer Animal Health http://www.pfizerah.com/ YH AquaVac ERM YH Killed oral vaccine Feline leukemia virus vaccine YH Art Vax YH Live temperature-sensitive mutant strain; spray inhalation or drinking water VSV vector expressing Y. pestis lcrV YH PMID: 16959385 BIOPHARM YH Plague vaccine USP A formalin-inactivated preparation that was manufactured by Cutter Biologicals (a division of Miles Laboratories, Inc.). It is now available only from Greer Laboratories, Inc. The killed or inactivated plague vaccine is prepared from Y. pestis organisms grown in artificial media and then inactivated in formaldehyde. URL: http://www.cdc.gov/mmwr/preview/mmwrhtml/00044836.htm YH PMID: 8578841 Cutter Biological YH Improvac YH Peptide-protein conjugate and water-miscible adjuvant; control of boar taint vaccine additive vaccine additive is a material that is added to the immunogen by the vaccine manufacturer for a specific purpose. Additives include adjuvants, preservatives and stablizers, as well as materials that are added to affect pH and isotonicity. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. YH vaccine preservative antimicrobial agent in vaccine YH vaccine preservative is an vaccine additive that is added to a vaccine formulation to prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during use. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. Periovac YH Killed vaccine against periodontitis vaccine stabilizer YH vaccine stabilizer is a vaccine additive that helps to protect the vaccine from adverse conditions such as the freeze-drying process (for those vaccines that are freeze-dried) or heat. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 75. vaccine residual Although no all manufacturing residuals may be identified and quantified, their presence and quantity is assumed to be constant because of the constancy of the manufacturing process. A vaccine residual is a part of vaccine that remains from the vaccine manufacturing process. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. YH inactivation residual in vaccine YH An inactivation residual in vaccine is a vaccine residual that is used to inactivate bacteria and viruses or to detoxify bacterial toxins. For example, formaldehyde is a frequently used inactivation agent in vaccine preparation. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78. cell culture residual in vaccine YH A cell culture residual in vaccine is a vaccine residual that is generatead from cell culture for vaccine preparation. Examples include: antibiotics, sensitizing substances, bacterial and cellular residuals, and adventitious agents. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78-81. vaccine-induced immune correlate of protection Immune correlate of protection is a host immune response to vaccine that correlates with protective induced by the vaccine. YH serologic correlate of protection YH Serological correlate of protection is an immune correlate of protection that is reflected by serologic antibody levels. cell mediated immune correlate of protection YH A cell mediated immune correlate of protection is an immune correlate of protection that is reflected by a cell mediated immune response. vaccine effectiveness YH Vaccine effectiveness is an effectiveness associated with a vaccine. Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. Bioproperties YH http://www.bioproperties.com.au/ Canada Canada is a country that exists in north America. YH Pirodog YH In vitro-cultured supernatant antigens, reduce clinical disease Canada licensed vaccine role a licensed status that occurs in Canada. YH Porphyromonas gulae vaccine YH Fluviral S/F YH Influvac Influvac is an Influenza virus vaccine that is manufactured by Solvay Pharma. YH Vaxigrip Vaxigrip is an Influenza virus vaccine that is manufactured by 'Sanofi Pasteur Limited. YH, Melanie Solvay Pharmaceuticals YH Babesia bigemina vaccine by local veterinary institutes YH Purevax Feline Rabies Canarypox virus-vectored vaccine YH Babesia bovis vaccine by local veterinary institutes YH PGA/ME YH pGPA-incorporated microemulsion PMID: 16730934 Anthrax Spore Vaccine Anthrax Spore Vaccine is a B. anthracis vaccine that is prepared with a relatively nonpathogenic, noncapsulated variant strain of B. anthracis, originally developed at the Onderstepoort Laboratory, Pretoria, South Africa. Further work was conducted in England, India and in many other countries. Vaccine Strain is Sterne 34F2. The vaccine is a suspension of viable Bacillus anthracis spores in saponin. YH B. anthracis Sterne strain spore vaccine PMID: 3084385 pSecTag-PA83 YH PMID: 15293452 pCMV/ER-PA83 PMID: 15293452 YH Websters Animal Health https://www.webstervet.com/app.aspx YH RECOMBITEKEquine WNV Canarypox virus-vectored vaccine YH Porphyromonas denticanis YH pCLF4 YH PMID: 11401993 PMID: 15068841 pCLF4 is a Bacillus anthracis vaccine that contains the N-terminal region (amino acids [aa] 10-254) of Bacillus anthracis LF cloned into the pCI expression plasmid. Equity YH Peptide-protein conjugate and proprietary adjuvant (immunostimulating complex); control of estrus and estrus-related behavior single-dose Vaxigrip multi-dose Vaxigrip YH, Melanie, and Allen The difference between single-dose and multi-dose Vaxigrip is that multi-dose Vaxigrip contains preservative thimoseral. We still have not made it defined class since we still need to figure out how to represent multi-dose vs. single dose. The previous method discussed brief needs vetting. --YH aluminum vaccine adjuvant a mineral salt vaccine adjuvant that is composed of aluminum salt. Aluminum vaccine adjuvant is a vaccine adjuvant that is composed of some aluminum compound. YH vaccine preservative role a role inhers in a vaccine component that when added into a vccine formmulation, it can prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during administrating process or the manufacturing process. P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al. YH,YL The CFR requires that, with certain defined exceptions, preservatives must be added to mulitdose vials of vaccine. (P73 Chapter 6, Vaccine 5th edition by Plotkin, S. et al.) oral route YH a route of administration that located in the mouth intradermal route a route of administration that inject the material(such as vaccines, allergens) into the skin itself. intradermal injection route YH,YL I.D. phenol vaccine preservative YH PleuroStar APP YH Recombinant ApxII, TbpB, CysL, OmlA(1), and OmlA(2) proteins Colorado Serum Company CZ Veterinaria http://www.colorado-serum.com/ YH phenoxy ethanol vaccine preservative YH Biken YH, ZX Schering-Plough http://www.schering-plough.com/ YH BHV-1 vaccine YH Baxter Healthcare Corporation YH, ZX http://www.baxter.com/ Merck Frosst YH, ZX http://www.merckfrosst.ca/ age at vaccination YH Age at vaccination is the age of an experiment animal at the time of vaccination. Theileria annulata vaccine by local veterinary institutes Culture-derived schizonts YH dose dose is a measurement data that measures the quantity of something that may be eaten by or administered to an organism, or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses. WEB: http://en.wikipedia.org/wiki/Dose_%28biochemistry%29 YH, MC challenge dose challenge dose is a dose of a virulent pathogen used for a vaccine challenge process. YH Boehringer-Ingelheim Vetmedica, Inc http://www.bi-vetmedica.com/ YH PROTEQ-FLU (European Union) Recombitek (United States) YH Canarypox virus-vectored vaccine secondary vaccination YH, Thom Todd Secondary vaccination is a vaccination that is performed immediately after the primary or the first vaccination. SBL Vaccine YH, ZX Wyeth Canada http://www.wyeth.ca/ YH, ZX Eimeria vaccine YH surface antigens from the zona pellucida YH Theileria annulata vaccine YH vaccine allergen YH, ZX vaccine allergen is a material entity that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals who has been vaccinated with a vaccine. passive immunization using natural maternal antibody 09-26-2011 YL http://pathmicro.med.sc.edu/ghaffar/immunization-ver2.htm passive immunization that Immunity is transferred from mother to fetus through placental transfer of IgG or colostral transfer of IgA. chicken egg protein allergen YH, ZX, MC Eegg protein may come from NCIS thesaurus egg - poultry, combination of minimal anatomy terminology and NCBI taxonomy... Eventually, this term chicken egg protein allergen may become a cross product of sevreal ontology terms. chicken egg protein allergen is a vaccine allergen that is composed of chicken egg protein. latex vaccine allergen YH, ZX Virbac YH http://www.virbac.com/ gelatin vaccine allergen YH, ZX protamine sulfate vaccine allergen YH, ZX polymyxin B vaccine allergen YH, ZX EURIFEL FeLV YH Canarypox virus-vectored vaccine vaccine antigen To create this term for cover some other vaccines such as cancer vaccine and so on. vaccine antigenic component YL, YH the vaccine component that is used as antigen to produce an immune responce protect against the specific pathogen or disease. This is a modified or partial form of the virus, bacteria or the toxin that causes the disease against which the vaccine protects. The vaccine antigen is altered from its original form so it no longer causes disease but it can produce an immune response.(Vaccine components FactSheet of NCIRS) bovine albumin YH, ZX bovine serum monosodium glutamate stabliizer YL,YH http://www.novaccine.com/vaccine-ingredients/results.asp?sc=13 a chemical that bears a vaccine stablizer's role. C5H8NNaO4 RECOMBITEK Corona MLV YH Modified live virus glutaraldehyde vaccine additive Babesia bovis vaccine Infected blood from splenectomized calves YH human albumin human serum Raboral Vaccinia virus recombinant YH Reference: http://www.raboral.com/ polysorbate 20 vaccine stabilizer Potential Acute Health Effects: Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Reference: http://www.sciencelab.com/msds.php?msdsId=9926640 YH, YL a vaccine additive that encourages the suspension of one liquid in another and has mild toxicity. http://www.novaccine.com/vaccine-ingredients/results.asp?sc=95 polysorbate 80 vaccine additive www.novaccine.com/vaccine-ingredients/results.asp?sc=19 YH,YL residual protein from cell culture Canine coronavirus vaccine YH ActHIB intramuscular vaccination sorbitol vaccine stabilizer glucitol Sorbitol, also known as glucitol, is a sugar alcohol that the human body metabolizes slowly. It can be obtained by reduction of glucose, changing the aldehyde group to a hydroxyl group. Sorbitol is found in apples, pears, peaches, and prunes. It is synthesized by sorbitol-6-phosphate dehydrogenase, and converted to fructose by succinate dehydrogenase and sorbitol dehydrogenase. Succinate dehydrogenase is an enzyme complex that participates in the citric acid cycle. (wikipedia) Sarcocystis neurona vaccine YH Suvaxyn Aujeszky YH gE- and thymidine kinase-deleted marker vaccine A vaccine that is made of a TK-negative (TK -) and gI/gE-negative (gI/gE -) pseudorabies virus (PRV) mutant to protect pigs against Aujeszky's disease. Aujeszky's disease is also known as pseudorabies. It is a disease primarily of pigs and is caused by porcine herpesvirus 1. This disease is characterized by respiratory, reproductive and nervous signs. sucrose albumin xanthan gum vaccine ajuvant PMID: 19608270 "XG is derived from Xanthomonas campestris, has a pentasaccharide repeating unit structure, and its terminus contains a mannose moiety which acts as a toll-like receptor 2 agonist." REF: Mucoadhesive liposomes for intranasal immunization with an avian influenza virus vaccine in chickens, by Chiou C. et al. Biomaterials, Volume 30, Issue 29, October 2009, Pages 5862-5868, ISSN 0142-9612, 10.1016/j.biomaterials.2009.06.046. (http://www.sciencedirect.com/science/article/pii/S0142961209006371) YL yeast extract yeast protein Apex-IHN YH DNA vaccine Diphtheria-Tetanus-Pertussis-Haemophilus b vaccine Diphtheria-Tetanus-Poliovirus vaccine Vibro-E.coli vaccine Measles-Rubella vaccine Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b-Hepatitis B vaccine PreveNile Live flavivirus chimera vaccine YH Streptococcus equi vaccine YH Mycoplasma gallisepticum vaccine YH Salmonella typhi-Hepatitis A vaccine Bayovac CSF E2 YH Baculovirus recombinant E2 protein without emulsion Dhori virus vaccine Tick-borne virus vaccine pharyngeal mucosal route Pharyngeal mucosal route is an oral route of administration. TT, YH Intervet Avian Influenza virus vaccine YH Chimera virus on NDV backbone; field trials in 2007 host survival to pathogen challenge after vaccination AE: ataxia MP: MP_0001393 According to the Vaccine Adverse Event Reporting System (VAERS), 'ataxia' is an adverse event that was mentioned in 555 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). ataxia inability to coordinate voluntary muscular movements skin adverse event AE: abnormal gait MP: MP_0001406 AE: gait disturbance According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal gait' is an adverse event that was mentioned in 998 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). SS, YH abnormal gait unusual or distinctive way of walking Embrex http://www.embrex.com/ YH AE: dehydration hypohydration MP: MP_0001429 According to the Vaccine Adverse Event Reporting System (VAERS), 'dehydration' is an adverse event that was mentioned in 603 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). YH, SS dehydration excessive water loss from the body or from an organ or bodily part AE: abnormal fluid regulation MP: MP_0001784 any anomaly in the control of intracellular and/or extracellular fluid AE: hyperglycemia MP: MP_0001559 According to the Vaccine Adverse Event Reporting System (VAERS), 'hyperglycemia'; is an adverse event that was mentioned in 268 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). abnormally high concentration of glucose in the blood; generally refers to a pathological state hyperglycemia Canine gonadotropinreleasing factor immunotherapeutic Peptide-protein conjugate and water-miscible adjuvant; treatment of benign prostatic hyperplasia YH Novartis Animal Health YH http://www.ah.novartis.com/ AE: abnormal circulating bilirubin level MP: MP_0001569 According to the Vaccine Adverse Event Reporting System (VAERS), 'bilirubinemia'; is an adverse event that was mentioned in 221 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). aberrant concentration in the blood of this yellow heme breakdown product AE: cyanosis According to the Vaccine Adverse Event Reporting System (VAERS), 'cyanosis' is an adverse event that was mentioned in 1,804 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001575 a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood