definition imported from has_specified_input A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. is_concretization_of Is a relationship between a generically dependent continuant and a specifically dependent continuant. A generically dependent continuant may inhere in more than one entity. It does so by virtue of the fact that there is, for each entity that it inheres, a specifically dependent *concretization* of the generically dependent continuant that is specifically dependent. For instance, consider a story, which is an information artifact that inheres in some number of books. Each book bears some quality that carries the story. The relation between this quality and the generically dependent continuant is that the former is the concretization of the latter. is_specified_input_of A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. has_quality has_specified_output A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. is_realized_by Relation between a realizable and a process. Reciprocal relation of realizes [GOC:cjm] is_manufactured_by c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this. has_function Relation between an independent continuant and a function. realizes is_specified_output_of A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. has_role A relation between a continuant C and a role R. The reciprocal relation of role_of. achieves_planned_objective This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. bearer_of inheres_in role_of A relation between a role R and an entity E. R role_of E iff: R inheres_in E and R is a role planned process A processual entity that realizes a plan which is the concretization of a plan specification. regulator role Regulator role is a regulatory role involved with making and/or enforcing relevant legislation and governmental orders regulation-assigned role Regulation-assigned role is a regulatory role defined by legislation or governmental orders regulatory role Regulatory role is a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body. processed material Is a material entity that is created or changed during material processing. assay A planned process with the objective to produce information about some evaluant material processing A planned process which results in physical changes in a specified input material population a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area organization An organization is a continuant entity which can play roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members. protocol a protocol is a plan specification which has sufficient level of detail and quantitative information to communicate it between domain experts, so that different domain experts will reliably be able to independently reproduce the process. adding a material entity into a target is a process with the objective to place a material entity bearing the 'material to be added role' into a material bearing the 'target of material addition role'. intraperitoneal injection is the injection of a material entity (bearing the administered substance role) into the peritoneum (bearing the target role) of an organism using a syringe material to be added role material to be added role is a protocol participant role realized by a material which is added into a material bearing the target of material addition role in a material addition process peritoneum is the serous membrane that forms the lining of the abdominal cavity syringe a processed material which is used to introduce or draw fluids from a material entity. A syringe is made of a piston and body. the movement of the piston in the body determines the amount/volume of fluid to inject or draw injection injection is process which aims at introducing a compound or a mixture into a material entity (either biological entity or instrument) by relying on devices such as syringe or injector connection, attached or forced into a vascular system (veins of an organism or tubes of a machine) or in a tissue. intraperitoneal administration The administration of a substance into the peritoneum of an organism adding material objective is the specification of an objective to add a material into a target material. The adding is asymmetric in the sense that the target material largely retains its identity assay objective is the specification of an objective to determine a specified type of information about an evaluated entity (independent continuant bearing evaluant role) target of material addition role target of material addition role is a role realized by an entity into which a material is added in a material addition process regulatory agency A regulatory agency is a organization that has responsibility over or for the legislation (acts and regulations) for a given sector of the government. material transformation objective is the objective to create an specific output object from input materials. scattered molecular aggregate A scattered molecular aggregate is a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates material combination is a material processing with the objective to combine two or more material entities as input into a single material entity as output. material combination objective is an objective to obtain an output material that contains several input materials. pathogen challenge A pathogen challenge is the administration of a live pathogenic organism to a host host role host role is a role played by an organism and realized by providing nourishment, shelter or a means of reproduction to another organism within the organism playing the host role material maintenance objective is the objective to maintain some or all of the qualities of a material over time. material maintenance a process with that achieves the objective to maintain some or all of the characteristics of an input material over time anatomical entity An anatomical entity is a material entity that is part of a multicellular organism, and which is large enough so that it forms an identifiable structure in the organism. Specifically, it excludes granular parts of the organism, such as atoms, molecules, cells, which can be removed from the organism without affecting it. It is defined as the union of 'multi-tissue structure', 'body substance' and 'portion of tissue' organism A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. phosphate buffered saline solution Phosphate buffered saline (abbreviated PBS) is a buffer solution commonly used in biochemistry. It is a salty solution containing sodium chloride, sodium phosphate and in some preparations potassium chloride and potassium phosphate. The buffer helps to maintain a constant pH. The concentration usually matches the human body (isotonic). data transformation A data transformation is a process which produces output data from input data collection (of entities of organismal origin) a collection is a bfo:aggregate object, that is a set of material object of the same kind chemical solution A material entity that is made up of at least 2 scattered molecular aggregates, one playing the role of solvent and the other one playing the role of solute. solvent role solvent role is a role played by a chemical entity capable of ensuring the dissolution of another chemical entity, thereby exhibiting solvatation properties solute role solute role is a role played by a chemical entity which is dissolved by another chemical entity (the solvent) when creating a solution storage storage is a process by which material entities are placed in well identified location and possibly under controlled environment in ad-hoc devices/structures in order to preserve and protect them from decay/alteration and maintain availability administering substance in vivo A process by which a substance is intentionally given to an organism antigen is a material entity that has the antigen role assay antigen role Any molecule recognized by the adaptive immune receptors? Recognized means bound with a certain affinity? From GO ag binding:Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. see OBI_1110120 below portion of tissue Anatomical structure, that consists of similar cells and intercellular matrix, aggregated according to genetically determined spatial relationships. multi-tissue structure Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. Body substance Material anatomical entity in a gaseous, liquid, semisolid or solid state, with or without the admixture of cells and biological macromolecules; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. Examples: saliva, semen, cerebrospinal fluid, inhaled air, urine, feces, blood, plasma, lymph. Viruses Bacteria Archaea Eukaryota