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VirmugenDB: A Database of Virulent Genes used for Development of Live Attenuated Vaccines

"Virmugen" is coined here to represent a gene that encodes for a virulent factor of a pathogen and has been proven feasible to make a live attenuated vaccine by knocking out this gene. Not all virulence factors can be used for vaccine development. Currently, VIOLIN includes 225 Virmugens that have been verified to be valuable for vaccine development against 57 pathogens. See detailed curated data:

Statistics: VirmugenDB includes 225 Virmugens for now.

Provenance: The data in VirmugenDB originates from our literature curation and boinformatics analyses.

Citation: Racz R, Chung M, Xiang Z, and He Y. Systematic annotation and analysis of “virmugens” - virulence factors whose mutants can be used as live attenuated vaccines. Vaccine. Available online December 6, 2012. DOI: 10.1016/j.vaccine.2012.11.066.