cyanosis AE: anemia According to the Vaccine Adverse Event Reporting System (VAERS), 'anemia' is an adverse event that was mentioned in 482 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001577 anemia less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs AE: hypotension MP: MP_0001596 According to the Vaccine Adverse Event Reporting System (VAERS), 'hypotension' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). blood pressure decreased, low blood pressure hypotension sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states AE: irregular heartbeat MP: MP_0001636 According to the Vaccine Adverse Event Reporting System (VAERS), 'arrhythmia'; is an adverse event that was mentioned in 164 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). uneven timing of heart contraction AE: abnormal heartbeat MP: MP_0004085 AE: arrhythmia SS, YH WEB: http://www.nlm.nih.gov/medlineplus/arrhythmia.html anomaly in the appearance of regularly spaced contractions of the heart Novartis http://www.novartis.com/ YH Aqua Health LHRH YH luteinizing hormone-releasing hormone AE: abnormal digestion MP: MP_0001664 altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy homeostasis AE MP: MP_0001764 anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues AE: edema oedema, swelling, dropsy MP: MP_0001785 an accumulation of an excessive amount of watery fluid in cells or intercellular tissues edema AE: inflammation SS, YH MP: MP_0001846 WEB: http://en.wikipedia.org/wiki/Inflammation AE: inflammation is an immune system disorder that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult AE: brain inflammation According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001847 local accumulation of fluid, plasma proteins, and leukocytes in the brain AE: increased susceptibility to otitis media According to the Vaccine Adverse Event Reporting System (VAERS), 'otitis media' is an adverse event that was mentioned in 1,538 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001850 greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection Bovilis IBR Marker Live or inactivated gE-deleted marker vaccine YH AE: eye inflammation MP: MP_0001851 local accumulation of fluid, plasma proteins, and leukocytes in the eye Porcilis Pesti YH Baculovirus recombinant E2 protein without emulsion AE: conjunctivitis MP: MP_0001852 According to the Vaccine Adverse Event Reporting System (VAERS), 'Conjunctivitis' is an adverse event that was mentioned in 860 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). conjunctivitis inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball AE: liver inflammation MP: MP_0001860 According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatitis' is an adverse event that was mentioned in 387 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). local accumulation of fluid, plasma proteins, and leukocytes in the liver AE: lung inflammation MP: MP_0001861 According to the Vaccine Adverse Event Reporting System (VAERS), 'pneumonia' is an adverse event that was mentioned in 879 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). local accumulation of fluid, plasma proteins, and leukocytes in the lung AE: respiratory system inflammation MP: MP_0002405 local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system AE: vasculitis It's an inflammation. MP: MP_0001864 According to the Vaccine Adverse Event Reporting System (VAERS), 'vasculitis' is an adverse event that was mentioned in 353 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). inflammation of a blood or lymph vessel vasculitis AE: salivary gland inflammation MP: MP_0001870 According to the Vaccine Adverse Event Reporting System (VAERS), 'staladenitis'; is an adverse event that was mentioned in 226 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland Theileria parva vaccine by local veterinary institutes YH Infection followed by drug treatment Novus International http://www.novusint.com/ YH AE: sinus inflammation SS, YH MP: MP_0001872 sinusitis According to the Vaccine Adverse Event Reporting System (VAERS), 'sinusitis'; is an adverse event that was mentioned in 298 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens AE: allergic response MP: MP_0001878 hypersensitivity caused by exposure to a specific antigen (allergen) resulting in a marked increase in reactivity to that antigen upon subsequent exposure AE: abnormal cerebrospinal fluid production MP: MP_0001911 According to the Vaccine Adverse Event Reporting System (VAERS), 'Cerebrospinal fluid abnormal' is an adverse event that was mentioned in 600 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord nervous system AE MP: MP_0003633 Toxoplasma gondii vaccine YH AE: abnormal respiration Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He MP: MP_0001943 According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). anomaly in the movement of gases into and out of the lung SpayVac SpayVac is a contraceptive vaccine that has proven highly effective in deer and can be used to control populations. Refernce: http://terramar.bc.ca/. YH no longer available Crude ZPA preparation; supplied to research groups only AE: apnea MP: MP_0001957 According to the Vaccine Adverse Event Reporting System (VAERS), 'apnea' is an adverse event that was mentioned in 1,618 VAERS reports (1.3%) during1991-2001 (Reference: PMID: 12825543). apnea temporary cessation of breathing; sometimes episodic AE: deafness According to the Vaccine Adverse Event Reporting System (VAERS), 'deafness'; is an adverse event that was mentioned in 287 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001967 deafness inability to hear gustatory system AE MP: MP_0001985 any anomaly in the perception of taste AE: taste sensitivity MP: MP_0001986 According to the Vaccine Adverse Event Reporting System (VAERS), 'taste perversion'; is an adverse event that was mentioned in 191 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system Biomune http://www.biomunecompany.com/ YH AE: photosensitivity According to the Vaccine Adverse Event Reporting System (VAERS), 'photosensitivity reaction'; is an adverse event that was mentioned in 131 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001999 alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes AE: blindness MP: MP_0002001 According to the Vaccine Adverse Event Reporting System (VAERS), 'blindness'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). blindness loss of the sense of sight AE: abnormal vision According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal vision' is an adverse event that was mentioned in 609 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002090 abnormal vision inability or decreased ability to see AE: seizures This term has another path from 'abnormal nervous system physiology' in MP. MP: MP_0002064 seizures sudden and often acute manifestation of epileptic attack, sometimes convulsive behavior/neurological AE MP: MP_0004924 any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls AE: movement disorder MP: MP_0002066 According to the Vaccine Adverse Event Reporting System (VAERS), 'movement disorder'; is an adverse event that was mentioned in 237 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). altered ability to coordinate voluntary movement or repetitive, compulsive movements Giardiavax Cultured trophozoites, reduces disease and cyst shedding YH plant-based Newcastle disease virus vaccine The plant-based Newcastle disease virus vaccine is a Newcastle disease virus vaccine that is developed by Dow AgroSciences LLC. It uses technology discovered at Washington University. It is the first plant-made animal vaccine approved for sale in the United States. HN recombinant produced in plant cell lines (registered but not on market) YH sensory capability AE MP: MP_0002067 inability or altered ability to respond to a sensory stimulus glucose homeostasis AE MP: MP_0002078 anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues Classical swine fever virus vaccine YH AE: hypersensitivity MP: MP_0002148 immune response that results in tissue injury AE: muscular atrophy MP: MP_0002269 According to the Vaccine Adverse Event Reporting System (VAERS), 'muscle atrophy'; is an adverse event that was mentioned in 140 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation AE: hyperventilation According to the Vaccine Adverse Event Reporting System (VAERS), 'Petechiae' is an adverse event that was mentioned in 510 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002320 increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal Vectormune FP-ND YH Fowlpox virus vectored AE: hypoventilation MP: MP_0002321 According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoventilation' is an adverse event that was mentioned in 321 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). hypoventilation reduced alveolar ventilation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal hematopoietic system AE MP: MP_0002396 any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells AE: mydriasis MP: MP_0002546 According to the Vaccine Adverse Event Reporting System (VAERS), 'mydriasis'; is an adverse event that was mentioned in 139 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). dilation of one or both pupils regardless of light conditions mydriasis Immucox Coccivac Paracox Nobilis Cox ATM Advent YH Sporulated oocysts of several or all of the avian species AE: increased heart rate MP: MP_0002626 tachycardia WEB: http://en.wikipedia.org/wiki/Tachycardia According to the Vaccine Adverse Event Reporting System (VAERS), 'tachycardia' is an adverse event that was mentioned in 1,269 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute Megan Vac1 WEB: http://www.fda.gov/ohrms/dockets/dockets/00n0504/00N-0504_emc-001650-02.pdf YH Megan Vac1 is a Salmoneela vaccine that consists of a double gene-deleted S. enterica serovar Typhimurium strain and is designed for protection of broilers to reduce Salmonella contamination. AE: hyperresponsive to tactile stimuli According to the Vaccine Adverse Event Reporting System (VAERS), 'hypesthesia'; is an adverse event that was mentioned in 238 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002738 exaggerated reflex action normally induced by touch or pain AE: opisthotonus According to the Vaccine Adverse Event Reporting System (VAERS), 'opisthotonos'; is an adverse event that was mentioned in 173 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002880 a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward opisthotonus AE: joint inflammation MP: MP_0002933 local accumulation of fluid, plasma proteins, and leukocytes in the joints AquaVac Furuvac Killed oral vaccine YH Lohman Animal Health International YH http://www.lahinternational.com/ AE: increased lactate dehydrogenase level MP: MP_0002944 According to the Vaccine Adverse Event Reporting System (VAERS), 'lactic dehydrogenase increased'; is an adverse event that was mentioned in 167 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate AE: increased circulating alkaline phosphatase level MP: MP_0002968 According to the Vaccine Adverse Event Reporting System (VAERS), 'alkaline phosphatase increased'; is an adverse event that was mentioned in 199 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood AE: arthritis According to the Vaccine Adverse Event Reporting System (VAERS), 'arthritis' is an adverse event that was mentioned in 972 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002993 arthritis joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures AE: dysphagia According to the Vaccine Adverse Event Reporting System (VAERS), 'dysphagia' is an adverse event that was mentioned in 603 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0003158 difficulty in swallowing food or liquid dysphagia AE: decreased lateral semicircular canal size According to the Vaccine Adverse Event Reporting System (VAERS), 'anxiety' is an adverse event that was mentioned in 391 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0003162 small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance Babesia bigemina vaccine YH AE: decreased platelet cell number MP: MP_0003179 platelet count decreased SS, YH According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenia' is an adverse event that was mentioned in 640 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation Yersinia ruckeri vaccine YH AE: nausea MP: MP_0003259 gastric discomfort associated with the inclination to vomit nausea AE: vomiting MP: MP_0003260 the retrograde expulsion of gastric contents through the oral cavity vomiting AE: constipation According to the Vaccine Adverse Event Reporting System (VAERS), 'constipation'; is an adverse event that was mentioned in 242 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0003267 constipation incomplete, infrequent or difficult evacuation of fecal matter AE: abnormal defecation MP: MP_0003866 anomaly in the production and excretion of feces AE: urinary incontinence MP: MP_0003280 According to the Vaccine Adverse Event Reporting System (VAERS), 'urinary incontinence'; is an adverse event that was mentioned in 237 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). inability to control the urinary excretory functions AE: intussusception According to the Vaccine Adverse Event Reporting System (VAERS), 'intussusception'; is an adverse event that was mentioned in 143 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0003294 intussusception telescoping of the intestine, or the prolapse of one part of the bowel to another; usually results in obstruction AE: pallor MP: MP_0003717 an unnatural paleness to the skin, generally attributable to anemia pallor AE: tinnitus According to the Vaccine Adverse Event Reporting System (VAERS), 'tinnitus'; is an adverse event that was mentioned in 268 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0003741 persistent sensation of buzzing, ringing, clicking, or other noises in the ear tinnitus AE: stomatitis MP: MP_0003746 According to the Vaccine Adverse Event Reporting System (VAERS), 'stomatitis'; is an adverse event that was mentioned in 121 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). This is a type of inflammation. inflammation of the mucous lining of the mouth stomatitis AE: mouth mucosal ulceration According to the Vaccine Adverse Event Reporting System (VAERS), 'mouth ulceration'; is an adverse event that was mentioned in 246 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0003747 lesions through the mucous membrane of the mouth, usually associated with loss of tissue AE: abnormal muscle tone MP: MP_0004142 anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation AE: hypertonia MP: