]> Barry Smith Chris Mungall Thomas Todd Richard H. Scheuermann 2009-11-30 Bjoern Peters Lindsay Cowell Alexander D. Diehl Ryan R. Brinkman Melanie Courtot Alan Ruttenburg An ontology for the annotation of the vaccine domain. Draft version OWL-DL The Vaccine Ontology (VO) is a biomedical ontology in the domain of vaccine. VO aims to standardize vaccine annotation, integrate various vaccine data, and support computer-assisted reasoning. VO supports basic vaccine R&D and clincal vaccine usage. VO is primarily developed by Dr. Yongqun "Oliver" He at the University of Michigan Medical School. VO is being developed as a community-based ontology with support and collaborations from the vaccine and bio-ontology communities. Vaccine Ontology Vision Release; 1.0.205 Yongqun "Oliver" He (YH) Zuoshuang "Allen" Xiang has_dose_specification YH, XZ has_dose_specification is a relation that specifies the dose of a vaccine used for a specific vaccination process. has_vaccine_contraindication YH This relation may be replaced by has_vaccine_allergen. We need to determine if any vaccine contraindicator is not a vaccine allergen. has_vaccine_contraindication is a relation that specifies contraindication of a vaccine. has_adverse_event_disposition YH, XZ has_adverse_event_disposition is a relation that specifies some adverse event disposition that a vaccine may have. infection_of infection_of is a relation between a disorder and an infectious pathogen. YH, XZ, MC, BP, AR The relation ‘infection_of’ is introduced to represent an infection caused by an infectious pathogen. A pathogen infection is a disorder. Since the number of pathogens is large, there are numerous infections. To make the description of a specific infection simple, the shortcut term ‘infection_of’ is defined: infection_of X = infection and has_part some (organism X and has_disposition some infectious disposition) administered_to_ameliorate administered_to_ameliorate is a relationship between a material entity (eg., vaccine) instance and an instance of a disorder which the material is developed with the function to ameliorate in a host organism (e.g., human). YH, XZ disease_caused_by YH administered_to_prevent administered_to_prevent is a relationship between a material entity (eg., vaccine) instance and an instance of a disorder against which the material is developed with the function to induce protection (prevention) in a host organism (e.g., human). "Vaccine A administered_to_prevent some 'HIV infection'": means that Vaccine A is administered to prevent HIV infection. YH vaccinates A relationship between a vaccine instance and an organism type such that if the vaccine instance is given to an instance of the organism by the process vaccination, then it changes the organism's disposition to have an immune response against a disease. "A vaccinates B" means that the vaccine A is used for vaccinating the host B (e.g., human). YH, AR, ZX, MC has_route_specification YH has_vaccination_route is a relation that specifies the route of a vaccine. has_vaccine_allergen has_vaccine_allegen is a relation that specifies an allegen to a vaccine. YH has_gene_mutation_of YH is_distributed_by YH, ZX is_distributed_by is a relation that specifies a company that distributes a product (e.g., vaccine). The company is very likely not the manufacturer of the product. participates_in part of organism in vaccine YH 'part of organism in vaccine' is a pathogen component in vaccine that contains only a part of the pathogen organism instead of the whole organism. vaccine MeSH: D014612 YH, BP, BS, MC, LC, XZ, RS Many vaccines are developed to protect against infectious pathogens. Many vaccines are also being developed against some diseases such as cancer and autoimmune diseases. Vaccine is developed against a disease. Allergy. A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine. vaccination Vaccination is: an ‘administering substance in vivo’ that involves in adding vaccine into a host (e.g., human, mouse) in vivo with the intend to invoke a protective immune response. YH, BP vaccine administration ACAM2000 ACAM2000 Smallpox (Vaccinia) Vaccine, Live YH ActHIB ActHIB Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate) PMID: 1735812 YH PMID: PMID: 1517908 Adacel Adacel Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed YH Afluria Afluria Influenza Virus Vaccine YH Attenuvax Attenuvax Measles Virus Vaccine, Live YH vaccine-induced lymphocyte activation YH vaccine-induced B cell antigen processing and presentation YH vaccine-induced B cell cytokine production YH B cell epitope in vaccine YH vaccine-induced B cell mediated immunity YH Bacillus anthracis vaccine MeSH: D022122 YH A vaccine that protects against Bacillus anthrax that causes anthrax. anthrax vaccine Biothrax Anthrax Vaccine Adsorbed Biothrax YH Boostrix Boostrix Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed YH AE: fever Fever is a frequent medical sign that describes an increase in internal body temperature to levels above normal. Fever is characterized as a temporary elevation in the body's thermoregulatory set-point, usually by about 1–2 °C (1.8-3.6 °F). YH pyrexia febrile response AE: rash This term is a COSTART term but not a MP term (3/17/2009). AE:rash is a vaccine induced skin adverse event. A rash is a change of the skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. YH B. abortus DNA vaccine pcDNA-SOD YH A Brucella abortus vaccine that expresses Cu/Zn SOD with DNA plasmid pcDNA. PMID: 15039330. AE: infection YH This term is a COSTART term but not a MP term (3/17/2009). Brucella abortus strain RB51 as vaccine vector YH B. abortus RB51 Brucella abortus vaccine RB51 is a Brucella abortus vaccine that is licensed in the USA since 1992. Brucella abortus vaccine RB51 is a live attenuated cattle vaccine against brucellosis that is currently used in the USA and many other coutries. PMID: 18836016 PMID: 8039890 PMID: 11768128 Websites: http://rb51.com PMID: 8890203 PMID: 7927779 PMID: 12119140 PMID: 8740701 PMID: 12704101 PMID: 7806364 YH PMID: 19439382 PMID: 11504238 PMID: 12438380 PMID: 11504226 PMID: 11193615 PMID: 11553603 PMID: 11500423 PMID: 17653832 Brucella RB-51 PMID: 19362381 PMID: 1439207 PMID: 10534009 PMID: 17894637 Brucella RB51 PMID: 16713034 PMID: 1908158 PMID: 7622248 B. abortus strain 19 Brucella S19 PMID: 11058778 PMID: 8039890 YH A live attenuated Brucella abortus vaccine that is licensed and used in many countries. Brucella strain-19 AE: syndrome This term is a COSTART term but not a MP term (3/17/2009). syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. YH AE: agitation This term is a COSTART term but not a MP term (3/17/2009). emotional state of excitement or restlessness YH Brucella vaccine brucellosis vaccine MeSH: D002004 YH A vaccine that protects against Brucella spp. that causes brucellosis in animals and humans. injection-site AE YH injection-site reaction This term is a COSTART term but not a MP term (3/17/2009). AE: injection-site hypersensitivity YH This term is a COSTART term but not a MP term (3/17/2009). Comvax Comvax Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) & Hepatitis B Vaccine (Recombinant) YH PMID: DAPTACEL DAPTACEL Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed YH DECAVAC DECAVAC Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH DNA of pathogen organism as vaccine component DNA from protective protein that is used as vaccine component. This is usually used for preparation of DNA vaccine. YH DNA vaccine synonym: naked DNA vaccine YH DNA vaccine is a vaccine that is composed of a plasmid vaccine vector (a circular double stranded DNA molecule) containing genes encoding one or more proteins of a pathogen. genetic vaccine naked DNA vaccine nucleic acid vaccine Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Inc Diphtheria & Tetanus Toxoids Adsorbed YH Diphtheria and Tetanus Toxoids Adsorbed by Sanofi Pasteur Ltd Diphtheria & Tetanus Toxoids Adsorbed YH Dryvax Dryvax Smallpox Vaccine, Dried, Calf Lymph Type YH ETEC vaccine ACAM2010 ACAM2007 is a vaccine candidate expressing CFA/II. PMID: 17566016 YH Engerix-B Engerix-B Hepatitis B Vaccine (Recombinant) YH vaccine persistence assay YH An assay that measures the persistent survival of live vaccine in a host in vivo. AE: injection-site edema YH This term is a COSTART term but not a MP term (3/17/2009). AE: injection-site pain This term is a COSTART term but not a MP term (3/17/2009). YH Escherichia coli vaccine A bacterial vaccine that prevents against Escherichia coli infection. MeSH: D022361 YH E. coli vaccine AE: injection-site inflammation YH This term is a COSTART term but not a MP term (3/17/2009). FluLaval FluLaval Influenza Virus Vaccine, Trivalent, Types A and B YH FluMist FluMist Influenza Virus Vaccine, Live, Intranasal YH Fluarix Fluarix Influenza Virus Vaccine, Trivalent, Types A and B YH Fluvirin Fluvirin Influenza Virus Vaccine, Trivalent, Types A and B YH Fluzone Fluzone Influenza Virus Vaccine, Trivalent, Types A and B YH intramuscular injection YH Gardasil Gardasil Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine YH HIV based lentivirus vaccine vector YH Balb/c mouse YH Havrix Havrix Hepatitis A Vaccine, Inactivated YH Neisseria meningitidis vaccine Meningococcal vaccine YH A bacterial vaccine that prevents Neisseria meningitidis infection. MeSH: D022401 IPOL IPOL Poliovirus Vaccine Inactivated (Monkey Kidney Cell) PMID: YH IgA YH IgE YH IgG YH IgG1 YH IgG2a YH IgG2b YH IgG3 YH IgM YH Imovax Rabies Imovax Rabies Vaccine YH Infanrix Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed Infanrix YH Influenza Virus Vaccine H5N1 by Sanofi Pasteur Inc Influenza Virus Vaccine, H5N1 (for National Stockpile) WEB: http://atomicnewsreview.org/2009/10/22/approval-for-the-arepanrix%E2%84%A2-gsk-vaccine-in-canada/ YH JE-Vax JE-Vax Japanese Encephalitis Virus Vaccine Inactivated YH KINRIX Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine KINRIX YH Listeria monocytogenes as vaccine vector YH M-M-R II M-M-R II Measles, Mumps, and Rubella Virus Vaccine, Live YH M-M-Vax M-M-Vax Measles and Mumps Virus Vaccine, Live YH Menactra Menactra Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine YH Menomune A C Y W135 Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined Menomune-A/C/Y/W-135 YH Meruvax II Meruvax II Rubella Virus Vaccine Live YH Mumpsvax Mumps Virus Vaccine Live Mumpsvax YH AE: injection-site hemorrhage This term is a COSTART term but not a MP term (3/17/2009). YH AE: injection-site mass This term is a COSTART term but not a MP term (3/17/2009). YH Mycobacterium tuberculosis vaccine MeSH: D032581 YH tuberculosis vaccine A vaccine that protects against Mycobacterium tuberculosis. Mycobax BCG Vaccine Mycobax Mycobax is a BCG vaccine that is made by Sanofi Pasteur, Ltd. Ref: http://www.biopharma.com/cgi/full6.lasso?Key=412.65916 YH O antigen of pathogen organism as vaccine compent YH AE: pruritus YH itching itch Itch (Latin: pruritus) is an unpleasant sensation that evokes the desire or reflex to scratch. This term is a COSTART term but not a MP term (3/17/2009). Influenza A (H1N1) 2009 Monovalent Vaccine by Novartis Pediarix Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Hepatitis B (recombinant) and Inactivated Poliovirus Vaccine Combined Pediarix YH PedvaxHIB Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) PedvaxHIB YH PMID: PMID: 2791073 Pentacel Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine Pentacel YH Plague Vaccine by Greer Laboratories Inc Plague Vaccine YH AE: pain This term is a COSTART term but not a MP term (3/17/2009). YH Plasmodium falciparum vaccine YH a malaria vaccine that protects against malaria caused by Plasmodium falciparum. Pneumovax 23 Pneumococcal Vaccine, Polyvalent Pneumovax 23 YH Poliovax Poliovax Poliovirus Vaccine Inactivated (Human Diploid Cell) YH Prevnar Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein) Prevnar YH ProQuad Measles, Mumps, Rubella and Varicella Virus Vaccine Live ProQuad YH RNA of pathogen organism as vaccine component RNA from protective protein that is used as vaccine component. This is usually used for preparation of RNA vaccine. YH ROTARIX ROTARIX Rotavirus Vaccine, Live, Oral YH RabAvert RabAvert Rabies Vaccine YH Rabies Vaccine Adsorbed by BioPort Corp Rabies Vaccine Adsorbed YH Recombivax HB Hepatitis B Vaccine (Recombinant) Recombivax HB YH RotaTeq RotaTeq Rotavirus Vaccine, Live, Oral, Pentavalent YH SIV based lentivirus vaccine vector YH AE: myalgia muscle pain YH Myalgia means "muscle pain" and is a symptom of many diseases and disorders. This term is a COSTART term but not a MP term (3/17/2009). vaccine-induced T-helper 1 type immune response YH vaccine-induced T-helper 2 type immune response YH TENIVAC TENIVAC Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH TICE BCG BCG Vaccine Intravesical TICE® BCG has been used as a therapy for, and to prevent recurrence of, tumors in patients with carcinoma in situ (CIS) of the urinary bladder, and to prevent recurrence of Stage Ta T1 papillary tumors of the bladder at high risk of recurrence. Refernce URL: http://www.ticebcg.com/Consumer/aboutTice/index.asp TICE BCG YH TYPHIM Vi TYPHIM Vi Typhoid Vi Polysaccharide Vaccine YH T cell epitope in vaccine YH vaccine-induced T cell mediated immunity YH T cell vaccine antigen processing and presentation YH Brucella abortus vaccine YH Tetanus Toxoid Adsorbed by Sanofi Pasteur Inc Tetanus Toxoid Adsorbed YH E. coli O157:H7 intimin vaccine PMID: 11500434 E. coli Int280a has been found to be a protective antigen. This subunit vaccine uses E. coli Int280a combined with adjuvant. This antigen can be used for development of type-specific EPEC or EHEC vaccine. YH Tetanus and Diphtheria Toxoids Adsorbed for Adult Use by Massachusetts Public Health Biologic Lab Tetanus & Diphtheria Toxoids Adsorbed for Adult Use YH Tripedia Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed Tripedia YH Twinrix Hepatitis A Inactivated and Hepatitis B (Recombinant) Vaccine Twinrix YH AE: urticaria This term is a COSTART term but not a MP term (3/17/2009). Urticaria is a kind of skin rash notable for dark red, raised, itchy bumps. YH hives vaccine-induced T cell activation AE: headache YH This term is a COSTART term but not a MP term (3/17/2009). respiratory system AE YH I created this term and make it to be an umbrella term for different disorder terms related to respiratory system. --Oliver He VAQTA Hepatitis A Vaccine, Inactivated VAQTA YH Varivax Varicella Virus Vaccine Live Varivax YH Vivotif Typhoid Vaccine Live Oral Ty21a Vivotif YH YF-Vax YF-Vax Yellow Fever Vaccine YH Yellow fever 17D as vaccine vector YH Yellow fever virus vaccine YH A viral vaccine that protects against infection with Yellow fever virus. MeSH: D022341 Zostavax Zostavax Zoster Vaccine, Live, (Oka/Merck) YH licensed turkey vaccine YH live attenuated pathogen as vaccine component YH aluminum hydroxide vaccine adjuvant alum YH aluminium phosphate vaccine adjuvant YH vaccination frequency Vaccination frequency is a qualitative term that represents how many times vaccination has occurred. YH AE: increased leukocyte cell number According to the Vaccine Adverse Event Reporting System (VAERS), 'leukocytosis' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000218 greater than normal number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue calcium phosphate vaccine adjuvant YH AE: decreased leukocyte cell number According to the Vaccine Adverse Event Reporting System (VAERS), 'leukopenia' is an adverse event that was mentioned in 417 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000221 reduction in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue Freund's emulsified oil adjuvant YH a vaccine adjuvant that consists of a water-in-oil emulsion of aqueous antigen in paraffin (mineral) oil of low specific gravity and low viscosity. It is named after Jules T. Freund (1890-1960), Hungarian-born American immunologist. It is a water in oil emulsion. vaccine-induced T cell proliferation vaccine-induced adaptive immune response YH adenovirus vaccine vector YH adjuvant role YH live virulent pathogen as vaccine component YH complete Freund's adjuvant is a Freund's emulsfied oil adjuvant that contains inactivated and dried mycobacteria, usually Mycobacterium tuberculosis (the pathogenic agent of tuberculosis). YH agglutinating antibody YH virulence factor YH incomplete Freund's adjuvant YH a Freud's adjuvant that does not contain the mycobacterial components. cholera toxin YH alphavirus vaccine vector YH vaccine vector role YH Corynebacterium-derived P40 vaccine adjuvant YH vaccine adjuvant role YH antibody YH antibody isotype YH antibody titer YH Antibody titer is a titer of antibody that shows how much antibody an organism has produced that recognizes a particular epitope, expressed as the greatest dilution ratio (or its reciprocal) that still gives a positive result. ELISA is a common means of determining antibody titers. WEB: http://en.wikipedia.org/wiki/Antibody_titer antigen YH Francisella tularensis vaccine YH toxoid vaccine preparation YH Brucella abortus sodC YH bacterial gene YH viral gene YH HIV gene YH AE: abnormal blood pressure MP: MP_0000230 altered tension of the blood within the systemic arteries live attenuated vaccine preparation by serial passages in vitro Brucella abortus cattle vaccine RB51 was developed by serial passages of virulent B. abortus strain 2308 in vitro in rifampin agar plates (Reference: PMID: 1908158). A live attenuated vaccine prepraration process that is performed by serial passages in vitro for pathogen attenuation. YH Influenza A (H1N1) 2009 Monovalent Vaccine by Sanofi Pasteur E. coli gene YH avirulent YH M. tuberculosis gene YH bacterial vaccine A vaccine that protects against some bacterial disease. MeSH: D001428 YH bacterial vaccine vector YH AE: asthenia Asthenia is a medical term denoting symptoms of physical weakness and loss of strength. Asthenia is a side effect of vaccines such as the HPV vaccine Gardasil. This term is a COSTART term but not a MP term (3/17/2009). YH Salmonella gene YH Shigella gene YH protozoan gene YH Plasmodium gene YH Plasmodium falciparum gene YH attenuated YH Leishmania gene YH AE: muscle ache YH muscle pain vaccine-induced T cell differentiation cancer vaccine neoplasm vaccine YH tumor vaccine A vaccine that prevents or treats cancer. It is produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced. MeSH: D019496 inactivated vaccine preparation Preparation of inactivated vaccine. YH part of vaccine YH vaccine component cardinal part of vaccine A 'part of vaccine' is a material entity that is a part or component of a vaccine. vaccine-induced cell activation YH lipopolysaccharide vaccine adjuvant YH vaccine-induced antibacterial agglutination antibody response YH Japanese encephalitis virus gene YH Ebola virus gene YH Influenza virus gene YH RNA vaccine A vaccine that uses RNA(s) derived from a pathogen organism. YH Using RNA may eliminate the problem of having to tailor a vaccine for each individual patient with their specific immunity. The advantage of RNA is that it can be used for all immunity types and can be taken from a single cell. DNA vaccines need to produce RNA which then prompts the manufacture of proteins. However, RNA vaccine eliminates the step from DNA to RNA. muramyl dipeptide MDP YH Dengue virus gene YH colony forming unit CFU WEB: http://en.wikipedia.org/wiki/Colony-forming_unit YH Colony-forming unit (CFU) is a titer measurement of viable bacterial or fungal numbers. Unlike in direct microscopic counts where all cells, dead and living, are counted, CFU measures viable cells. By convenience the results are given as CFU/mL (colony-forming units per milliliter) for water, and CFU/g (colony-forming units per gram) for soil or other porous material. squalene a vaccine adjuvant that contains an organic polymer with some antigenic epitopes which might be shared with other organic polymers acting as immunostimulators. YH arlacel A YH Montanide 103 YH Bordetella pertussis component vaccine adjuvant a vaccine adjuvant that contains components from killed Bordetella pertussis. The killed B. pertussis has a strong adjuvant effect on the diphtheria and tetanus toxoids in the DPT vaccines. YH PCV2 vaccine YH conjugate vaccine YH Conjugate vaccine is vaccine that conjugates/links antigens to the molecules that form the outer coat of disease-causing bacteria to promote an immune response. Conjugate vaccines are designed primarily for very young children because their immune systems can not recognize the outer coats of certain bacteria. recombinant vector vaccine preparation Preparation of recombinant vector vaccine YH West Nile virus gene YH chickenpox virus gene YH Rubella virus gene YH Hepatitis B virus gene YH Porcilis-PCV2 YH Characteristics: Inactivated baculovirus expressed PCV2 ORF2 protein; adjuvanted Hepatitis A virus gene YH Suvaxyn PCV2 YH Characteristics: Inactivated PCD1-2 chimera; adjuvanted Intervet http://www.intervet.com/ YH Fort Dodge http://www.wyeth.com/divisions/fort_dodge.asp YH licensed pig vaccine YH contraindication a contraindication is a condition or factor that increases the risks involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity. YH vaccine in research role YH vaccine in research role is a 'regulation-assigned roleof a vaccine that is not licensed or in clinical trial; instead, it is currently in laboratory research. AE: maculopapular rash A maculopapular rash is a rash with flat, red area on the skin that is covered with small confluent bumps. YH This term is a COSTART term but not a MP term (3/17/2009). hemagglutination-inhibition assay HI assay an immune response detection assay that detects specific antiviral antibodies in a test serum. The serum, usually a twofold dilution series, is mixed with a standard number, usually 4 to 8 HA units, of virus and incubated prior to the addition of a standard suspension of erythrocytes. The highest dilution of serum that inhibits hemagglutination is the HI titer of the serum. For example, influenza (AI) viruses agglutinate erythrocytes through the interaction of the virus surface glycoprotein, the hemagglutinin (HA), with receptors on the surface of the erythrocyte. Inhibition of the agglutination reaction by HA subtype-specific antisera is the basis of the hemagglutination-inhibition (HI) assay. YH inactivated YH AE: arthralgia YH This term is a COSTART term but not a MP term (3/17/2009). Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. hypersensitivity to chicken product YH AE: vesiculobullous rash YH This term is a COSTART term but not a MP term (3/17/2009). vesiculobullous rash is a blistering rash characterized by serous-fluid-filled vesicles (blisters) AE: screaming syndrome This term is a COSTART term but not a MP term (3/17/2009). YH dizziness Dizziness describes a number of subjective symptoms, which the patient may describe as feelings of lightheadedness, floating, wooziness, giddiness, confusion, disorientation or loss of balance. Medical terms include vertigo, disequilibrium, pre-syncope or syncoptic episode. Causes may stem from a variety of failures of equilibrioception, hypotension, cerebral hypoxia or a reaction to environmental chemicals or drugs. YH This term is a COSTART term but not a MP term (3/17/2009). AE: peripheral edema This term is a COSTART term but not a MP term (3/17/2009). YH hypersensitivity to chicken egg YH vaccine solvent solution YH A vaccine solvent solution is a vaccine additive that helps to dissolve all vaccine components in liquid. malaise YH Malaise is a feeling of general discomfort or uneasiness, an "out of sorts" feeling. Malaise is often the first indication of an infection or other disease. Vaccination may induce malaise. This term is a COSTART term but not a MP term (3/17/2009). AE: somnolence This term is a COSTART term but not a MP term (3/17/2009). YH Somnolence (or "drowsiness") is a state of near-sleep, a strong desire for sleep, or sleeping for unusually long periods (c.f. hypersomnia). drowsiness paresthesia This term is a COSTART term but not a MP term (3/17/2009). Paresthesia is a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect. It is more generally known as the feeling of "pins and needles" or of a limb being "asleep" (although this is not directly related to the phenomenon of sleep). The manifestation of paresthesia may be transient or chronic. YH AE: crying abnormal YH This term is a COSTART term but not a MP term (3/17/2009). hypersensitivity to antibiotic YH hypersensitivity to neomycin YH hypersensitivity to polymyxin YH reaction to previous vaccination YH chills This term is a COSTART term but not a MP term (3/17/2009). Chills refers to feeling cold after an exposure to a cold environment. The word can also refer to an episode of shivering, accompanied by paleness and feeling cold. YH AE: stupor Stupor is the lack of critical cognitive function and level of consciousness wherein a sufferer is almost entirely unresponsive and only responds to base stimuli such as pain. The word derives from the Latin stupure, meaning insensible. Being characterised by impairments of reactions to external stimuli, in this case, vaccine immunization. YH This term is a COSTART term but not a MP term (3/17/2009). AE: anorexia This term is a COSTART term but not a MP term (3/17/2009). YH anorexia nervosa Anorexia is the decreased sensation of appetite. life-threatening reaction to previous vaccination YH AE: face edema YH This term is a COSTART term but not a MP term (3/17/2009). life-threatening reaction to previous influenza vaccination YH AE: cough increased This term is a COSTART term but not a MP term (3/17/2009). YH hypersensitivity to gentamicin YH dominant epitope in vaccine YH vaccine-induced down-regulated gene expression YH hypersensitity to gelatin YH vaccine preparation using heat inactivation A vaccine prepraration process that is performed by heat inactivation of virulent pathogen. YH CFU reduction assay CFU reduction assay is an assay that measures the reduction of the colony forming units of infected pathogens in vaccine-vaccinated animals compared to nonvaccinated animals. YH assay of CFU reduction in spleen YH assay of CFU reduction in spleen is a CFU reduction assay that is measured using the extracted spleen as the tissue for isolation of infected pathogens. hypersensitity to arginine YH Arginine is a conditionally essential amino acid, meaning most of the time it can be manufactured by the human body, and does not need to be obtained directly through the diet. The biosynthetic pathway however does not produce sufficient arginine, and some must still be consumed through diet. Individuals who have poor nutrition or certain physical conditions may be advised to increase their intake of foods containing arginine. Infants are unable to meet their requirements and thus arginine is nutritionally essential for infants. edibility A physical quality inhering in a bearer by virtue of the bearer being fit to be eaten. Melanie has submitted this term and its two subclasses to PATO: http://sourceforge.net/tracker/?func=detail&aid=2873643&group_id=76834&atid=595654 YH, MC edible YH A quality of edibility that inheres in a bearer by virtue of the bearer being suitable for oral ingestion as food, drug, or vaccine. This term may be submitted to PATO. vaccine efficacy YH Vaccine efficacy is an efficacy of a vaccine in induction of protective immune response in vivo or protection against infection of a virulent pathogen. Specifically, vaccine efficacy (VE) is the percentage reduction in disease incidence attributable to vaccination, calculated by means of the following equation: VE(%) = (U - V)/U x 100 where U = the incidence in unvaccinated people and V = the incidence in vaccinated people. Ref: Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. history of asthma YH vaccine-induced antiviral neutralizing antibody response YH AE: flu syndrome YH This term is a COSTART term but not a MP term (3/17/2009). peptide of pathogen organism as vaccine component YH peptide of pathogen that is used as vaccine component. This peptide may function as epitope to stimulate protective immunity. syncope Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. This term is a COSTART term but not a MP term (3/17/2009). YH fainting AE: sweating YH According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,301 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). vaccination with a licensed cattle vaccine YH usage of bronchodilator YH AE: abdominal pain According to the Vaccine Adverse Event Reporting System (VAERS), 'abdominal pain' is an adverse event that was mentioned in 2,254 VAERS reports (1.8%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: hypertension According to the Vaccine Adverse Event Reporting System (VAERS), 'hypertension' is an adverse event that was mentioned in 1,038 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000231 hypertension sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states AE: lab test abnormal According to the Vaccine Adverse Event Reporting System (VAERS), 'sweating' is an adverse event that was mentioned in 2,056 VAERS reports (1.6%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: myasthenia According to the Vaccine Adverse Event Reporting System (VAERS), 'myasthenia' is an adverse event that was mentioned in 1,812 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). YH myasthenia gravis Myasthenia represenats myasthenia gravis, a neuromuscular disease leading to fluctuating muscle weakness and fatiguability. This term is a COSTART term but not a MP term (3/17/2009). vaccine-induced follicular dendritic cell activation YH usage of steroid YH AE: chest pain YH According to the Vaccine Adverse Event Reporting System (VAERS), 'chest pain' is an adverse event that was mentioned in 1,752 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). sodB(Ft) YH PMID: 16923916 PMID: 18692537 sodBFt is a live vaccine strain mutant of Francisella tularensis with reduced Fe-superoxide dismutase gene expression. Ref: PMID: 18692537. licensed human vaccine role YH, ZX licensed human vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for human use. Oliver He: The previous OWL definition includes: contained_in some 'homo sapiens' However, the contained_in relation is not right. On the other hand, we have not found an appropriate way to define it by including the species name like 'homo sapiens'. We will look into it later. licensed cattle vaccine role licensed cattle vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for cattle use. YH fungal disease YH fungal vaccine A vaccine that protects against infection with some fungus. MeSH: D005657 YH licensed dog vaccine role YH, XZ licensed dog vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for dog use. licensed pig vaccine role YH, XZ licensed pig vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for pig use. F. tularensis vaccine LVS A live attenuated Francisella tularensis vaccine. It is available in American Type Culture Collection with ATCC ID: 29684. PMID: 16912944 YH PMID: 8757866 AE: exacerbation of underlying condition YH According to the Vaccine Adverse Event Reporting System (VAERS), 'exacerbation of underlying condition' is an adverse event that was mentioned in 1,606 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: insomnia YH Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity. Insomnia is a symptom, not a stand-alone diagnosis or a disease. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'insomnia' is an adverse event that was mentioned in 1,526 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). AE: twitching Involuntary sudden movement of part of the body. According to the Vaccine Adverse Event Reporting System (VAERS), 'twitching' is an adverse event that was mentioned in 1,511 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: febrile seizure According to the Vaccine Adverse Event Reporting System (VAERS), 'febrile seizure' is an adverse event that was mentioned in 1,490 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: asthma This term is a COSTART term but not a MP term (3/17/2009). Asthma is a common chronic lung disease. It has been defined by the National Heart, Lung and Blood Institute as a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness (bronchospasm), and an underlying inflammation. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'asthma' is an adverse event that was mentioned in 1,373 VAERS reports (1.1%) during1991-2001 (Reference: PMID: 12825543). vaccine function YH, MC, XZ, and AR PERSPN: Oliver He: There has been hot discussion about whether we use 'vaccine function' or 'vaccine role'. Vaccine role may not be the good term to use. Vaccine is designed to be 'vaccine', so it should be vaccine function. One special case is cowpox virus. The cowpox virus can be mixed with some liquid like water and used as a smallpox vaccine. In this case, people often say: the cowpox virus has a 'vaccine role'. However, the cowpox virus vaccine is a processed material of a mix of the virus with water. The virus is a virus, it is not a vaccine per se. Therefore, vaccine role may not be an accurate term. vaccine function is a function that enheres in a vaccine that induces protective immune response against a disease. It is realized in the vaccination process in the host. AE: neck pain YH According to the Vaccine Adverse Event Reporting System (VAERS), 'neck pain' is an adverse event that was mentioned in 1,323 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: positive rechallenge According to the Vaccine Adverse Event Reporting System (VAERS), 'positive rechallenge' is an adverse event that was mentioned in 1,292 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). In contrast, positive dechallenge occurs when the adverse reaction disappears once the drug is stopped. YH Positive rechallenge occurs when the adverse reaction re-emerges once a drug (e.g., vaccine) is restrarted. This term is a COSTART term but not a MP term (3/17/2009). heat killed pathogen in vaccine YH AE: back pain According to the Vaccine Adverse Event Reporting System (VAERS), 'back pain' is an adverse event that was mentioned in 1,277 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH herpesvirus vaccine vector YH AE: alopecia According to the Vaccine Adverse Event Reporting System (VAERS), 'alopecia'; is an adverse event that was mentioned in 260 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000414 VAE absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition alopecia AE: gastrointestinal hemorrhage MP: MP_0000465 According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal hemorrhage'; is an adverse event that was mentioned in 183 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). bleeding in the stomach and/or the intestines vaccine-induced host gene response YH vaccine-induced host immune response YH vaccine-induced host response a process that specifies host response to a vaccine. YH host response to vaccine adjuvant YH a process that specifies host response to a vaccine adjuvant. host response to vaccine component YH a process that specifies host response to a vaccine component. host response to vaccine antigen YH a process that specifies host response to a vaccine antigen. host response to vaccine vaccine vector a process that specifies host response to a vaccine vector. YH AE: eyes gaze upward According to the Vaccine Adverse Event Reporting System (VAERS), 'eyes gaze upward' is an adverse event that was mentioned in 1,249 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). YH AE: neuropathy Neuropathy is a medical term describing disorders of the nerves of the peripheral nervous system (specifically excluding encephalopathy and myelopathy, which refer to the central nervous system.) It is usually considered equivalent to peripheral neuropathy. YH This term is a COSTART term but not a MP term (3/17/2009). peripheral neuropathy According to the Vaccine Adverse Event Reporting System (VAERS), 'neuropathy' is an adverse event that was mentioned in 1,154 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). human immunodeficiency virus vaccine MeSH: D016915 AIDS vaccine HIV vaccine YH A viral vaccine that protects against infection with human immunodeficiency virus that causes AIDS. licensed horse vaccine role YH, XZ licensed horse vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for horse use. AE: skin nodule This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'skin nodule' is an adverse event that was mentioned in 1,134 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). AE: arthrosis This term is a COSTART term but not a MP term (3/17/2009). A degenerative disease of a joint. Arthrosis is an articular illness that produces fibrosis or degeneration of the cartilage. According to the Vaccine Adverse Event Reporting System (VAERS), 'arthrosis' is an adverse event that was mentioned in 1,129 VAERS reports (0.9%) during1991-2001 (Reference: PMID: 12825543). YH company YH B. melitensis strain VTRM1 YH AE: hypokinesia Hypokinesia refers to slow or diminished movement of body musculature. YH AE: muscle twitching muscle fasciculation YH muscle contraction B. suis strain VTRS1 PMID: 17428946 YH AE: skin discoloration YH According to the Vaccine Adverse Event Reporting System (VAERS), 'skin discoloration' is an adverse event that was mentioned in 909 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). AE: herpes zoster According to the Vaccine Adverse Event Reporting System (VAERS), 'herpes zoster' is an adverse event that was mentioned in 892 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). Herpes zoster is a viral disease characterized by a painful skin rash with blisters in a limited area on one side of the body, often in a stripe. The initial infection with varicella zoster virus (VZV) causes the acute (short-lived) illness chickenpox, and generally occurs in children and young people. Once an episode of chickenpox has resolved, the virus is not eliminated from the body but can go on to cause shingles—an illness with very different symptoms—often many years after the initial infection. YH This term is a COSTART term but not a MP term (3/17/2009). shingles zoster AE: laryngismus According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngismus' is an adverse event that was mentioned in 881 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). sudden laryngeal spasm with crowing inhalation and cyanosis. It is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. laryngospasm YH This term is a COSTART term but not a MP term (3/17/2009). KKF24 YH KKF24 is a recombinant strain of Francisella novicida U112 with iglC mutation (F. novicida delta-iglC::ermC). PMID: 14680699. PMID: 16552035 F. tularensis vaccine LVS LPS F. tularensis vaccine LVS lipopolysaccharide YH PMID: 10722593 vaccine-induced antibody mediated immune response immunoglobulin mediated immune response to vaccine YH immunologic adjuvant YH B. melitensis lipopolysaccharide vaccine YH B. melitensis