Table of ROC Areas Under Curve (AUCs)
To evaluate the performance of the Vaxitope epitope prediction program in Vaxign, the Areas Under Curve (AUCs) of the ROC analysis were calculated using individual allele specific PSSMs. The positive and negative testing dataset was obtained from http://mhcbindingpredictions.immuneepitope.org/dataset.html. Specific positive alelles were used to calculate the True Positive Rates, and the negative alleles were used to calculate the False Postive Rates. This table includes results for those MHC alleles that we have randomly chosen for AUC calculation, but it does not include all MHC alleles available in the Vaxign database.
| MHC Allele |
Sequence Length |
AUC |
| HLA B*3501 |
9 |
0.828865 |
| HLA B*2705 |
9 |
0.835768 |
| HLA A*1101 |
10 |
0.839276 |
| HLA A*1101 |
9 |
0.878545 |
| H-2 Dd |
9 |
0.886707 |
| HLA A*0301 |
10 |
0.888508 |
| HLA B*4001 |
9 |
0.893311 |
| HLA A*0301 |
9 |
0.911066 |
| Mamu A*02 |
9 |
0.924069 |
| HLA A*0201 |
10 |
0.928179 |
| HLA A*0201 |
9 |
0.92897 |
| Mamu A*02 |
10 |
0.930062 |
| H-2 Kb |
8 |
0.938811 |
| H-2 Kb |
9 |
0.941873 |
| HLA B*0702 |
9 |
0.944153 |
| HLA B*0702 |
10 |
0.962072 |
| HLA A*0101 |
9 |
0.965481 |
| Mamu A*01 |
8 |
0.968087 |
| H-2 Kk |
8 |
0.970085 |
| Mamu A*11 |
9 |
0.970158 |
| Mamu A*01 |
9 |
0.974998 |
| HLA A*2402 |
9 |
0.977331 |
| Patr B*0101 |
9 |
0.977889 |
| Mamu A*01 |
10 |
0.983409 |
| HLA A*2402 |
10 |
0.983464 |
| HLA B*3501 |
10 |
0.988771 |
| H-2 Db |
9 |
0.990377 |
| Mamu B*17 |
9 |
0.990852 |
| H-2 Kd |
10 |
0.991269 |
| H-2 Kk |
9 |
0.991727 |
| Mamu A*11 |
10 |
0.992015 |
| H-2 Kd |
9 |
0.996438 |
| H-2 Db |
10 |
0.99777 |
| H-2 Ld |
9 |
0.99842 |
| Mamu B*17 |
10 |
0.999134 |
| H-2 Kk |
10 |
0.999164 |
| Mamu B*01 |
9 |
0.999779 |