MP_0004143 hypertonia increased muscle tension resulting in stiffness of the muscles in the resting state AE: hypotonia MP: MP_0004144 decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness hypotonia Vaxsafe MS YH Live temperature-sensitive mutant strain; eye drop administration AE: myositis MP: MP_0004510 According to the Vaccine Adverse Event Reporting System (VAERS), 'myositis'; is an adverse event that was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle myositis AE: muscle inflammation MP: MP_0004511 local accumulation of fluid, plasma proteins, and leukocytes in muscle AE: increased lymphocyte cell number MP: MP_0005013 According to the Vaccine Adverse Event Reporting System (VAERS), 'lymphocytosis'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells Nobivac Piro In vitro-cultured supernatant antigens, reduce clinical disease YH Equilis StrepE YH Live submucosal vaccine; deletions in aroA gene AE: diarrhea AE: diarrhoea MP: MP_0005036 abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel diarrhea AE: hypoxia According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoxia' is an adverse event that was mentioned in 566 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0005039 hypoxia reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases AE: sepsis According to the Vaccine Adverse Event Reporting System (VAERS), 'sepsis' is an adverse event that was mentioned in 416 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0005044 presence of various pathogenic organisms, or their toxins, in the blood or tissues sepsis Centre for Ticks and Tickborne Disease, Malawi YH AE: hematuria MP: MP_0005161 According to the Vaccine Adverse Event Reporting System (VAERS), 'hematuria'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). hematuria presence of blood in the urine AE: abnormal enzyme level MP: MP_0005319 altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances Theileria parva vaccine YH AE: decreased heart rate bradycardia WEB: http://en.wikipedia.org/wiki/Bradycardia According to the Vaccine Adverse Event Reporting System (VAERS), 'bradycardia' is an adverse event that was mentioned in 359 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0005333 fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute urinary system AE MP: MP_0005502 functional anomaly of any of the organs involved in the production or excretion of urine AE: decreased body temperature MP: MP_0005534 According to the Vaccine Adverse Event Reporting System (VAERS), 'hypothermia'; is an adverse event that was mentioned in 275 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). less than the level of heat natural to a living being Neospora caninum vaccine YH AE: abnormal body temperature MP: MP_0005535 deviation in the level of heat natural to a living being AE: neuritis MP: MP_0006082 According to the Vaccine Adverse Event Reporting System (VAERS), 'neuritis'; is an adverse event that was mentioned in 195 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord AE: double vision MP: MP_0006150 According to the Vaccine Adverse Event Reporting System (VAERS), 'diplopia'; is an adverse event that was mentioned in 150 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). double vision two images are perceived when only a single object is present ImmunoVaccine Technologies, Canada http://www.immunovaccine.com YH AE: hypochromic anemia MP: MP_0008387 According to the Vaccine Adverse Event Reporting System (VAERS), 'hypochromic anemia'; is an adverse event that was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs AquaVac Vibrio YH Killed oral vaccine Reference: http://www.spaquaculture.com/default.aspx?pageid=553 AE: petechiae According to the Vaccine Adverse Event Reporting System (VAERS), 'hyperventilation' is an adverse event that was mentioned in 539 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0008816 petechiae very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage AE: nervous According to the Vaccine Adverse Event Reporting System (VAERS), 'nervousness' is an adverse event that was mentioned in 583 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0008912 increased, skittish, behavior induced by stimulation such as handling, touching or noise nervous Babesia canis vaccine YH AE: ecchymosis MP: MP_0009276 According to the Vaccine Adverse Event Reporting System (VAERS), 'ecchymosis' is an adverse event that was mentioned in 1,347 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis ecchymosis vaccination with a licensed goat and sheep vaccine YH Mycoplasma synoviae vaccine YH vaccination with a licensed fish vaccine YH Local veterinary institutes YH Androstenedione YH vaccination with a licensed cat vaccine YH vaccination with a licensed ferret vaccine YH Giardia duodenalis vaccine protozoan vaccine that is used to protect against Giardia intestinalis infection YH vaccination with a licensed bird vaccine YH Chlamydophila abortus vaccine YH vaccination with a licensed deer vaccine YH vaccination with a licensed chicken vaccine YH 2009 H1N1 vaccine protocol YH CDC recommendation of the use of Influenza A (h1N1) 2009 vaccine YH, XZ WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm vaccination target group vaccination target group is a population group that have priority for vaccination when a vaccine is first available. YH, XZ Poulvac FluFend I AI H5N3 RG YH Chimera H5N3 virus, inactivated in oil-based adjuvant USDA YH 2009 H1N1 Influenza A vaccine target group YH, XZ WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm a vaccination target group for 2009 H1N1 Influenza monovalent vaccine. pregnant women XY, XZ WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm passive immunization by injecting pre-made immune element 09-26-2011 YL passive immunization by injecting a recipient with pre-made antibody, antitoxin, epitope, etc. Ovastim YH Increased ovulation/twinning RECOMBITEK rDistemper YH Canarypox virus-vectored vaccine (HA and F antigens) persons living with or providing care for infants aged <6 months WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm XY, XZ health-care and emergency medical services personnel WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm XY, XZ persons aged 6 months--24 years XY, XZ WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm persons aged 25--64 years with medical conditions at higher risk for influenza-related complications WEB: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm XY, XZ vaccination target role vaccination target role is a regulation-assigned role to a group of population with priority of getting some vaccination (e.g., 2009 H1N1 Influenza vaccine). YH inactivation YH, MC, and XZ inactivation is a processual entity that produces inactive material. serious adverse event WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA WEB: http://en.wikipedia.org/wiki/Serious_adverse_event YH, MC serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death. WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm Lawsonia intracellularis vaccine YH adverse event with outcome of death a serious adverse event with a direct outcome of the patient's death. YH WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm life-threating adverse event YH WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm a serious adverse event during which a patient was at substantial risk of dying or it is suspected that the use or continued use of the product would result in the patient's death. adverse event leading to hospitalization a serious adverse event that results in admission to the hospital or prolongation of a hospital stay. YH WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm adverse event leading to disability a serious adverse event that resulted in a significant, persistent, or permanent change, impairment, damage or disruption in the patient's body function/structure, physical activities or quality of life. WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm YH Fecundin Linked to human serum albumin; increased ovulation/twinning YH withdrawn adverse event leading to congenital anomaly WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm YH a serious adverse event that leads to suspicions that exposure to a medical product prior to conception or during pregnancy resulted in an adverse outcome in the child. adverse event that requires intervention to prevent permanent impairment or damage a serious adverse event that leads to suspicions that the use of a medical product may result in a condition which required medical or surgical intervention to preclude permanent impairment or damage to a patient. YH WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm CoxAbic YH Gametocyte antigen(s); transmission blocking through maternal antibody transfer Bordetella avium vaccine YH non-serious adverse event WEB: http://www.google.ca/url?sa=t&source=web&ct=res&cd=1&ved=0CA4QFjAA&url=http%3A%2F%2Fwww.irrd.ca%2Fethics%2Fimages%2FAdverse-event-definition.doc&ei=eqFMS-yFNZSoswOt6siKAQ&usg=AFQjCNGnQcwI8OXH7dqxwo4RgZEEn8X6lg&sig2=UNngkCdO5ZTFvbIB1pKuaA YH, MC an adverse event that is considered not serious. survival of live vaccine inside host YH survival of live vaccine inside host is a processual entity that represents the survival of a live vaccine inside its host. The time of the survival is often important for the success of the live vaccine. persistence of vaccine induced immune response YH persistence of vaccine induced immune response is a processual entity that indicates the persistence of an immune reponse induced by a vaccine in a vaccinated host. AE: low-grade fever YH AE: low-grade fever is a fever adverse event with a temperature usually less than 38.5 C. Merial,Inc http://www.merial.com/ YH Bovilis Neoguard YH Killed tachyzoites, reduces abortion AE: moderate-grade fever AE: moderate-grade fever is a fever adverse event with a temperature usually in between 38.6 - 40 C. YH AE: high-grade fever YH AE: high-grade fever is a fever adverse event with a temperature usually in between 40 and 41.1 C. RECOMBITEK Canine Parvo Modified live virus YH AE: hyperpyrexia YH WEB: http://en.wikipedia.org/wiki/Hyperpyrexia AE: hyperpyrexia is a fever adverse event that shows an excessive and unusual elevation of set body temperature greater than or equal to 41 degree C (105.8 degree F). It is an extremely high fever. Such a high temperature is considered a medical emergency as it may indicate a serious underlying condition such as sepsis. Eimeria maxima vaccine YH Agriflu YH CVX: 140 live attenuated Brucella vaccine CVX: 135 live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella infection. YH AE: musculoskeletal pain SS, YH WEB: http://www.webmd.com/pain-management/guide/musculoskeletal-pain Musculoskeletal pain is pain that affects the muscles, ligaments and tendons, along with the bones. AE: injection-site erythema SS, YH WEB: http://en.wikipedia.org/wiki/Erythema AE: injection-site erythema is an injection-site AE that results in redness of skin, caused by hyperermia of the capillaries in the lower layers of the skin at the physical area of injection Actinobacillus pleuropneumoniae vaccine YH AE: erythema MP:0001190 Erythema AE is a skin adverse event that showns redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin. WEB: http://en.wikipedia.org/wiki/Erythema SS, YH reddish skin assay of CFU reduction in liver YH assay of CFU reduction in liver is a CFU reduction assay that is measured using the extracted liver as the tissue for isolation of infected pathogens. assay of CFU reduction in lung YH assay of CFU reduction in lung is a CFU reduction assay that is measured using the extracted lung as the tissue for isolation of infected pathogens. live attenuated Brucella abortus vaccine live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella abortus infection. YH live attenuated Brucella melitensis vaccine YH live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella melitensis infection. live attenuated Brucella suis vaccine live attenuated Brucella vaccine is a live attenuated vaccine that protects against a Brucella melitensis infection. YH Eimeria tenella vaccine YH Ovilis Toxovax S48 strain with a lost ability to form cysts after passages in mice YH vaccine viability YH, ZX vaccine viability is a viability of a vaccine. West Nile-Innovator DNA YH DNA vaccine Brucella DNA vaccine Brucella DNA vaccine is a DNA vaccine that protects against a Brucella infection. YH Leishmania donovani vaccine YH DNA encoding pathogen protein as vaccine component YH Brucella DNA vaccine encoding chimera BLSOmp31 pCIBLSOmp31 PMID: 17600596 YH vaccine being viable vaccine being viable is a vaccine viability that indicates a vaccine uses live organism. YH, ZX vaccine being dead vaccine being dead is a vaccine viability that indicates a vaccine uses dead or killed organism. YH, ZX IL-12 vacince adjuvant a cytokine vaccine adjuvant that includes IL-12. IL-12 vaccine adjuvant is a vaccine adjuvant that contains IL-12. YH, ZX no vaccine protection YH, ZX significant vaccine protection YH, ZX enhanced significant protection YH, ZX Piscirickettsia salmonis vaccine YL bacterial vaccine that is used to protect against Piscirickettsia salmonis infection generated using OntoRat AE: sinus headache YH, SS AE: sinus headache is a headache located over the sinuses, (forehead, corners of the eye, and cheek areas). On occasion, the pain will be felt behind the eyes, in the back of the neck, or may extend into the upper teeth. WEB: http://american-rhinologic.org/patientinfo.headache.phtml Androvax Increased ovulation/twinning YH B. abortus HSA-L7/L12 YH Brucella abortus Human serum albumin (HAS)-L7/L12 PMID: 19293473 B. abortus L7/L12 is a B. abortus subunit vaccine using L7/L12 that is formed by recombinant Human Serum Albumin (HAS)-L7/L12 fusion protein. AE: pneumonia AE: pneumonia is a respiratory system AE that results in an abnormal inflammatory condition of the lung. It is often characterized as including inflammation of the parenchyma of the lung (that is, the alveoli) and abnormal alveolar filling with fluid (consolidation and exudation). WEB: http://en.wikipedia.org/wiki/Pneumonia SS, YH AE: lobar pneumonia AE: lobar pneumonia is a form of pneumonia that affects a large and continuous area of the lobe of a lung WEB: http://en.wikipedia.org/wiki/Lobar_pneumonia SS, YH AE: axillary pain AE: axillary pain is an AE: pain that occurs in the underarm (the area on the human body directly under the join where the arm connects to the shoulder). SS, YH Porcilis APP Extracted ApxI, ApxII, ApxIII, and outer membrane proteins YH PUREVAX Ferret Distemper Canarypox virus-vectored vaccine YH PUREVAX Ferret