LPS-GBOMP noncovalent complex vaccine YH PMID: 8723881 AE: speech disorder This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'speech disorder' is an adverse event that was mentioned in 848 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). YH AE: hemorrhage According to the Vaccine Adverse Event Reporting System (VAERS), 'hemorrhage' is an adverse event that was mentioned in 338 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001914 hemorrhage loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels inactivated vaccine killed vaccine YH inactivated organism vaccine A vaccine that is made from whole viruses or bacteria that have been inactivated with chemicals or heat. AE: neck rigidity This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'Neck rigidity' is an adverse event that was mentioned in 829 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). YH AE: Guillain-Barré syndrome Guillain-Barré syndrome is a disorder in which the body's immune system attacks part of the peripheral nervous system. The first symptoms of this disorder include varying degrees of weakness or tingling sensations in the legs. In many instances, the weakness and abnormal sensations spread to the arms and upper body. These symptoms can increase in intensity until the muscles cannot be used at all and the patient is almost totally paralyzed. In these cases, the disorder is life-threatening and is considered a medical emergency. Usually Guillain-Barré occurs a few days or weeks after the patient has had symptoms of a respiratory or gastrointestinal viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. Reference: http://www.ninds.nih.gov/disorders/gbs/gbs.htm. YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'Guillain-Barré syndrome' is an adverse event that was mentioned in 820 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). AE: nausea and vomiting This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'nausea and vomiting' is an adverse event that was mentioned in 812 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). This term will most likely removed since it is just a combination of nausea and vomiting. YH AE: sudden infant death This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'sudden infant death' is an adverse event that was mentioned in 808 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). AE: chills and fever YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'chills and fever' is an adverse event that was mentioned in 722 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). successive stages of chills and fever. This is a symptom of malaria. B. abortus DNA vaccine expressiong BCSP31, SOD and L7/L12 PMID: 17570767 YH AE: personality disorder YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'personality disorder' is an adverse event that was mentioned in 678 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). B. abortus subunit vaccine using L7/L12 YH AE: lung disorder YH According to the Vaccine Adverse Event Reporting System (VAERS), 'lung disorder' is an adverse event that was mentioned in 614 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). B. melitensis 16M DNA vaccine expressing Omp31 PMID: 17428946 YH muscle adverse event YH AE: liver/biliary system disorder YH AE: enlarged liver MP: MP_0000599 According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatomegaly'; is an adverse event that was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). enlarged liver larger than average size of the liver licensed goat and sheep vaccine role licensed goat and sheep vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for goat and sheep use. YH inedible YH, MC A quality of edibility that inheres in a bearer by virtue of the bearer being not suitable for oral ingestion. AE: meningitis YH Meningitis is a medical condition caused by inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'meningitis' is an adverse event that was mentioned in 592 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). tertiary vaccination YH, Thom Todd tertiary vaccination is a vaccination that is performed at the third time in a row. licensed cat vaccine role licensed cat vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for cat use. YH, XZ digestive system AE YH vaccine injection site YH AE: facial paralysis According to the Vaccine Adverse Event Reporting System (VAERS), 'facial paralysis' is an adverse event that was mentioned in 580 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). YH AE: confusion YH According to the Vaccine Adverse Event Reporting System (VAERS), 'confusion' is an adverse event that was mentioned in 579 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). B. melitensis bp26 deletion vaccine PMID: 16519974 Brucella CGV26 YH A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the bp26 deletion. It has similar vaccien efficacy to Rev. 1. Its advantage compared to Rev. 1 is that this feature of bp26 deletion promotes diagnosis. PMID: 17070627. F. tularensis vaccine FSC043 YH A spontaneous mutant of the SCHU S4 strain that protects against virulent F. tularensis infection. PMID: 16299332. PMID: 16299332 intramuscular route YH intranasal route YH intranasal route by drop YH intranasal route by spray YH intraperitoneal route YH B. melitensis WR201 YH AE: joint disorder This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'joint disorder' is an adverse event that was mentioned in 562 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH B. abortus bacA mutant PMID: 17196866 YH Influenza A (H1N1) 2009 Monovalent Vaccine by CSL Limited Influenza A (H1N1) 2009 Monovalent Vaccine from MedImmune LLC Arepanrix MC, YH vaccine host a vaccine host is a role that inheres in an organism that is the target of a vaccine administration (vaccination process). B. abortus DNA vaccine pcDNA-SOD YH PMID: 15039330 AE: eye disorder This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'eye disorder' is an adverse event that was mentioned in 543 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH B. ovis microparticle subunit vaccine YH AE: autism This term is a COSTART term but not a MP term (3/17/2009). YH Autism is a brain development disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. According to the Vaccine Adverse Event Reporting System (VAERS), 'autism' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). AE: sedimentation rate increased sedrate This term is a COSTART term but not a MP term (3/17/2009). erythrocyte sedimentation rate YH According to the Vaccine Adverse Event Reporting System (VAERS), 'sedimentation rate increased' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). ESR Sedimentation rate is a diagnostic test for inflammation. The test measures the rate at which red blood cells fall to the bottom of a tube over time. An increased sedimentation rate corresponds to increased non-specific inflammation in the body. It is often called "sedrate" for short. AE: accidental injury YH According to the Vaccine Adverse Event Reporting System (VAERS), 'accidental injury' is an adverse event that was mentioned in 530 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). an injury that occurs accidentally. Brucella recombinant SurA protein vaccine PMID: 17686554 YH lentivirus vaccine vector YH AE: amblyopia YH According to the Vaccine Adverse Event Reporting System (VAERS), 'amblyopia' is an adverse event that was mentioned in 507 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). vaccine-induced leukocyte activation YH licensed human vaccine in USA a human vaccine with license that is commercially used in the USA. YH licensed vaccine YH A vaccine that is licensed for commercial use. AE: mental retardation This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'mental retardation' is an adverse event that was mentioned in 498 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). lipopolysaccharide of pathogen organism as vaccine component YH liposome-based vaccine adjuvant YH a vaccine adjuvant that contains particles made up of concentric lipid membranes containing phospholipids and other lipids in a bilayer configuration separated by aqueous compartments. It is a relatively stable but non-covalently-bound complex of saponin adjuvant Quil-A, cholesterol and amphipathic antigen in a molar ratio of approximately 1:1:1. The spectrum of viral capsid antigens and non-viral amphipathic antigens of relevance for human vaccination, incorporated into ISCOMs, comprises influenza, measles, rabies, gp340 from EB-virus, gp120 from HIV, Plasmodium falciparum and Trypanosoma cruzi. Ref: http://www.vaccination.inoz.com/adjuvants.html. live attenuated vaccine attenuated vaccine YH A live vaccine that is made from microbes that have been attenuated (weakened) in the laboratory so that they can’t cause disease. live pathogen organism as vaccine component YH live vaccine A vaccine that is made of live whole organism. YH live virulent vaccine YH quaternary vaccination quaternary vaccination is a vaccination that is performed at the fourth time in a row. YH, Thom Todd AE: erythema multiforme YH According to the Vaccine Adverse Event Reporting System (VAERS), 'erythema multiforme' is an adverse event that was mentioned in 483 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). brain inflammation local accumulation of fluid, plasma proteins, and leukocytes in the brain Brucella recombinant DnaK protein vaccine PMID: 17686554 YH divalent DNA B. abortus vaccine using L7/L12 and Omp16 PMID: 16622210 YH AE: SGOT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGOT increased' is an adverse event that was mentioned in 477 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). Increased level of SGOT. SGOT respresents serum glutamic oxaloacetic transaminase, an enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGOT levels. SGOT is also called aspartate aminotransferase (AST). This term is a COSTART term but not a MP term (3/17/2009). YH AE: SGPT increased According to the Vaccine Adverse Event Reporting System (VAERS), 'SGPT increased' is an adverse event that was mentioned in 459 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH Increased level of SGPT. SGPT represents serum glutamic pyruvic transaminase, an enzyme that is normally present in liver and heart cells. SGPT is released into blood when the liver or heart are damaged. The blood SGPT levels are thus elevated with liver damage (for example, from viral hepatitis) or with an insult to the heart (for example, from a heart attack). Some medications can also raise SGPT levels. SGPT is also called alanine aminotransferase (ALT). AE: thinking abnormality According to the Vaccine Adverse Event Reporting System (VAERS), 'thinking abnormality' is an adverse event that was mentioned in 457 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: dyspepsia This term is a COSTART term but not a MP term (3/17/2009). Dyspepsia is popularly known as indigestion, meaning hard or difficult digestion. It is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'dyspepsia' is an adverse event that was mentioned in 454 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). AE: anaphylactoid reaction is an acute systemic (multi-system) and very severe Type I Hypersensitivity allergic reaction in humans and other mammals. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. According to the Vaccine Adverse Event Reporting System (VAERS), 'anaphylactoid reaction' is an adverse event that was mentioned in 452 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: gastrointestinal disorder This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'gastrointestinal disorder' is an adverse event that was mentioned in 449 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH AE: previous reaction This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'previous reaction' is an adverse event that was mentioned in 442 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). AE: serum sickness YH Serum sickness is a reaction to proteins in antiserum derived from an animal source. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). According to the Vaccine Adverse Event Reporting System (VAERS), 'serum sickness' is an adverse event that was mentioned in 428 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: injection-site abscess YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'injection-site abscess' is an adverse event that was mentioned in 426 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). AE: abnormal electroencephalogram According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal electroencephalogram' is an adverse event that was mentioned in 420 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). Abnormal results of electroencephalography (EEG). EEG is the recording of electrical activity along the scalp produced by the firing of neurons within the brain. In clinical contexts, EEG refers to the recording of the brain's spontaneous electrical activity over a short period of time, usually 20-40 minutes, as recorded from multiple electrodes placed on the scalp. In neurology, the main diagnostic application of EEG is in the case of epilepsy, as epileptic activity can create clear abnormalities on a standard EEG study. A secondary clinical use of EEG is in the diagnosis of coma and encephalopathies. EEG used to be a first-line method for the diagnosis of tumors, stroke and other focal brain disorders, but this use has decreased with the advent of anatomical imaging techniques such as MRI and CT. This term is a COSTART term but not a MP term (3/17/2009). YH B. abortus DNA vaccine encoding L7/L12 and P39 PMID: 16537031 YH attenuated B. abortus with deletion of znuA YH PMID: 16790759 mucosal immune response to vaccine YH nanoparticle vaccine adjuvant YH licensed fish vaccine role YH, XZ licensed fish vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for fish use. licensed bird vaccine role licensed bird vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for bird use. YH, XZ licensed rabbit vaccine role licensed rabbit vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for rabbit use. YH, XZ licensed ferret vaccine role YH, XZ licensed ferret vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for ferret use. licensed turkey vaccine role YH, XZ licensed turkey vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for turkey use. licensed chicken vaccine role licensed chicken vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for chicken use. YH, XZ licensed deer vaccine role YH, XZ licensed deer vaccine role is a licensed vaccine role that is specifically dedicated a vaccine for deer use. licensed rabbit vaccine neutralizing antibody YH microencapsulated B. melitensis mutant vaccine YH A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant vjbR::Tn5 (BMEII1116) delivered using alginate microspheres that is coated with a protein of the parasite Fasciola hepatica (vitelline protein B [VpB]). PMID: 18362129. A B. melitensis vaccine that is composed of live Brucella melitensis attenuated mutant delivered using a microsphere delivery system. PMID: 18362129 vertigo This term is a COSTART term but not a MP term (3/17/2009). Vertigo is a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is actually stationary with respect to the surroundings. The effects of vertigo may be slight. It can cause nausea and vomiting and, in severe cases, it may give rise to difficulties with standing and walking. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'vertigo' is an adverse event that was mentioned in 412 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). AE: heart arrest asystole heart arrest is the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole. According to the Vaccine Adverse Event Reporting System (VAERS), 'heart arrest' is an adverse event that was mentioned in 410 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). cardiopulmonary arrest cardiac arrest circulatory arrest YH This term is a COSTART term but not a MP term (3/17/2009). AE: bronchitis YH Bronchitis is an inflammation of the air passages within the lungs. It occurs when the trachea (windpipe) and the large and small bronchi (airways) within the lungs become inflamed because of infection or other causes. According to the Vaccine Adverse Event Reporting System (VAERS), 'bronchitis' is an adverse event that was mentioned in 407 VAERS reports 0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). AE: grand malconvulsion A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). According to the Vaccine Adverse Event Reporting System (VAERS), 'grand malconvulsion' is an adverse event that was mentioned in 402 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH complex of porin and S-LPS from B. abortus strain 2308 YH PMID: 2844673 B. abortus RB51WboA YH PMID: 15327798 AE: liver function tests abnormal According to the Vaccine Adverse Event Reporting System (VAERS), 'liver function tests abnormal' is an adverse event that was mentioned in 717 VAERS reports (0.6%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000609 aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage AE: ear disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'ear disorder' is an adverse event that was mentioned in 362 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). recombinant O. anthropi 49237SOD PMID: 11953393 YH organ or tissue specific immune response to vaccine YH licensed horse vaccine YH AE: infect viral According to the Vaccine Adverse Event Reporting System (VAERS), 'infect viral' is an adverse event that was mentioned in 358 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH B. melitensis Bp26 and Tf vaccine YH B. melitensis P39 recombinant protein vaccine A Brucella subunit vaccine that uses recombinant Brucella melitensis 16M P39, a putative periplasmic binding protein. PMID: 11447155. PMID: 11447155 YH chimerical BLSOmp31 YH Panvax Panvax is an H1N1 unadjuvanted monovalent vaccine. WEB: http://www.infowars.com/h1n1-panvax-training-powerpoint-received-by-health-care-workers-in-australia/ MC, YH parasite YH intravenous route YH, Thom Todd protozoan vaccine A vaccine that protects against some protozoan disease. MeSH: D016052 parasitic vaccine YH AE: lacrimation disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'lacrimation disorder' is an adverse event that was mentioned in 334 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). Disorder of lacrimation. Lacrimation is the production, secretion, and shedding of tears. YH AE: jaundice MP: MP_0000611 According to the Vaccine Adverse Event Reporting System (VAERS), 'jaundice' is an adverse event that was mentioned in 317 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes jaundice pathogen component in vaccine a part of vaccine that originates from pathogen. YH B. abortus pcDNA-BLS YH AE: abscess According to the Vaccine Adverse Event Reporting System (VAERS), 'abscess' is an adverse event that was mentioned in 318 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). An abscess is a collection of pus (dead neutrophils) that has accumulated in a cavity formed by the tissue on the basis of an infectious process (usually caused by bacteria or parasites) or other foreign materials (e.g. splinters, bullet wounds, or injecting needles). It is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body. YH This term is a COSTART term but not a MP term (3/17/2009). abscessus escheriosome-encapsulated B. abortus L7/L12 YH PMID: 17931756 AE: eye pain According to the Vaccine