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Vaccine Comparison
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Yersinia pestis guaBA mutant vaccine |
| Vaccine Information |
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- guaA
gene engineering:
- Type: Gene mutation
- Description: This guaBA operon is from Yersinia pestis (Oyston et al., 2010).
- Detailed Gene Information: Click Here.
- guaB
gene engineering:
- Type: Gene mutation
- Description: This guaBA operon is from Yersinia pestis (Oyston et al., 2010).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| References |
Oyston et al., 2010: Oyston PC, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS. A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection. Microbial pathogenesis. 2010; 48(5); 191-195. [PubMed: 20096773].
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Yersinia pestis IpxM mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002941
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse, guinea pig
- IpxM
gene engineering:
- Type: Gene mutation
- Description: This IpxM mutant is from Yersinia pestis CO92 (Feodorova et al., 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: subcutaneous injection
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| References |
Feodorova et al., 2007: Feodorova VA, Pan'kina LN, Savostina EP, Sayapina LV, Motin VL, Dentovskaya SV, Shaikhutdinova RZ, Ivanov SA, Lindner B, Kondakova AN, Bystrova OV, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA, Anisimov AP. A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Vaccine. 2007; 25(44); 7620-7628. [PubMed: 17913308].
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Yersinia pestis nlpD mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002942
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- nlpD
gene engineering:
- Type: Gene mutation
- Description: This nlpD mutant is from Yersinia pestis (Tidhar et al., 2009).
- Detailed Gene Information: Click Here.
- Immunization Route: subcutaneous injection
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| References |
Tidhar et al., 2009: Tidhar A, Flashner Y, Cohen S, Levi Y, Zauberman A, Gur D, Aftalion M, Elhanany E, Zvi A, Shafferman A, Mamroud E. The NlpD lipoprotein is a novel Yersinia pestis virulence factor essential for the development of plague. PloS one. 2009; 4(9); e7023. [PubMed: 19759820].
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Yersinia pestis pcm mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002943
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- pcm
gene engineering:
- Type: Gene mutation
- Description: This pcm mutant is from Yersinia pestis (Flashner et al., 2004).
- Detailed Gene Information: Click Here.
- Immunization Route: subcutaneous injection
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| References |
Flashner et al., 2004: Flashner Y, Mamroud E, Tidhar A, Ber R, Aftalion M, Gur D, Lazar S, Zvi A, Bino T, Ariel N, Velan B, Shafferman A, Cohen S. Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates. Infection and immunity. 2004; 72(2); 908-915. [PubMed: 14742535].
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Yersinia pestis smpB/ssrA mutant vaccine |
| Vaccine Information |
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- smpB
gene engineering:
- Type: Gene mutation
- Description: This smpB/ssrA mutant is from Yersinia pestis (Okan et al., 2010).
- Detailed Gene Information: Click Here.
- ssrA
gene engineering:
- Type: Gene mutation
- Description: This smpB/ssrA mutant is from Yersinia pestis (Okan et al., 2010).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| References |
Okan et al., 2010: Okan NA, Mena P, Benach JL, Bliska JB, Karzai AW. The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection. Infection and immunity. 2010; 78(3); 1284-1293. [PubMed: 20065026].
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Yersinia pestis yopH mutant vaccine |
| Vaccine Information |
- Vaccine Ontology ID: VO_0002946
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- YopH from Y. pestis strain: CO92, biovar: Orientalis
gene engineering:
- Type: Gene mutation
- Description: This yopH mutant is from Yersinia pestis CO92 (Bubeck and Dube, 2007).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| References |
Bubeck and Dube, 2007: Bubeck SS, Dube PH. Yersinia pestis CO92 delta yopH is a potent live, attenuated plague vaccine. Clinical and vaccine immunology : CVI. 2007; 14(9); 1235-1238. [PubMed: 17652523].
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