Distemper is a lyophilized ferret vaccine of a recombinant canarypox vector expressing the HA and F glycoproteins of canine distemper virus. Reference: http://www.drugs.com/vet/purevax-ferret-distemper.html. vaccination dose sepcification YH, ZX challenge dose specification YH, ZX specification of vaccination-challenge interval YH, ZX specification of time interval after vaccination for challenge is a plan specification that specifies the time interval after vacciation for challenge pathogen challenge protocol YH, ZX pathogen challenge protocol is a protocol that is used for a pathogen challenge process. reduction of colony forming unit reduction of colony-forming unit (CFU) is a titer measurement of viable bacterial or fungal numbers. It equals to a reduction of a CFU count from another CFU count. This term is often used as a measurement of a vaccine protection study. YH, ZX intraperitoneal pathogen challenge YH, ZX intraperitoneal pathogen challenge is a pathogen challenge process that occurs in the intraperitoneal site of a host. intraperitoneal vaccination a vaccination process that occurs in the intraperitoneal route YH, ZX AE: haematoma AE: haematoma is an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise. SS, YH AE: hematoma, bruise, ecchymoses WEB: http://en.wikipedia.org/wiki/Hematoma reproductive system AE reproductive system AE is an AE that occurs in the reproductive system. YH, SS E. coli DNA vaccine E. coli DNA vaccine is a DNA vaccine that protects against an E. coli infection. YH Brucella subunit vaccine YH Brucella subunit vaccine is a subunit vaccine that protects against a Brucella infection. B. melitensis Rev. 1 with bp26 and omp31 deletions PMID: 17070627 YH CGV2631 B. melitensis bp26 and omp31 deletion vaccine is a Brucella melitensis vaccine that has double deletions of bp26 and omp31. pCIOmp31 YH pCIOmp31 is a B. melitensis DNA vaccine expressing Omp31 that uses the pCI plasmid. PMID: 16177328 pTargeTomp31 YH pTargeTomp31 is a B. melitensis DNA vaccine expressing Omp31 that uses the pTargeT mammalian expression system vector (Promega, USA). PMID: 17014873 Schering-Plough Animal Health YH Intervet has merged with Schering-Plough Animal Health and become Intervet/Schering-Plough Animal Health™ (YL.) http://www.intervet.com/ B. abortus L7/L12 fused to MBP B. abortus L7/L12 fused to MBP is a B. abortus subunit vaccine using L7/L12 that uses recombinant L7/L12 fused on maltose binding protein MBP. PMID: 8873388 YH inactivated influenza vaccine YH inactivated influenza vaccine is an inactivated viral vaccine that targets at influenza viral infections. Livacox YH Precocious and egg-passaged lines live attenuated influenza vaccine live attenuated influenza vaccine is a live attenuated vaccine that protects against influenza viral infection. YH Bayer Leverkusen http://www.bayer.com/ YH laboratory test Vaxsafe MG YH Live temperature-sensitive mutant strain; eye drop administration ANOVA Oliver: It's temporary. We will get this term from OBI eventually. GonaCon YH registration reported to be in progress Peptide conjugated to keyhole limpet hemocyanin in mycobacterium-oil adjuvant (AdjuVac); contraceptive vaccine to control wildlife vaccine protection ANOVA Inovocox YH In ovo delivery using proprietary platform injection system vaccine protection data set YH intramuscular vaccination YH, YL a vaccination that occurs in the intramuscular route. vaccine strain data set YH vaccine viability data set YH IL-12 vaccine adjuvant data set YH vaccine protective antigen data set YH mutated gene in vaccine strain data set YH vaccination mouse strain data set YH biological sex data set YH vaccination route data set YH vaccination dose data set YH animal age at vaccination data set YH pathogen strain for challenge data set YH pathogen challenge data set YH Leishmune Native fucose-mannose-ligand antigen complex YH Enterisol Ileitis Live oral vaccine YH challenge dose data set YH vaccination-challenge interval data set YH CFU per volume data set YH CFU reduction data set YH vaccine protection efficacy data set YH p-value data set B. abortus BLS-L7/L12 YH B. abortus BLS-L7/L12 is a B. abortus subunit vaccine using L7/L12 that is made as a recombinant BLS-L7/L12 fusion protein vaccine. recombinant Brucella BLS-L7/L12 fusion protein vaccine PMID: 19596411 recombinant Brucella lumazine synthase and L7/L12 fusion protein vaccine vaccine protection efficacy measurement YH vaccine protection efficacy measurement is an assay that measures the protection efficayc of a vaccine. lipopolysaccharide subunit vaccine YH recombinant bacterial vector vaccine YH, XZ Coopers Animal Health YH http://www.coopersanimalhealth.com.au/ recombinant viral vector vaccine YH, ZX inactivated bacterial vaccine YH Vaxstrate LHRH peptide conjugated to ovalbumin; oil emulsion adjuvant withdrawn in 1996 YH inactivated Brucella vaccine YH live attenuated bacterial vaccine YH veterinary vaccine YH Veterinary vaccine is a vaccine that is used for animals (excluding humans), for example, pet, domestic, wildlife, and livestock animals. Dow AgroSciences YH http://www.dowagro.com/homepage/index.htm?DCSext.das=dowagro.com live attenuated viral vaccine YH Brucella abortus subunit vaccine YH Newcastle disease virus vaccine YH Brucella melitensis subunit vaccine YH Brucella suis subunit vaccine YH Brucella abortus DNA vaccine YH Brucella melitensis DNA vaccine YH Brucella suis DNA vaccine YH inactivated Brucella abortus vaccine recombinant bacterial vector vaccine for Brucella recombinant bacterial vector vaccine for Brucella abortus human vaccine Human vaccine is a vaccine that is used for human. YH protective antigen YH, ZX viral vaccine preparation YH, ZX A vaccine preparation that results in the generation of a viral vaccine protozoan vaccine preparation YH, ZX A vaccine preparation that results in the generation of a protozoan vaccine fungal vaccine preparation A vaccine preparation that results in the generation of a fungal vaccine YH, ZX preparation of cancer vaccine A vaccine preparation that results in the generation of a cancer vaccine CpG DNA vaccine adjuvant YH A microbial derivative vaccine adjuvant compsed of CpG DNA. PMID: 12899580 Ribi vaccine adjuvant Ribi vaccine adjuvant is an emulsion vaccine adjuvant that is a stable oil-in-water emulsion. http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=M6661%7CSIGMA&N25=0&QS=ON&F=SPEC SGS RC529 vaccine adjuvant a synthetic vaccine adjuvant named RC529 that is a lipid A mimetic. PMID: 16204643 SGS aluminum potassium sulfate adjuvant An aluminum vaccine adjuvant that is aluminum potassium sulfate (AlK(SO4)2). ZX, SGS Alhydrogel ZX, SGS An aluminum hydroxide vaccine adjuvant that is a gel that is made by precipitation of aluminum hydroxide Al(OH)3 under alkaline conditions. PMID: 7551218 cholera toxin B subunit CTB SGS A microbial derivative vaccine adjuvant made of the B subunit of the cholera toxin from Vibrio cholerae. Prevnar 13 ZX VIOLIN Vaccine ID: 1114 CVX: 133 Synflorix ZX VIOLIN Vaccine ID: 1115 Menveo VIOLIN Vaccine ID: 1113 CVX: 136 AREPANRIX H1N1 VIOLIN Vaccine ID: 1116 Intanza VIOLIN Vaccine ID: 1117 RC529-AF vaccine adjuvant RC529-AF can be obtained from Corixa Corporation (Seattle, WA). Reference: PMID: 15308371 RC529 vaccine adjuvant in an aqueour formulation an aqueous formula of the synthetic vaccine adjuvant RC529. MPL vaccine adjuvant PMID: 7551218 SGS 3D-MLA PMID: 10768940 A microbial derivative vaccine adjuvant derived from the lipopolysaccharide (LPS) of Salmonella minnesota R595. 3-O-deacylated monophosphoryl lipid A vaccine adjuvant LTK63 vaccine mutant A microbial derivative vaccine adjuvant that is a mutant form of LT containing a Ser-Lys substitution in position 63 which has been shown to be totally devoid of toxicity stable to protease treatment and able to act as mucosal adjuvant. PMID: 10790422; PMID: 17920733 PMID: 9607006 LTK63 is an enzymatically inactive mutant of the heat-labile enterotoxin of Escherichia coli. It can be used as a potent mucosal adjuvant. SGS toxoid YH WEB: http://en.wikipedia.org/wiki/Toxoid is a bacterial toxin (usually an exotoxin) whose toxicity has been weakened or suppressed either by chemical (formalin) or heat treatment, while other properties, typically immunogenicity, are maintained. capsular polysaccharide subunit vaccine YH capsular polysaccharide of pathogen organism as vaccine component YH polysaccharide subunit vaccine YH polysaccharide of pathogen organism as vaccine component YH prevention of disorder objective YH is the specification of an objective to prevent a disorder. amelioration of disorder objective is the specification of an objective to ameliorate a disorder. YH killed Corynebacterium parvum vaccine adjuvant SGS PMID: 4596278; PMID: 7591056 PMID: 5483667 A microbial derivative vaccine adjuvant derived from heat-killed Corynebacterium parvum. Titermax Gold URL: http://www.titermax.com/i_gold4.htm Titermax Gold is an emulsion vaccine adjuvant which is a water-in-oil adjuvant with CRL-8300 (a block copolymer), squalene, and sorbitan monooleate. SGS It's a water-in-oil emulsion adjuvant. Reference: http://www.titermax.com/i_gold4.htm. DDA vaccine adjuvant PMID: 1439129 a synthetic vaccine adjuvant that is dimethyldioctadecylammonium bromide (DDA), a lipophilic quaternary ammonium salt known as a good adjuvant when co-administered systemically or nasally with an antigen. SGS Dimethyl dioctadecyl ammonium bromide cationic liposomal vaccine adjuvant DDA:TDB SGS A liposome-based vaccine adjuvant that have a positive surface charge. PMID: 19874860 QuilA vaccine adjuvant a tenosactive compound vaccine adjuvant that contains purified extract from the bark of the South American tree Quillaja saponaria Molina. SGS PMID: 7551218 AS02 vaccine adjuvant monophosphoryl lipid A (MPL), QS21 and an oil in water emulsion. PMID: 15780441; PMID: 15187142 SGS A combination vaccine adjuvant comprised of monophosphoryl lipid A (MPL), QS21 and an oil in water emulsion. AS04 vaccine adjuvant AS04 is a combination vaccine adjuvant that is a combination of 50 μg of the immunoenhancer MPL (3-O-desacyl-4′-monophosphoryl lipid A) with 500 μg of aluminium salt. SGS PMID: 21527299 VSA-3 PMID:16187717 VSA-3 is an emulsion vaccine adjuvant which is an emulsion plus DDA. Emulsigen D SGS saponin vaccine adjuvant a tensoactive compound vaccine adjuvant that is derived from saponin, a compound that is an immunostimulator found in the plant P. senega. Montanide ISA 720 PMID: 15752840 A Montanide vaccine adjuvant that is formulated as water-in-oil emulsions and induces high antibody titers in several animal species. It is a vaccine adjuvant composed of metabolizable oil and a surfactant system designed to make a water-in-oil emulsion. It has been used since 1992 in more than 50 clinical trials related to therapeutic vaccines against various diseases such as cancer and malaria. WEB: http://www.seppic.com/human-health/vaccine-adjuvant/montanide-isa-720-@/view-1044-seproduit.html?menuid=,979,&lang=en YH, SGS Montanide ISA 720 VG Montanide incomplete Seppic adjuvant a montanide vaccine adjuvant that is a mineral oil adjuvant. Montanide ISA51 A montanide vaccine adjuvant that is a vaccine adjuvant composed of a light mineral oil and a surfactant system designed to make a water-in-oil emulsion. WEB: http://www.seppic.com/human-health/vaccine-adjuvant/montanide-isa-51-@/view-1042-seproduit.html?menuid=,979,&lang=en SGS Montanide vaccine adjuvant An emulsion vaccine adjuvant developed by Montanide (http://www.montanide.com/). YH, SS EtxB vaccine adjuvant B subunit of E. coli heat-labile enterotoxin YH, SS A microbial derivative vaccine adjuvant composed of the B subunit of E. coli heat-labile toxin. Polygen vaccine adjuvant A synthetic vaccine adjuvant with the tradename Polygen. YH, SS URL: http://www.mvp-technologies.com/adjuvants/Polygen%20Final%20Technical%20Bulletin.pdf vaccine host role YH, ZX a role of host that contains vaccine. It is a role that inheres in an organism that is the target of a vaccine administration (vaccination process). immunization target role a role that represents a target (i.e., some disorder) of immunization. YH, ZX bacterial vaccine immunization YH, ZX viral vaccine immunization YH, ZX cancer vaccine immunization YH, ZX parasite vaccine immunization YH, ZX immunization target role of pathogen immunization target role of bacterial pathogen YH, ZX immunization target role of viral pathogen YH, ZX immunization target role of parasite pathogen YH, ZX immunization target role of fungal pathogen YH, ZX Algal Glucan vaccine adjuvant SGS A nonantigenic carbohydrate adjuvant, which enhances both humoral and cell-mediated immunity to oligopeptides in experimental animal models. PMID: 7551218 Algammulin vaccine adjuvant PMID:1887671 SGS A suspension of 1-2μm ovoids of immune stimulant gamma inulin (g-IN) in which alum is embedded as a carrier for protein or other anionic antigens. BAY R1005 a synthetic vaccine adjuvant that is Bay R1005 (N-(2-Deoxy-2-L-leucylamino β-D-glucopyranosyl)-N-octadecyldodecanoylamide hydroacetate ). N-( 2-Deoxy-2-L-leucylamino-β-D-glucopyranosyl)-N-octadecyldodecanoylamide hydroacetate SGS PMID: 7551218 Avridine SGS N, N-dioctadecyl-N′, N′-bis( 2-hydroxyethyl) propanediamine CP20,96 PMID:7551218 A synthetic vaccine adjuvant that is N, N-dioctadecyl-N′, N′-bis( 2-hydroxyethyl) propanediamine (Avridine). calcium phosphate gel SGS PMID: 7551218 a calcium phosphate vaccine adjuvant that is a gel prepared by precipitating soluable calcium and phosphate salts. Cholera toxin A1-subunit-ProteinA D-fragment fusion protein SGS CTA1-DD gene fusion protein PMID: 7551218 A microbial derivative vaccine adjuvant composed of the CTA1-DD fusion protein. DOC/Alum Complex SGS A mineral salt vaccine adjuvant that is composed of Deoxycholic acid sodium salt (DOC) complexed with aluminum hydroxide. PMID:7551218 gamma Inulin vaccine adjuvant PMID: 3265692; PMID: 7551218 SGS gamma inulin is a carbohydrate adjuvant that is a highly specific activator of the alternative pathway of complement in vitro and in vivo, and is composed of linear (unbranched) b-D-(2-1) polyfructofuranosyl-a-D-glucose. Gerbu vaccine adjuvant Gerbu adjuvant is a combination vaccine adjuvant that is comprised of a mixture of GMDP, DDA, and Zinc L-proline salt complex (ZnPro8). SGS PMID: 7551218 PMID: 15953835 GM-CSF vaccine adjuvant a cytokine vaccine adjuvant that includes GM-CSF. YH, SGS GMDP N-acetylglucosaminyl-(b1-4)-N-acetylmuramyl-L-alanyl-D-isoglutamine PMID: 7551218 SGS A synthetic vaccine adjuvant containing GMDP, a higly effective primary adjuvant. recombinant hIFN-gamma/Interferon-g vaccine adjuvant an IFN-gamma vaccine