Adverse Event Reporting System (VAERS), 'eye pain' is an adverse event that was mentioned in 316 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). palpitation YH According to the Vaccine Adverse Event Reporting System (VAERS), 'palpitations' is an adverse event that was mentioned in 313 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). A palpitation is an abnormal awareness of the beating of the heart, whether it is too slow, too fast, irregular, or at its normal frequency. persistence of vaccine induced immune response YH phase 1 vaccine trial YH A vaccine clinical trial that investigates the safety profile of a vaccine in a small group (10-50) of healthy volunteers. phase 2 vaccine trial YH A vaccine clinical trial that studies vaccine efficacy with a target population (numbering 50-100). Different dosage levels will also be explored at this stage to determine the optimum dose. phase 3 vaccine trial YH A vaccine clinical trial that takes the trial to a large-scale safety and efficacy study in a relevant patient population, usually in excess of 3,000. phase 4 vaccine trial The final stage of vaccine clinical evaluation. Phase IV occurs after a vaccine or therapy is licensed and is being used by large numbers of people. These studies are not always required or completed. YH rLm/iglC Seven F. tularensis proteins including IglC (rLm/iglC) were expressed in recombinant L. monocytogenes (rLm) vaccines. These 7 F. tularensis proteins are: AcpA, Bfr, DnaK, GroEL, IglC, Pld and KatG from SchuS4 strain. YH nontypeable H. influenzae Hap Protein Vaccine PMID: 15557618 A subunit nontypeable H. influenzae vaccine that uses Hap protein. YH AE: tongue edema According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue edema'; is an adverse event that was mentioned in 310 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: ear pain According to the Vaccine Adverse Event Reporting System (VAERS), 'ear pain'; is an adverse event that was mentioned in 302 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH plasmid vaccine vector YH B. melitensis DNA vaccine encoding Omp31 boosted with Omp31 YH AE: angioedema Angioedema is the rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues. It is very similar to urticaria, but urticaria, commonly known as hives, occurs in the upper dermis. This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'angioedema'; is an adverse event that was mentioned in 296 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: rheumatoid arthritis YH an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body According to the Vaccine Adverse Event Reporting System (VAERS), 'rheumatoid arthritis'; is an adverse event that was mentioned in 295 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). licensed cattle vaccine in USA role YH, XZ vaccine approval process WEB: http://www.examiner.com/x-7707-Infectious-Disease-Examiner~y2009m9d15-News-Release-H1N1-vaccines-get-FDA-approval-expected-to-be-available-in-4-weeks @2009/10/06. H1N1 vaccines get FDA approval. Food and Drug Administration announced today that it has approved four vaccines against the 2009 H1N1 influenza virus. Obtaining FDA licensure of this vaccine for A (H1N1) pandemic response is a key milestone that will enable Sanofi Pasteur to provide a licensed vaccine to the U.S. government to support pandemic immunization efforts WEB: http://www.hhs.gov/nvpo/factsheets/fs_tableII_doc2.htm @2009/10/06 #Following the FDA's review of a license application, the sponsor and the FDA may present their findings to the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC). This non-FDA expert committee (scientists, physicians, biostatisticians, and a consumer representative) provides advice to the Agency regarding the safety and efficacy of the vaccine for the proposed indication. WEB: http://energycommerce.house.gov/images/stories/Documents/PDF/publications/109_health.pdf @2009/10/06. This is the US Health Law which includes a section about vaccine. YH, ZX, AR, and MC vaccine product approval process WEB: http://news.prnewswire.com/ViewContent.aspx?ACCT=109&STORY=/www/story/09-15-2009/0005094621&EDATE @2009/10/06 vaccine candidate role vaccine candidate role is the role of a material entity in an investigation, which is tested for its capability to serve as a vaccine. This role should be a subclass of 'test substance role', which will be mireoted from OBI by OntoFox. BP, YH CFU measurement assay CFU measurement assay is an assay that measures the colony forming unit (CFU) of a bacterium in a specific location (e.g., spleen of a mouse). YH, MC vaccine effectiveness rate vaccine effectiveness rate is a measurement datum that measues the vaccine effectiveness. It is assessed with respect to prevention of the disease against which the vaccine is given. One simple method to estimate vaccine effectiveness is to use routine data on notifications of disease cases in vaccinated and unvaccinatted children and to compare the porportion of cases vaccinated with the vaccine covervage among the same age group in the general population. If p is the proportion vaccinated in the population and c is the proportion of cases reported to be vaccinated, then VE = (p-c)/p(1-c) x 100%. Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. WEB: http://en.wikipedia.org/wiki/Influenza_vaccine YH, MC vaccine licensing YH, ZX vaccine licensing is a vaccine approval process that involves in licensing a vaccine. licensed chicken vaccine YH, XZ poxvirus vaccine vector YH AE: immune system disorder YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'immune system disorder'; is an adverse event that was mentioned in 292 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: antinuclear antibody present The presence of anti-nuclear antibodies (ANAs) that are antibodies directed against contents of the cell nucleus. ANAs are present in higher than normal numbers in autoimmune disease. The ANA test measures the pattern and amount of autoantibody which can attack the body's tissues as if they were foreign material. Autoantibodies are present in low titers in the general population, but in about 5% of the population, their concentration is increased, and about half of this 5% have an autoimmune disease. YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'antinuclear antibody present'; is an adverse event that was mentioned in 288 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). anti-nuclear factor present heat-killed processed nonpathogenic Alphaproteobacteria YH PMID: 17715332 AE: myelitis YH Myelitis is a disease involving inflammation of the spinal cord, which disrupts central nervous system functions linking the brain and limbs. According to the Vaccine Adverse Event Reporting System (VAERS), 'myelitis'; is an adverse event that was mentioned in 280 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). preventive vaccine function YH prophylactic vaccine function preventive vaccine function is a vaccine function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which protects against a specific disorder. prime boost regimen YH APEC vaccine using GST-Iss fusion protein YH Colibacillosis, caused by avian pathogenic Escherichia coli (APEC), is a major problem for the poultry industry in the world. prophylactic vaccine a vaccine that is used for prevention against a disease. YH protection efficacy YH Protection efficacy is an efficiency that is associated with protection by a biological product (e.g., vaccine) against a disease. protective antigen YH Protective antigen is an antigen that stimulates protective immunity when used in vivo. E. coli LB-T vaccine YH PMID: 11500434 E. coli heat-labile enterotoxin B-subunit (LB-T) vaccine E. coli O157:H7 subunit vaccine expressing Esps and Tir PMID: 14670317 YH AE: migraine A migraine is a very painful type of headache. People who get migraines often describe the pain as pulsing or throbbing in one area of the head. During migraines, people are very sensitive to light and sound. They may also become nauseated and vomit. According to the Vaccine Adverse Event Reporting System (VAERS), 'migraine'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). migraine headache YH This term is a COSTART term but not a MP term (3/17/2009). AE: thrombocytopenic purpura YH This term is a COSTART term but not a MP term (3/17/2009). Thrombocytopenic purpura are purpura associated with a reduction in circulating blood platelets which can result from a variety of causes. According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenic purpura'; is an adverse event that was mentioned in 267 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: multiple sclerosis encephalomyelitis disseminata YH Multiple sclerosis is an autoimmune condition in which the immune system attacks the central nervous system, leading to demyelination. disseminated sclerosis MS This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'multiple sclerosis'; is an adverse event that was mentioned in 264 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: amnesia YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'amnesia'; is an adverse event that was mentioned in 262 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). Amnesia is a short term memory condition in which memory is disturbed. In simple terms it is the loss of memory. protein of pathogen organism as vaccine component YH AE: incoordination YH According to the Vaccine Adverse Event Reporting System (VAERS), 'incoordination'; is an adverse event that was mentioned in 261 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). a lack of normal adjustment of muscular action so that the intended movement of the limb or other part is not made smoothly and harmoniously, and does not accurately achieve its objective. If the abnormality is hypermetric, the condition is referred to as ataxia. If it is inclined to weakness, e.g. knuckling at the turn, stumbling, failure to flex limbs properly, or to misdirection as in a proprioceptive deficit, it is called incoordination. soybean-expressed E. coli LTB vaccine YH PMID: 17188785 AE: voice alteration This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'voice alteration'; is an adverse event that was mentioned in 259 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH AE: abortion According to the Vaccine Adverse Event Reporting System (VAERS), 'abortion'; is an adverse event that was mentioned in 257 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: shock acute stress disorder mental shock This term is a COSTART term but not a MP term (3/17/2009). YH psychological shock Mental shock (or shock) is a psychological condition arising in response to a terrifying event. It should not be confused with the unrelated circulatory condition of shock. acute stress reaction According to the Vaccine Adverse Event Reporting System (VAERS), 'shock'; is an adverse event that was mentioned in 253 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: purpura This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'purpura'; is an adverse event that was mentioned in 251 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). Purpura is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This is common with typhus and can be present with meningitis caused by meningococcal meningitis or septicaemia. Reference: http://en.wikipedia.org/wiki/Purpura. nontypeable H. influenzae vaccine YH nontypeable Haemophilus influenzae YH Nontypeable Haemophilus influenzae (NTHi) is a nonencapsulated Haemophilus influenzae (a gram-negative bacterium). It is the cause of a number of human respiratory tract diseases, such as otitis media, sinusitis, bronchitis, and pneumonia. NTHi non-typeable H. influenzae rLP4/rLP6 and Moraxella catarrhalis UspA2 protein vaccine rLP4/rLP6/UspA2 YH PMID: 15308371 killed nontypeable H. influenzae whole-cell vaccine PMID: 1859055 PMID: 1953532 PMID: 2184330 PMID: 2867396 YH AE: bacterial infection event According to the Vaccine Adverse Event Reporting System (VAERS), 'bacterial infection'; is an adverse event that was mentioned in 250 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). radiated pathogen as vaccine component YH AE: skin striae YH stretch marks striae distensae According to the Vaccine Adverse Event Reporting System (VAERS), 'skin striae'; is an adverse event that was mentioned in 247 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). Skin striae are irregular areas of skin that look like bands, stripes, or lines. Striae are seen when a person grows or gains weight rapidly or has certain diseases or conditions. E. coli vaccine using intimin polypeptide PMID: 17258324 PMID: 14688094 YH nontypeable H. influenzae cell membrane vaccine (CM-Hi) PMID: 10353870 YH nontypeable H. influenzae LOS-TT conjugate vaccine YH PMID: 12706701 Nontypeable H. influenzae lipooligosaccharide-tetanus toxoid conjugate vaccine PMID: 9353024 E. coli subunit vaccine using IroN YH PMID: 17145948 recombinant protein vaccine preparation A vaccine preparation process that uses recombinant molecular technology to prepare recombinant protein. YH recombinant subunit vaccine A subunit vaccine that is made using recombinant DNA technology to engineer the antigen molecules of the particular microbe. YH recombinant vector vaccine YH A vaccine that uses a modified virus or bacterium to deliver genes that code for microbial antigens to cells of the body. E. coli subunit vaccine using CO393 PMID: 17145948 YH vaccination with a licensed pig vaccine YH AE: acute brain syndrome According to the Vaccine Adverse Event Reporting System (VAERS), 'acute brain syndrome'; is an adverse event that was mentioned in 240 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). E. coli subunit vaccine using FyuA PMID: 14688094 PMID: 17258324 YH vaccination with a licensed horse vaccine YH immunization YH, XZ, BP immunization is a process that primes or modifies an adaptivie immune response to some antigens. WEB: http://en.wikipedia.org/wiki/Immunization active immunization YH, XZ Active immunization is an immunization process that entails the introduction of a foreign molecule into the body, which causes the body itself to generate adaptive immunity against the target. WEB: http://en.wikipedia.org/wiki/Immunization passive immunization YH, XZ Currently, antibodies can be used for passive immunization. This method of immunization works very quickly. However, it is short lasting. The antibodies are naturally broken down. If there are no B cells to produce more antibodies, they will disappear. WEB: http://en.wikipedia.org/wiki/Immunization Passive immunization is an immunization process where pre-synthesized elements of the immune system are transferred to an organism so that the body does not need to produce these elements itself. natural active immunization WEB: http://en.wikipedia.org/wiki/Immunization natural active immunization is an active immunization that occur naturally when a person or animal comes in contact with antigens includeing microbes. YH, XZ artificial active immunization artificial active immunization is an active immunization that occurs when a person or animal is vaccinated with a specific vaccine. WEB: http://en.wikipedia.org/wiki/Immunization YH, XZ induction of adaptive immune response to antigen induction of adaptive immune response to antigen is an active immunization process that results in induction of adaptive immune response to some antigens, for example, in a vaccine. YH, XZ disorder prevention YH, XZ disorder prevention is a process that prevents a disorder that is the physical basis of a disease. disorder treatment disorder treatment is a process that leads to treat a disorder that is the physical basis of a disease. YH, XZ modification of adaptive immune response to antigen YH, XZ modification of adaptive immune response to antigen is an active immunization process that results in modification of an adaptive immune response to some antigens, for example, in a therapeutic vaccine. preventive infectious disease vaccine function YH, XZ infection disorder prevention YH, XZ infection disorder prevention is a process that prevents a disorder that is the physical basis of an infectious disease. E. coli vaccine using verocytotoxin toxoid PMID: 17145948 YH Inactivated ETEC expressing expressing CFA/I and CFA/II YH PMID: 1612730 coma According to the Vaccine Adverse Event Reporting System (VAERS), 'coma'; is an adverse event that was mentioned in 230 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). Coma is a profound state of unconsciousness. A comatose person cannot be awakened, fails to respond normally to pain or light, does not have sleep-wake cycles, and does not take voluntary actions. AE: hyperkinesia YH Hyperkinesia is an abnormal increase in muscular activity. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'hyperkinesia'; is an adverse event that was mentioned in 227 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). EHEC O157 subunit vaccine using his-tagged N-terminal intimin YH PMID: 1612730 AE: cardiovascular disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'cardiovascular disorder'; is an adverse event that was mentioned in 225 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: encephalopathy This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalopathy'; is an adverse event that was mentioned in 224 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH Encephalopathy is disorder or disease of the brain. AE: urine abnormality YH According to the Vaccine Adverse Event Reporting System (VAERS), 'urine abnormality'; is an adverse event that was mentioned in 223 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). nontypeable H. influenzae P5 peptide MVF/H3 vaccine YH PMID: 10603411 nontypeable H. influenzae rTbpB vaccine YH PMID: 10225866 ETEC vaccine ACAM2007 ACAM2007 is a vaccine candidate expressing CFA/II. YH AE: gastroenteritis YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'gastroenteritis'; is an adverse event that was mentioned in 218 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). AE: peripheral vascular disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'peripheral vascular disorder'; is an adverse event that was mentioned in 215 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH AE: urinary tract infection According to the Vaccine Adverse Event Reporting System (VAERS), 'urinary tract infection'; is an adverse event that was mentioned in 213 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). rough phenotype YH AE: increased salivation According to the Vaccine Adverse Event Reporting System (VAERS), 'increased salivation' is an adverse event that was mentioned in 336 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000622 greater than normal amounts of flowing saliva ETEC vaccine ACAM2017 PMID: 17566016 YH ACAM2017 was derived from ACAM2007. Genes aroC, ompC, and ompF were deleted, while CS1 and pStrep were added. B. anthracis DNA vaccine encoding PA63 This DNA vaccine contains the gene fragment encoding AAs 173–764 of PA. YH PMID: 9987172 depression This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'depression'; is an adverse event that was mentioned in 196 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH AE: diabetes mellitus Diabetes mellitus, often referred to simply as diabetes, is a syndrome of disordered metabolism, usually due to a combination of hereditary and environmental causes, resulting in abnormally high blood sugar levels (hyperglycemia). diabetes According to the Vaccine Adverse Event Reporting System (VAERS), 'diabetes mellitus'; is an adverse event that was mentioned in 196 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). B. anthracis DNA vaccine encoding PA83 and LF PMID: 15342913 YH DAAV using PA and PGA YH PMID: 12960361 smooth phenotype YH AE: laryngitis According to the Vaccine Adverse Event Reporting System (VAERS), 'laryngitis'; is an adverse event that was mentioned in 190 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH Laryngitis is an inflammation of the larynx. It causes hoarse voice or the complete loss of the voice because of irritation to the vocal folds (vocal cords). This term is a COSTART term but not a MP term (3/17/2009). AE: generalized spasm According to the Vaccine Adverse Event Reporting System (VAERS), 'generalized spasm'; is an adverse event that was mentioned in 186 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). An involuntary contraction of a muscle or group of muscles. Spasms may involve skeletal muscle (MUSCLE, SKELETAL) or smooth muscle (MUSCLE, SMOOTH). This term is a COSTART term but not a MP term (3/17/2009). YH rPA with adjuvant Nanoemulsion PMID: 17502384 YH AE: reflexes decreased This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'reflexes decreased'; is an adverse event that was mentioned in 178 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). reflexes decreased is an abnormal movement that showed decrease in an involuntary response to a peripheral stimulus M. tuberculosis arabinomannan-protein conjugate PMID: 12922145 Xref: VIOLIN vaccine ID: 223. YH AE: dry mouth dryness of the mouth resulting from reduced salivary secretion According to the Vaccine Adverse Event Reporting System (VAERS), 'dry mouth'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH xerostomia AE: optic neuritis According to the Vaccine Adverse Event Reporting System (VAERS), 'optic neuritis'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: thrombocythemia This term is a COSTART term but not a MP term (3/17/2009). Thrombocythemia (primary thrombocythemia) is a disorder in which excess platelets are produced, leading to abnormal blood clotting or bleeding. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocythemia'; is an adverse event that was mentioned in 171 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). subcutaneous route YH subdominant epitope in vaccine YH subunit vaccine YH A vaccine that is composed of a purified protein(s) or other antigenic determinant(s) from a disease-causing organism. A subunit vaccine does not include pathogen nucleic acids. The subunits have less risk of causing adverse reactions. recombinant S. typhimurium secreting M. tuberculosis ESAT-6 PMID: 11427279 Xref: VIOLIN vaccineID: 176. YH Ag85B and ESAT-6 fusion protein YH PMID: AE: epistaxis YH nosebleed According to the Vaccine Adverse Event Reporting System (VAERS), 'epistaxis'; is an adverse event that was mentioned in 163 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). Epistaxis is the relatively common occurrence of hemorrhage from the nose, usually noticed when the blood drains out through the nostrils. AE: lupus syndrome This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'lupus syndrome'; is an adverse event that was mentioned in 163 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). AE: photophobia Photophobia is a symptom of excessive sensitivity to light and the aversion to sunlight or well-lit places. In medical terms it is not fear, but an experience of discomfort or pain to the eyes due to light exposure. YH According to the Vaccine Adverse Event Reporting System (VAERS), 'photophobia'; is an adverse event that was mentioned in 163 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). survival of live vaccine inside host YH AE: abnormal salivary gland physiology MP: MP_0005310 any functional anomaly of any of the glands in the mouth that secrete saliva hallucination YH A hallucination, in the broadest sense, is a perception in the absence of a stimulus. In a stricter sense, hallucinations are defined as perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space. According to the Vaccine Adverse Event Reporting System (VAERS), 'hallucinations'; is an adverse event that was mentioned in 157 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). attenuated M. bovis strain WAg539 YH PMID: 15784584 tongue disorder According to the Vaccine Adverse Event Reporting System (VAERS), 'tongue disorder'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). AE: neuralgia This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'neuralgia'; is an adverse event that was mentioned in 155 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). Neuralgia or neuropathic pain can be defined most simply as non-nociceptive pain. Neuralgia is pain produced by a change in neurological structure or function. Unlike nociceptive pain, Neuralgia exists with no continuous nociceptive input. Neuralgia falls into two categories: central Neuralgia and peripheral Neuralgia. target YH AE: lung edema This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'lung edema'; is an adverse event that was mentioned in 152 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH circumoral paresthesia According to the Vaccine Adverse Event Reporting System (VAERS), 'circumoral paresthesia'; is an adverse event that was mentioned in 152 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH numbness around the mouth. bacterial phenotype YH therapeutic vaccine A vaccine that is used for treatment for a disease. YH vaccination with a licensed vaccine licensed use of vaccine is a vaccination process that follows a protocol for a licensed vaccine. YH, BP, XZ attenuated M. bovis strain WAg520 YH PMID: 10225931 AE: thirst YH Thirst is the craving for liquids, resulting in the basic instinct of humans or animals to drink. It is an essential mechanism involved in fluid balance. This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'thirst'; is an adverse event that was mentioned in 148 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). AE: bone disorder This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'bone disorder'; is an adverse event that was mentioned in 145 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH titer A titer (or titre) is a measure of concentration. Titer testing employs serial dilution to obtain approximate quantitative information from an analytical procedure that inherently only evaluates as positive or negative. The titer corresponds to the highest dilution factor that still yields a positive reading; for example, positive readings in the first 8 serial twofold dilutions translate into a titer of 1:256. YH WEB:http://en.wikipedia.org/wiki/Titer vaccination with a licensed human vaccine YH, XZ licensed use of vaccine is a vaccination process that involves the vaccination of a licensed human vaccine. attenuated M. bovis strain WAg522 PMID: 10225931 YH recombinant nontypeable H. influenzae protein P6 with AdDP PMID: 15031801 YH adamantylamide dipeptide vaccine adjuvant AdDP YH toxin YH toxoid vaccine YH A vaccine containing a toxoid, used to protect against toxins produced by certain bacteria. A toxoid (also called inactivated toxin) is a processed toxin that has been treated by chemical means, heat, or irradiation and is no longer capable of causing disease. therapeutic vaccine function The therapeutic vaccine function is a function realized by the process of vaccination and leading to induction of an adaptive immune response to the antigens in a vaccine, which ameliorates a specific disorder. YH AE: fetal disorder This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'fetal disorder'; is an adverse event that was mentioned in 142 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). M. tuberculosis secA2 mutant YH PMID: 17671656 rBCG-Ag85A[Tokyo] PMID: 17720625 YH emotional liability According to the Vaccine Adverse Event Reporting System (VAERS), 'emotional liability'; is an adverse event that was mentioned in 138 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH This term is a COSTART term but not a MP term (3/17/2009). DNA vaccine Rv1806-1807 PMID: 16520093 YH AE: muscle spasm MP: MP_0000743 an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions muscle spasm vaccine-induced up-regulated gene expression YH AAV vaccine vector YH vaccination protocol YH AE: tendon disorder YH A tendon (or sinew) is a tough band of fibrous connective tissue that usually connects muscle to bone and is capable of withstanding tension. Tendon disorder is a medical condition that results in a tendon not functioning normally. According to the Vaccine Adverse Event Reporting System (VAERS), 'tendon disorder'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). route of administration YH vaccine candidate During our call, we decided not to say vaccine candidate is an output of vaccine preparation, which may be reserved for vaccine alone. -- Aug 4, 2009. YH, AR, BP, LC, MC, and ZX vaccine candidate is a processed material that is designed to prevent or ameliorate a disorder in a target organism by modulating adaptive immune responses in that organism by administrating the vaccine. thimerosal vaccine preservative Thimerosal vaccine preservative is a vaccine preservative that contains the chemical thimerosal. YH peptide vaccine YH Peptide vaccine is a subunit vaccine that uses small peptide(s) as immunoepitopes. H1N1 Influenza vaccine H1N1 Influenza vaccine is an Influenza virus vaccine that is used to vaccinate against H1N1 Influenza subtype vaccine. YH status YH vaccine adjuvant a vaccine component that is chemical substance added to vaccine and enhance and direct immune response to protective antigen. Many of vaccine adjuvants cause a range of serious side-effects. YH H. influenzae gene YH vaccine license application A vaccine regulatory process that is for vaccine producer to apply for vaccine license. YH nontypeable H. influenzae gene hel (encoding P4) Encodes for protein P4 YH immune response detection assay An assay that is used to detect the immune response of a host to vaccination of a vaccine. YH vaccination with a licensed dog vaccine YH AE: hostility This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'hostility'; is an adverse event that was mentioned in 136 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH M. tuberculosis phoP mutant SO2 YH PMID: 17084814 PMID: 16564606 AE: visual field defect According to the Vaccine Adverse Event Reporting System (VAERS), 'visual field defect'; is an adverse event that was mentioned in 131 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). YH vaccine preparation vaccine production YH, BP vaccine preparation is a manufacturing process to produce a vaccine. vaccine generation vaccine protection assay An assay that is used to detect if a vaccine protects a host against infection of virulent pathogen after vaccine immunization. YH vaccine challenge experiment AE: myopathy MP: MP_0000751 According to the Vaccine Adverse Event Reporting System (VAERS), 'myopathy'; is an adverse event that was mentioned in 199 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). any abnormal condition or disease of the skeletal muscle myopathy vaccine specific T cell cytokine production YH vaccine specific T cell mediated cytotoxicity YH vaccine clinical trial YH A process by which a vaccine is tested clinically for safety and effectiveness. Clinical trials are conducted in phases. Classically, clinical trials unfold in three phases in order to gather data and information about a vaccine and its performance. This will form the basis of a dossier submitted to regulatory authorities by way of an application for licensure. After a vaccine is licensed and is being used by large numbers of people, a Phase IV study may or may not be taken for vaccine clinical evaluation. Most vaccines against a pathogen (e.g., HIV) are not tested by vaccinating people and then deliberately exposing them to virulent pathogen (e.g., HIV). This strategy is never for a vaccine against a disease as serious as HIV. The best way to determine if a vaccine is effective is to test it in a randomized, controlled, double-blind clinical trial. This type of trial is often referred to as the gold standard in medical research and provides the strongest evidence for the efficacy of a vaccine. vaccine using part of organism YH A vaccine that uses part of pathogen organism. vaccine using whole organism YH A vaccine t that uses the whole pathogen organism. vaccine vector a vaccine component that functions as a vector that carries an inserted antigen (protein recognized by the body as foreign) from a disease causing agent to the vaccinee. YH vaccinia virus vector YH AE: apathy Apathy is a state of indifference, or the suppression of emotions such as concern, excitement, motivation and passion. An apathetic individual has an absence of interest or concern to emotional, social, or physical life. They may also exhibit an insensibility or sluggishness. impassivity perfunctoriness This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'apathy'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH AE: hemiplegia This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'hemiplegia'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). YH Hemiplegia is total paralysis of the arm, leg, and trunk on the same side of the body. Hemiplegia is more severe than hemiparesis, wherein one half of the body is weakened but not paralysed. BCG mutant secreting listeriolysin YH AE: pustular rash YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'pustular rash'; is an adverse event that was mentioned in 128 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). Pastular rash is a rash that is composed of pustular lesions. AE: creatine phosphokinase increased YH This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'creatine phosphokinase increased'; is an adverse event that was mentioned in 127 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). An abnormal lab test that has increased creatine phosphokinase. Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissue types. It catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). ΔureC hly+ rBCG PMID: 16110326 YH Hiberix AE: intracranial hypertension YH According to the Vaccine Adverse Event Reporting System (VAERS), 'intracranial hypertension'; is an adverse event that was mentioned in 118 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). viral vaccine A vaccine that protects against some viral disease. MeSH: D014765 YH viral vaccine vector YH virulence YH virulent YH AE: gamma glutamyl transpeptidase increased GGTP increased According to the Vaccine Adverse Event Reporting System (VAERS), 'gamma glutamyl transpeptidase increased'; is an adverse event that was mentioned in 117 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). GGT increased An abnormal lab test that has increased gamma glutamyl transpeptidase (GGT). GGT is involved in the transfer of amino acids across the cellular membrane. Gamma-GT increased YH This term is a COSTART term but not a MP term (3/17/2009). Nontypeable H. influenzae protein P6 with cholera toxin YH PMID: 15297063 AE: abnormal stool This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal stools'; is an adverse event that was mentioned in 111 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH animal model of vaccine research Animal model of vaccine research is a role played by some organism (e.g., mouse) that is used for vaccine research. YH AE: bone pain This term is a COSTART term but not a MP term (3/17/2009). YH According to the Vaccine Adverse Event Reporting System (VAERS), 'bone pain'; is an adverse event that was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). AE: cerebrovascular accident YH stroke This term is a COSTART term but not a MP term (3/17/2009). Cerebrovascular accident: The sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A CVA is also referred to as a stroke. According to the Vaccine Adverse Event Reporting System (VAERS), 'cerebrovascular accident'; is an adverse event that was mentioned in 106 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). vaccination with a licensed turkey vaccine VO_0000619 YH pathogen challenge YH A pathogen challenge is the administration of a live pathogenic organism to a host. laboratory animal model of vaccine research Animal model of vaccine research is a role played by some organism (e.g., mouse) that is used for vaccine research in the laboratory. YH AE: parotid gland enlargement According to the Vaccine Adverse Event Reporting System (VAERS), 'parotid gland enlargement'; is an adverse event that was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH AE: flatulence YH Flatulence is the production of a mixture of gases in the digestive tract of mammals or other animals that are byproducts of the digestion process. Such a mixture of gases is known as flatus, and is expelled from the rectum in a process colloquially referred to as "passing gas" or "farting". According to the Vaccine Adverse Event Reporting System (VAERS), 'flatulence'; is an adverse event that was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). This term is a COSTART term but not a MP term (3/17/2009). whole pathogen organism in vaccine YH AE: liver damage This term is a COSTART term but not a MP term (3/17/2009). According to the Vaccine Adverse Event Reporting System (VAERS), 'liver damage'; is an adverse event that was mentioned in 102 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). YH survival assessment YH Need to point out more specifically that survival / death is measured. Survival assessment is an assay that measures the occurence of death events in one or more organisms that are monitored over time. H. influenzae Type b capsular polysaccharide vaccine PMID: 6387614 YH PMID: 335348 vaccination with a licensed rabbit vaccine YH B. anthracis recombinant vaccine using PA domain 4 PMID: 11854261 PMID: 15935874 YH licensed vaccine role licensed vaccine role is a regulation-assigned role that indicates that a vaccine obtains official approval for commercial production and selling on the market. YH vaccine in clinical trial role YH vaccine in clinical trial role is a regulation-assigned role that inheres in a vaccine that is currently in clinical trial. In medical research, clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. Imovax Polio B. melitensis P39 deletion vaccine A B. melitensis vaccine that is recombinant B. melitensis Rev. 1 vaccine with the p39 gene deletion. PMID: 9784574. YH licensed human vaccine a vaccine with license that is for human use. YH AE: sore throat YH Clostridium vaccine A bacterial vaccine that protects against infection with Clostridium spp. YH Clostridium tetani vaccine YH a Clostridium vaccine that protects against infection with Clostridium tetani that causes tenanus. tetanus vaccine combination vaccine MeSH: D017778 YH Combination vaccine is a vaccine that induces protection against multiple infectious diseases or several different serotypes of the same organism. The anitgens contained in combination vaccines are either formulated together by the manufacturer or physically mixed by a health care provider just prior to administration. Both approaches require licensure. Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1624. combo vaccine Influenza virus vaccine A viral vaccine that protects against infection with influenza virus. MeSH: D007252 Influenza vaccine YH licensed cattle vaccine a vaccine with license that is used for cattle. YH Hepatitis B virus vaccine A viral vaccine that protects against infection with Hepatitis B virus. MeSH: D017325 YH licensed fish vaccine YH Hepatitis A virus vaccine MeSH: D022362 A viral vaccine that protects against infection with Hepatitis A virus. YH licensed goat and sheep vaccine YH Yersinia pestis vaccine YH MeSH: D010931 A bacteria vaccine that prevents against Yersinia pestis infection that causes plague. Plague vaccine licensed dog vaccine YH Rabies virus vaccine YH A viral vaccine that protects against infection with Rabies virus. MeSH: D011819 Smallpox virus vaccine A viral vaccine that protects against infection with Smallpox virus. YH MeSH: D012900 licensed cat vaccine YH licensed ferret vaccine YH Measles virus vaccine Measles vaccine YH MeSH: D008458 A viral vaccine that protects against infection with Measles virus. licensed deer vaccine YH Mumps virus vaccine YH MeSH: D009108 A viral vaccine that protects against infection with Mumps virus. licensed bird vaccine YH Rotavirus vaccine MeSH: D022243 YH A viral vaccine that protects against infection with Rotavirus. HIBTITER PMID: 2057256 In most cases HibTITER was administered concomitantly with other vaccines including DTP, DTaP, hepatitis B vaccine, IPV, OPV, pneumococcal 7-valent conjugate vaccine, MMR, and/or meningococcal group C conjugate vaccine (not licensed in the US). PMID: YH PMID: 9353019 ProHIBiT PMID: 2057256 YH Ref: http://www.rxlist.com/prohibit-drug.htm Haemophilus vaccine MeSH: D018073 YH A bacterial vaccine that protects against infection with Haemophilus. Haemophilus influenzae serotype b vaccine Haemophilus b vaccine YH SC602 A live attenuated Shigella flexneri 2a vaccine that carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding aerobactin). PMID: 10377124. YH PMID: 10377124 Poliovirus vaccine A viral vaccine that protects against infection with Poliovirus. MeSH: D023321 YH Japanese encephalitis virus vaccine YH A viral vaccine that protects against infection with Japanese encephalitis virus. Japanese encephalitis vaccine MeSH: D022321 CVD 1208 CVD 1208 is derived from wild type Shigella flexneri 2a strain 2457T and has defined deletions in four genes: (1) the guaBA chromosomal operon that encodes two enzymes (inositol 5'-monophosphate dehydrogenase and guanosine 5'synthase) essential for de novo purine biosynthesis; (2) set, a locus in a chromosomal pathogenicity island that encodes Shigella enterotoxin (ShET); (3) Pic, an autotransporter mucinase encoded on the opposite strand from set; and (4) sen, an invasiveness plasmid gene encoding ShET. PMID: 15499528 YH human papillomavirus vaccine YH CVD 1208S PMID: 17938573 CVD 1208S is the same thing as CVD 1208, but CVD 1208S was prepared using animal-free media. PMID: 17938573. YH Varicella-zoster virus vaccine YH EcSf2a-2 This vaccine is an aro-D mutant derivative of EcSf2a-1. PMID: 1587589. YH PMID: 1587589 Salmonella typhi vaccine YH heat-killed virulent Shigella flexneri 2a YH PMID: 10102148 Shigella Sfl 124 vaccine YH PMID: 1937767 Recombinant SFL124-27 expressing S. dysenteriae type 1 O antigen PMID: 9169740 YH Streptococcus pneumoniae vaccine YH S. dysenteriae 1 strain WRSd1 PMID: 12010984 YH S. flexneri 2a strain CVD 1207 YH A live attenuated Shigella flexneri 2a vaccine with specific deletion mutations in virG, sen, set, and guaBA. PMID: 10678904 S. sonnei strain WRSS1 PMID: 11895966 YH A stable attenuated Shigella sonnei strain with virG mutation. PMID: 9712824. PMID: 9712824 Shigella sonnei vaccine YH Shigella flexneri vaccine YH Shigella dysenteriae vaccine YH S. flexneri 2a LPS vaccine complexed with N. meningitidis proteosomes YH PMID: 8500877 vaccine regulation YH A process that regulates vaccine-related processes, such as vaccine trial, vaccine license application. vaccine transportation YH A process of transporting vaccine from one place to another place. AE: paralysis According to the Vaccine Adverse Event Reporting System (VAERS), 'paralysis' is an adverse event that was mentioned in 574 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0000753 loss of power of voluntary movement in a muscle through injury or disease of its nerve supply paralysis Acambis, Inc http://www.acambis.com/ YH Berna Biotech, Ltd YH http://www.crucell.com/ BioPort Corp http://www.bioport.com/ YH CSL Limited YH http://www.csl.com.au/ GlaxoSmithKline Biologicals YH http://www.gsk-bio.com/english/index.html Greer Laboratories Inc YH http://www.greerlabs.com/ ID Biomedical Corp of Quebec http://www.ctidirectory.com/search/company.cfm?company=129584 YH Massachusetts Public Health Biologic Lab YH MedImmune Vaccines, Inc http://www.medimmune.com/ YH Merck & Co, Inc http://www.merck.com/ YH Novartis Vaccines and Diagnostics YH http://www.novartis.com/about-novartis/our-businesses/vaccines-diagnostic.shtml Organon Teknika Corp YH Research Foundation for Microbial Diseases of Osaka University YH http://read.jst.go.jp/public/cs_kkn_004EventAction.do?action5=event&lang_act5=E&kcd1_act5=9535000000&judge_act5=2 Sanofi Pasteur Limited http://www.sanofipasteur.com YH Sanofi Pasteur, Inc YH http://www.sanofipasteur.us Wyeth Pharmaceuticals Inc YH http://www.wyeth.com/ Inactivated Poliomyelitis Vaccine - IPV Sanofi Pasteur, SA http://www.sanofipasteur.co.za/ YH vaccine specific antibody test YH vaccine trial regulation A vaccine regulation process for vaccine clinical trials. YH primary vaccination YH A vaccination process that occurs at the first time. prime vaccination boost vaccination YH A vaccination process that occurs after the primer vaccination with a purpose to boost host immune response to vaccine antigen. Brucella melitensis vaccine YH Brucella melitensis strain Rev. 1 PMID: 13416171 YH inactivated viral vaccine killed viral vaccine vaccine allergen role YH licensed human vaccine in Canada DNA vaccine preparation YH Preparation of DNA vaccine conjugate vaccine preparation Preparation of conjugate vaccine YH subunit vaccine preparation Preparation of subunit vaccine YH live attenuated vaccine preparation YH Preparation of live attenuated vaccine. RNA vaccine preparation YH Preparation of RNA vaccine. B. abortus strain RB51SOD YH PMID: 10816475 Brucella suis vaccine YH B. suis "strain 2" Brucella suis S2 An orally administrable brucellosis vaccine that was was developed in China. It is effective for oral vaccination of sheep, goats, cattle and pigsPMID: 3541425. YH B. abortus strain 45/20 PMID: 8236802 YH cytomegalovirus vaccine YH Dengue virus vaccine YH A viral vaccine that protects against infection with Dengue virus. MeSH: D053059 Dengue vaccine Ebola virus vaccine YH A viral vaccine that protects against infection with Ebola virus. MeSH: D046129 Ebola vaccine Herpesvirus vaccine A viral vaccine that protects against infection with Herpesvirus. MeSH: D022283 YH chickenpox virus YH Herpes simplex virus vaccine YH Marek disease vaccine YH Measles-Mumps-Rubella vaccine YH Diphtheria-Tetanus vaccine A combination vaccine that is used to vaccinate against infections with both Clostridium tetani and Corynebacterium diphtheriae. YH CVD 1204(pGA1-CS2) YH PMID: 11292735 CVD 1204(pGA1-CS3) PMID: 11292735 YH Corynebacterium diphtheriae vaccine YH diphtheria vaccine A bacterial vaccine that protects against infection with Corynebacterium diphtheriae that causes Diphtheria. Measles-Mumps vaccine YH Measles-Mumps-Rubella-Vericella vaccine YH Diphtheria-Tetanus-Pertussis vaccine YH Shigella ribosome-based Vaccine (SRB) YH PMID: 17507120 P. falciparum vaccine Combination B PMID: 14604568 A malaria vaccine that comprises recombinant Plasmodium falciparum (P. falciparum) blood-stage proteins MSP1, MSP2 and RESA, formulated with the adjuvant Montanide ISA 720. PMID: 14604568. YH Haemophilus influenzae serotype b YH Diphtheria-Tetanus-Pertussis-Poliovirus vaccine YH Diphtheria-Tetanus-Pertussis-Poliovirus-Hepatitis B vaccine YH Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b vaccine YH Hepatitis A&B vaccine YH Haemophilus b and Hepatitis B vaccine YH DNA and MVA encoding ME-TRAP PMID: 16988273 YH A vaccine that contains DNA and modified vaccinia virus Ankara (MVA) encoding thrombospondin-related adhesion protein (TRAP) with a multiple-epitope string ME (ME-TRAP). This vaccine is used with a prime-boost regime by DNA priming and MVA boosting. PMID: 16988273. Papillomavirus vaccine A viral vaccine that protects against infection with Papillomavirus. YH MeSH: D053918 Parainfluenza virus vaccine A viral vaccine that protects against infection with Parainfluenza virus. YH MeSH: D022241 parainfluenza vaccine Pseudorabies virus vaccine pseudorabies vaccine MeSH: D022421 A viral vaccine that protects against infection with Pseudorabies virus. YH Simian immunodeficiency virus vaccine MeSH: D018449 YH SAIDS vaccine A viral vaccine that prevents against infection with Simian immunodeficiency virus. West Nile virus vaccine A viral vaccine that protects against West Nile virus infection. MeSH: D053060 YH Respiratory syncytial virus vaccine A viral vaccine that prevents infection with Respiratory syncytial virus. MeSH: D022261 YH marker vaccine YH A vaccine that is used in conjunction with diagnostic tests to differentiate vaccinated animals from carrier animals. It can be a subunit or a gene-deleted vaccine. MeSH: D022581 edible vaccine YH A vaccine that is edible and derived from an edible plant. The transgenic plant is used as recombinant protein production system. The edible plant tissue functions as an oral vaccine. MeSH: D022462 acellular vaccine acellular vaccine is a subunit vaccine that is produced by using only the antigenic part of the disease causing organism. It often requires a "booster" every few years to maintain their effectiveness. MeSH term: D20.215.894.860.900. YH ISCOM The immunostimulating complex ISCOM is a vaccine adjuvant that consists of an assembly of antigens in multimeric form and presents an antigen to induce specific immunologic responses. The assembly is attached to a matrix with a built-in adjuvant, saponin. ISCOMs induce strong serum antibody responses, and are used as highly immunogenic forms of subunit vaccines. MeSH term: D20.215.894.860.449. YH Plasmodium vivax vaccine YH contraceptive vaccine A vaccine that is used to prevent conception. antifertility vaccine MeSH: D022642 YH Alzheimer vaccine YH MeSH: D023582 A vaccine that prevents or treats Alzheimer disease. malaria vaccine Plasmodium vaccine is a vaccine that prevents against Plasmodium species causing malaria. It is made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents. malarial Vaccine MeSH: D017780 Plasmodium vaccine YH Leishmania vaccine a protozoan vaccine that prevents against infection with Leishmania. Leishmaniasis vaccine MeSH: D054332 YH Vibrio cholerae vaccine YH A bacterial vaccine that prevents infection with Vibrio cholera. MeSH: D022121 Lyme disease vaccine MeSH: D022123 YH A vaccine that prevents Lyme disease caused by Borrelia burgdorferi. Borrelia burgdorferi vaccine Bordetella pertussis vaccine YH A bacterial vaccine that prevents against Bordetella pertussis infection that causes pertussis or whooping cough. Pertussis vaccine MeSH: D010567 Pseudomonas vaccine YH A bacterial vaccine that protects against infection with Pseudomonas. MeSH: D054406 Rickettsial vaccine YH A bacterial vaccine that protects against diseases caused by various species of Rickettsia. MeSH: D012290 Salmonella vaccine YH A bacterial vaccine that protects against infections by various Salmonella species. MeSH: D022562 Shigella vaccine MeSH: D022281 YH A bacterial vaccine that protects against infections with Shigella species. Staphylococcal vaccine A bacterial vaccine that protects against infection with Staphylococcus. Staphylococcus vaccine MeSH: D013209 Staph vaccine YH BCG vaccine BCG Vaccine is a Mycobacterium tuberculosis vaccine that is a live attenuated strain of Mycobacterium bovis (Bacillus Calmette Guerin; BCG). YH Bacillus Calmette Guerin Streptococcal vaccine A bacterial vaccine that prevents streptococcal infections. MeSH: D022541 Streptococcus vaccine YH MSP3-LSP with aluminium hydroxide YH PMID: 17280744 RTS,S/AS02A RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. PMID: 15488216. PMID: 15488216 YH P. falciparum MSP1 from transgenic mice with Freund's adjuvant YH PMID: 11752405 P. vivax PVS25 with Montanide ISA-720 YH PMID: 16291764 FMP1/AS02A YH PMID: 17442466 FMP2.1/AS02A is a recombinant E. coli-expressed protein based upon the apical membrane antigen-1 (AMA-1) of the 3D7 clone formulated with the AS02A adjuvant. PMID: 17442466. recombinant ABRA protein vaccine PMID: 11489167 PMID: 9400530 YH NP-VRP An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus NP protein. YH GP-VRP YH An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus GP protein. VRP expressing VP24 PMID: 11485406 alphavirus replicon expressing VP24 YH An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP24 protein. VRP expressing VP30 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP30 protein. PMID: 11485406 alphavirus replicon expressing VP30 YH VRP expressing VP35 alphavirus replicon expressing VP35 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP35 protein. YH PMID: 11485406 VRP expressing VP40 An Ebola virus vaccine that is composed of VEE replicon particle (VRP) encoding Ebola virus VP40 protein. YH PMID: 11485406 alphavirus replicon expressing VP40 DNA vaccine expressing sGP YH PMID: 9427604 A DNA vaccine that encodes for a secreted form of Ebola virus GP protein. DNA and adenoviral vector Ad5 expressing SIV gag protein A vaccine combination that includes a DNA vaccine and a recombinant adenovirus Ad5 expressing the same codon-optimized SIV gag gene. The DNA vaccine is used for priming, and the Ad5 vaccine is used for boosting. PMID: 11797011. PMID: 11797011 YH gene The term 'gene' has appears in several ontologies, such as Sequence Ontology (SO) and Protein Ontology (PRO). We may choose to use a 'gene' term from other ontologies. The 'gene' term in SO has ID: SO:0000704. YH A gene that is a pathogen gene used for vaccine preparation or a host gene encoding for an immune factor important in induction of protective immunity. a vaccine-associated gene that exists in a pathogen and has been engineered for vaccine develoment. This gene can encode for protective antigen that is overexpressed for vaccine development. This gene can also be a virulence factor that is mutated to attenuate a virulent pathogen with the purpose of making attenuated vaccine. adenoviral vector Ad5 expressing SIV gag protein YH PMID: 11797011 A recombinant adenovirus (Ad5) expressing the codon-optimized SIV gag gene. PMID: 11797011. DNA and Ad5/35 vector expressing HIV gp160 protein PMID: 16079886 YH A vaccine combination that includes a DNA vaccine and a replication-defective chimeric Ad5 vector with the Ad35 fiber (Ad5/35) that express the same codon-optimized SIV gag gene. The DNA vaccine is used for priming, and the Ad5/35 vaccine is used for boosting. PMID: 16079886. Brucella gene YH human gene YH mouse gene YH Brucella abortus gene YH Brucella abortus wboA YH Brucella abortus gene wboA is interrupted in Brucella abortus cattle vaccine RB51. mouse Ifng YH Interferon-gamma (IFN-g) is an indicative of Th1 immune response. It is produced in host immunized by vaccines such as Brucella abortus cattle vaccine RB51. human ifng YH Interferon-gamma (IFN-g) is an indicative of Th1 immune response. cattle gene YH cattle Ifng Interferon-gamma (IFN-g) is an indicative of Th1 immune response. It is produced in host immunized by vaccines such as Brucella abortus cattle vaccine RB51. YH vaccine storage YH a storage process that is specifically for vaccine. vaccine storage at room temperature YH a vaccine storage that is execuated at room temperature. Room temperature is also referred to as ambient temperature. Room temperature denotes a certain temperature within enclosed space at which humans are accustomed. Room temperature is usually indicated by general human comfort, with the common range of 10°C (50°F) to 28°C (82.4 °F). vaccine storage in refrigerator YH vaccine storage that is executed in refrigerator, usually 0-10^C. vaccine storage in freezer YH vaccine storage that is executed in freezer under 0^C. effectiveness YH Effectiveness is physical quality that represents the capability of a single physical entity (e.g., vaccine) producing an effect (e.g, protection against a disease). effective YH ineffective YH adverse event An vaccine adverse event is an event associated with the use the a vaccine, regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of pharmacologic action. Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623. side effect YH VAE rapid vaccination A vaccination process that is implemented fast. YH vaccine rapid implementation vaccination coverage WEB: http://www.sanofipasteur.com/sanofi-pasteur2/front/index.jsp?siteCode=SP_CORP&codeRubrique=19 A measure datum that measures the coverage of vaccination in a specific area during a specific time period. immunization coverage WEB: http://www.who.int/immunization_monitoring/routine/immunization_coverage/en/ YH, MC DNA/MVA prime-boost HIV vaccine PMID: 17328232 YH An HIVA.DNA/modified vaccinia Ankara (MVA) prime-boost vaccine for the potential prevention of infection with HIV subtype A. The vaccination strategy consists of priming with a DNA vaccine made from HIV-1 clade A gag p24/p17 consensus sequence (pTHr.HIVA) then boosting with a MVA virus expressing HIVA (MVA.HIVA). PMID: 2152500. epitope YH licensed human vaccine in USA role licensed human vaccine in USA role is a licensed human vaccine role that indicates the vaccine occurs in USA. YH cattle vaccine with license in USA YH a cattle vaccine with license that is used in USA. vaccination dose YH A dose used in a vaccination. monthly YH biweekly YH DNA vaccine expressing multiple HIV epitopes YH PMID: 16359234 A HIV vaccine that is composed of a DNA vaccine expressing conserved, multiple HIV epitopes. PMID: 16359234. AE: weight loss MP: MP_0001263 According to the Vaccine Adverse Event Reporting System (VAERS), 'weight loss' is an adverse event that was mentioned in 415 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). progressive reduction of body weight below normal average for age weight loss recombinant HIV gp120 with adjuvant NanoEmulsion PMID: 18260780 A HIV vaccine that is made of recombinant HIV gp120 protein adjuvanted with the adjuvant NanoEmulsion. PMID: 18260780. YH Aeromonas salmonicida vaccine YH Vetech Labs YH http://www.vetechinc.com/ Gag-VRPs PMID: 12120997 Gag-VRPs is a cocktail vaccine of V3014-packaged VRPs expressing the SIVsm H-4i nonmyristylated matrix-capsid region, full-length gp160, and a secreted form of gp160 (gp140). PMID: 12120997. PMID: 10462249 YH Vibrio anguillarum vaccine YH MVA expressing HIV Gag, Pol and Env proteins YH A recombinant modified vaccinia Ankara (MVA) expressing HIV Gag, Pol, and Env proteins. PMID: 16472543. PMID: 16472543 DNA and poxvirus priming-boosting SIV vaccine PMID: 15258286 A SIV vaccine that is composed of a DNA vaccine and a poxvirus vector expressing the same SIV antigens. PMID: 15258286. YH B. abortus P39 deletion vaccine YH A B. abortus vaccine that is recombinant B. abortus strain 19vaccine with the p39 gene deletion. PMID: 9784574. AdsecV PMID: 17041851 YH A Yersinia pestis vaccine that uses a recombinant Ad5–based vector (E1a, partial E1b, and partial E3 deletion) to express Y. pestis V antigen. Yersinia EV76 PMID: 4988692 A Yersinia pestis vaccine that is a pigmentation negative mutant of Y. pestis derived from a fully virulent strain. Yersinia EV-76 PMID: 8578841 YH Y. pestis F1 protein vaccine PMID: 312163 A Yersinia pestis subunit vaccine that uses Y. pestis F1 protein as antigen. PMID: 8675324 YH rF1 + rV vaccine YH A Y. pestis subunit vaccine that uses recombinant F1 and V antigens. PMID: 312163. PMID: 10930691 PMID: 15908389 PMID: 12922126 Recombinant Y. pestis V antigen vaccine PMID: 7622205 A Y. pestis subunit vaccine that uses recombinant Y. pestis V antigen. PMID: 7622205. YH modified Y. pestis with TLR4-stimulating LPS PMID: 16980981 YH Yersinia PAV PMID: 7622225 A Yersinia pestis subunit vaccine that contains staphylococcal protein A-V antigen fusion peptide (PAV). PMID: 7622225. YH recombinant Y. pestis YopD protein vaccine PMID: 10024607 PMID: 8890210 YH Epm vaccine In vitro-cultured merozoites, chemically inactivated YH Y. pestis YscF subunit vaccine YH PMID: 15978133 A Y. pestis subunit vaccine that uses Y. pestis YscF protein as antigen. PMID: 15978133. microencapsulated Caf1 and LcrV vaccine PMID: 16546306 YH Ovilis Enzovax Live temperature-sensitive mutant strain for subcutaneous or intramuscular injection YH Trovac AI H5 Fowlpox virus-vectored H5 YH recombinant Yersinia rV10 vaccine YH A Y. pestis vaccine that uses the recombinant V10 (rV10), a variant (lacking residues 271 to 300) of Yersinia pestis LcrV. PMID: 16861680. PMID: 16861680 Pfizer Animal Health http://www.pfizerah.com/ YH AquaVac ERM Killed oral vaccine YH Feline leukemia virus vaccine YH Art Vax Live temperature-sensitive mutant strain; spray inhalation or drinking water YH VSV vector expressing Y. pestis lcrV PMID: 16959385 YH BIOPHARM YH Plague vaccine USP A formalin-inactivated preparation that was manufactured by Cutter Biologicals (a division of Miles Laboratories, Inc.). It is now available only from Greer Laboratories, Inc. The killed or inactivated plague vaccine is prepared from Y. pestis organisms grown in artificial media and then inactivated in formaldehyde. URL: http://www.cdc.gov/mmwr/preview/mmwrhtml/00044836.htm YH PMID: 8578841 Cutter Biological YH Improvac YH Peptide-protein conjugate and water-miscible adjuvant; control of boar taint vaccine additive YH vaccine additive is a material that is added to the immunogen by the vaccine manfacturer for a specific purpose. Additives include adjuvants, preservatives and stablizers, as well as materials that are added to affect pH and isotonicity. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. vaccine preservative antimicrobial agent in vaccine YH vaccine preservative is an vaccine additive that is added to a vaccine formulation to prevent the growth of bacteria or fungi that inadvertently may be introduced into the vaccine during use. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. Periovac YH Killed vaccine against periodontitis vaccine stabilizer YH vaccine stabilizer is a vaccine additive that helps to protect the vaccine from adverse conditions such as the freeze-drying process (for those vaccines that are freeze-dried) or heat. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 75. vaccine residual Although no all manufacturing residuals may be identified and quantified, their presence and quantity is assumed to be constant because of the constancy of the manufacturing process. YH A vaccine residual is a part of vaccine that remains from the vaccine manufacturing process. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 73. inactivation residual in vaccine An inactivation residual in vaccine is a vaccine residual that is used to inactivate bacteria and viruses or to detoxify bacterial toxins. For example, formaldehyde is a frequently used inactivation agent in vaccine preparation. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78. YH cell culture residual in vaccine YH A cell culture residual in vaccine is a vaccine residual that is generatead from cell culture for vaccine preparation. Examples include: antibiotics, sensitizing substances, bacterial and cellular residuals, and adventitious agents. Ref: Finn TM and Egan W, in Vaccines fifth edition, 2008. Page 78-81. immune correlate of protection Immune correlate of protection is a host immune response to vaccine that correlates with protective induced by the vaccine. YH serologic correlate of protection Serological correlate of protection is an immune correlate of protection that is reflected by serologic antibody levels. YH cell mediated immune correlate of protection YH A cell mediated immune correlate of protection is an immune correlate of protection that is reflected by a cell mediated immune response. vaccine effectiveness Vaccine effectiveness is an effectiveness associated with a vaccine. YH Hadler TC, et al. Immunization in developing countries. In: Vaccines. Editors: Plotkin S, et al. 2008. p1542-71. Bioproperties YH http://www.bioproperties.com.au/ Canada YH Canada is a country that exists in north America. Pirodog YH In vitro-cultured supernatant antigens, reduce clinical disease licensed human vaccine in Canada role The 'licensed in Canada' is a licensed status that occurs in Canada. YH Porphyromonas gulae vaccine YH Fluviral S/F YH Influvac YH Influvac is an Influenza virus vaccine that is manufactured by Solvay Pharma. Vaxigrip YH, Melanie Vaxigrip is an Influenza virus vaccine that is manufactured by 'Sanofi Pasteur Limited. Solvay Pharmaceuticals YH Babesia bigemina vaccine by local veterinary institutes YH Purevax Feline Rabies YH Canarypox virus-vectored vaccine Babesia bovis vaccine by local veterinary institutes YH PGA/ME PMID: 16730934 YH pGPA-incorporated microemulsion Anthrax Spore Vaccine Anthrax Spore Vaccine is a B. anthracis vaccine that is prepared with a relatively nonpathogenic, noncapsulated variant strain of B. anthracis, originally developed at the Onderstepoort Laboratory, Pretoria, South Africa. Further work was conducted in England, India and in many other countries. Vaccine Strain is Sterne 34F2. The vaccine is a suspension of viable Bacillus anthracis spores in saponin. YH B. anthracis Sterne strain spore vaccine PMID: 3084385 pSecTag-PA83 YH PMID: 15293452 pCMV/ER-PA83 YH PMID: 15293452 Websters Animal Health YH https://www.webstervet.com/app.aspx RECOMBITEKEquine WNV YH Canarypox virus-vectored vaccine Porphyromonas denticanis YH pCLF4 PMID: 15068841 YH PMID: 11401993 pCLF4 is a Bacillus anthracis vaccine that contains the N-terminal region (amino acids [aa] 10-254) of Bacillus anthracis LF cloned into the pCI expression plasmid. Equity YH Peptide-protein conjugate and proprietary adjuvant (immunostimulating complex); control of estrus and estrus-related behavior single-dose Vaxigrip multi-dose Vaxigrip YH, Melanie, and Allen We still have not made it defined class since we still need to figure out how to represent multi-dose vs. single dose. The previous method discussed brief needs vetting. --YH The difference between single-dose and multi-dose Vaxigrip is that multi-dose Vaxigrip contains preservative thimoseral. aluminum vaccine adjuvant Aluminum vaccine adjuvant is a vaccine adjuvant that is composed of some aluminum compound. YH vaccine preservative role Vaccine preservative role is a role realized by a material which is added into vaccine as a preservative to protect the vaccine. YH oral route YH Oral route is a route of administration of a material entity such as vaccine. interdermal route YH interdermal route is a route of administration of material entity such as vaccine. phenol vaccine preservative YH PleuroStar APP YH Recombinant ApxII, TbpB, CysL, OmlA(1), and OmlA(2) proteins Colorado Serum Company CZ Veterinaria YH http://www.colorado-serum.com/ phenoxy ethanol vaccine preservative YH Biken YH, ZX Schering-Plough YH http://www.schering-plough.com/ BHV-1 vaccine YH Baxter Healthcare Corporation YH, ZX http://www.baxter.com/ Merck Frosst http://www.merckfrosst.ca/ YH, ZX age at vaccination YH Age at vaccination is the age of an experiment animal at the time of vaccination. Theileria annulata vaccine by local veterinary institutes Culture-derived schizonts YH dose YH, MC dose is a measurement data that measures the quantity of something that may be eaten by or administered to an organism, or that an organism may be exposed to. Quantities of nutrients, drugs, vaccines and toxins are referred to as doses. WEB: http://en.wikipedia.org/wiki/Dose_%28biochemistry%29 challenge dose YH challenge dose is a dose of a virulent pathogen used for a vaccine challenge process. Boehringer-Ingelheim Vetmedica http://www.bi-vetmedica.com/ YH PROTEQ-FLU (European Union) Recombitek (United States) Canarypox virus-vectored vaccine YH secondary vaccination Secondary vaccination is a vaccination that is performed immediately after the primary or the first vaccination. YH, Thom Todd SBL Vaccine YH, ZX Wyeth Canada YH, ZX http://www.wyeth.ca/ Eimeria vaccine YH surface antigens from the zona pellucida YH Theileria annulata vaccine YH vaccine allergen YH, ZX vaccine allergen is a material entity that is capable of stimulating a type-I hypersensitivity reaction in atopic individuals who has been vaccinated with a vaccine. Infectious hematopoietic necrosis virus vaccine YH chicken egg protein allergen chicken egg protein allergen is a vaccine allergen that is composed of chicken egg protein. Eegg protein may come from NCIS thesaurus egg - poultry, combination of minimal anatomy terminology and NCBI taxonomy... Eventually, this term chicken egg protein allergen may become a cross product of sevreal ontology terms. YH, ZX, MC latex vaccine allergen YH, ZX Virbac http://www.virbac.com/ YH gelatin vaccine allergen YH, ZX protamine sulfate vaccine allergen YH, ZX polymyxin B vaccine allergen YH, ZX EURIFEL FeLV Canarypox virus-vectored vaccine YH other addictive bovine albumin YH, ZX bovine serum glutamate RECOMBITEK Corona MLV YH Modified live virus glutaraldehyde Babesia bovis vaccine Infected blood from splenectomized calves YH human albumin human serum Raboral Reference: http://www.raboral.com/ Vaccinia virus recombinant YH polysorbate 20 polysorbate 80 residual protein from cell culture Canine coronavirus vaccine YH saccharin sorbitol Sarcocystis neurona vaccine YH Suvaxyn Aujeszky YH gE- and thymidine kinase-deleted marker vaccine A vaccine that is made of a TK-negative (TK -) and gI/gE-negative (gI/gE -) pseudorabies virus (PRV) mutant to protect pigs against Aujeszky's disease. Aujeszky's disease is also known as pseudorabies. It is a disease primarily of pigs and is caused by porcine herpesvirus 1. This disease is characterized by respiratory, reproductive and nervous signs. sucrose albumin xanthan gum yeast extract yeast protein Apex-IHN YH DNA vaccine Diphtheria-Tetanus-Pertussis-Haemophilus b vaccine Diphtheria-Tetanus-Poliovirus vaccine Vibro-E.coli vaccine Measles-Rubella vaccine Diphtheria-Tetanus-Pertussis-Poliovirus-Haemophilus b-Hepatitis B vaccine PreveNile Live flavivirus chimera vaccine YH Streptococcus equi vaccine YH Mycoplasma gallisepticum vaccine YH Salmonella typhi-Hepatitis A vaccine Bayovac CSF E2 Baculovirus recombinant E2 protein without emulsion YH Dhori virus vaccine Tick-borne virus vaccine pharyngeal mucosal route TT, YH Pharyngeal mucosal route is an oral route of administration. Intervet Avian Influenza virus vaccine YH Chimera virus on NDV backbone; field trials in 2007 host survival to pathogen challenge after vaccination AE: ataxia According to the Vaccine Adverse Event Reporting System (VAERS), 'ataxia' is an adverse event that was mentioned in 555 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001393 ataxia inability to coordinate voluntary muscular movements skin adverse event AE: abnormal gait According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal gait' is an adverse event that was mentioned in 998 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001406 abnormal gait unusual or distinctive way of walking Embrex YH http://www.embrex.com/ AE: dehydration According to the Vaccine Adverse Event Reporting System (VAERS), 'dehydration' is an adverse event that was mentioned in 603 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001429 dehydration excessive water loss from the body or from an organ or bodily part AE: abnormal fluid regulation MP: MP_0001784 any anomaly in the control of intracellular and/or extracellular fluid AE: hyperglycemia According to the Vaccine Adverse Event Reporting System (VAERS), 'hyperglycemia'; is an adverse event that was mentioned in 268 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001559 abnormally high concentration of glucose in the blood; generally refers to a pathological state hyperglycemia Canine gonadotropinreleasing factor immunotherapeutic YH Peptide-protein conjugate and water-miscible adjuvant; treatment of benign prostatic hyperplasia Novartis Animal Health http://www.ah.novartis.com/ YH AE: abnormal circulating bilirubin level MP: MP_0001569 According to the Vaccine Adverse Event Reporting System (VAERS), 'bilirubinemia'; is an adverse event that was mentioned in 221 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). aberrant concentration in the blood of this yellow heme breakdown product AE: cyanosis According to the Vaccine Adverse Event Reporting System (VAERS), 'cyanosis' is an adverse event that was mentioned in 1,804 VAERS reports (1.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001575 a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood cyanosis AE: anemia According to the Vaccine Adverse Event Reporting System (VAERS), 'anemia' is an adverse event that was mentioned in 482 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001577 anemia less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs AE: hypotension According to the Vaccine Adverse Event Reporting System (VAERS), 'hypotension' is an adverse event that was mentioned in 1,021 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001596 hypotension sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states AE: irregular heartbeat MP: MP_0001636 According to the Vaccine Adverse Event Reporting System (VAERS), 'arrhythmia'; is an adverse event that was mentioned in 164 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). uneven timing of heart contraction AE: abnormal heartbeat MP: MP_0004085 anomaly in the appearance of regularly spaced contractions of the heart Novartis Aqua Health http://www.novartis.com/ YH LHRH YH luteinizing hormone-releasing hormone AE: abnormal digestion MP: MP_0001664 altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy homeostasis AE MP: MP_0001764 anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues AE: edema MP: MP_0001785 an accumulation of an excessive amount of watery fluid in cells or intercellular tissues edema AE: inflammation MP: MP_0001846 greater than expected response to injury, infection, or insult AE: brain inflammation MP: MP_0001847 According to the Vaccine Adverse Event Reporting System (VAERS), 'encephalitis' is an adverse event that was mentioned in 480 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). local accumulation of fluid, plasma proteins, and leukocytes in the brain AE: increased susceptibility to otitis media According to the Vaccine Adverse Event Reporting System (VAERS), 'otitis media' is an adverse event that was mentioned in 1,538 VAERS reports (1.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001850 greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection Bovilis IBR Marker YH Live or inactivated gE-deleted marker vaccine AE: eye inflammation MP: MP_0001851 local accumulation of fluid, plasma proteins, and leukocytes in the eye Porcilis Pesti YH Baculovirus recombinant E2 protein without emulsion AE: conjunctivitis According to the Vaccine Adverse Event Reporting System (VAERS), 'Conjunctivitis' is an adverse event that was mentioned in 860 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001852 conjunctivitis inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball AE: liver inflammation MP: MP_0001860 According to the Vaccine Adverse Event Reporting System (VAERS), 'hepatitis' is an adverse event that was mentioned in 387 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). local accumulation of fluid, plasma proteins, and leukocytes in the liver AE: lung inflammation MP: MP_0001861 According to the Vaccine Adverse Event Reporting System (VAERS), 'pneumonia' is an adverse event that was mentioned in 879 VAERS reports (0.7%) during1991-2001 (Reference: PMID: 12825543). local accumulation of fluid, plasma proteins, and leukocytes in the lung AE: respiratory system inflammation MP: MP_0002405 local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system AE: vasculitis MP: MP_0001864 It's an inflammation. According to the Vaccine Adverse Event Reporting System (VAERS), 'vasculitis' is an adverse event that was mentioned in 353 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). inflammation of a blood or lymph vessel vasculitis AE: salivary gland inflammation According to the Vaccine Adverse Event Reporting System (VAERS), 'staladenitis'; is an adverse event that was mentioned in 226 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001870 local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland Theileria parva vaccine by local veterinary institutes YH Infection followed by drug treatment Novus International YH http://www.novusint.com/ AE: sinus inflammation According to the Vaccine Adverse Event Reporting System (VAERS), 'sinusitis'; is an adverse event that was mentioned in 298 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001872 increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens AE: allergic response MP: MP_0001878 hypersensitivity caused by exposure to a specific antigen (allergen) resulting in a marked increase in reactivity to that antigen upon subsequent exposure AE: abnormal cerebrospinal fluid production MP: MP_0001911 According to the Vaccine Adverse Event Reporting System (VAERS), 'Cerebrospinal fluid abnormal' is an adverse event that was mentioned in 600 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord nervous system AE MP: MP_0003633 Toxoplasma gondii vaccine YH AE: abnormal respiration Not sure if it is same as respiratory system disorder or abnormal respiration. --Oliver He According to the Vaccine Adverse Event Reporting System (VAERS), 'respiratory disorder' is an adverse event that was mentioned in 556 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001943 anomaly in the movement of gases into and out of the lung SpayVac Crude ZPA preparation; supplied to research groups only YH SpayVac is a contraceptive vaccine that has proven highly effective in deer and can be used to control populations. Refernce: http://terramar.bc.ca/. no longer available AE: apnea MP: MP_0001957 According to the Vaccine Adverse Event Reporting System (VAERS), 'apnea' is an adverse event that was mentioned in 1,618 VAERS reports (1.3%) during1991-2001 (Reference: PMID: 12825543). apnea temporary cessation of breathing; sometimes episodic AE: deafness MP: MP_0001967 According to the Vaccine Adverse Event Reporting System (VAERS), 'deafness'; is an adverse event that was mentioned in 287 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). deafness inability to hear gustatory system AE MP: MP_0001985 any anomaly in the perception of taste AE: taste sensitivity According to the Vaccine Adverse Event Reporting System (VAERS), 'taste perversion'; is an adverse event that was mentioned in 191 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0001986 changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system Biomune YH http://www.biomunecompany.com/ AE: photosensitivity MP: MP_0001999 According to the Vaccine Adverse Event Reporting System (VAERS), 'photosensitivity reaction'; is an adverse event that was mentioned in 131 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes AE: blindness MP: MP_0002001 According to the Vaccine Adverse Event Reporting System (VAERS), 'blindness'; is an adverse event that was mentioned in 137 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). blindness loss of the sense of sight AE: abnormal vision MP: MP_0002090 According to the Vaccine Adverse Event Reporting System (VAERS), 'abnormal vision' is an adverse event that was mentioned in 609 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). abnormal vision inability or decreased ability to see AE: seizures This term has another path from 'abnormal nervous system physiology' in MP. MP: MP_0002064 seizures sudden and often acute manifestation of epileptic attack, sometimes convulsive abnormal behavior AE MP: MP_0004924 any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls AE: movement disorder MP: MP_0002066 According to the Vaccine Adverse Event Reporting System (VAERS), 'movement disorder'; is an adverse event that was mentioned in 237 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). altered ability to coordinate voluntary movement or repetitive, compulsive movements Giardiavax Cultured trophozoites, reduces disease and cyst shedding YH plant-based Newcastle disease virus vaccine The plant-based Newcastle disease virus vaccine is a Newcastle disease virus vaccine that is developed by Dow AgroSciences LLC. It uses technology discovered at Washington University. It is the first plant-made animal vaccine approved for sale in the United States. YH HN recombinant produced in plant cell lines (registered but not on market) sensory capability AE MP: MP_0002067 inability or altered ability to respond to a sensory stimulus glucose homeostasis AE MP: MP_0002078 anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues Classical swine fever virus vaccine YH AE: hypersensitivity MP: MP_0002148 immune response that results in tissue injury AE: muscular atrophy According to the Vaccine Adverse Event Reporting System (VAERS), 'muscle atrophy'; is an adverse event that was mentioned in 140 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002269 a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation AE: hyperventilation MP: MP_0002320 According to the Vaccine Adverse Event Reporting System (VAERS), 'Petechiae' is an adverse event that was mentioned in 510 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). increased alveolar ventilation relative to metabolic carbon dioxide production; results in carbon dioxide pressure decreasing below normal Vectormune FP-ND Fowlpox virus vectored YH AE: hypoventilation According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoventilation' is an adverse event that was mentioned in 321 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002321 hypoventilation reduced alveolar ventilation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal hematopoietic system AE MP: MP_0002396 any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells AE: mydriasis MP: MP_0002546 According to the Vaccine Adverse Event Reporting System (VAERS), 'mydriasis'; is an adverse event that was mentioned in 139 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). dilation of one or both pupils regardless of light conditions mydriasis Coccivac Paracox Immucox Advent Nobilis Cox ATM YH Sporulated oocysts of several or all of the avian species AE: increased heart rate According to the Vaccine Adverse Event Reporting System (VAERS), 'tachycardia' is an adverse event that was mentioned in 1,269 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002626 greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute Megan Vac1 MeganEgg YH Double gene-deleted S. enterica serovar Typhimurium strain AE: hyperresponsive to tactile stimuli According to the Vaccine Adverse Event Reporting System (VAERS), 'hypesthesia'; is an adverse event that was mentioned in 238 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002738 exaggerated reflex action normally induced by touch or pain AE: opisthotonus According to the Vaccine Adverse Event Reporting System (VAERS), 'opisthotonos'; is an adverse event that was mentioned in 173 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0002880 a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward opisthotonus AE: joint inflammation MP: MP_0002933 local accumulation of fluid, plasma proteins, and leukocytes in the joints AquaVac Furuvac YH Killed oral vaccine Lohman Animal Health International YH http://www.lahinternational.com/ AE: increased lactate dehydrogenase level MP: MP_0002944 According to the Vaccine Adverse Event Reporting System (VAERS), 'lactic dehydrogenase increased'; is an adverse event that was mentioned in 167 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate AE: increased circulating alkaline phosphatase level MP: MP_0002968 According to the Vaccine Adverse Event Reporting System (VAERS), 'alkaline phosphatase increased'; is an adverse event that was mentioned in 199 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood AE: arthritis MP: MP_0002993 According to the Vaccine Adverse Event Reporting System (VAERS), 'arthritis' is an adverse event that was mentioned in 972 VAERS reports (0.8%) during1991-2001 (Reference: PMID: 12825543). arthritis joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures AE: dysphagia MP: MP_0003158 According to the Vaccine Adverse Event Reporting System (VAERS), 'dysphagia' is an adverse event that was mentioned in 603 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). difficulty in swallowing food or liquid dysphagia AE: decreased lateral semicircular canal size MP: MP_0003162 According to the Vaccine Adverse Event Reporting System (VAERS), 'anxiety' is an adverse event that was mentioned in 391 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance Babesia bigemina vaccine YH AE: decreased platelet cell number MP: MP_0003179 According to the Vaccine Adverse Event Reporting System (VAERS), 'thrombocytopenia' is an adverse event that was mentioned in 640 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation Yersinia ruckeri vaccine YH AE: nausea MP: MP_0003259 gastric discomfort associated with the inclination to vomit nausea AE: vomiting MP: MP_0003260 the retrograde expulsion of gastric contents through the oral cavity vomiting AE: constipation MP: MP_0003267 According to the Vaccine Adverse Event Reporting System (VAERS), 'constipation'; is an adverse event that was mentioned in 242 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). constipation incomplete, infrequent or difficult evacuation of fecal matter AE: abnormal defecation MP: MP_0003866 anomaly in the production and excretion of feces AE: urinary incontinence MP: MP_0003280 According to the Vaccine Adverse Event Reporting System (VAERS), 'urinary incontinence'; is an adverse event that was mentioned in 237 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). inability to control the urinary excretory functions AE: intussusception MP: MP_0003294 According to the Vaccine Adverse Event Reporting System (VAERS), 'intussusception'; is an adverse event that was mentioned in 143 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). intussusception telescoping of the intestine, or the prolapse of one part of the bowel to another; usually results in obstruction AE: pallor MP: MP_0003717 an unnatural paleness to the skin, generally attributable to anemia pallor AE: tinnitus MP: MP_0003741 According to the Vaccine Adverse Event Reporting System (VAERS), 'tinnitus'; is an adverse event that was mentioned in 268 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). persistent sensation of buzzing, ringing, clicking, or other noises in the ear tinnitus AE: stomatitis MP: MP_0003746 This is a type of inflammation. According to the Vaccine Adverse Event Reporting System (VAERS), 'stomatitis'; is an adverse event that was mentioned in 121 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). inflammation of the mucous lining of the mouth stomatitis AE: mouth mucosal ulceration MP: MP_0003747 According to the Vaccine Adverse Event Reporting System (VAERS), 'mouth ulceration'; is an adverse event that was mentioned in 246 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). lesions through the mucous membrane of the mouth, usually associated with loss of tissue AE: abnormal muscle tone MP: MP_0004142 anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation AE: hypertonia MP: MP_0004143 hypertonia increased muscle tension resulting in stiffness of the muscles in the resting state AE: hypotonia MP: MP_0004144 decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness hypotonia Vaxsafe MS YH Live temperature-sensitive mutant strain; eye drop administration AE: myositis According to the Vaccine Adverse Event Reporting System (VAERS), 'myositis'; is an adverse event that was mentioned in 103 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0004510 inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle myositis AE: muscle inflammation MP: MP_0004511 local accumulation of fluid, plasma proteins, and leukocytes in muscle AE: increased lymphocyte cell number MP: MP_0005013 According to the Vaccine Adverse Event Reporting System (VAERS), 'lymphocytosis'; is an adverse event that was mentioned in 129 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells Nobivac Piro In vitro-cultured supernatant antigens, reduce clinical disease YH Equilis StrepE Live submucosal vaccine; deletions in aroA gene YH AE: diarrhea MP: MP_0005036 abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel diarrhea AE: hypoxia According to the Vaccine Adverse Event Reporting System (VAERS), 'hypoxia' is an adverse event that was mentioned in 566 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0005039 hypoxia reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases AE: sepsis According to the Vaccine Adverse Event Reporting System (VAERS), 'sepsis' is an adverse event that was mentioned in 416 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0005044 presence of various pathogenic organisms, or their toxins, in the blood or tissues sepsis Centre for Ticks and Tickborne Disease, Malawi YH AE: hematuria MP: MP_0005161 According to the Vaccine Adverse Event Reporting System (VAERS), 'hematuria'; is an adverse event that was mentioned in 156 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). hematuria presence of blood in the urine AE: abnormal enzyme level MP: MP_0005319 altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances Theileria parva vaccine YH AE: decreased heart rate MP: MP_0005333 According to the Vaccine Adverse Event Reporting System (VAERS), 'bradycardia' is an adverse event that was mentioned in 359 VAERS reports (0.3%) during1991-2001 (Reference: PMID: 12825543). fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute urinary system AE MP: MP_0005502 functional anomaly of any of the organs involved in the production or excretion of urine AE: decreased body temperature MP: MP_0005534 According to the Vaccine Adverse Event Reporting System (VAERS), 'hypothermia'; is an adverse event that was mentioned in 275 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). less than the level of heat natural to a living being Neospora caninum vaccine YH AE: abnormal body temperature MP: MP_0005535 deviation in the level of heat natural to a living being AE: neuritis MP: MP_0006082 According to the Vaccine Adverse Event Reporting System (VAERS), 'neuritis'; is an adverse event that was mentioned in 195 VAERS reports (0.2%) during1991-2001 (Reference: PMID: 12825543). local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord AE: double vision According to the Vaccine Adverse Event Reporting System (VAERS), 'diplopia'; is an adverse event that was mentioned in 150 VAERS reports (0.1%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0006150 double vision two images are perceived when only a single object is present ImmunoVaccine Technologies, Canada http://www.immunovaccine.com YH AE: hypochromic anemia MP: MP_0008387 According to the Vaccine Adverse Event Reporting System (VAERS), 'hypochromic anemia'; is an adverse event that was mentioned in 109 VAERS reports (<0.1%) during1991-2001 (Reference: PMID: 12825543). hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs AquaVac Vibrio Reference: http://www.spaquaculture.com/default.aspx?pageid=553 YH Killed oral vaccine AE: petechiae According to the Vaccine Adverse Event Reporting System (VAERS), 'hyperventilation' is an adverse event that was mentioned in 539 VAERS reports (0.4%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0008816 petechiae very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage AE: nervous According to the Vaccine Adverse Event Reporting System (VAERS), 'nervousness' is an adverse event that was mentioned in 583 VAERS reports (0.5%) during1991-2001 (Reference: PMID: 12825543). MP: MP_0008912 increased, skittish, behavior induced by stimulation such as handling, touching or noise nervous Babesia canis vaccine YH AE: ecchymosis MP: MP_0009276 According to the Vaccine Adverse Event Reporting System (VAERS), 'ecchymosis' is an adverse event that was mentioned in 1,347 VAERS reports (1.0%) during1991-2001 (Reference: PMID: 12825543). an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis ecchymosis vaccination with a licensed goat and sheep vaccine YH Mycoplasma synoviae vaccine YH vaccination with a licensed fish vaccine YH Local veterinary institutes YH Androstenedione YH vaccination with a licensed cat vaccine YH vaccination with a licensed ferret vaccine YH Giardia duodenalis vaccine YH vaccination with a licensed bird vaccine YH Chlamydophila abortus vaccine YH vaccination with a licensed deer vaccine YH vaccination with a licensed chicken vaccine YH Poulvac FluFend I AI H5N3 RG Chimera H5N3 virus, inactivated in oil-based adjuvant YH USDA YH Canine parvovirus-1 vaccine YH Ovastim YH Increased ovulation/twinning RECOMBITEK rDistemper Canarypox virus-vectored vaccine (HA and F antigens) YH Lawsonia intracellularis vaccine YH Fecundin withdrawn YH Linked to human serum albumin; increased ovulation/twinning CoxAbic Gametocyte antigen(s); transmission blocking through maternal antibody transfer YH Bordetella avium vaccine YH Merial YH http://www.merial.com/ Bovilis, Neoguard Killed tachyzoites, reduces abortion YH RECOMBITEK Canine Parvo YH Modified live virus Eimeria maxima vaccine YH Actinobacillus pleuropneumoniae vaccine YH Eimeria tenella vaccine YH Ovilis Toxovax YH S48 strain with a lost ability to form cysts after passages in mice West Nile-Innovator DNA YH DNA vaccine Leishmania donovani vaccine YH Androvax Increased ovulation/twinning YH Porcilis APP YH Extracted ApxI, ApxII, ApxIII, and outer membrane proteins PUREVAX Ferret Distemper Canarypox virus-vectored vaccine YH PUREVAX Ferret Distemper is a lyophilized ferret vaccine of a recombinant canarypox vector expressing the HA and F glycoproteins of canine distemper virus. Reference: http://www.drugs.com/vet/purevax-ferret-distemper.html. Schering-Plough Animal Health YH http://www.intervet.com/ Livacox Precocious and egg-passaged lines YH Bayer Leverkusen YH http://www.bayer.com/ Vaxsafe MG YH Live temperature-sensitive mutant strain; eye drop administration GonaCon Peptide conjugated to keyhole limpet hemocyanin in mycobacterium-oil adjuvant (AdjuVac); contraceptive vaccine to control wildlife YH registration reported to be in progress Inovocox In ovo delivery using proprietary platform injection system YH Canine distemper virus vaccine YH Leishmune Native fucose-mannose-ligand antigen complex YH Enterisol Ileitis Live oral vaccine YH Coopers Animal Health YH http://www.coopersanimalhealth.com.au/ Vaxstrate withdrawn in 1996 YH LHRH peptide conjugated to ovalbumin; oil emulsion adjuvant Dow AgroSciences YH http://www.dowagro.com/homepage/index.htm?DCSext.das=dowagro.com Newcastle disease virus vaccine YH country YH USA YH USA is a country that exists in north America. Rubella virus vaccine MeSH: D012411 A viral vaccine that protects against infection with Rubella virus. YH vaccine saftey regulation YH A vaccine regulation for vaccine safety. review of vaccine license application A vaccine regulatory process that is for vaccine regulatory agent to review vaccine license application from vaccine producer. YH Actacel Actacel todo: Proteins + Conjugate YH, ZX Avaxim Avaxim todo: Killed virus YH, ZX Avaxim - Pediatric Avaxim - Pediatric todo: Killed virus YH, ZX BCG Vaccine (Freeze-Dried) BCG Vaccine (Freeze-Dried) todo: Live bacteria YH, ZX DT Polio Adsorbed DT Polio Adsorbed todo: Proteins + killed virus YH, ZX Dukoral Dukoral todo: Proteins + killed bacteria YH, ZX Engerix-B Engerix-B todo: Recombinant protein YH, ZX Eolarix Eolarix todo: Live virus todo: assign parent immunogen: M, R YH, ZX Epaxal Epaxal todo: Killed virus YH, ZX FSME - IMMUN FSME - IMMUN todo: Inactivated whole virus YH, ZX todo: assign parent immunogen: TBE Hiberix Hiberix todo: Conjugate YH, ZX Imovax Polio Imovax Polio todo: Killed virus YH, ZX Imovax Rabies Imovax Rabies todo: Killed virus YH, ZX Inactived Poliomyelitis Vaccine - IPV Inactived Poliomyelitis Vaccine - IPV todo: Killed virus YH, ZX Infanrix-hexa Infanrix-hexa todo: Proteins + killed viruses + conjugate YH, ZX Infanrix/Hib Infanrix/Hib todo: Proteins + conjugate YH, ZX Infanrix-IPV Infanrix-IPV todo: Proteins + killed virus YH, ZX Infanrix -IPV/Hib Infanrix -IPV/Hib todo: Proteins + killed virus + conjugate YH, ZX Liquid Pedvax HIB Liquid Pedvax HIB todo: Conjugate YH, ZX Meningitec Meningitec todo: Conjugate YH, ZX Meningococcal Polysaccharide Vaccine, Groups A & C, Menomune A/C Meningococcal Polysaccharide Vaccine, Groups A & C, Menomune A/C todo: Polysaccharide YH, ZX Menjugate Menjugate todo: Conjugate YH, ZX Menomune A/C/Y/W-135 Menomune A/C/Y/W-135 todo: Polysaccharide YH, ZX Mutacol Mutacol todo: Live bacteria YH, ZX Neisvac-C Neisvac-C todo: Conjugate YH, ZX Pediacel Pediacel todo: Proteins, killed virus + conjugate YH, ZX Pneumo 23 Pneumo 23 todo: Polysaccharide YH, ZX Pneumovax 23 Pneumovax 23 todo: Polysaccharide YH, ZX Prevnar Prevnar todo: Conjugate YH, ZX Priorix Priorix todo: Live virus YH, ZX Priorix-Tetra Priorix-Tetra todo: Live virus YH, ZX todo: assign parent immunogen: M, M, R, Var Quadracel Quadracel todo: Proteins + killed virus YH, ZX Recombivax HB Recombivax HB todo: Recombinant protein YH, ZX Rotarix Rotarix todo: Live virus todo: assign parent immunogen: ROT YH, ZX Td Adsorbed Td Adsorbed todo: Proteins YH, ZX Tripacel Tripacel todo: Proteins YH, ZX Twinrix Junior Twinrix Junior todo: Recombinant protein + killed virus YH, ZX Typherix Typherix todo: Polysaccharide YH, ZX Vaqta Vaqta todo: Killed virus YH, ZX Varilrix Varilrix todo: Live virus YH, ZX Varivax III Varivax III todo: Live virus YH, ZX ViVaxim ViVaxim todo: Polysaccharide + killed virus YH, ZX todo: assign parent immunogen: Typh-I + (HA) Vivotif Vivotif todo: Live virus YH, ZX influenza live disorder A causally relatively isolated combination of physical components that is (a) clinically abnormal and (b) maximal, in the sense that it is not part of some larger such combination. Disorders are the physical basis of disease.