adjuvant that is composed of recombinant hIFN-gamma. YH, SGS interleukin-1b vaccine adjuvant a cytokine vaccine adjuvant that includes IL-1b. YH, SGS interleukin-2 YH, SGS a cytokine vaccine adjuvant that includes IL-2. interleukin-7 YH, SGS a cytokine vaccine adjuvant that includes IL-7. Loxoribine 7-allyl-8-oxoguanosine SGS a synthetic vaccine adjuvant loxoribine is a guanosine analog derivatized at position N7 and C8, and activates TLR-7. PMID: 7551218 MF59 PMID: 20488726 An emulsion vaccine adjuvant consisting of an oil (squalene)-in-water nano emulsion. SGS MTP-PE Liposomes MTP-PE liposomes are a liposome-based vaccine adjuvant that consists of liposomes containing the synthetic lipophilic analog of muramyl dipeptide, muramyl tripeptide phosphatidylethanolamine (MTP-PE). PMID: 1431559 SGS MTP-PE Murametide SGS PMID: 7551218 a synthetic vaccine adjuvant made of murametide that has adjuvant activity similar to MDP. Nac-Mur-L-Ala-D-Gln-OCH3 Murapalmitine PMID: 7551218 Nac-Mur-L-Thr-D-isoGIn-sn-glyceroI dipalmitoyl SGS a synthetic vaccine adjuvant called murapalmitine. D-Murapalmitine Nac-Mur-D-Ala-D-isoGln-sn-glycerol dipalmitoyl PMID: 7551218 SGS a synthetic adjuvant that is an MDP analog called D-Murapalmitine. NAGO SGS PMID: 7551218 a synthetic vaccine adjuvant that is composed of neuraminidase-galactose oxidase (NAGO) a mixture of mixture of the two enzymes-neuraminidase and galactose oxidase. Neuraminidase-galactose oxidase non-ionic surfactant vesicles a synthetic vaccine adjuvant consisting of multi-lamellar vesicles comprising a mixture of non-ionic surfactant (e.g., 1-monopalmitoyl-rac-glycerol), cholesterol and dicetyl phosphate used as a primary vaccine adjuvant for entrapped antigen. PMID: 7551218 SGS NISV PMMA PMID: 7551218 a synthetic vaccine adjuvant made from the emulsion polymerization of methyl methacrylate. Polymethyl methacrylate SGS protein cochleates PMID: 7551218 SGS a synthetic vaccine adjuvant synthesized from stable protein phospholipid-calcium precipitates. QS-21 a tensoactive compound vaccine adjuvant that is composed of extracts from the bark of the Quillaja saponaria Molina tree. SGS PMID: 7551218 Stimulon™ QS-21 Adjuvant Rehydragel HPA SGS PMID: 7551218 An aluminum vaccine adjuvant that is a synthetic oxyhydroxide of aluminum (aluminum hydroxide) prepared by acid-base precipitation. Rehydragel LV An aluminum hydroxide vaccine adjuvant that is a low visosity aluminum hydroxide gel. PMID: 7551218 SGS Sclavo peptide IL-1β 163-171 peptide YH, SGS a cytokine vaccine adjuvant that contains the 163-171 peptide of IL-1β. Specol SGS PMID: 1439130 Specon is an emulsion vaccine adjuvant that is a water-in-oil emulsion that is used as an adjuvant and has immunostimulating properties similar to Freund's complete adjuvant (FCA). SPT (Antigen Formulation) SPT is an emulsion vaccine adjuvant that is an emulsion of squalane (5%), Tween 80( 0.2%), Pluronic L121( 1.25%), phosphate-buffered saline pH 7.4, and antigen. PMID: 7551218 SGS stearyl tyrosine a synthetic vaccine adjuvant stearyl tyrosine is considered an "organic equivelant" of aluminum hydroxide. SGS PMID: 7551218 Theramide PMID: 7551218 a synthetic vaccine adjuvant called Theramide that is composed of N-acetylglucosaminyl-N-acetylinuramyl-L-Ala-D-isoGlu-L-Ala-dipalmitoxy propylamide (DTP-DPP). SGS CRL1005 PMID: 10717336 a synthetic vaccine adjuvant that is a copolymer (CRL1005), based on a 12 kDa polyoxypropylene (POP) core with 5% POE. SGS nanoemulsion vaccine adjuvant SGS Nanoemulsion vaccine adjuvant is an emulsion vaccine adjuvant and is made from non-toxic lipid droplets a few hundred nanometers in diameter and made from surfactants approved for human consumption and common food substances that are 'Generally Recognized as Safe' (GRAS) by the FDA. http://nano.med.umich.edu/platforms/Nanoemulsions.html AS03 PMID: 21256188 SGS AS03 is an emusion vaccine adjuvant that contains α-tocopherol and squalene, two biodegradable polyprenyls, in an oil-in-water emulsion. LTR192G PMID: 11803061 A microbial deriviative vaccine adjuvant that is a mutant form of E.coli heat-labile toxin. SGS E. coli heat-labile toxin, LT LT Oral Adjuvant A microbial derivative vaccine adjuvant containing E. coli heat-labile toxin. PMID: 7551218 SGS LT-OA amorphous aluminum hydroxyphosphate sulfate adjuvant (AAHSA) AAHSA Merck Aluminum Adjuvant PMID: 17581283 An aluminum vaccine adjuvant that is a a proprietary aluminum hydroxyphosphate sulfate formulation that is both physically and functionally distinct from traditional aluminum phosphate and aluminum hydroxide adjuvants. SGS Matrix-S Brucella abortus subunit vaccine using Bfr PMID: 11447155 Brucella BFR antigen vaccine recombinant Brucella abortus Bfr protein vaccine Brucella abortus subunit vaccine using Omp16 PMID: 18981242 Brucella abortus Omp16 vaccine B. melitensis DNA vaccine encoding Bp26 and Tf imiquimod vaccine adjuvant S26308 a synthetic vaccine adjuvant contiaing imiquimod a imidazoquinoline. 1-(2-methypropyl)-IH-imidazo[4,5-c]quinolin-4-amine R-837 SGS PMID: 7551218, PMID: 18566444 Aldara™ resiquimod vaccine adjuvant a synthetic vaccine adjuvant, resiquimod is a chemical analog of imiquimod. SGS PMID: 15068862 AF03 vaccine adjuvant PMID:20193791 SGS An emulsion vaccine adjuvant containing 2.5% squalene. Flagellin vaccine adjuvant PMID: 16428759, PMID: 21048152 FliC SGS A microbial derivative vaccine adjuvant composed of flagellin from gram-negative bacteria. poly(I:C) vaccine adjuvant SGS a synthetic vaccine adjuvant containing Poly(I:C), a synthetic double stranded analog of RNA. WEB: http://en.wikipedia.org/wiki/Polyinosinic:polycytidylic_acid polyriboinosinic-polyribocytidylic acid ISCOMATRIX vaccine adjuvant ISCOMATRIX is identical to ISCOMs except that it does not contain antigen. Ref: PMID: 17336431. a particulate antigen delivery system that is a vaccine adjuvant comprising cholesterol, phospholipid and saponin but without antigen. SGS PMID: 19450632 Abisco-100 vaccine adjuvant SGS, YH WEB: http://www.isconova.com/products/abisco-research-reagent/abisco-100.aspx a tensoactive compound vaccine adjuvant that is made from highly purified saponins. albumin-heparin microparticles vaccine adjuvant a particulate antigen delivery system that is albumin-heparin microparticles vaccine adjuvant that is prepared from albumin and heparin stabilized by cross-linking reaction with EDC. PMID: 16734558 SGS AS-2 vaccine adjuvant http://www.pasteur.fr/applications/euroconf/vaccins/vaccins-abs.html SGS SmithKline Beecham adjuvant system 2 (AS-2) is a combination vaccine adjuvant and is based on the combination of Monophosphoryl Lipid A(MPL), QS21 (a purified fraction of Saponin extracted from Quillarja Saponaria), and a proprietary oil in water emulsion. B7-2 vaccine adjuvant a cytokine vaccine adjuvant that includes B7-2. YH, SGS Bupivacaine vaccine adjuvant a synthetic vaccine adjuvant that is a local anaesthetic drug belonging to the amino amide group, and is used as a vaccine adjuvant in DNA vaccines. PMID: 15246629, WEB: http://en.wikipedia.org/wiki/Bupivacaine SGS cationic liposome-DNA complex JVRS-100 PMID: 19285425 SGS A liposome-based vaccine adjuvant that is composed of virus sized liposomes that contain a DNA plasmid. DHEA vaccine adjuvant prasterone a synthetic vaccine adjuvant that is DHEA, which is relatively stable and can be directly incorporated into vaccine formulations. SGS transdehydroandrosterone DHA androstenolone 5-androsten-3β-ol-17-one Dehydroepiandrosterone PMID: 7551218 DL-PGL (Polyester poly (DL-lactide-co-glycolide)) vaccine adjuvant a synthetic vaccine adjuvant that is PLGA, which has been used in the controlled delivery of peptide drugs. PLGA PMID: 15560948 PLGA microspheres SGS Polyester poly (DL-lactide-co-glycolide) IL-15 vaccine adjuvant a cytokine vaccine adjuvant that includes IL-15. YH, SGS immunoliposomes containing antibodies to costimulatory molecules SGS immunoliposomes containing antibodies to costimulatory molecules is a liposome-based vaccine adjuvant which is prepared from dehydration-rehydration vesicles (DRVs). PMID: 7551218 LTK72 vaccine adjuvant SGS A microbial derivative vaccine adjuvant that is a mutant form of heat-labile Escherichia coli enterotoxin (LT) that contains a substitution Ala → Arg in position 72 of the A subunit. PMID: 9529328 MPL-SE vaccine adjuvant SGS A microbial derivative vaccine adjuvant containing MPL and squalene. PMID: 12213399 formaldehyde vaccine preservative WEB: http://www.mja.com.au/public/issues/184_04_200206/eld10500_fm.pdf a vaccine preservative that contains formaldehyde. YH, SGS non-toxic mutant E112K of Cholera Toxin mCT-E112K A microbial derived vaccine adjuvant made of E112K mC, a mutated CT created by substituting a single amino acid in the ADP-ribosyltransferase active centre, glutamate to lysine at position 112. SGS mCT PMID: 11251876: cholera toxin derived vaccine adjuvant YH, SGS a microbial derivative vaccine adjuvant that is derived from cholera toxin. SAF-1 vaccine adjuvant PMID: 7551218 SAF-1 is a combination vaccine adjuvant that is composed of threonyl-MDP (0.05-1%) in an emulsion vehicle [5% squalane, 2.5% Pluronic® L121, 0.2% Polysorbate 80 and phosphate buffered saline (pH 7.4)]. SGS Sendai Proteoliposomes, Sendai-containing Lipid Matrices A liposome-based vaccine adjuvant that includes the glycoproteins of Sendai virus. SGS PMID: 7551218 threonyl muramyl dipeptide (TMDP) vaccine adjuvant [thr1 ]-MDP a synthetic vaccine adjuvant that is threonyl muramyl dipeptide (TMDP). Termurtide™ PMID: 7551218 N-acetyl muramyl-L-threonyl-D-isoglutamine SGS ty particles vaccine adjuvant PMID: 7551218 A microbial derivative vaccine adjuvant made of virus like particles (VLPS) containing the yeast retrotransposon Ty which has the amino acids 1-381 of the pI protein encoded. SGS Ty-VLPs cytokine vaccine adjuvant YH, SGS a vaccine adjuvant that contains active cytokine compound. combination vaccine adjuvant YH, SGS a vaccine adjuvant that is composed of differnt compounds under more than one category. emulsion vaccine adjuvant particulate antigen delivery system a vaccine adjuvant that serves as a particulate antigen delivery system. YH, SGS synthetic vaccine adjuvant YH, SGS A vaccine aduvant that contains synthetic material. tensoactive compound vaccine adjuvant a vaccine adjuvant that includes tensioactive material. Tensioactive materials, surfactants or active surface agents are chemical substances with a polar-non polar structure. These substances have a tendency to locate themselves at the surface creating an adsorbed monomolecular layer on the interface. WEB: http://www.citt.ufl.edu/team/sepulveda/html/en_tensioactivos.htm tensioactive compound vaccine adjuvant YH, SGS carbohydrate vaccine adjuvant YH, SGS a vaccine adjuvant that is primarily composed of carbohydrates. IFN-gamma vaccine adjuvant YH, SGS a cytokine vaccine adjuvant that includes IFN-gamma. virmugen role YH, YL a role that is inherenced in a gene that can be mutated in a virulent pathogen, leading to an attenuated strain serving as a live attenuated vaccine strain. allergy vaccine YL, YH YL,YH a vaccine that targets for allergy. Clostridium perfringens vaccine bacterial vaccine that is used to protect against Clostridium perfringens infection YL generated using OntoRat human immunization objective vaccine target role heat-inactivated vaccine an inactivation vaccine that is prepared by heat inactivation. YH, YL irradiation-inactivated vaccine an inactivation vaccine that is prepared by irradiation inactivation. YH, YL H2O2-inactivated vaccine YH, YL an inactivation vaccine that is prepared by H2O2 inactivation. formalin-inactivated vaccine an inactivation vaccine that is prepared by formalin inactivation. YH, YL preparation of vaccine using H2O2 inactivation YH A vaccine prepraration process that is performed by H2O2 inactivation of virulent pathogen. unimmunized an organismal quality that indicates an organism (e.g., human) is not yet immunized against a disease. YH immunized by vaccination with a licensed vaccine YH an organismal quality that indicates an organism (e.g., human) is immunized against a disease through vaccination with a licensed vaccine. vaccinated organism Vaccinee an organism that is vaccinated with a vaccine YH, YL, MC organism vaccinated with a licensed vaccine a vaccinated organism that is vaccinated with a licensed vaccine vaccinee YH, YL, MC vaccinated an organismal quality that indicates an organism (e.g., human) is vaccinated with a vaccine. YH unvaccinated YH an organismal quality that indicates an organism (e.g., human) is unvaccinated with any vaccine. vaccinated with a licensed vaccine a vaccinated quality that indicates an organism is vaccinated with a licensed vaccine. YH unvaccinated with a licensed vaccine YH a unvaccinated quality that indicates an organism has not been vaccinated with a licensed vaccine. B16 vaccine adjuvanted by loxoribine a cancer vaccine that protects mice against tumor growth following challenge with live B16 cells. YH PMID: 8306370 immunized organism an organism that is immunized for a disease YH, YL, MC organism immunized with a licensed vaccine YH, YL, MC an immunized organism that is immunized by vaccination with a licensed vaccine unvaccinated organism an organism that is unvaccinated with a vaccine YH, YL, MC Actinobacillus pleuropneumoniae gene a bacterial gene from Actinobacillus pleuropneumoniae. YH, RR Trypanosoma cruzi vaccine YH T. cruzi vaccine A vaccine that protects against Trypanosoma cruzi. T. cruzi DNA vaccine encoding CRP-10 YH A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi CRP-10 protein. VIOLIN Vaccine ID: 803 T. cruzi DNA vaccine encoding G2 A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi G2 protein. YH VIOLIN Vaccine ID: 807 T. cruzi DNA vaccine encoding G4 YH VIOLIN Vaccine ID: 809 A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi G4 protein. T. cruzi DNA vaccine encoding TSA-1 A T. cruzi DNA vaccine that uses a DNA plasmid expressing T. cruzi TSA-1 protein. VIOLIN Vaccine ID: 812 YH T. cruzi DNA vaccine pGFP-TSA1 YH A T. cruzi DNA vaccine that uses a DNA plasmid pGFP expressing T. cruzi TSA-1 protein. VIOLIN Vaccine ID: 811 T. cruzi PAR1 protein vaccine VIOLIN Vaccine ID: 806 A T. cruzi subunit vaccine that uses T. cruzi PAR1 protein as protective antigen. YH T. cruzi PAR2 protein vaccine YH A T. cruzi subunit vaccine that uses T. cruzi PAR2 protein as protective antigen. VIOLIN Vaccine ID: 810 T. cruzi vaccine using attenuated Salmonella expressing T. cruzi Cruzipain A T. cruzi vaccine that uses attenuated Salmonella to express T. cruzi Cruzipain protein. VIOLIN Vaccine ID: 804 YH T. cruzi vaccine using Sendai virus vector expressing amastigote surface protein-2 YH A T. cruzi vaccine that uses Sendai virus vector to express T. cruzi amastigote surface protein-2. VIOLIN Vaccine ID: 802 vaccine cocktail containing two vaccines YH a vaccine that contains two individual vaccines made with different preperation methods (e.g., DNA vaccine and protein subunit vaccine). These two vaccines are usually administrated at different times to the same patient to achieve improved immune effects. vaccine containing subunit vaccine and inactivated whole organism vaccine YH a vaccine that contains both subunit vaccine and inactivated whole organism vaccines. vaccine containing DNA vaccine for priming and subunit vaccine for boosting YH a vaccine that contains a DNA vaccine for priming and a subunit vaccine for boosting vaccine containing DNA vaccine for priming and Ad vector vaccine for boosting a vaccine that contains a DNA vaccine for priming and a subunit vaccine for boosting YH funsion protein vaccine An example of fusion protein vaccine is Mtb72f fusion protein vaccine. Reference: PubMed: 15187142. Funsion protein vaccine is a subunit vaccine that fuses more than one open reading frames of protective antigens. YH Brucella melitensis gene YH, RR A Brucella gene that is from B. melitensis. Brucella suis gene A Brucella gene that is from B. suis. YH Bacillus anthracis gene A bacterial gene that is from Bacillus anthracis. YH, RR Listeria monocytogenes gene YH, RR A bacterial gene that is from Listeria monocytogenes. Mycobacterium avium gene YH, RR A bacterial gene that is from Mycobacterium avium. Staphylococcus aureus gene A bacterial gene that is from Staphylococcus aureus. YH, RR Aeromonas hydrophila gene YH, RR A bacterial gene that is from Aeromonas hydrophila. Bordetella bronchiseptica gene YH, RR A bacterial gene that is from Bordetella bronchiseptica. Aeromonas salmonicida gene YH, RR A bacterial gene that is from Aeromonas salmonicida. Bordetella pertussis gene A bacterial gene that is from Bordetella pertussis. YH, RR Borrelia burgdorferi gene A bacterial gene that is from Borrelia burgdorferi. YH, RR Burkholderia pseudomallei gene YH, RR A bacterial gene that is from Burkholderia pseudomallei. Edwardsiella ictaluri gene A bacterial gene that is from Burkholderia pseudomallei. YH, RR Edwardsiella tarda gene YH, RR A bacterial gene that is from Edwardsiella tarda. Francisella tularensis gene A bacterial gene that is from Francisella tularensis. YH, RR Mannheimia haemolytica gene YH, RR A bacterial gene that is from Mannheimia haemolytica. Mycoplasma gallisepticum gene A bacterial gene that is from Mycoplasma gallisepticum. YH, RR Neisseria meningitidis gene YH, RR A bacterial gene that is from Neisseria meningitidis. Pasteurella multocida gene A bacterial gene that is from Pasteurella multocida. YH, RR Salmonella Typhi gene A bacterial gene that is from Salmonella Typhi. YH, RR Salmonella Gallinarum gene A bacterial gene that is from Salmonella Gallinarum. YH, RR 'Salmonella Typhimurium gene YH, RR A bacterial gene that is from Salmonella Typhimurium. Salmonella Enteritidis gene YH, RR A bacterial gene that is from Salmonella Enteritidis. Vibrio cholerae gene A bacterial gene that is from Vibrio cholerae. YH, RR Bovine herpesvirus 1 gene YH, RR A viral gene that is from Bovine herpesvirus 1. Yersinia enterocolitica gene A bacterial gene that is from Yersinia enterocolitica. YH, RR Yersinia pestis gene YH, RR A bacterial gene that is from Yersinia pestis. Yersinia pseudotuberculosis gene A bacterial gene that is from Yersinia pseudotuberculosis. YH, RR Yersinia ruckeri gene A bacterial gene that is from Yersinia ruckeri. YH, RR Bovine Respiratory Syncytial Virus gene A viral gene that is from Bovine Respiratory Syncytial Virus. YH, RR Classical swine fever virus gene YH, RR A viral gene that is from Classical swine fever virus. Equid herpesvirus gene A viral gene that is from Equid herpesvirus 1. YH, RR Feline herpesvirus 1 gene YH, RR A viral gene that is from Feline herpesvirus 1. Feline immunodeficiency virus gene YH, RR A viral gene that is from Feline immunodeficiency virus. Feline infectious peritonitis virus gene A viral gene that is from Feline infectious peritonitis virus. YH, RR Gallid herpesvirus 1 gene YH, RR A viral gene that is from Gallid herpesvirus 1. Hepatitis B virus gene A viral gene that is from Hepatitis B virus. YH, RR Human herpesvirus 1 gene A viral gene that is from Human herpesvirus 1. YH, RR Human metapneumovirus gene A viral gene that is from Human metapneumovirus. YH, RR Human Respiratory Syncytial Virus gene A viral gene that is from Human Respiratory Syncytial Virus. YH, RR Infectious Hematopoietic Necrosis Virus gene A viral gene that is from Infectious Hematopoietic Necrosis Virus. YH, RR Porcine respiratory and reproductive syndrome virus gene YH, RR A viral gene that is from Porcine respiratory and reproductive syndrome virus. Pseudorabies virus gene Suid herpesvirus 1 gene A viral gene that is from Pseudorabies virus. YH, RR Rabies virus gene A viral gene that is from Rabies virus. YH, RR SARS-CoV gene YH, RR A viral gene that is from SARS-CoV. Simian Immunodeficiency Virus gene A viral gene that is from Simian Immunodeficiency Virus. YH, RR Tick-borne Encephalitis Virus gene A viral gene that is from Tick-borne Encephalitis Virus. YH, RR VEE Virus gene YH, RR A viral gene that is from VEE Virus. West Nile virus gene YH, RR A viral gene that is from West Nile virus. Western equine encephalomyelitis virus gene YH, RR A viral gene that is from Western equine encephalomyelitis virus. Leishmania donovani gene A protozoan gene that is from Leishmania donovani. YH, RR Plasmodium berghei gene YH, RR A Plasmodium gene that is from Plasmodium berghei. Plasmodium yoelii gene A Plasmodium gene that is from Plasmodium yoelii. YH, RR Toxoplasma gondii gene YH, RR A protozoan gene that is from Toxoplasma gondii. 'Human herpesvirus 2 gene' A viral gene that is from Human herpesvirus 2. YH, RR vaccination with Afluria Erysipelothrix rhusiopathiae vaccine YL generated using OntoRat bacterial vaccine that is used to protect against Erysipelothrix rhusiopathiae infection Trichomonas foetus vaccine protozoan vaccine that is used to protect against Tritrichomonas suis infection YL generated using OntoRat International Duck Research Cooperative, Inc. YL http://www.duckhealth.com/idrc.html Eimeria spp. vaccine protozoan vaccine that is used to protect against Eimeria spp. (Eimeria) infection YL generated using OntoRat Orf Virus vaccine YL generated using OntoRat viral vaccine that is used to protect against Orf Virus infection Aves vaccine Vaccine that used for immunizing Aves. YL. fish vaccine YL. vaccine that used for immunizing fishes Fowlpox virus vaccine viral vaccine that is used to protect against Fowlpox virus infection generated using OntoRat YL carnivora vaccine YL vaccine that used for immunizing carnivora. cat vaccine vaccine that used for immunizing cat (felis catus) cattle vaccine dog vaccine chicken vaccine Ducks vaccine catfish vaccine gray wolf vaccine horse vaccine parrot vaccine pig vaccine sei whale vaccine sheep vaccine salmoninae vaccine YL vaccine that used for immunizing salmoninae (tourts, salmons & chars ) turkey vaccine vaccine target specification The objective that intends to produce vaccine via the vaccine preparation process. YH Pigeonpox virus vaccine generated using OntoRat YL viral vaccine that is used to protect against Pigeonpox virus infection Bovine herpesvirus 1 vaccine generated using OntoRat viral vaccine that is used to protect against Bovine herpesvirus 1 infection YL Avipoxvirus vaccine Canary Pox Modified Live Virus Vaccine (USDA: 1623.10) USA licensed vaccine Equid herpesvirus 1 vaccine generated using OntoRat viral vaccine that is used to protect against Equid herpesvirus 1 infection YL Feline herpesvirus 1 vaccine generated using OntoRat YL viral vaccine that is used to protect against Feline herpesvirus 1 (Felid herpesvirus 1) infection Gallid herpesvirus 1 vaccine viral vaccine that is used to protect against Gallid herpesvirus 1 infection generated using OntoRat YL Canine adenovirus type 1 vaccine viral vaccine that is used to protect against Canine adenovirus type 1 (Canine adenovirus 1) infection YL generated using OntoRat Canine Adenovirus Type 2 vaccine viral vaccine that is used to protect against Canine Adenovirus Type 2 (Canine adenovirus 2) infection YL generated using OntoRat Bovine papillomavirus vaccine YL generated using OntoRat viral vaccine that is used to protect against Bovine papillomavirus infection Avian Polyomavirus vaccine YL generated using OntoRat viral vaccine that is used to protect against Avian Polyomavirus infection Mink enteritis virus vaccine viral vaccine that is used to protect against Mink enteritis virus infection YL generated using OntoRat Porcine parvovirus vaccine YL generated using OntoRat viral vaccine that is used to protect against Porcine parvovirus infection Porcine rotavirus vaccine generated using OntoRat YL viral vaccine that is used to protect against Porcine rotavirus infection Equine rotavirus vaccine YL generated using OntoRat viral vaccine that is used to protect against Equine rotavirus infection Infectious Bursal Disease Virus vaccine generated using OntoRat viral vaccine that is used to protect against Infectious Bursal Disease Virus (IBDV) infection YL Eastern Equine Encephalitis Virus vaccine YL generated using OntoRat viral vaccine that is used to protect against Eastern Equine Encephalitis Virus infection VEE Virus vaccine generated using OntoRat viral vaccine that is used to protect against VEE Virus (Venezuelan equine encephalitis virus) infection YL Equine arteritis virus vaccine YL generated using OntoRat viral vaccine that is used to protect against Equine arteritis virus infection Bovine viral diarrhea virus 1 vaccine YL viral vaccine that is used to protect against Bovine viral diarrhea virus 1 infection generated using OntoRat Infectious Bronchitis Virus vaccine viral vaccine that is used to protect against Infectious Bronchitis Virus (IBV) infection YL generated using OntoRat Bovine coronavirus vaccine viral vaccine that is used to protect against Bovine coronavirus infection generated using OntoRat YL Feline infectious peritonitis virus vaccine viral vaccine that is used to protect against Feline infectious peritonitis virus infection generated using OntoRat YL Transmissible gastroenteritis virus vaccine generated using OntoRat viral vaccine that is used to protect against Transmissible gastroenteritis virus infection YL Bovine Parainfluenza 3 Virus vaccine generated using OntoRat YL viral vaccine that is used to protect against Bovine Parainfluenza 3 Virus (BPIV-3) (Bovine parainfluenza virus 3) infection Bovine Respiratory Syncytial Virus vaccine viral vaccine that is used to protect against Bovine Respiratory Syncytial Virus infection generated using OntoRat YL Feline immunodeficiency virus vaccine viral vaccine that is used to protect against Feline immunodeficiency virus infection generated using OntoRat YL Feline calicivirus vaccine viral vaccine that is used to protect against Feline calicivirus infection YL generated using OntoRat Chicken Anemia Virus vaccine YL generated using OntoRat viral vaccine that is used to protect against Chicken Anemia Virus infection Porcine respiratory and reproductive syndrome virus vaccine YL generated using OntoRat viral vaccine that is used to protect against Porcine respiratory and reproductive syndrome virus (Porcine reproductive and respiratory syndrome virus) infection Riemerella anatipestifer vaccine generated using OntoRat YL bacterial vaccine that is used to protect against Riemerella anatipestifer infection Avian Reovirus vaccine viral vaccine that is used to protect against Avian Reovirus (Avian orthoreovirus) infection YL generated using OntoRat Avian pneumovirus vaccine generated using OntoRat viral vaccine that is used to protect against Avian pneumovirus (Avian metapneumovirus) infection YL Bluetongue virus vaccine viral vaccine that is used to protect against Bluetongue virus infection YL generated using OntoRat Turkey hemorrhagic enteritis virus vaccine generated using OntoRat YL viral vaccine that is used to protect against Turkey hemorrhagic enteritis virus (Turkey adenoirus 3) infection Canarypox virus vaccine viral vaccine that is used to protect against Canarypox virus infection YL generated using OntoRat Psittacid herpesvirus 1 vaccine generated using OntoRat YL viral vaccine that is used to protect against Psittacid herpesvirus 1 infection Vibrio anguillarum vaccine YL generated using OntoRat bacterial vaccine that is used to protect against Vibrio anguillarum (Listonella anguillarum) infection Infectious salmon anemia virus vaccine viral vaccine that is used to protect against Infectious salmon anemia virus infection generated using OntoRat YL Edwardsiella ictaluri vaccine YL generated using OntoRat bacterial vaccine that is used to protect against Edwardsiella ictaluri infection Avian Encephalomyelitis Virus vaccine YL generated using OntoRat viral vaccine that is used to protect against Avian Encephalomyelitis Virus infection Mannheimia haemolytica vaccine bacterial vaccine that is used to protect against Mannheimia haemolytica infection YL generated using OntoRat Porcine circovirus 2 vaccine YL generated using OntoRat viral vaccine that is used to protect against Porcine circovirus 2 infection Duck enteritis virus vaccine generated using OntoRat YL viral vaccine that is used to protect against Duck enteritis virus (Anatid herpesvirus 1) infection Canine parainfluenza virus vaccine viral vaccine that is used to protect against Canine parainfluenza virus infection YL generated using OntoRat Avian Paramyxovirus vaccine viral vaccine that is used to protect against Avian Paramyxovirus infection generated using OntoRat YL Duck hepatitis virus 1 vaccine generated using OntoRat YL viral vaccine that is used to protect against Duck hepatitis virus 1 (Duck hepatitis A virus) infection VacciCel, Inc. YL Vaccicel, Inc. has a location in Belton, TX. Active officers include Andre Menchu, Andres Menchu, Kathryn M Baker, Katheryn Becker and Andres Menches. Vaccicel, Inc. filed as a Domestic For-Profit Corporation on Tuesday, August 22, 1995 in the state of Texas and is currently active. Andres Menchu serves as the registered agent for this organization.The company's line of business includes Mfg Research & Development Veterinary Bacterial Vaccines. (http://www.corporationwiki.com/Texas/Belton/vaccicel-inc/34296230.aspx) Canary Pox Modified Live Virus Vaccine (USDA: 1623.10) YL USDA: 1623.10 violinID:1557 generated using OntoRat Pigeon Pox Live Virus Vaccine (USDA: 1881.10) violinID:2092 generated using OntoRat USDA: 1881.10 YL Pigeon Pox Live Virus Vaccine (USDA: 1881.12) YL violinID:2093 USDA: 1881.12 generated using OntoRat Pigeon Pox Live Virus Vaccine (USDA: 1881.14) YL violinID:2094 generated using OntoRat USDA: 1881.14 Quail Pox Live Virus Vaccine (USDA: 18E1.10) generated using OntoRat violinID:2111 USDA: 18E1.10 YL Fox Encephalitis Killed Virus Vaccine (USDA: 1635.20) USDA: 1635.20 YL generated using OntoRat violinID:1925 Mink Distemper Modified Live Virus Vaccine (USDA: 1451.00) USDA: 1451.00 YL violinID:1967 generated using OntoRat Mink Distemper Modified Live Virus Vaccine (USDA: 1451.01) YL USDA: 1451.01 generated using OntoRat violinID:1968 Mink Distemper Modified Live Virus Vaccine (USDA: 1451.20) YL generated using OntoRat USDA: 1451.20 violinID:1969 Mink Enteritis Vaccine () generated using OntoRat violinID:1972 YL Feline calicivirus Killed Virus Vaccine (USDA: 15C5.21) USDA: 15C5.21 generated using OntoRat YL violinID:1766 Feline calicivirus Modified Live Virus Vaccine (USDA: 15C1.22) YL generated using OntoRat USDA: 15C1.22 violinID:1765 Feline immunodeficiency virus Killed Virus Vaccine (USDA: 15A5.21) YL violinID:1767 USDA: 15A5.21 generated using OntoRat Feline immunodeficiency virus Killed Virus Vaccine (USDA: 15A5.23) YL USDA: 15A5.23 generated using OntoRat violinID:1768 Feline Infectious Peritonitis Modified Live Virus Vaccine (USDA: 15A1.20) generated using OntoRat violinID:1771 YL USDA: 15A1.20 Feline Leukemia Killed Virus Vaccine (USDA: 1555.20) generated using OntoRat violinID:1772 YL USDA: 1555.20 Feline Leukemia Killed Virus Vaccine (USDA: 1555.21) generated using OntoRat USDA: 1555.21 YL violinID:1773 Feline Leukemia Killed Virus Vaccine (USDA: 1555.22) USDA: 1555.22 violinID:1774 YL generated using OntoRat Feline Leukemia Killed Virus Vaccine (USDA: 1555.R1) generated using OntoRat USDA: 1555.R1 YL violinID:1775 Feline Leukemia Live Canarypox Vector Vaccine (USDA: 1555.R3) USDA: 1555.R3 violinID:1776 generated using OntoRat YL Feline Panleukopenia Killed Virus Vaccine (USDA: 1565.20) USDA: 1565.20 YL generated using OntoRat violinID:1819 Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.00) USDA: 1561.00 YL violinID:1815 generated using OntoRat Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.20) generated using OntoRat violinID:1816 USDA: 1561.20 YL Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.21) USDA: 1561.21 violinID:1817 generated using OntoRat YL Feline Panleukopenia Modified Live Virus Vaccine (USDA: 1561.23) generated using OntoRat YL violinID:1818 USDA: 1561.23 Feline Rhinotracheitis Modified Live Virus Vaccine (USDA: 16A1.22) YL generated using OntoRat violinID:1820 USDA: 16A1.22 Edwardsiella ictaluri Avirulent Live Culture Vaccine (USDA: 1531.00) generated using OntoRat USDA: 1531.00 YL violinID:1714 Anthrax Spore live culture Vaccine (USDA: 1011.00) violinID:1122 YL generated using OntoRat USDA: 1011.00 Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.20) USDA: 1095.20 violinID:1179 generated using OntoRat YL Bovine Respiratory Syncytial Virus Killed Virus Vaccine (USDA: 1095.21) YL generated using OntoRat violinID:1180 USDA: 1095.21 Bovine Respiratory Syncytial Virus Vaccine Modified Live Virus (USDA: 1091.20) USDA: 1091.20 YL violinID:1178 generated using OntoRat Bovine Rhinotracheitis Killed Virus Vaccine (USDA: 1105.20) YL violinID:1186 generated using OntoRat USDA: 1105.20 Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.00) YL violinID:1181 generated using OntoRat USDA: 1101.00 Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.20) YL generated using OntoRat violinID:1182 USDA: 1101.20 Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.21) USDA: 1101.21 generated using OntoRat violinID:1183 YL Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.22) USDA: 1101.22 YL generated using OntoRat violinID:1184 Bovine Rhinotracheitis Modified Live Virus Vaccine (USDA: 1101.B0) generated using OntoRat YL USDA: 1101.B0 violinID:1185 Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.00) violinID:1354 USDA: 1205.00 generated using OntoRat YL Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.20) generated using OntoRat YL violinID:1355 USDA: 1205.20 Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.21) generated using OntoRat YL violinID:1356 USDA: 1205.21 Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.22) violinID:1357 USDA: 1205.22 YL generated using OntoRat Bovine Virus Diarrhea Killed Virus Vaccine (USDA: 1205.25) violinID:1358 generated using OntoRat YL USDA: 1205.25 Bovine Virus Diarrhea Modified Live Virus Vaccine (USDA: 1201.00) violinID:1351 YL USDA: 1201.00 generated using OntoRat Bovine Virus Diarrhea Modified Live Virus Vaccine (USDA: 1201.20) YL generated using OntoRat USDA: 1201.20 violinID:1352 Bovine Virus Diarrhea Modified Live Virus Vaccine (USDA: 1201.22) generated using OntoRat YL USDA: 1201.22 violinID:1353 Brucella Abortus Strain 19, Live Culture Vaccine (USDA: 1251.01) USDA: 1251.01 YL violinID:1383 generated using OntoRat Brucella Abortus Strain 19, Live Culture, Reduced Dose Vaccine (USDA: 1251.02) violinID:1384 YL USDA: 1251.02 generated using OntoRat Brucella Abortus Strain RB-51, Live Culture Vaccine (USDA: 1261.00) USDA: 1261.00 YL violinID:1385 generated using OntoRat Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1841.00) generated using OntoRat YL violinID:2077 USDA: 1841.00 Parainfluenza 3 Modified Live Virus Vaccine (USDA: 1841.20) generated using OntoRat violinID:2078 USDA: 1841.20 YL Salmonella Choleraesuis Avirulent Live Culture Vaccine (USDA: 19A1.00) violinID:2121 generated using OntoRat YL USDA: 19A1.00 Salmonella Choleraesuis Avirulent Live Culture Vaccine (USDA: 19A1.01) USDA: 19A1.01 violinID:2122 generated using OntoRat YL Salmonella Dublin Live Culture Vaccine (USDA: 19D1.R0) YL violinID:2123 USDA: 19D1.R0 generated using OntoRat Trichomonas Foetus Killed Protozoa Vaccine (USDA: 1859.00) violinID:2143 USDA: 1859.00 generated using OntoRat YL Wart Killed Virus Vaccine (USDA: 1985.50) violinID:2144 YL generated using OntoRat USDA: 1985.50 Avian Encephalomyelitis Killed Virus Vaccine (USDA: 1015.I0) generated using OntoRat USDA: 1015.I0 YL violinID:1124 Avian Encephalomyelitis Live Virus Vaccine (USDA: 1051.10) violinID:1125 USDA: 1051.10 YL generated using OntoRat Avian Encephalomyelitis Live Virus Vaccine (USDA: 1051.11) YL generated using OntoRat violinID:1126 USDA: 1051.11 Avian Encephalomyelitis Live Virus Vaccine (USDA: 1051.12) violinID:1127 generated using OntoRat USDA: 1051.12 YL Avian Influenza H10N9 Subtype, Killed Virus Vaccine (USDA: 1057.H0) generated using OntoRat USDA: 1057.H0 violinID:1147 YL Avian Influenza H2N2 Subtype, Killed Virus Vaccine (USDA: 1057.H2) YL USDA: 1057.H2 violinID:1149 generated using OntoRat Avian Influenza H3N4 Subtype, Killed Virus Vaccine (USDA: 1057.H3) generated using OntoRat USDA: 1057.H3 violinID:1150 YL Avian Influenza H4N6 Subtype, Killed Virus Vaccine (USDA: 1057.H4) generated using OntoRat YL USDA: 1057.H4 violinID:1151 Avian Influenza H5N2 Subtype, Killed Virus Vaccine (USDA: 1057.H5) violinID:1152 YL USDA: 1057.H5 generated using OntoRat Avian Influenza H5N9 Subtype, Killed Virus Vaccine (USDA: 1057.14) USDA: 1057.14 violinID:1146 YL generated using OntoRat Avian Influenza H6N8 Subtype, Killed Virus Vaccine (USDA: 1057.H6) YL violinID:1153 USDA: 1057.H6 generated using OntoRat Avian Influenza H7N2 Subtype, Killed Virus Vaccine (USDA: 10F5.12) generated using OntoRat violinID:1158 YL USDA: 10F5.12 Avian Influenza H7N3 Subtype, Killed Virus Vaccine (USDA: 1057.H7) YL generated using OntoRat USDA: 1057.H7 violinID:1154 Avian Influenza H7N3 Subtype, Killed Virus Vaccine (USDA: 10F5.13) generated using OntoRat YL USDA: 10F5.13 violinID:1159 Avian Influenza H1N1 Subtype, Killed Virus Vaccine (USDA: 1057.H1) USDA: 1057.H1 generated using OntoRat violinID:1148 YL Avian Influenza H5N2 Subtype, Killed Virus Vaccine (USDA: 10F5.10) USDA: 10F5.10 generated using OntoRat violinID:1157 YL Avian Influenza H5N3 Subtype, Killed Virus Vaccine (USDA: 1057.R3) generated using OntoRat YL violinID:1156 USDA: 1057.R3 Avian Influenza H9N2 Subtype, Killed Virus Vaccine (USDA: 1057.H9) USDA: 1057.H9 violinID:1155 generated using OntoRat YL Avian Paramyxovirus Type 1, Killed Virus Vaccine (USDA: 10C5.11) USDA: 10C5.11 violinID:1163 generated using OntoRat YL Avian Paramyxovirus Type 3, Killed Virus Vaccine (USDA: 10C5.10) generated using OntoRat violinID:1162 YL USDA: 10C5.10 Avian Pneumovirus Modified Live Virus Vaccine (USDA: 1A31.20) violinID:1164 YL USDA: 1A31.20 generated using OntoRat Avian Reovirus Killed Virus Vaccine (USDA: 1045.00) YL USDA: 1045.00 generated using OntoRat violinID:1166 Avian Reovirus Killed Virus Vaccine (USDA: 1045.01) violinID:1167 YL USDA: 1045.01 generated using OntoRat Avian Reovirus Killed Virus Vaccine (USDA: 1045.02) violinID:1168 YL generated using OntoRat USDA: 1045.02 Avian Reovirus Killed Virus Vaccine (USDA: 1045.30) USDA: 1045.30 violinID:1169 generated using OntoRat YL Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.11) violinID:1361 USDA: 1231.11 generated using OntoRat YL Bronchitis Ark Type, Live Virus Vaccine (USDA: 1231.1M) YL USDA: 1231.1M generated using OntoRat violinID:1373 Bronchitis Ark Type, Live Virus Vaccine (USDA: 1231.20) USDA: 1231.20 YL violinID:1375 generated using OntoRat Bronchitis Ark Type, Live Virus Vaccine (USDA: 1231.21) generated using OntoRat YL violinID:1376 USDA: 1231.21 Bronchitis Ark Type, Live Virus Vaccine (USDA: 1231.22) USDA: 1231.22 violinID:1377 generated using OntoRat YL Bronchitis Conn Type, Live Virus Vaccine (USDA: 1231.15) YL generated using OntoRat violinID:1365 USDA: 1231.15 Bronchitis Delaware Type, Modified Live Virus Vaccine (USDA: 1231.1D) YL violinID:1368 generated using OntoRat USDA: 1231.1D Bronchitis Georgia Type, Live Virus Vaccine (USDA: 1231.1J) USDA: 1231.1J generated using OntoRat YL violinID:1371 Bronchitis Georgia Type, Live Virus Vaccine (USDA: 1231.1L) generated using OntoRat violinID:1372 USDA: 1231.1L YL Bronchitis Mass & Ark Types, Killed Virus Vaccine (USDA: 1235.15) YL USDA: 1235.15 generated using OntoRat violinID:1382 Bronchitis Mass & Ark Types, Live Virus Vaccine (USDA: 1231.13) USDA: 1231.13 generated using OntoRat YL violinID:1363 Bronchitis Mass & Conn Types, Live Virus Vaccine (USDA: 1231.14) violinID:1364 USDA: 1231.14 YL generated using OntoRat Bronchitis Mass & Conn Types, Live Virus Vaccine (USDA: 1231.1G) violinID:1370 YL generated using OntoRat USDA: 1231.1G Bronchitis Mass & Conn Types, Live Virus Vaccine (USDA:1231.1N) USDA:1231.1N YL violinID:1374 generated using OntoRat Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.12) generated using OntoRat YL violinID:1362 USDA: 1231.12 Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.18) USDA: 1231.18 generated using OntoRat YL violinID:1366 Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.1A) violinID:1367 generated using OntoRat YL USDA: 1231.1A Bronchitis Mass Type, Live Virus Vaccine (USDA: 1231.1F) YL violinID:1369 USDA: 1231.1F generated using OntoRat Bronchitis Mass Type, Live Virus Vaccine (USDA: 1232.10) violinID:1378 USDA: 1232.10 generated using OntoRat YL Bronchitis Mass Type, Live Virus Vaccine (USDA: 1232.15) YL USDA: 1232.15 generated using OntoRat violinID:1379 Bronchitis Mass Type, Live Virus Vaccine (USDA: 1233.10) YL generated using OntoRat violinID:1380 USDA: 1233.10 Bronchitis Mass Type, Live Virus Vaccine (USDA: 1235.10) generated using OntoRat USDA: 1235.10 violinID:1381 YL Bursal Disease Killed Virus Vaccine (USDA: 1275.00) violinID:1403 YL USDA: 1275.00 generated using OntoRat Bursal Disease Killed Virus Vaccine (USDA: 1275.02) violinID:1404 YL generated using OntoRat USDA: 1275.02 Bursal Disease Killed Virus Vaccine (USDA: 1275.20) YL USDA: 1275.20 violinID:1405 generated using OntoRat Bursal Disease Live Virus Vaccine (USDA: 1271.00) violinID:1386 USDA: 1271.00 generated using OntoRat YL Bursal Disease Live Virus Vaccine (USDA: 1271.01) generated using OntoRat violinID:1387 USDA: 1271.01 YL Bursal Disease Live Virus Vaccine (USDA: 1271.02) USDA: 1271.02 violinID:1388 YL generated using OntoRat Bursal Disease Live Virus Vaccine (USDA: 1271.04) generated using OntoRat violinID:1389 USDA: 1271.04 YL Bursal Disease Live Virus Vaccine (USDA: 1271.0A) USDA: 1271.0A generated using OntoRat violinID:1390 YL Bursal Disease Live Virus Vaccine (USDA: 1271.10) violinID:1391 USDA: 1271.10 YL generated using OntoRat Bursal Disease Live Virus Vaccine (USDA: 1271.11) violinID:1392 YL USDA: 1271.11 generated using OntoRat Bursal Disease Live Virus Vaccine (USDA: 1271.12) USDA: 1271.12 violinID:1393 YL generated using OntoRat Bursal Disease Live Virus Vaccine (USDA: 1271.13) violinID:1394 USDA: 1271.13 generated using OntoRat YL Bursal Disease Live Virus Vaccine (USDA: 1271.16) generated using OntoRat YL violinID:1396 USDA: 1271.16 Bursal Disease Live Virus Vaccine (USDA: 1271.17) generated using OntoRat violinID:1397 YL USDA: 1271.17 Bursal Disease Live Virus Vaccine (USDA: 1271.18) violinID:1398 YL USDA: 1271.18 generated using OntoRat Bursal Disease Live Virus Vaccine (USDA: 1271.19) violinID:1399 USDA: 1271.19 generated using OntoRat YL Bursal Disease Live Virus Vaccine (USDA: 1271.40) USDA: 1271.40 generated using OntoRat violinID:1400 YL Bursal Disease Live Virus Vaccine (USDA: 1271.41) violinID:1401 USDA: 1271.41 YL generated using OntoRat Bursal Disease Live Virus Vaccine (USDA: 1272.00) YL generated using OntoRat violinID:1402 USDA: 1272.00 Bursal Disease Modified Live VirusVaccine (USDA: 1271.15) generated using OntoRat YL violinID:1395 USDA: 1271.15 Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.01) YL violinID:1409 generated using OntoRat USDA: 12B5.01 Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.40) violinID:1410 USDA: 12B5.40 YL generated using OntoRat Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.41) YL USDA: 12B5.41 generated using OntoRat violinID:1411 Bursal Disease Standard & Variant, Killed Virus Vaccine (USDA: 12B5.4A) violinID:1412 generated using OntoRat USDA: 12B5.4A YL Bursal Disease Standard & Variant, Live Virus Vaccine (USDA: 12B1.00) generated using OntoRat USDA: 12B1.00 YL violinID:1407 Bursal Disease Standard & Variant, Live Virus Vaccine (USDA: 12B1.01) USDA: 12B1.01 violinID:1408 YL generated using OntoRat Bursal Disease Variant, Killed Virus Vaccine (USDA: 12A5.00) USDA: 12A5.00 YL generated using OntoRat violinID:1406 Bursal Disease Variant, Live Virus Vaccine (USDA: 12L1.00) violinID:1413 USDA: 12L1.00 YL generated using OntoRat Chicken Anemia Virus Live Virus Vaccine (USDA: 10A1.00) violinID:1697 USDA: 10A1.00 generated using OntoRat YL Chicken Anemia Virus Live Virus Vaccine (USDA: 10A1.01) YL violinID:1698 generated using OntoRat USDA: 10A1.01 Chicken Anemia Virus Modified Live Virus Vaccine (USDA: 10A1.10) USDA: 10A1.10 YL violinID:1699 generated using OntoRat Coccidiosis Live Oocysts Vaccine (USDA: 1431.50) violinID:1702 generated using OntoRat USDA: 1431.50 YL Coccidiosis Live Oocysts Vaccine (USDA: 1431.51) YL USDA: 1431.51 generated using OntoRat violinID:1703 Coccidiosis Live Oocysts Vaccine (USDA: 1431.56) YL generated using OntoRat violinID:1705 USDA: 1431.56 Coccidiosis Live Oocysts Vaccine (USDA: 1431.57) USDA: 1431.57 generated using OntoRat YL violinID:1706 Coccidiosis Live Oocysts Vaccine (USDA: 1431.58) violinID:1707 USDA: 1431.58 YL generated using OntoRat Coccidiosis Live Oocysts Vaccine (USDA: 1431.59) violinID:1708 generated using OntoRat USDA: 1431.59 YL Coccidiosis Live Oocysts Vaccine (USDA: 1431.5C) YL violinID:1709 USDA: 1431.5C generated using OntoRat Coccidiosis Live Oocysts, Chicken Isolates Vaccine (USDA: 1431.55) USDA: 1431.55 violinID:1704 YL generated using OntoRat Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.01) USDA: 1601.01 YL violinID:1903 generated using OntoRat Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.02) generated using OntoRat violinID:1904 YL USDA: 1601.02 Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.11) YL generated using OntoRat violinID:1905 USDA: 1601.11 Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.13) generated using OntoRat USDA: 1601.13 violinID:1906 YL Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.14) USDA: 1601.14 YL violinID:1907 generated using OntoRat Fowl Laryngotracheitis Modified Live Virus Vaccine (USDA: 1601.15) generated using OntoRat violinID:1908 YL USDA: 1601.15 Fowl Pox Live Virus Vaccine (USDA: 1621.00) generated using OntoRat violinID:1913 YL USDA: 1621.00 Fowl Pox Live Virus Vaccine (USDA: 1621.10) generated using OntoRat violinID:1914 YL USDA: 1621.10 Fowl Pox Live Virus Vaccine (USDA: 1621.11) violinID:1915 YL generated using OntoRat USDA: 1621.11 Fowl Pox Live Virus Vaccine (USDA: 1621.13) generated using OntoRat YL violinID:1916 USDA: 1621.13 Fowl Pox Live Virus Vaccine (USDA: 1621.14) USDA: 1621.14 violinID:1917 generated using OntoRat YL Fowl Pox Live Virus Vaccine (USDA: 1622.00) generated using OntoRat violinID:1918 YL USDA: 1622.00 Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.00) violinID:1945 USDA: 16L1.00 YL generated using OntoRat Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.04) USDA: 16L1.04 generated using OntoRat violinID:1948 YL Marek's Disease Serotype 1, Live Virus Vaccine (USDA: 16L1.09) generated using OntoRat violinID:1952 YL USDA: 16L1.09 Marek's Disease Serotype 2, Live Virus Vaccine (USDA: 1631.00) violinID:1934 generated using OntoRat USDA: 1631.00 YL Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.00) USDA: 1641.00 generated using OntoRat violinID:1936 YL Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.01) USDA: 1641.01 YL generated using OntoRat violinID:1937 Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 1641.06) generated using OntoRat YL USDA: 1641.06 violinID:1938 Marek's Disease Serotype 3, Live Virus Vaccine (USDA: 16L1.06) YL generated using OntoRat violinID:1949 USDA: 16L1.06 Marek's Disease Serotypes 1 & 2 & 3, Live Virus Vaccine (USDA: 16L1.01) YL violinID:1946 generated using OntoRat USDA: 16L1.01 Marek's Disease Serotypes 1 & 3, Live Herpesvirus Chimera Vaccine (USDA: 1631.R0) violinID:1935 YL generated using OntoRat USDA: 1631.R0 Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16G1.02) YL violinID:1944 USDA: 16G1.02 generated using OntoRat Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16L1.02) USDA: 16L1.02 generated using OntoRat YL violinID:1947 Marek's Disease Serotypes 1 & 3, Live Virus Vaccine (USDA: 16L1.08) generated using OntoRat USDA: 16L1.08 violinID:1951 YL Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.00) USDA: 1651.00 YL violinID:1939 generated using OntoRat Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.01) USDA: 1651.01 YL generated using OntoRat violinID:1940 Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.02) YL USDA: 1651.02 generated using OntoRat violinID:1941 Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 1651.05) generated using OntoRat USDA: 1651.05 violinID:1942 YL Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 16G1.00) generated using OntoRat YL USDA: 16G1.00 violinID:1943 Marek's Disease Serotypes 2 & 3, Live Virus Vaccine (USDA: 16L1.07) YL USDA: 16L1.07 violinID:1950 generated using OntoRat Mycoplasma Gallisepticum Live Culture Vaccine (USDA: 1751.00) YL violinID:1973 generated using OntoRat USDA: 1751.00 Mycoplasma Gallisepticum Live Culture Vaccine (USDA: 1751.01) violinID:1974 YL generated using OntoRat USDA: 1751.01 Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.10) USDA: 1711.10 generated using OntoRat YL violinID:1981 Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.12) USDA: 1711.12 violinID:1982 YL generated using OntoRat Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.14) violinID:1983 generated using OntoRat USDA: 1711.14 YL Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 1711.18) violinID:1984 generated using OntoRat USDA: 1711.18 YL Newcastle Disease B1 Type, B1 Strain, Live Virus Vaccine (USDA: 17A2.10) YL USDA: 17A2.10 generated using OntoRat violinID:1991 Newcastle Disease B1 Type, C2 Strain, Live VirusVaccine (USDA: 17B1.10) generated using OntoRat violinID:1993 USDA: 17B1.10 YL Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.0A) violinID:1985 USDA: 1721.0A YL generated using OntoRat Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.10) generated using OntoRat violinID:1986 YL USDA: 1721.10 Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.11) YL USDA: 1721.11 generated using OntoRat violinID:1987 Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.15) USDA: 1721.15 YL generated using OntoRat violinID:1988 Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.16) USDA: 1721.16 generated using OntoRat YL violinID:1989 Newcastle Disease B1 Type, LaSota Strain, Live Virus Vaccine (USDA: 1721.17) YL generated using OntoRat USDA: 1721.17 violinID:1990 Newcastle Disease Killed Virus Vaccine (USDA: 1705.10) violinID:1977 YL generated using OntoRat USDA: 1705.10 Newcastle Disease Killed Virus Vaccine (USDA: 1705.11) USDA: 1705.11 violinID:1978 YL generated using OntoRat Newcastle Disease Killed Virus Vaccine (USDA: 1705.13) violinID:1979 generated using OntoRat USDA: 1705.13 YL Newcastle Disease Killed Virus Vaccine (USDA: 1705.15) violinID:1980 USDA: 1705.15 YL generated using OntoRat Newcastle Disease VG/GA Strain, Live Virus Vaccine (USDA: 1701.10) violinID:1976 generated using OntoRat USDA: 1701.10 YL Newcastle Disease VG/GA Strain, Live Virus Vaccine (USDA: 17A2.V1) YL USDA: 17A2.V1 violinID:1992 generated using OntoRat Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.01) YL violinID:2087 USDA: 1871.01 generated using OntoRat Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.02) generated using OntoRat YL USDA: 1871.02 violinID:2088 Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.03) violinID:2089 YL USDA: 1871.03 generated using OntoRat Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.04) generated using OntoRat USDA: 1871.04 violinID:2090 YL Pasteurella Multocida Avirulent Live Culture, Avian Isolate Vaccine (USDA: 1871.05) YL violinID:2091 USDA: 1871.05 generated using OntoRat Salmonella Typhimurium Live Culture Vaccine (USDA: 19C1.00) generated using OntoRat violinID:2124 USDA: 19C1.00 YL Salmonella Typhimurium Live Culture Vaccine (USDA: 19C1.01) generated using OntoRat YL USDA: 19C1.01 violinID:2125 Salmonella Typhimurium Live Culture Vaccine (USDA: 19C1.02) YL violinID:2126 generated using OntoRat USDA: 19C1.02 Tenosynovitis Live Virus Vaccine (USDA: 1951.10) USDA: 1951.10 violinID:2139 YL generated using OntoRat Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.01) YL USDA: 1951.01 violinID:2135 generated using OntoRat Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.02) YL generated using OntoRat USDA: 1951.02 violinID:2136 Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.03) USDA: 1951.03 generated using OntoRat violinID:2137 YL Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.04) violinID:2138 generated using OntoRat YL USDA: 1951.04 Tenosynovitis Modified Live Virus Vaccine (USDA: 1951.11) YL violinID:2140 USDA: 1951.11 generated using OntoRat Tenosynovitis Modified Live Virus Vaccine (USDA: 1952.01) YL USDA: 1952.01 generated using OntoRat violinID:2141 Duck Virus Enteritis Modified Live Virus Vaccine (USDA: 1461.10) violinID:1712 USDA: 1461.10 generated using OntoRat YL Duck Virus Hepatitis Modified Live Virus Vaccine (USDA: 14B1.10) USDA: 14B1.10 generated using OntoRat YL violinID:1713 Riemerella Anatipestifer Avirulent Live Culture Vaccine (USDA: 1811.00) USDA: 1811.00 generated using OntoRat violinID:2120 YL Flavobacterium Columnare Avirulent Live Culture Vaccine (USDA: 17F1.00) generated using OntoRat USDA: 17F1.00 violinID:1902 YL Bordetella Bronchiseptica Avirulent Live Culture Vaccine (USDA: 1081.00) generated using OntoRat violinID:1172 USDA: 1081.00 YL Bordetella Bronchiseptica Avirulent Live Culture Vaccine (USDA: 1081.01) YL generated using OntoRat USDA: 1081.01 violinID:1173 Canine Coronavirus Killed Virus Vaccine (USDA: 14P5.20) violinID:1562 YL generated using OntoRat USDA: 14P5.20 Canine Coronavirus Killed Virus Vaccine (USDA: 14P5.21) YL violinID:1563 USDA: 14P5.21 generated using OntoRat Canine Coronavirus Modified Live Virus Vaccine (USDA: 14P1.20) USDA: 14P1.20 violinID:1561 YL generated using OntoRat Canine Influenza H3N8, Killed Virus Vaccine (USDA: 15K5.20) YL generated using OntoRat violinID:1691 USDA: 15K5.20 Canine Parainfluenza Modified Live Virus Vaccine (USDA: 1421.21) violinID:1692 USDA: 1421.21 YL generated using OntoRat Distemper Live Canarypox Vector Vaccine (USDA: 1471.R0) USDA: 1471.R0 generated using OntoRat violinID:1711 YL Distemper Modified Live Virus Vaccine (USDA: 1471.10) generated using OntoRat YL violinID:1710 USDA: 1471.10 Giardia Lamblia Killed Protozoa Vaccine (USDA: 18G5.00) generated using OntoRat USDA: 18G5.00 YL violinID:1926 Neospora Caninum Killed Protozoa Vaccine (USDA: 1N11.00) violinID:1975 generated using OntoRat YL USDA: 1N11.00 Parvovirus Killed Virus Vaccine (USDA: 18P5.20) generated using OntoRat USDA: 18P5.20 violinID:2085 YL Parvovirus Killed Virus Vaccine (USDA: 18P5.21) YL violinID:2086 USDA: 18P5.21 generated using OntoRat Parvovirus Modified Live Virus Vaccine (USDA: 18M1.20) YL violinID:2079 USDA: 18M1.20 generated using OntoRat Parvovirus Modified Live Virus Vaccine (USDA: 18M1.21) generated using OntoRat USDA: 18M1.21 YL violinID:2080 Parvovirus Modified Live Virus Vaccine (USDA: 18M1.22) generated using OntoRat violinID:2081 USDA: 18M1.22 YL Parvovirus Modified Live Virus Vaccine (USDA: 18M1.23) YL violinID:2082 generated using OntoRat USDA: 18M1.23 Parvovirus Modified Live Virus Vaccine (USDA: 18M1.25) violinID:2083 generated using OntoRat YL USDA: 18M1.25 Parvovirus Modified Live Virus Vaccine (USDA: 18M1.29) violinID:2084 USDA: 18M1.29 YL generated using OntoRat Rabies Killed Virus Vaccine (USDA: 1905.20) violinID:2115 USDA: 1905.20 YL generated using OntoRat Rabies Killed Virus Vaccine (USDA: 1905.21) YL USDA: 1905.21 violinID:2116 generated using OntoRat Rabies Killed Virus Vaccine (USDA: 1905.22) violinID:2117 generated using OntoRat USDA: 1905.22 YL Rabies Killed Virus Vaccine (USDA: 1905.23) generated using OntoRat violinID:2118 USDA: 1905.23 YL Rabies Killed Virus Vaccine (USDA: 1905.24) YL violinID:2119 USDA: 1905.24 generated using OntoRat Rabies Live Canarypox Vector Vaccine (USDA: 1901.R1) USDA: 1901.R1 violinID:2113 YL generated using OntoRat Rabies Live Canarypox Vector Vaccine (USDA: 1901.R6) YL USDA: 1901.R6 violinID:2114 generated using OntoRat Rabies Live Vaccinia Vector Vaccine (USDA: 1901.R0) generated using OntoRat YL violinID:2112 USDA: 1901.R0 Equine Arteritis Modified Live Virus Vaccine (USDA: 1531.20) YL generated using OntoRat USDA: 1531.20 violinID:1731 Equine Influenza Killed Virus Vaccine (USDA: 1505.10) violinID:1735 USDA: 1505.10 YL generated using OntoRat Equine Influenza Killed Virus Vaccine (USDA: 1505.20) YL violinID:1736 generated using OntoRat USDA: 1505.20 Equine Influenza Killed Virus Vaccine (USDA: 1505.21) YL violinID:1737 USDA: 1505.21 generated using OntoRat Equine Influenza Killed Virus Vaccine (USDA: 1505.24) generated using OntoRat YL violinID:1738 USDA: 1505.24 Equine Influenza Killed Virus Vaccine (USDA: 1505.25) generated using OntoRat violinID:1739 USDA: 1505.25 YL Equine Influenza Killed Virus Vaccine (USDA: 1505.28) YL USDA: 1505.28 violinID:1740 generated using OntoRat Equine Influenza Live Canarypox Vector Vaccine (USDA: 1501.R0) USDA: 1501.R0 violinID:1734 generated using OntoRat YL Equine Influenza Modified Live Virus Vaccine (USDA: 1501.10) USDA: 1501.10 YL violinID:1732 generated using OntoRat Equine Influenza Modified Live Virus Vaccine (USDA: 1501.20) violinID:1733 generated using OntoRat YL USDA: 1501.20 Equine Rhinopneumonitis Killed Virus Vaccine (USDA: 1525.20) YL USDA: 1525.20 generated using OntoRat violinID:1742 Equine Rhinopneumonitis Killed Virus Vaccine (USDA: 1525.21) YL violinID:1743 USDA: 1525.21 generated using OntoRat Equine Rhinopneumonitis Killed Virus Vaccine (USDA: 1525.22) generated using OntoRat YL USDA: 1525.22 violinID:1744 Equine Rhinopneumonitis Killed Virus Vaccine (USDA: 1525.24) YL violinID:1745 USDA: 1525.24 generated using OntoRat Equine Rhinopneumonitis Modified Live Virus Vaccine (USDA: 1521.20) generated using OntoRat USDA: 1521.20 violinID:1741 YL Equine Rotavirus Killed Virus Vaccine (USDA: 1E15.20) USDA: 1E15.20 violinID:1756 generated using OntoRat YL Streptococcus Equi Live Culture Vaccine (USDA: 1831.00) violinID:2127 generated using OntoRat USDA: 1831.00 YL Avian Polyomavirus Killed Virus Vaccine (USDA: 1A15.00) USDA: 1A15.00 YL violinID:1165 generated using OntoRat Chlamydia Psittaci Killed Chlamydia Vaccine (USDA: 1585.20) YL USDA: 1585.20 generated using OntoRat violinID:1701 Chlamydia Psittaci Modified Live Chlamydia Vaccine (USDA: 1581.20) YL violinID:1700 generated using OntoRat USDA: 1581.20 Pacheco's Disease Killed Virus Vaccine (USDA: 18C5.00) YL violinID:2076 generated using OntoRat USDA: 18C5.00 Erysipelothrix Rhusiopathiae Avirulent Live Culture Vaccine (USDA: 1541.00) generated using OntoRat violinID:1757 USDA: 1541.00 YL Erysipelothrix Rhusiopathiae Avirulent Live Culture Vaccine (USDA: 1541.01)